Medicine and Health Sciences Commons^™

The Effects Of Nicotine Administration On Behavior And Markers Of Brain Plasticity In A Rodent Model Of Psychosis, Marla K. Perna

Electronic Theses and Dissertations

Schizophrenia affects about 1% of the population. A hallmark of the disorder is increased dopamine D2 receptor sensitivity in the brain. Studies have shown that schizophrenics smoke cigarettes at approximately 4 times the rate of the general population. It has been suggested that nicotine use is a form of self-medication for symptoms in schizophrenia. Smoking behaviors typically begin in adolescence. We assessed effects of nicotine on behavior and brain plasticity in an adolescent rodent model of schizophrenia with the goal of identifying targets for smoking cessation. Methods: Rats were neonatally treated with quinpirole (a D2/D3 agonist) or saline and sensitized …

Effects Of Burn Injury On Biological Ethanol And Ethyl Glucuronide Concentrations, Trista Haupt Wright

Electronic Theses and Dissertations

Alcohol is the most abused drug in the United States and most frequently performed assay in forensic laboratories. Alcohol is routinely present in biological specimens from fatal residential fires and forensic toxicologists must interpret if these individuals are impaired by determination of their blood alcohol concentrations on post-incineration blood collected at autopsy. There is no known data available to confirm or refute blood alcohol concentrations and impairment in fire-related deaths. Ethyl glucuronide (EtG), a non-volatile minor ethanol metabolite, may provide a better biomarker for ethanol consumption prior to burn injury. The literature does not address the possibility that ethanol or …

Exploring The Unique Characteristics Of Cancer In Adolescents And Young Adults In Tennessee, Megan Quinn

Electronic Theses and Dissertations

Adolescents and Young Adults (AYAs) ages 15-39 years with cancer have received little attention in the medical and health fields, resulting in a lack of progress for this age group. Little is known about the unique biologic, epidemiologic, and psychosocial issues that play an integral role in the AYA cancer journey. The purposes of this study were to use the Tennessee Cancer Registry for all new cancer cases from 2004-2008 to determine 1) the main types of cancer that affect AYAs in TN, 2) the predictors of late-stage diagnosis of melanoma, and 3) the factors that predict a total thyroidectomy …

Remarkable Resilience Of Teeth (How Are Teeth So Brittle Yet So Resilient), Paul J. Constantino

Biological Sciences Faculty Research

Tooth enamel is inherently weak, with fracture toughness comparable with glass, yet it is remarkably resilient, surviving millions of functional contacts over a lifetime. We propose a microstructural mechanism of damage resistance, based on observations from ex situ loading of human and sea otter molars (teeth with strikingly similar structural features). Section views of the enamel implicate tufts, hypomineralized crack-like defects at the enamel–dentin junction, as primary fracture sources. We report a stabilization in the evolution of these defects, by ‘‘stress shielding’’ from neighbors, by inhibition of ensuing crack extension from prism interweaving (decussation), and by self-healing. These factors, coupled …

Random Inter Stimulus Interval Increases Signal-To-Noise Ratio., Juliane Armstrong

Undergraduate Honors Theses

Incremental improvements are continuously being made to P300-Speller BCI paradigms. Accurate classification depends on a high signal-to-noise ratio (SNR) between the target and nontarget items. Fixed presentation rates produce a large flash-evoked response that persists throughout the recording epoch, which can potentially undermine the classification of P300-responses. By introducing a random interstimulus interval (ISI) to a previously improved P300-Speller paradigm (i.e., Checkerboard Paradigm; CBP) we expect to reduce the deleterious flash-evoked responses and increase the P300 classification SNR. Data were recorded from 32 EEG locations (right mastoid referenced) from 13 subjects using the CBP with two conditions. In the Random …

Clinical Simulation Laboratories: Bridging The Gap Between Academia And The Private Care Hospital Setting., Caitlin Carney

Undergraduate Honors Theses

Many academic medical programs present students with the chance to experience scenario based learning. This is often achieved through the use of clinical simulation laboratories which utilize computer-based scenarios that realistically imitate the human body and how it responds to various situations. This interactive style of learning has proven to be successful at integrating theories taught in textbooks and practice gained through clinical experience without posing any harm to human patients. Literature has shown documentation of the effectiveness of using clinical simulation laboratories in both the academic and clinical setting; however, some clinical facilities have been slow to adapt the …

Eating And Physical Activity Habits Of College Students., Crystal D. D. West

Undergraduate Honors Theses

No abstract.

An Integrated Bioinformatics And Computational Biology Approach Identifies New Bh3-Only Protein Candidates, Robert G. Hawley, Yuzhong Chen, Irene Riz, Chen Zeng

Anatomy and Regenerative Biology Faculty Publications

FoxD4L1 is a forkhead transcription factor that expands the neural ectoderm by down-regulating genes that promote the onset of neural differentiation and up-regulating genes that maintain proliferative neural precursors in an immature state. We previously demonstrated that binding of Grg4 to an Eh-1 motif enhances the ability of FoxD4L1 to down-regulate target neural genes but does not account for all of its repressive activity. Herein we analyzed the protein sequence for additional interaction motifs and secondary structure. Eight conserved motifs were identified in the C-terminal region of fish and frog proteins. Extending the analysis to mammals identified a high scoring …

An Early Assessment Of The Potential Impact Of Texas' "Affiliation" Regulation On Access To Care For Low-Income Women, Peter Shin, Jessica Sharac, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

This analysis provides an initial assessment of the implications for low-income women of Texas' "affiliation regulation," which would bar Planned Parenthood Federation of America (PPFA) clinics from participating in the Texas Women's Health Program (WHP). In 2010, more than 183,000 women were enrolled in the WHP, which provides health screening, family planning and birth control to low-income women, and nearly 106,000 received care through the program. In our analysis of WHP provider data, we find:

• Planned Parenthood (PPFA) clinics are by far the dominant source of care under the WHP. In FY 2010, PPFA clinics accounted for approximately 49 percent …

Revised: An Early Assessment Of The Potential Impact Of Texas’ “Affiliation” Regulation On Access To Care For Low-Income Women, Peter Shin, Jessica Sharac, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

No abstract provided.

Factor Structure Of A Multidimensional Gender Identity Scale In A Sample Of Chinese Elementary School Children, Lu Yu, Dong Xie, Daniel T. L. Shek

Pediatrics Faculty Publications

This study examined the factor structure of a scale based on the four-dimensional gender identity model (Egan and Perry, 2001) in 726 Chinese elementary school students. Exploratory factor analyses suggested a three-factor model, two of which corresponded to "Felt Pressure" and "Intergroup Bias" in the original model. The third factor "Gender Compatibility" appeared to be a combination of "Gender Typicality" and "Gender Contentment" in the original model. Follow-up confirmatory factor analysis (CFA) indicated that, relative to the initial four-factor structure, the three-factor model fits the current Chinese sample better. These results are discussed in light of cross-cultural similarities and differences …

Combining Electrospun Polydioxanone Scaffolds, Schwann Cells, And Matrigel To Improve Functional Recovery After A Complete Spinal Cord Transection In Rats, Ashok Kannan

Theses and Dissertations

Spinal cord injury (SCI) has presented itself as a multifaceted pathology that is largely inhibitory to regeneration, and therefore to functional recovery, even though spinal cord neurons have been found to be innately regenerative. Thus, having identified the key players in the inhibition of this innate regeneration, SCI researchers have focused on two major types of approaches: (1) blocking inhibitory cues and (2) promoting innate regeneration. Schwann cells (SCs) have long been shown to promote and enhance functional recovery after SCI through providing supplemental myelination and trophic and tropic factors to regenerating axons, though singular approaches rarely address the complex …

Spatial Frequency Domain Tomography Of Protoporphyrin Ix Fluorescence In Preclinical Glioma Models, Soren D. Konecky, Chris M. Owen, Tyler Rice, Pablo A. ValdéS, Chris M. Owen, Pablo A. Valdes, David W. Roberts, Kolbein Kolste, Frederic Leblond, Keith D. Paulsen, Brian C. Wilson

Dartmouth Scholarship

Multifrequency (0 to 0.3  mm−1), multiwavelength (633, 680, 720, 800, and 820 nm) spatial frequency domain imaging (SFDI) of 5-aminolevulinic acid-induced protoporphyrin IX (PpIX) was used to recover absorption, scattering, and fluorescence properties of glioblastoma multiforme spheroids in tissue-simulating phantoms and in vivo in a mouse model. Three-dimensional tomographic reconstructions of the frequency-dependent remitted light localized the depths of the spheroids within 500 μm, and the total amount of PpIX in the reconstructed images was constant to within 30% when spheroid depth was varied. In vivo tumor-to-normal contrast was greater than ∼ 1.5 in reduced scattering coefficient for all wavelengths …

Today - May 4, 2012, Loma Linda University

TODAY

Inside this issue:

-- Construction projects impact LLU and LLUMC campuses
-- Public health doctoral nutrition students launches breastfeeding education program in Cameroon
-- School of Nursing opens its doors to alumni during reunion weekend
-- Loma Linda researchers detail method to quantify muscle damage
-- Public health alumna recognized for 'Good Morning America' appearances
-- MBA students compete in Southern California college bowl
-- LLU nutrition researcher featured on 'NBC Latino' show
-- School of Nursing brunch celebrates friends and donors
-- Nurses invited to visit booth celebrating RN pediatric residency program
-- Civil War medicine exhibit headlined with …

A Study Of The Reasons And Functions Of Non-Suicidal Self-Injury (Nssi) Among Students In Hong Kong And United Kingdom, Sze Yiu, Cindy Wong

Bachelor of Social Sciences – Senior Theses

This study examines non-suicidal self-injury (NSSI) in a community sample of adolescents and young adults in Hong Kong and United Kingdom. Non-suicidal self‐injury (NSSI) refers to direct, deliberate destruction of one’s own body tissue in the absence of intent to die. Apart from investigating the reasons and functions of non-suicidal self‐injury (NSSI), this study also examined the gender as well as cultural differences in self‐injurious behaviors. Functional Assessment of Self‐Mutilation (FASM) was used to examine non‐suicidal self-injury (NSSI).

Overall, 17.1% (n=46) out of 269 participants (n=269) endorsed engaging in non-suicidal self‐injury (NSSI) in the past 12 months, with more females …

Effect Of A Multimedia Intervention On Outcomes Expectations And Perceived Self-Efficacy For The Sex Educator Role For Parents/Caregivers Of African American Adolescent Males, Carmon V.N. Weekes

Nursing Theses and Dissertations

Risky sexual behavior among youth is a national concern and places adolescents at high risk for undesirable health outcomes. According to the Youth Risk Behavior Surveillance System, African American males are more likely to engage in intercourse before age 13 than other racial groups. Research reporting positive impact of parent-adolescent sex communication on influencing risky behaviors has rarely included parents of African American adolescent males. A systematic review of the literature examining health literacy in African Americans supported the importance of including non-print sources of information for this population. The purpose of this study was to test the effect of …

Investigating Motor Training In People Who Stutter Using Fnirs, Kristen Michelle Johnson

Masters Theses, 2010-2019

This pilot study investigated motor learning and neuroplasticity in persons who do and do not stutter before and after participation in a phonation onset training protocol. Outcomes included phonation onset time and percent change in oxygenation level of hemoglobin using fNIRS in prescribed brain areas as a result of training. The authors hypothesized that people who stutter (PWS) would 1) exhibit a breakdown in auditory perception to motor production interactions, 2) demonstrate a difference in the way in which they perceive and learn motor information compared to someone who does not stutter (nPWS), and 3) exhibit reduced brain activity correlations …

A Step Backward For Italy's Meritocracy., Ignazio Roberto Marino

Department of Surgery Faculty Papers

Italian scientists have long lamented the lack of resources, political attention, and meritocracy in assigning taxpayers’ money.

Research Brief: "Combat Exposure And Mental Health: The Long-Term Effects Among Vietnam And Gulf War Veterans", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about how combat exposure and exposure to dead, dying, and wounded people can predict decreases in mental health among Vietnam and Gulf War veterans. In practice and policy, the VA can better provide resources for veterans based on their combat exposure, and the VA should take into account varying combat experiences among veterans when providing mental health care. Suggestions for future research include using more precise measurements for combat exposure than the one used in this study.

Virulence Markers Of Helicobacter Pylori In Patients With Diarrhoea-Dominant Irritable Bowel Syndrome., Javed Yakoob, Zaigham Abbas, S. Naz, M. Islam, Waseem Jafri

Department of Medicine

Recent studies suggest that irritable bowel syndrome (IBS) is associated with low-grade inflammation. This study aims to determine the distribution of Helicobacter pylori cytotoxin-associated gene A (cagA) and vacuolating cytotoxin A (vacA) alleles (e.g., s1 and s2) in Patients with diarrhoea-dominant IBS (IBS-D) as the latter causes vacuolation in colonic epithelial cells in vitro. One hundred and seventy Patients meeting Rome III criteria for IBS-D (mean age: 40 +/- 15 years) were enrolled. Gastric biopsy was assessed histologically and DNA extraction was performed by polymerase chain reaction (PCR) for H. pylori genus 16S ribosomal DNA (16S rDNA), cagA and vacA …

Synaptic And Intrinsic Activation Of Gabaergic Neurons In The Cardiorespiratory Brainstem Network, Julie G. Frank, David Mendelowitz

Pharmacology and Physiology Faculty Publications

GABAergic pathways in the brainstem play an essential role in respiratory rhythmogenesis and interactions between the respiratory and cardiovascular neuronal control networks. However, little is known about the identity and function of these GABAergic inhibitory neurons and what determines their activity. In this study we have identified a population of GABAergic neurons in the ventrolateral medulla that receive increased excitatory post-synaptic potentials during inspiration, but also have spontaneous firing in the absence of synaptic input. Using transgenic mice that express GFP under the control of the Gad1 (GAD67) gene promoter, we determined that this population of GABAergic neurons is in …

Advanced Protein Modeling Method: Benchmarking And Applications In Computer-Aided Drug Discovery, Sharangdhar S. Phatak

Dissertations and Theses (Open Access)

Development of homology modeling methods will remain an area of active research. These methods aim to develop and model increasingly accurate three-dimensional structures of yet uncrystallized therapeutically relevant proteins e.g. Class A G-Protein Coupled Receptors. Incorporating protein flexibility is one way to achieve this goal. Here, I will discuss the enhancement and validation of the ligand-steered modeling, originally developed by Dr. Claudio Cavasotto, via cross modeling of the newly crystallized GPCR structures. This method uses known ligands and known experimental information to optimize relevant protein binding sites by incorporating protein flexibility. The ligand-steered models were able to model, reasonably reproduce …

Comparison Of Root Canal Irrigation Systems In Reducing Intracanal Microorganisms Using Saline-An In Vitro Study, Pranav Desai

Theses and Dissertations

Mechanical and chemical debridement plays an important role in reducing intracanal microorganisms. Effective root canal irrigation depends on both the root canal irrigant and irrigation system. The objective of this study was to evaluate the debridement efficiency of four root canal irrigation systems, Endovac®, PiezoFlow™, EndoActivator® and traditional needle irrigation using saline as an irrigant. Seventy-five, single canal, extracted, mature teeth were selected. Teeth were standardized to canal lengths of 15 mm and instrumented to Master Apical File size #40 with 4% taper. Teeth were mounted in a centrifuge tube using PVS impression material. Teeth were randomly divided into four …

Chronic Kidney Disease Educational Sessions: Assessment Of Current Practices And Attendance Barriers And Facilitators, Della Connor

Nursing Theses and Dissertations

Chronic kidney disease (CKD) educational sessions, whether part of a multidisciplinary plan of care or separate entities, have been increasingly utilized over the last 20 years. Although literature reviews exist in which randomized controlled studies concerning CKD educational sessions are addressed, none of the studies reviewed specifically addressed the low attendance rates of CKD educational sessions. The purpose of this research was to describe current and recommended CKD (predialysis) educational interventions and outcomes in controlled and multidisciplinary studies, examine documented issues related to attendance, and determine barriers and facilitators that affect attendance at educational sessions for CKD patients.

Spinal Muscular Atrophy:Clinical Spectrum And Genetic Mutations In Pakistani Children, S. H. Ibrahim, Tariq Moatter, Ali Faisal Saleem

Department of Paediatrics and Child Health

Background: In Pakistan the rate of consanguineous marriages is high, thus, the chance of incidence of autosomal recessive disorders is likely to be high. The aim of this study is to investigate the clinical characteristics and genetics of spinal muscular atrophy (SMA) in children who presented to Aga Khan University, Karachi.
Materials and Methods: This study was a retrospective review of the medical charts of children (neonate: 15 years) with discharge diagnosis of SMA during last 10 years. Demographic features, consanguinity, and diagnostic analysis (including genetic analysis) were noted.
Results: During the study period 67 children had a discharge diagnosis …

The Effect Of Guided Observation On Learning Outcomes In Simulation-Based Learning, Jamil Norman

Nursing Theses and Dissertations

Nurse educators have been faced with the challenge of providing adequate clinical preparation for nursing students. Implementation of simulation-based learning (SBL) has been used to meet these challenges. Current research indicates that students and faculty are both satisfied with simulation; however, faculty concerns with improving student learning during SBL have led to a research intervention on the use of an Observation Guide. The purpose of this research was to examine differences in knowledge, self-confidence, satisfaction, and collaboration between baccalaureate nursing students using an Observation Guide when observing a simulated clinical experience (SCE) and those observers without an Observation Guide. Additionally, …

The Use Of Positive Deviance To Deliver Patient-Centered Care, Jodie Gary

Nursing Theses and Dissertations

What happens when critical care nurses find themselves in situations where patient care needs are not covered by practice guidelines or standard orders or when the needs conflict with those guidelines and orders? Sometimes usual practices such as call the supervisor, call the physician, or follow the protocol just do not meet the needs of the patient at the exact time and place. Experienced critical care nurses often discuss such situations in private; however, there is little information in the literature about the types of situations encountered and the decision- making processes used in these situations. Those discussions that were …

Performance Changes During A Weeklong High Altitude Training Camp In Lowlander Youth Athletes, Jay R. Hydren

Master's Theses

No abstract provided.

Infection With Chlamydia Pneumoniae Alters Calcium-Associated Gene Regulation And Processes In Neuronal Cells And Monocytes: Implications For Alzheimer’S Disease, Keith G. Williams, Juliana Zoga, Susan T. Hingley, Brian J. Balin, Denah M. Appelt, Marcus G. Bell

Research Day

Background: First proposed by Khachaturian in 1994, the calcium hypothesis postulates that sustained disturbance of intracellular calcium is the leading cause of neurodegenerative disorders. Studies showing alteration in calcium signaling in both sporadic and familial Alzheimer’s disease (AD) support this hypothesis. Intracellular calcium signaling is tightly regulated in time, intensity, and space, and is responsible for a variety of neuronal functions. Calcium influx from the extracellular environment modulates calcium levels, as do intracellular stores in the endoplasmic reticulum. The focus of this study was to test various calcium related genes in both monocytes and neuronal cells. Previous studies have shown …

The Effect Of Progressive Non-Aerobic High-Intensity Maximal Effort Exercise (Mee) On The Health-Related Quality Of Life In Patients With Multiple Sclerosis, Olufolake Odutola, Michael L. Kuchera, R T. Dombroski, T Vardy, F Thomas, S O’Brien, P Yagnik, K Wenzel, S Stoll, Bruce C. Stouch, M T. W, I Vargas, Hilda Lai

Research Day

Background: Studies indicate that Multiple Sclerosis (MS) patients are less satisfied with the quality of their lives than healthy individuals in similar circumstances. Common symptoms experienced include fatigue, cognitive dysfunction, pain, spasticity, depression, bladder/bowel dysfunction and sexual dysfunction. Several pharmacological and non-pharmacological methods have been employed for such symptoms to try to increase quality of life and reduce the mortality rate. Non-pharmacological methods recommended for MS patients include lifestyle modifications, exercise programs and physical therapy. MS patients easily fatigue during aerobic exercise but a non-aerobic progressive maximal effort exercise (MEE) protocol consisting of a few short, duration isometric and eccentric …