Predictors Of 3pq And Quickboard Performance In Power-Oriented Collegiate Athletes, Brendan Putney

Honors Scholar Theses

The measuring of athletic performance via pre participation experiments has been the norm for a long time from high school sports, all the way to professional athletics. These tests help gauge an athlete's physical growth over the offseason, as well as aid in predicting their potential performance in the future. However, performance may diminish as multiple maximum effort assessments are completed due to fatigue. The purpose of this study was to examine targeted assessments for possible novel qualities as performance predictors. Baseline data was taken from a larger performance enhancement study for analysis. Twenty-six men (age: 25+4 yr; height 1.78+0.07m; …

Generating Induced Pluripotent Stem Cells From Human Fibroblast Utilizing Controlled Expression Of Transcription Factors, Ju-Sung Song

Honors Scholar Theses

Human Embryonic stem cells (hESCs) represent a pluripotent cell population derived from the inner cell mass (ICM) of the blastocyst stage of the developing embryo. Ethical concerns have been raised regarding the derivation process, as the procedure ultimately results in the destruction of the embryos. Recently, alternative approach has been devised that encompasses reprogramming of terminally differentiated cells into an hESC-like state. This process relies on the over-expression of four pluripotency-associated factors, and successfully reprogrammed cells are termed induced pluripotent stem cells (iPSCs). These cells hold great promise for the use in future cell-based therapeutics such as evaluating drug induced …

Growth And Expression Of Halorhodopsin For Application In A Protein-Based Artificial Retina, Megan Ryan Gillespie

Honors Scholar Theses

Halorhodopsin (HR), a light-activated chloride ion pump, demonstrates potential for use as the scaffolding in an artificial retina. Retinal implants are needed to restore vision to people afflicted with ophthalmic diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). A protein-based chloride ion-patch would be utilized by the eye to create an influx of chloride ions, similar to ion concentrations in healthy retinas during the conversion of light stimuli to electrochemical signals. This protein-based retinal prosthesis will directly stimulate the bipolar cells of the retina, replacing the function of damaged photoreceptor cells. Other alternative treatments for AMD and …

Oral Health Needs Assessment Of An Inner-City Homeless Population And Follow-Up Of Dental Referrals, Jennifer R. Jaskolka

Master's Theses

Background: The University of Connecticut (UConn) School of Dental Medicine (SODM) routinely recruits dental students and faculty volunteers to conduct no-cost dental health screenings for transient residents at South Park Inn Homeless Shelter in Hartford, CT. Once screened, patients are referred to UConn or another hospital-based dental clinic in the area for treatment. The purpose of this study was to determine the demographics and oral health needs of the homeless population at South Park Inn and referrals to UConn SODM were followed to verify patient presentation at UCONN SODM. Dental students’ attitudes towards working with the underserved were also assessed. …

Perceived Occlusion And Comfort In Receiver-In-The-Ear Hearing Aids, Sara A. Conrad

Dissertations, 2014-2019

Purpose: In this study participants rated self-perceived occlusion and physical comfort for receiver-in-the-ear (RITE) hearing aids with different sizes of standard domes. Perceived occlusion was rated across listening and own voice conditions. Method: Twenty-one older adults with hearing impairment were fitted with bilateral RITE hearing aids and tested with three dome size conditions: open, plus, and power domes, and one control condition: the participants' own aids. Participants ranked self-perceived occlusion across the dome size conditions as well as across listening and own voice conditions, and also ranked level of physical comfort across dome sizes. Results: Self-perceived occlusion increased as dome …

Headturn Preference Of 10-Month Infants For Familiar And Unfamiliar Signs, Steven Thomas Kulsar

Dissertations, 2014-2019

Most deaf babies born in the United States are born into hearing families and show a developmental lag in spoken language acquisition, reading, writing, and social development when compared to deaf babies of deaf parents or hearing babies of hearing parents, due to limited language access. A modified headturn paradigm has been devised to assess infant preference to various familiar and unfamiliar ASL stimuli, to determine parallels between auditory-spoken and visual-spatial languages. If visual perception of first signs parallels auditory perception of first words, we would expect infants exposed to ASL as their native language to show a preference for …

A Comparison Of Vibrotactile And Air Puff Stimulation For Inducing Swallowing, Kathryn Diane White

Dissertations, 2014-2019

The purpose of this study was to evaluate the effectiveness of two types of non-invasive, sensory stimulation on increasing the rate of swallowing and for inducing cortical activity associated with swallowing. The types of stimulation investigated were vibrotactile stimulation to the external throat area surrounding the laryngeal tissues and oral air puff stimulation to the anterior faucial pillars. A functional near infrared spectroscopy (fNIRS) system measured relative changes in the concentration of oxygenated hemoglobin (HbO) in cortical sensorimotor regions as an indirect measure of brain activity. The experiment included 16 healthy adult participants between the ages of 28 and 60 …

The Effects Of Age On The Mismatch Negativity Response To Differences In Place Of Articulation, Meredith Robotti

Dissertations, 2014-2019

The Mismatch negativity (MMN) response measures the auditory system’s response to change in stimulus. This measurement can be used to identify if the auditory system can physiologically discriminate two speech sounds. To date, studies that have recorded MMNs in response to differing place of articulation show conflicting data. One possibility for the conflicting results is due to the lack of carefully controlled stimuli. The purpose of this study was to evaluate the differences in amplitude and latency between adult and infant MMN responses when manipulating place of articulation for speech. Additionally, this study sought to determine if all adults showed …

Book Review: Dream Of Ding Village By Yan Lianke, Mike Frick

China Beat Blog: Archive 2008-2012

Unsurprisingly, the Chinese government levied a “three nos” ban—no sales, no distribution, and no promotion—against Dream of Ding Village after its publication in 2005. Though the storytelling relies heavily on dream sequences, Yan takes little poetic license when exposing the depth of the state’s culpability in spreading HIV among poor, medically-naïve farmers. He is just as uncompromising when detailing how officials denied responsibility for the ensuing AIDS epidemic, even as they profited from its human tragedy. No one in Ding Village receives medical care, mental health counseling, food assistance, or a chance to hold the blood heads legally accountable. Cast …

Predictors Of Success To Pass The National Physical Therapy Exam: Is There A Correlation Between Gre/Gpa Scores And Success Rates?, Kelsey Taylor

Undergraduate Honors Theses

The Graduate Record Exam (GRE) is an admission criterion for many different graduate programs including the Doctorate of Physical Therapy (DPT). Upon completion of a DPT program, the National Physical Therapy Exam (NPTE) must be passed with a minimum score of 600 in order to practice as a physical therapist. This study analyzes the relationship between GRE and graduate grade point average (GGPA) and NPTE scores to explore the ability of GRE and GGPA scores to predict NPTE success. Similar studies have been done in the past, but the results vary between studies. GRE, GGPA, and NPTE records were gathered …

Associations Between Retinol-Binding Protein 4 And Cardiometabolic Risk Factors And Subclinical Atherosclerosis In Recently Postmenopausal Women: Cross-Sectional Analyses From The Keeps Study, Gary Huang, Dan Wang, Unab I. Khan, Irfan Zeb, Joann E. Manson, Virginia Miller, Howard N. Hodis, Matthew J. Budoff, George R. Merriam, Mitchell S. Harman, Eliot A. Brinton, Marcelle Cedars, Yali Su, Rogerio A. Lobo, Frederick Naftolin, Nanette Santoro, Hugh S. Taylor,, Rachel P. Wildman

Department of Family Medicine

Background: The published literature regarding the relationships between retinol-binding protein 4 (RBP4) and cardiometabolic risk factors and subclinical atherosclerosis is conflicting, likely due, in part, to limitations of frequently used RBP4 assays. Prior large studies have not utilized the gold-standard western blot analysis of RBP4 levels.
Methods: Full-length serum RBP4 levels were measured by western blot in 709 postmenopausal women screened for the Kronos Early Estrogen Prevention Study. Cross-sectional analyses related RBP4 levels to cardiometabolic risk factors, carotid artery intima-media thickness (CIMT), and coronary artery calcification (CAC). Results: The mean age of women was 52.9 (± 2.6) years, and the …

Selectivity Of The Ubiquitin-Binding Modules, Simin Rahighi, Ivan Dikic

Pharmacy Faculty Articles and Research

Ubiquitin-binding modules are constituents of cellular proteins that mediate the effects of ubiquitylation by making transient, non-covalent interactions with ubiquitin molecules. While some ubiquitin- binding modules bind single ubiquitin moieties, others are selective for specific ubiquitin chains of different linkage types and lengths. In recent years, functions of ubiquitin chains that are polymerized through their Lys or N-terminal Met (i.e. linear chains) residues have been linked to a variety of cellular processes. Selectivity of ubiquitin-binding modules for different ubiquitin chain types appears as a key to the distinct regulatory consequences during protein quality control pathways, receptor endocytosis, gene transcription, signaling …

Healthcare Technology: A Strategic Approach To Medical Device Management, Chad A. Kinley

Electronic Theses and Dissertations

The constant evolution of medical technology has increased the demand for managing medical devices to ensure safety and effectiveness. In this paper I will investigate how biomedical engineering has addressed the issue of equipment management and identifies strategies to successfully maintain an inventory of medical devices. Through research, on-the-job experience, and in-depth discussions with various biomedical engineering managers, I have been able to document possible equipment strategies and best practices for managing medical devices. There is really no "one size fits all" to medical equipment management due to the various clinical environments, but there are many aspects that remain necessary …

Creating An Interactive Dnp Project Repository:A Model For Change, Sara D. Guido Dr.

Doctor of Nursing Practice (DNP) Projects

The creation of systems that can provide bridges to information technology requires rethinking old ways of doing business. In the past, individual universities and colleges would accommodate theses and dissertations on their library sites. Some of these sites are public and can be accessed by everyone, while some require university-specific affiliation.

This project aims to apply knowledge and skills related to information systems and technology. With the growth of the DNP clinical doctorate programs, and final outcome projects there is a need for specialized DNP database for a new method of data entry and retrieval for DNP’s. The creation of …

Improved Tumor Contrast Achieved By Single Time Point Dual-Reporter Fluorescence Imaging, Kenneth M. Tichauer, Kimberley S. Samkoe, Kristian J. Sexton, Jason R. Gunn, Tayyaba Hasan, Brian W. Pogue

Dartmouth Scholarship

In this study, we demonstrate a method to quantify biomarker expression that uses an exogenous dual-reporter imaging approach to improve tumor signal detection. The uptake of two fluorophores, one nonspecific and one targeted to the epidermal growth factor receptor (EGFR), were imaged at 1 h in three types of xenograft tumors spanning a range of EGFR expression levels (n  =  6 in each group). Using this dual-reporter imaging methodology, tumor contrast-to-noise ratio was amplified by >6 times at 1 h postinjection and >2 times at 24 h. Furthermore, by as early as 20 min postinjection, the dual-reporter imaging signal …

Examination Of Preseason Hydration Strategy Of Ncaa Division I Men's Soccer Athletes, Lesley Willis

Master's Theses

Context: Dehydration can have negative effects on performance and mood during intense exercise.

Objective: To examine a soccer program to determine the effectiveness of their hydration protocol during preseason training.

Design: 9-day mixed methods study of preseason training sessions (97.3±21.3 min) and scrimmages (123±14.1 min) for men’s soccer athletes on an NCAA division I soccer team with post-hoc interviews of staff members.

Setting: Outdoor soccer field and indoor training facility.

Participants:21 male NCAA division I soccer athletes (age 20±1 years, height 187.5±2 cm).

Main Outcome Measures: Hydration (BML ,U_col­, USG, U_osmo), Mood (thirst, thermal, ESQ, POMS), …

Normal And Mutant Murine Auditory Brainstem Responses (Abrs), Kristin Shearer

Dissertations, 2014-2019

Spatial organization and topographic maps begin in the periphery and are preserved throughout the central auditory system. The Eph and ephrin family of signaling proteins is involved in the patterning and arrangement of auditory afferents which code information about frequency, intensity, and time. The present study utilizes the ABR as a physiological measure of the electrical potentials occurring in the brainstem following acoustic stimulation. We recorded this measure following click and tone pip stimulation in ephrin-B3 and EphA4 deficient mice at 2-3 months of age and compared them to wild type controls. Significant findings included elevated auditory thresholds, prolonged latency …

Do Different Methods Of Hearing Aid Information Delivery Influence Knowledge Acquisition?, Lindsey Ann Parr

Dissertations, 2014-2019

The main purposes of this study were to examine whether or not there was a difference in knowledge acquisition as a function of training method (these included: face-to-face session, DVD, and pamphlet); to determine which information included in hearing aid orientation was commonly known prior to training and which showed the most learning after training; and to evaluate which training method is the most popular among participants. A sample of 65 young college students with no prior hearing aid experience completed a pre- and post-multiple-choice test of hearing aid knowledge and gave their opinion of the hearing aid orientation immediately …

Hip Abductor Strength And Hip External Rotator Strength Effects On Medial Knee Displacement In Post Pubescent Females, Megan A. Barry

Master's Theses

ABSTRACT

Hip Abductor Strength and Hip External Rotator Strength Effects on Medial Knee Displacement in Post-Pubescent Females

Megan A. Barry, University of Connecticut

Purpose: The purpose of the study was to investigate the relationship between hip abductor (ABD) and hip external rotator (ER) strength with medial knee displacement (MKD) when in post-pubescent high school female athletes.

Methods: Twenty-five post-pubescent high school female athletes (age= 16 ±1, mass= 58.6 kg ± 7.4 kg, height= 166 cm ± 8 cm) volunteered to participate in this study. Maximal isometric hip ABD and ER strength were measured using hand-held dynamometry, and MKD …

Sudden Death In Sport At The Secondary School Level: A Perspective Of The Head Football Coach, Benjamin Mcgrath

Master's Theses

Context: Prior research has examined the first aid knowledge and decision making among high school coaches, but little is known about their knowledge of sudden death in sport or their relationship with an athletic trainer. Objective: Evaluate the knowledge of the secondary school football coach regarding sudden death in sport and their relationship with their athletic trainer. Results: There were four themes from the data: level of preparedness, misconceptions about sudden death in sport, activity modification strategies, and positive coach/athletic trainer relationships. Conclusion: The secondary coach is unaware of the potential causes of sudden death in sport …

Impact Of Adiposity Status On The Association Of Regular Statin Use And Increased Number Of Aberrant Crypt Foci, Homaira Rasool

Master's Theses

INTRODUCTION: While animal studies consistently show a preventive role of statin use in colon cancer development, evidence from human studies is conflicting with recent reports suggesting an increased risk of aberrant crypt foci and adenoma. We hypothesize that insufficient control of confounding due to indication bias for prescribing of statins, particularly obesity-induced physiologic dysregulation, might partly explain discrepant results. METHODS: We analyzed data from patients receiving standard colonoscopy at the Colon Cancer Prevention Program of the University of Connecticut Health Center, which was followed by chromoendoscopy for ACF detection. ACF number was categorized at low (RESULTS: Participants who reported regular …

Clinician Approaches To The Diagnosis Of The Patient With Suspected Lyme Disease, Tyler W. Hudon

Master's Theses

No abstract provided.

Raccoon Acclimation Towards Traps And Its Effect On Surveillance And Monitoring Of Zoonotic Diseases, Lindsay Rollend

Master's Theses

Raccoons (Procyon lotor) serve as a source of infection with various pathogens for people, most notably, rabies. Raccoons are specifically targeted for the control of rabies in the United States, primarily due to the 100% fatality rate in humans and animals. There is no cure or treatment for rabies and vaccines may be administered to people if it is administered promptly. In order to evaluate how successful trapping of raccoons is by using conventional methods, motion sensing cameras were placed on traps in order to captured raccoon behaviors. Pictures were coded based on these behaviors (around the trap but not …

Violence During Pregnancy Among Young Married Women In Nepal, Prakrity Silwal

Master's Theses

No abstract provided.

Cholesterol Lowering Effects Of Milk With Added Phytosterols, Laura Kells Cusack

Master's Theses

Foods incorporating plant sterols (PS) reduce Low-density lipoprotein (LDL) on average approximately 10%. PS with a higher lipid solubility may promote greater reductions. We examined the cholesterol lowering effect of a novel triglyceride recrystallized phystosterol (TRP). Twenty subjects (mean ± SD; age, 56 ± 10 years; BMI, 27 ± 5) with elevated LDL (>100 mg/dL) participated in three 4-week phases; Phase I, 2% milk; Phase II, milk with 2.0 grams (g) free PS; Phase III, milk with 2.0 g TRP. Before and after each phase two fasting blood draws were obtained for determination of serum cholesterol. Between the 2% …

The Effects Of Phytosterols On Lipoprotein Particle Size, Laura J. Kunces

Master's Theses

Phytosterols (PS) have become a recent popular medication alternative for treatment of hypercholesterolemia and have proven effective. Whether PS decrease risk of cardiovascular disease through other mechanisms, such as lipoprotein particle size and inflammatory markers, remains unclear. PURPOSE: The primary aim of this study was to examine the effects of two forms of PS in milk on lipoprotein particle size, inflammatory markers and fat-soluble vitamins. METHODS: Twenty subjects (13 males, 7 females; age; 55±6.1 years, height; 169±10 cm, weight; 77.9±16.9 kg, BMI; 27.3) consumed 16oz of cow’s milk daily for 12 weeks. The three sequential four-week phases consisted of 2% …

The Effect Of Different Set-Repetition Protocols On Squat Technique In Resistance Trained Individuals, Ashley Pandit

Master's Theses

The effect of different set-repetition protocols on squat technique in resistance trained individuals.

Pandit, AL, Kraemer, WJ, Hooper, DR.

Purpose: The purpose of this investigation is to determine whether or not the increase in repetitions within a set will change the technique of the exercise, and how repetition number in a set affects exercise technique in resistance trained individuals in three different set-repetition protocols equated by total volume.

Methods: 10 men (24.3 ± 2.8 yrs; 179.7 ± 5.7 cm; 85.5 ± 12.5 kg) and 10 women (23.9 ± 2.4 yrs; 166.2 ± 9.1 cm; 66.8 ± 8.4 kg) were the …

Addressing Congenital Syphilis In Rural Haiti: Beyond Maternal Screening And Treatment, Cheryl Bayart

Master's Theses

No abstract provided.

A Measurement Of Readiness For Tennessee Hospitals To Implement “Meaningful Use” Criteria Resulting From The American Recovery And Reinvestment Act, 2009, Kathryn Wallin Wilhoit

Electronic Theses and Dissertations

In 2009, the American Recovery and Reinvestment Act was signed into law. This legislation provided for monetary rewards for those acute-care hospitals that meet "meaningful use" computerization and reporting criteria.

The study used a descriptive, nonexperimental design to answer three research questions (1) What is the level of readiness to meet "meaningful use" criteria in the Tennessee Hospital Association (THA) member hospitals; (2) What is the level of readiness to meet "meaningful use" criteria in the rural THA member hospitals; and (3) Is there a difference in the readiness to meet "meaningful use" criteria between rural and urban THA member …

A Consensus Model For Electroencephalogram Data Via The S-Transform, Andrew Coady Young

Electronic Theses and Dissertations

A consensus model combines statistical methods with signal processing to create a better picture of the family of related signals. In this thesis, we will consider 32 signals produced by a single electroencephalogram (EEG) recording session. The consensus model will be produced by using the S-Transform of the individual signals and then normalized to unit energy. A bootstrapping process is used to produce a consensus spectrum. This leads to the consensus model via the inverse S-Transform of the consensus spectrum. The method will be applied to both a control and experimental EEG to show how the results can be used …