Medicine and Health Sciences Commons^™

Does She Or Doesn't She?, David B. Nash Md, Mba

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Health Policy Newsletter Spring 2012 Download Full Text Pdf

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Application Of A Novel Method For Assessing Cumulative Risk Burden By County, Jennifer J. Salinas, Manasi Shah, Bassent Abdelbary, Jennifer L. Gay, Ken Sexton

Physician Assistant Studies Faculty Publications

The purpose of this study is to apply the Human Security Index (HSI) as a tool to detect social and economic cumulative risk burden at a county-level in the state of Texas. The HSI is an index comprising a network of three sub-components or “fabrics”; the Economic, Environmental, and Social Fabrics. We hypothesized that the HSI will be a useful instrument for identifying and analyzing socioeconomic conditions that contribute to cumulative risk burden in vulnerable counties. We expected to identify statistical associations between cumulative risk burden and (a) ethnic concentration and (b) geographic proximity to the Texas-Mexico border. Findings from …

The Effects Of Music Genre On Rate Of Perceived Exertion In Aerobics Classes, Hannah Hogue

Honors Theses

Upon entering an exercise facility it would be inconceivable not to hear some form of music playing while people are exercising. Whether music is playing over the loudspeakers, or individuals are listening to their iPods, music is a vital part of exercise for many individuals. With so much emphasis on listening to music during physical activity the question arises, “What makes music such a popular component of exercise?” Many studies have assessed the effects of music on exercise (Elliott, 2007; Karageorghis, 1999; Karageorghis & Priest, 2008; Kravitz, 1994; Matesic & Cromartie, 2002). These studies indicate that music has positive effects …

The Effect Of Socioeconomic Status On Local School Wellness Policy Implementation In Mississippi Public Schools, Rebecca Masters

Honors Theses

In recent years, rates of overweight and obesity have increased dramatically in America due to nutritionally poor diets and more sedentary lifestyles. Research has shown that obesity is a risk factor for numerous other conditions such as stroke, heart disease, cancer, type 2 diabetes, and sleep apnea. Unfortunately, overweight and obesity do not only affect the adults in our nation. Rates of overweight and obesity have also increased among American children. Approximately 17% of American children are obese, which is three times the rate of 1980 (Menifield, Doty, & Fletcher, 2008). In order to improve the overall health of America’s …

Parental Involvement In Speech-Language Intervention, Victoria Beech Finley

Honors Theses

This thesis examines how parents of children who are successful in therapy are involved, from the parent’s perspective. Literature on parental involvement in therapy is limited, especially findings from the parent’s perspective. This thesis follows a phenomenological qualitative design. The investigator interviewed three mothers regarding their participation. The investigator then transcribed the interviews and cyclically analyzed them to find salient themes across all three. There were two shared themes, acceptance and emotions. It is hoped that this study will provide insight for other parents so that they can contribute to their children’s success in speech-language intervention.

Symptom Clusters In Lung Cancer Patients, Debra Rattican

Theses and Dissertations

SYMPTOM CLUSTERS IN LUNG CANCER PATIENTS By Debra Rattican, PhD, RN A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Director: Debra E. Lyon, PhD. Professor and Chair Family and Community Health Nursing The purpose of the study was to examine selected relationships among symptoms common to individuals with lung cancer. The specific aims were: 1) To examine the relationship between the symptoms of dyspnea and anxiety in patients with lung cancer. 2) To examine the relationships among the symptoms of dyspnea, anxiety, and …

Structural Basis For Calmodulin As A Dynamic Calcium Sensor, Miao Zhang, Cameron Abrams, Liping Wang, Anthony Gizzi, Liping He, Ruihe Lin, Yuan Chen, Patrick J. Loll, John M. Pascal, Ji-Fang Zhang

Pharmacy Faculty Articles and Research

Calmodulin is a prototypical and versatile Ca2+ sensor with EF-hands as its high-affinity Ca2+ binding domains. Calmodulin is present in all eukaryotic cells, mediating Ca2+-dependent signaling. Upon binding Ca2+, calmodulin changes its conformation to form complexes with a diverse array of target proteins. Despite a wealth of knowledge on calmodulin, little is known on how target proteins regulate calmodulin’s ability to bind Ca2+. Here, we take advantage of two splice variants of SK2 channels, which are activated by Ca2+-bound calmodulin, but show different sensitivity to Ca2+ for their activation. Protein crystal structures and other experiments show that depending on which …

A Multi-Component Intervention To Reduce Alcohol Consumption In College Freshmen, Kimberley L. Jelinek

Evidence-Based Practice Project Reports

Alcohol consumption is a health concern on all college campuses in the United States. College students’ alcohol consumption is a highly prevalent behavior, with 44% reporting that they are consuming alcohol at the binge level or greater (Wechsler & Nelson, 2008). The purpose of this evidence-based practice (EBP) project was to answer the clinical question: In college freshmen, how does a multi-component intervention influence alcohol consumption over a four-month period? The Transtheoretical Model of Behavioral Change (TTM) and Diffusion of Innovations (DoI) were used to guide the project. Evidence demonstrates that implementing brief intervention, promoting substance-free events, and increasing campus …

Synthesis And Biological Evaluation Of Second Generation Anibamine Analogues As Novel Anti-Prostate Cancer Agents, Shilpa Singh

Theses and Dissertations

Prostate cancer is the most prevalent non-cutaneous cancer among men. Since the 19th century when Virchow first introduced the concept of inflammation in cancer, chemokines and their receptors have garnered a lot of interest. Chemokine receptor CCR5 has been especially implicated in many disease states and recently found to be over expressed in prostate cancer cell lines. Anibamine, a natural CCR5 antagonist discovered in 2004, has been found to have significant anti-prostate cancer activity at micromolar level. To optimize this compound and also discover a novel pharmacophore, exploration of the original structure was carried out. Significant modifications were made to …

Interleukin-1Β Mediates Metalloproteinase-Dependent Renal Cell Carcinoma Tumor Cell Invasion Through The Activation Of Ccaat Enhancer Binding Protein Β, Brenda L. Petrella, Matthew P. P. Vincenti

Dartmouth Scholarship

Effective treatment of metastatic renal cell carcinoma (RCC) remains a major medical concern, as these tumors are refractory to standard therapies and prognosis is poor. Although molecularly targeted therapies have shown some promise in the treatment of this disease, advanced RCC tumors often develop resistance to these drugs. Dissecting the molecular mechanisms underlying the progression to advanced disease is necessary to design alternative and improved treatment strategies. Tumor-associated macrophages (TAMs) found in aggressive RCC tumors produce a variety of inflammatory cytokines, including interleukin-1 b (IL-1b). Moreover, the presence of TAMs and high serum levels of IL-1b in RCC patients correlate …

Prescriptions For Excellence In Health Care Spring 2012 Download Full Pdf

Prescriptions for Excellence in Health Care Newsletter Supplement

No abstract provided.

Deciphering Mechanisms Of Staphylococcal Biofilm Evasion Of Host Immunity., Mark L. Hanke, Tammy Kielian

Journal Articles: Pathology and Microbiology

Biofilms are adherent communities of bacteria contained within a complex matrix. Although host immune responses to planktonic staphylococcal species have been relatively well-characterized, less is known regarding immunity to staphylococcal biofilms and how they modulate anti-bacterial effector mechanisms when organized in this protective milieu. Previously, staphylococcal biofilms were thought to escape immune recognition on the basis of their chronic and indolent nature. Instead, we have proposed that staphylococcal biofilms skew the host immune response away from a proinflammatory bactericidal phenotype toward an anti-inflammatory, pro-fibrotic response that favors bacterial persistence. This possibility is supported by recent studies from our laboratory using …

Dna Methylation Arrays As Surrogate Measures Of Cell Mixture Distribution, Eugene Houseman, William P. Accomando, Devin C. Koestler, Brock C. Christensen, Carmen J. Marsit

Dartmouth Scholarship

There has been a long-standing need in biomedical research for a method that quantifies the normally mixed composition of leukocytes beyond what is possible by simple histological or flow cytometric assessments. The latter is restricted by the labile nature of protein epitopes, requirements for cell processing, and timely cell analysis. In a diverse array of diseases and following numerous immune-toxic exposures, leukocyte composition will critically inform the underlying immuno-biology to most chronic medical conditions. Emerging research demonstrates that DNA methylation is responsible for cellular differentiation, and when measured in whole peripheral blood, serves to distinguish cancer cases from controls.

Effect Of The Total Girl Wellness Program On Wellness Behaviors In Adolescent Females, Jenifer M. Chilton

Nursing Theses and Dissertations

Adolescent females perceive themselves to be healthy but research suggests this population engages in unhealthy and risky behaviors. Health habits established during youth transition into adulthood and may contribute to chronic diseases later in life. Guided by Bandura's Social Cognitive Theory (SCT), the purpose of this study was to test the effect of a comprehensive wellness intervention on overall wellness, physical fitness, and self-efficacy for health promoting behaviors in female adolescents. A multidisciplinary concept analysis of shame suggested components of shame can impact environment, personal factors, and behavior, the key concepts of SCT. An intervention based on SCT and titled …

The Benefits Of Exercise During Pregnancy, Nikelle Holbrook Hunsaker

Undergraduate Honors Capstone Projects

People are often confused about the effects and recommendations of exercise during pregnancy. A review of the literature demonstrates that regular physical activity provides benefits to both mother and fetus during pregnancy. These benefits range from decreasing the risk of gestational diabetes mellitus to improving the mother's psychological well-being and can be obtained without causing harm to the fetus. The recommendations for physical activity during pregnancy include thirty minutes of physical activity on most, if not all, days of the week. These recommendations are the same as those for non-pregnant individuals. Contrary to popular opinion, a sedentary lifestyle during pregnancy …

The Task Force Initiative: Local Interventions At The Department Level—A Key Component Of A Multi-Tiered Approach To Promote Institutional Change, Emily Conant, Patricia Scott, Josef Reum, Alyssa Westring, Susmita Pati, Lucy Tuton, Mary Sammel, Rebecca Speck, Jean Grisso, Stephanie Abbuhl

Health Policy and Management Faculty Posters and Presentations

This NIH Transforming Academic Culture (NIH-TAC) trial is a multi-level coordinated intervention to enhance institutional culture, increase academic productivity, and improve job satisfaction for women faculty. This poster details a task force initiative in which each department and division reviewed their current practices and policies to recommend and implement change. This particular task force resulted in a list of interventions which were disseminated and implemented throughout the institution.

Daily Experiences Of Older Adults With Mild Cognitive Impairment, Elizabeth Hahn

USF Tampa Graduate Theses and Dissertations

Rationale and study aims: Persons with mild cognitive impairment (MCI) experience declines in everyday functioning and cognitive performance greater than what is experienced in normal aging but less than that of dementia. Daily stress and daily memory complaints associated with cognitive deficits may contribute to greater psychological distress in the day-to-day experiences of persons with MCI. However, research examining the occurrence of daily stressors, daily memory complaints and psychological distress in MCI is limited, and it is not clear how the daily processes of stress and affect in persons with MCI compare to cognitively healthy older adults. This dissertation examined …

Inducible Cre Transgenic Mouse Strain For Skeletal Muscle-Specific Gene Targeting, John J. Mccarthy, Ratchakrit Srikuea, Tyler J. Kirby, Charlotte A. Peterson, Karyn A. Esser

Center for Muscle Biology Faculty Publications

BACKGROUND: The use of the Cre/loxP system for gene targeting has been proven to be a powerful tool for understanding gene function. The purpose of this study was to create and characterize an inducible, skeletal muscle-specific Cre transgenic mouse strain.

METHODS: To achieve skeletal muscle-specific expression, the human α-skeletal actin promoter was used to drive expression of a chimeric Cre recombinase containing two mutated estrogen receptor ligand-binding domains.

RESULTS: Western blot analysis, PCR and β-galactosidase staining confirmed that Cre-mediated recombination was restricted to limb and craniofacial skeletal muscles only after tamoxifen administration.

CONCLUSIONS: A transgenic mouse was created that allows …

Function Of Insulin-Like Growth Factor Binding Protein 7 (Igfbp7) In Hepatocellular Carcinoma, Dong Chen

Theses and Dissertations

Title of Dissertation: FUNCTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7(IGFBP7) IN HEPATOCELLULAR CARCINOMA By Dong Chen. Purpose: Hepatocellular carcinoma (HCC) is a highly virulent malignancy with no effective treatment, thus requiring the development of innovative and effective targeted therapies. The oncogene Astrocyte Elevated Gene-1 (AEG-1) plays a seminal role in hepatocarcinogenesis and profoundly downregulates Insulin-like Growth Factor Binding Protein-7 (IGFBP7). The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the relevance of IGFBP7 downregulation in mediating AEG-1 function. Experimental Design: IGFBP7 expression was detected by immunohistochemistry in HCC tissue microarrays by real-time PCR …

Ada News - 05/07/2012, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Exploratory Study Of Immigrant Kenyan Mothers Knowledge, Beliefs And Attitudes About Health And Nutrition, Akua Smith

Health and Kinesiology Theses

The focus of this study was Sub Saharan African women living in the U.S. and their knowledge, beliefs and attitudes about good health and nutrition and how their knowledge, beliefs and attitudes affect their behaviors and the behaviors of their children. Social Cognitive Theory was selected as the best fit behavioral model and was utilized in this study. The research method used for this study was traditional focus groups, which provide a forum for both researcher and participant to expound on the study subject matter through guided discussion, combined with photo voice, a visual elicitation method. In this study the …

Early Term Infant Care: Hospital Utilization And Breastfeeding Practices, Debra Craighead

Nursing Theses and Dissertations

Early term infants (ETI), with gestational ages from 37 to 38 weeks, have higher morbidity and mortality rates when compared with later term infant counterparts born at 39 to 41 weeks. Although this newly identified term infant subcategory is gaining attention, the immediate and long term health outcomes and care needs of ETI remain largely unexplored. The purpose of this research project was to examine the current research documenting ETI health and explore care practices that are currently utilized to promote ETI health. The original research study describes care practices used to promote health for ETIs born in Louisiana in …

Predictors Of Sexual Relationship Power, Communication And Sexual Decision Making Among Latino Couples, Yui Matsuda

Theses and Dissertations

Unintended pregnancy (UP) is increasing among Latinos in the United States. Unintended pregnancy contributes to many negative consequences for infants, mothers and families. Concurrently, various factors affect Latino couples’ sexual relationship power, communication and decision making about family planning, including sexual relationship power, relationship commitment, dyadic adjustment, individual background, and cultural characteristics. Previous research has not focused on understanding the factors that affect Latino couples’ sexual relationship power, communication and sexual decision making from each partner’s perspective. The purpose of this study was to examine the association between sexual relationship power, communication, and sexual decision making from each partner’s perspective …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Broadening the Impact of JPHCOPH

The Use Of Provider Audit And Feedback On Improving Hypertension Control In The Type 2 Diabetic Population, Kara Painton

Evidence-Based Practice Project Reports

As the seventh leading cause of death, diabetes affects more than 25 million Americans and contributes to major cardiovascular diseases and complications (CDC, 2011). The cost of care for these Americans is astounding: $174 billion dollars was spent on diabetes care in 2007 (ADA, 2011). Furthermore, an estimated 75% of patients with type 2 diabetes have concomitant hypertension, and nearly one-half of these patients have uncontrolled hypertension (Thomas & Kodack, 2011; USDHHS, 2011). An initial chart audit at an outpatient, rural clinic in east central Illinois revealed that 90% of the type 2 diabetic population had concomitant hypertension, and only …

Influence Of Diet-And Weight-Related Behaviors And Social Norms On Obesity In Texas Eighth And Eleventh Grade Adolescents, Brianna Moore

Health and Kinesiology Theses

Introduction: Adolescent obesity and overweight is now of critical concern for Texas. The aim of this study was to understand the influence of diet- and weight-related behaviors and perceived social norms on weight status in Texas adolescents. Methods: This study analyzed of 2004-2005 School Physical Activity and Nutrition data. Multinomial logistic regression tested the associations between overweight and obese (compared with underweight/normal) and the influence of diet- and weight-related social norms and behaviors, adjusting for demographics. Results: Certain factors were associated with a decreased risk of obesity: (a) Breakfast skipping (Male/Eleventh grade); (b) Adequate dairy consumption (African American/Eighth grade); and …

Medical School Watercooler Newsletter - May 6, 2012, Lindsey Lyle

Watercooler Newsletter

This is the May 6, 2012 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Seniors Prepare for Graduation, Residency Assignments
• Books Collected During National Library Week Delivered to USA Children's Medical Center
• Dr. Brevard Receives Distinguished Alumnus Award from St. Paul's Episcopal School
• Medical Student Kickball Team Wins Championship Game
• USA Center for Autism and Developmental Disabilities To Host Autism Grand Rounds

Dmft And Its Possible Determinants In The Honduran Population, Patrick T. Cooper

Honors Scholar Theses

Objectives: This study was designed to investigate the dental health status of several communities in Honduras in terms of the DMFT index (decayed missing and filled teeth). Specifically the study focused on comparisons of the Garifuna (a maroon community in Tela) with the people of San Jose, Copan, and others who traveled from other regions to come to a medical clinic. These results were also compared to other populations of developing and developed countries. Through looking at each participant’s DMFT score, many possible correlations to oral health were explored including region, age, gender, snacking, tobacco use, and oral hygiene. …

Do Physicians Contribute To Economic Growth? An Empirical Analysis, Mary Reilly

Honors Scholar Theses

Physicians may contribute to economic growth in two distinct, opposite ways. On the one hand, an efficient number of physicians may keep people healthy, which raises the productivity of laborers and allows them to return to work quickly after an illness. This type of profit-seeking behavior by physicians should raise the growth of the economy. On the other hand, too many physicians may exist in a market area, which leads to supplier-induced demand (SID). The SID may keep laborers out of work for longer periods and thereby negatively impact the growth of the economy. Moreover, the extra number of physicians …