Medicine and Health Sciences Commons^™

Complete Resolution Of Gastric Amyloidosis After Autologous Stem Cell Transplantation., Dinu Cherian, Kristin Braun, Neal Flomenberg, Juan P. Palazzo, David Kastenberg

Division of Gastroenterology and Hepatology Faculty Papers

A 48-year-old female with multiple myeloma (MM) and amyloidosis presented with massive upper gastrointestinal (GI) bleeding one week after autologous stem cell transplantation (autologous-SCT). Esophagogastroduodenoscopy (EGD) demonstrated necrotic, purple, pigmented, friable lesions throughout the stomach (Figure 1a), along with a bleeding ulcer in the cardia (Figure 1b, Video 1) which was successfully treated with epinephrine (1:10,000) injections. Biopsies demonstrated nodular amyloid deposition (Figures 2) which was Congo red positive. The patient had no further hematemesis and was discharged home 4 days later. Ten months after autologous-SCT, EGD revealed a normal stomach (Figure 3, Video 2) with …

The Chilean Pension System At 25 Years: The Evolution Of A Revolution, Gregory J. Buchholz, Alberto Coustasse, Patricio Silva, Peter E. Hilsenrath

Eberhardt School of Business Faculty Articles

The 1981 reform of the Chilean pension system was revolutionary at its time. It was the first instance of a mature public Pay-As-You-Go social security system being converted into a mandatory defined contribution system managed by the private sector. This paper contends that a unique confluence of events were responsible for this change. The rise of a dictatorship in Chile, a struggling public retirement system, and a cadre of Chicago oriented economists determined to make Chile a model free market neoliberal economy. This was later followed by the Washington Consensus and the promotion of Chilean reform by the World Bank. …

Healing Young People Thru Empowerment (H.Y.P.E.): A Hip-Hop Therapy Program For Black Adolescent Males, Adia B. Mcclellan

Browse all Theses and Dissertations

Treating Black adolescent males with disruptive behavior disorders can be challenging for psychologists and other mental health professionals The negative perception of this group within society, as well as the absence of clinical training exploring issues pertinent to Black adolescent males, among other things, may hinder a professional’s ability to effectively work with this population. This doctoral project discussed the research in several areas currently pertinent to Black adolescent males, as well as factors that have historically been oppressive to Black Americans. It then describes several DSM-IV-TR diagnoses and legal classifications associated with Disruptive Behavior Disorders. In addition, research analyzing …

Spot Urine Protein: Creatinine Ratio Versus 24 Hour Urine Protein At Various Levels Of Gfr Patients Referred To A Tertiary Care Hospital Of Pakistan, Absar Ali, Naila Asif, Sonia Yaqub, Waqar Kashif, Diamond Merchant, Iffat Yazdant

Department of Pathology and Laboratory Medicine

OBJECTIVE: To determine the correlation of "random single voided urine protein: creatinine ratio" to "twenty four hour urine protein" at different levels of glomerular filtration rate (GFR) in Pakistani population.

METHODS: A total of 107 patients were included in this cross section study. Patients were divided into five groups according to the GFR. Spot urine protein: creatinine ratio and 24 hour urine protein was measured by the standard methods. The correlation coefficient ( r) between the two was calculated in each group separately.

RESULTS: The GFR in groups 1 to 5 was > or =90, 60-89, 30-59, 15-29, and /minute/1.73 m2 …

Experimental Optic Neuritis Induced By A Demyelinating Strain Of Mouse Hepatitis Virus., Kenneth S. Shindler, Lawrence C. Kenyon, Mahasweta Dutt, Susan T. Hingley, Jayasri Das Sarma

Department of Neurology Faculty Papers

Optic neuritis (ON), an inflammatory demyelinating optic nerve disease, occurs in multiple sclerosis (MS). Pathological mechanisms and potential treatments for ON have been studied via experimental autoimmune MS models. However, evidence suggests that virus-induced inflammation is a likely etiology triggering MS and ON; experimental virus-induced ON models are therefore required. We demonstrate that MHV-A59, a mouse hepatitis virus (MHV) strain that causes brain and spinal cord inflammation and demyelination, induces ON by promoting mixed inflammatory cell infiltration. In contrast, MHV-2, a nondemyelinating MHV strain, does not induce ON. Results reveal a reproducible virus-induced ON model important for the evaluation of …

Editorial, C Nayak

Indian Journal of Research in Homoeopathy

No abstract provided.

Ficus Religiosa: A Multicentric Double Blind Homoeopathic Pathogenetic Trial (Drug Proving) Carried Out By Ccrhfnx01, N Dey, K Das, Yogendra Rai, V Siddiqui, Rajpal Singh

Indian Journal of Research in Homoeopathy

Objective: Objective of the study was to elicit the pharmacodynamic response of the drug, Ficus religiosa on healthy human beings in non-toxic doses. Methodology: Drug was proved through a double-blind method and was a multi-centric study. Trial drug was proved in two potencies (30C and 200C) on 24 volunteers who were selected and declared apparently healthy during their pre-trial medical examination by specialists. The volunteers took 56 doses of each of the two potencies in three stages including one control stage for a varying period. The symptoms generated during the trial period were noted by the volunteers and elaborated and …

Menopausal Flushes: A Bane For Women, Bindu Sharma

Indian Journal of Research in Homoeopathy

This case report highlights the positive role of homoeopathic treatment in the management of the endocrinal syndrome of ′Menopause′. The improvement registered was not only subjective but also on patho-physiological parameters. This is evident from the data with regard to subjective and objective manifestations and pathological investigations recorded at the commencement of treatment and on conclusion of the treatment. The improvement in psychosomatic manifestations was corroborated by improvement in hormonal levels where FSH level came down from 54.61 to 15.72 mIU/ml. The psychosomatic manifestations included anxiety and depression, palpitation, insomnia, memory lapses, mood swings, hot flushes and night sweats; all …

Assessment Of Psychosocial Impact Of Dental Aesthetics, Munizeh Khan, Mubassar Fida

Section of Dental-Oral Maxillofacial Surgery

OBJECTIVE: To assess the psychosocial impact of dental aesthetics using the 'Psychosocial Impact of Dental Aesthetics Questionnaire' (PIDAQ) and self-rated Aesthetic Component (AC) of the Index of Orthodontic Treatment Need (IOTN).

STUDY DESIGN: Cross-sectional study.

PLACE AND DURATION OF STUDY: Dental Section, the Aga Khan University Hospital, Karachi, from August to September 2006.

METHODOLOGY: Adults with no prior orthodontic treatment were asked to complete a modified version of the 'Psychosocial Impact of Dental Aesthetics Questionnaire' (PIDAQ). A total of four variables including 'Dental Self-confidence', 'Social impact', 'Psychological impact' and 'Perceived orthodontic treatment need' were assessed by a series of statements, …

Freedom For The Bulgarian Nurses And A Palestinian Doctor., Lawrence Parish

Department of Dermatology and Cutaneous Biology Faculty Papers

On July 24, 2007, the five Bulgarian nurses and the Palestinian, unjustly accused of infecting Libyan children with the AIDS virus, were freed by the Libyan government. They had spent a tumultuous seven years in prison, much of the time on death row, having been accused of injecting the children with tainted blood they had brought with them. This was not only preposterous but also an impossibility as the particular strain of the AIDS virus had been found in Libya, two years prior. [1]

Punishing My Parents: Juveniles’ Perspectives On Parental Responsibility, Eve M. Brank, Jodi Lane

Department of Psychology: Faculty Publications

Interviews of 147 juveniles in postadjudication residential facilities revealed that the juveniles generally did not believe their parents were responsible for the illegal activities of the juvenile. A vast majority of juveniles said that their parents were not responsible at all and also said that if they had known that their parents would also be punished for their crimes, they would have been less likely to commit the crimes. No patterns emerged for these questions based on the demographic or social characteristics of the juveniles. Implications of the juveniles’ perspective are considered, focusing particularly on the juveniles’ lack of willingness …

Domain-Oriented Reduction Of Rule-Based Network Models, Nikolay M. Borisov, Alexander S. Chistopolsky, James R. Faeder, Boris N. Kholodenko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The coupling of membrane-bound receptors to transcriptional regulators and other effector functions is mediated by multi-domain proteins that form complex assemblies. The modularity of protein interactions lends itself to a rule-based description, in which species and reactions are generated by rules that encode the necessary context for an interaction to occur, but also can produce a combinatorial explosion in the number of chemical species that make up the signaling network. We have shown previously that exact network reduction can be achieved using hierarchical control relationships between sites/domains on proteins to dissect multi-domain proteins into sets of non-interacting sites, allowing the …

Supporting A Community Of Individuals With Intellectual And Developmental Disabilities In Grieving, Sarah Ailey, Marilyn O'Rourke, Susan Breakwell, Anna Murphy

College of Nursing Faculty Research and Publications

Individuals with intellectual and developmental disabilities are living longer and experiencing deaths among their family and peers, yet their grieving is not well recognized. Staff members who provide care for these individuals witness the aging and death of their clients, yet they also receive little preparation to work through issues surrounding bereavement for their clients and themselves. The End of Life Nursing Education Consortium developed a national initiative to improve end-of-life and bereavement care education. Recommendations from the End of Life Nursing Education Consortium were incorporated into a home care/hospice/community health course and practicum for second-degree BSN students. The following …

Resting Energy Expenditure And Delayed-Onset Muscle Soreness After Full-Body Resistance Training With An Eccentric Concentration, Kyle J. Hackney, Hermann J. Engels, Randall J. Gretebeck

College of Nursing Faculty Research and Publications

The purpose of this investigation was to determine the effect of an acute bout of high-volume, full-body resistance training with an eccentric concentration on resting energy expenditure (REE) and indicators of delayed-onset muscle soreness (DOMS). Eight resistance trained (RT) and eight untrained (UT) participants (mean: age = 23.5 years; height = 180.76 cm; weight = 87.58 kg; body fat = 19.34%; lean mass = 68.71 kg) were measured on four consecutive mornings for REE and indicators of DOMS: creatine kinase (CK) and rating of perceived muscle soreness (RPMS). Delayed-onset muscle soreness was induced by performing eight exercises, eight sets, and …

Expanding Circle Of Inhibition: Small-Molecule Inhibitors Of Bcl-2 Asanticancer Cell And Antiangiogenic Agents, Benjamin David Zeitlin, Isaac J. Zeitlin, Jacques E. Nör

All Dugoni School of Dentistry Faculty Articles

The specific targeting of diseases, particularly cancer, is a primary aim in drug development, as specificity reduces unwelcome effects on healthy tissue and increases drug efficacy at the target site. Drug specificity can be increased by improving the delivery system or by selecting drugs with affinity for a molecular ligand specific to the disease state. The role of the prosurvival Bcl-2 protein in maintaining the normal balance between apoptosis and cellular survival has been recognized for more than a decade. Bcl-2 is vital during development, much less so in adults. It has also been noted that some cancers evade apoptosis …

Lsuhsc Facilities Daily Update: September 2008, Lsuhsc Property And Facilities Management

LSUHSC Facilities Daily Updates: 2008

LSUHSC Dailly Facilities Updates from September 2008. These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Lsuhsc Facilities Biweekly Update: September 2008, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2008

LSUHSC Facilities Biweekly Update from September 26, 2008.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Direct Estimation Of Evoked Hemoglobin Changes By Multimodality Fusion Imaging, Theodore J. Huppert, Solomon G. Diamond, David A. Boas

Dartmouth Scholarship

In the last two decades, both diffuse optical tomography (DOT) and blood oxygen level dependent (BOLD)-based functional magnetic resonance imaging (fMRI) methods have been developed as noninvasive tools for imaging evoked cerebral hemodynamic changes in studies of brain activity. Although these two technologies measure functional contrast from similar physiological sources, i.e., changes in hemoglobin levels, these two modalities are based on distinct physical and biophysical principles leading to both limitations and strengths to each method. In this work, we describe a unified linear model to combine the complimentary spatial, temporal, and spectroscopic resolutions of concurrently measured optical tomography and fMRI …

Wavelength Band Optimization In Spectral Near-Infrared Optical Tomography Improves Accuracy While Reducing Data Acquisition And Computational Burden, Matthew E. Eames, Jia Wang, Brian W. Pogue, Hamid Dehghani

Dartmouth Scholarship

Multispectral near-infrared (NIR) tomographic imaging has the potential to provide information about molecules absorbing light in tissue, as well as subcellular structures scattering light, based on transmission measurements. However, the choice of possible wavelengths used is crucial for the accurate separation of these parameters, as well as for diminishing crosstalk between the contributing chromophores. While multispectral systems are often restricted by the wavelengths of laser diodes available, continuous-wave broadband systems exist that have the advantage of providing broadband NIR spectroscopy data, albeit without the benefit of the temporal data. In this work, the use of large spectral NIR datasets is …

Is American Health Care Uniquely Inefficient?, Alan M. Garber, Jonathan Skinner

Dartmouth Scholarship

No abstract provided.

An Approach To The Failed Ankle Arthrodesis, Steven M. Raikin, Venkat Rampuri

Department of Orthopaedic Surgery Faculty Papers

Ankle arthrodesis remains the gold standard of surgical treatment for advanced ankle joint arthritis. Failure can occur as a result of infection, nonunion or malunion, resulting in pain and poor function. This paper offers a systematic approach to preventing, and managing these problems should they occur. Revision arthrodesis performed with a detailed understanding of the appropriate alignment and mechanics of the ankle joint, combined with meticulous attention to understanding and reversing the cause of the failure can result in successful salvage and restoration of function.

Effect Of Diclofenac Suppository On Tramadol Consumption In Posthysterectomy Pain, Aziza Mohammad Hussain, Fauzia A Khan, Lumaan Sheikh

Department of Anaesthesia

OBJECTIVE: To determine reduction in dose of tramadol and side effects in posthysterectomy patients on addition of diclofenac on rectal suppository.

STUDY DESIGN: Randomized double blinded placebo controlled study.

PLACE AND DURATION OF STUDY: The Aga Khan University Hospital, Karachi, Pakistan, from August 2004 to January 2006. Methodology: Seventy ASA I and II females, aged 20 and above, who underwent elective abdominal hysterectomy, were included in this study. Patients received identical looking suppository of either 100 mg diclofenac sodium or placebo after induction of anaesthesia and then 12 hourly for 24 hours. General anaesthesia was standardized and tramadol was given …

Role Of Psoas Compartment And Caudal Epidural Steroid Injection In Spinal Stenosis Patients Associated With Low Back Pain And Lower Limb Radiculopathy, Mueen Ullah Khan, S. Zaki Hussain

Department of Anaesthesia

OBJECTIVE: To study the efficacy, safety and patient satisfaction of psoas compartment and caudal epidural steroid injection in patients with spinal stenosis and lumbosaccral radiculopathy.

METHODS: Patients with a diagnosis of spinal stenosis and lumbosaccral radiculopathy having visual analogue score (VAS) less than five were included in the study. Bilateral psoas compartment and caudal epidural injection was given to all patients. In group-A patients haemodynamics and complications were examined immediately after injection. In group-B the same patients were examined through a questionnaire after eight weeks, for pain relief, duration of pain relief, reduction in painkillers and overall improvement in activities …

The Correlation Between Plasma L-Carnitine And Growth Performance In Suckling Pigs In Respect Of Mrna Expression Of A Carnitine Transporter, Octn2, In Lactating Porcine Mammary Tissues, Boonrit Thongsong, Sarinee Kalandakanond-Thongsong

The Thai Journal of Veterinary Medicine

Two objectives of this study were to investigate the weekly change in plasma L-carnitine concentration during the 28 day suckling period and to determine the relative mRNA expression level of a L-carnitine transporter, OCTN2, in porcine mammary tissue at early and peak lactation. The results showed that the L-carnitine concentration of piglets after giving birth was 3.94±0.13 mg/L. L-carnitine levels on day 7 were significantly decreased (p<0.05) compared to those on the 1st day. On day 14, L-carnitine level increased significantly (p<0.05) to the concentration of 3.99±0.55 mg/L and maintained this level until weaning day. As with the increase in plasma L-carnitine concentration 1 week following suckling age, the body weight also increased significantly (p<0.05). The linear correlation of suckling ages and L-carnitine levels has a significant and positive correlation (R2Adj=0.1328, p<0.05). The mRNA expression of OCTN2 found in these lactating sow mammary tissues showed the relative abundance of this carnitine transporter. It tended to be decreased in lactating mammary tissue of sows at their peak compared to those at early lactation (p=0.065). Therefore, the significant change or maintenance in plasma L-carnitine concentration and body weight gain during suckling period provided an insight into the effects of L-carnitine in suckling piglets. Additionally, the mRNA expression of OCTN2 in the lactating mammary cells will be further investigated in cellular and molecular regulatory mechanisms to transport L-carnitine from dams to their piglets via the mammary glands.

The Evaluation Of Selected 13 Polymorphic Microsatellite Markers For The Parentage Test Of Thai Holstein Cattle, Lerdchai Chintapitaksakul, Rapiphan Uavechanichkul

The Thai Journal of Veterinary Medicine

Nineteen families of 44 Thai Holstein cattle were evaluated for microsatellite characteristics and the parentage test. A total of 13 microsatellite markers were selected from the genome database and the genomic DNAs were isolated and used as templates for amplification. Multiplex PCR of these thirteen markers in a single reaction showed that only ten markers; b1, b2, b3, b4, b6, b7, b10, b11, b12 and b13 could amplify the fragments ranging from 5 to 12. Nine markers were highly informative with PIC of more than 0.5. An accuracy test revealed that seven markers (b2, b4, b6, b7, b10, b11 and …

Effects Of The Renin-Angiotensin Blockade On Renal Functions, Renal Norepinephrine Contents And Oxidative Stress In Cyclosporine Induced Nephrosis Rats, Suvaporn Panasjaroen, Sarinee Kalandakanond-Thongsong, Chollada Buranakarl

The Thai Journal of Veterinary Medicine

The experiment was conducted to investigate the effects of renin-angiotensin blockade on renal function, renal norepinephrine (NE) contents and renal oxidative stress in Cyclosporine A (CsA) induced renal impairment in rats. Rats were assigned into three groups; group 1 (control group), receiving vehicle (propylene glycol) 1 ml/kg./day, subcutaneously (s/c). for 28 days; group 2 (CsA group), receiving CsA 15 mg/kg/day, s/c for 28 days; group 3 (CsA and losartan (LST) group), receiving CsA 15 mg/kg./day, s/c with the administration of LST 10 mg/k.g./day orally for 28 days. The results showed that CsA administration alone elevated mean arterial pressure (MAP), reduced …

J Am Coll Dent 2008 75 3

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

A Functional Collagen Adhesin Gene, Acm, In Clinical Isolates Of Enterococcus Faecium Correlates With The Recent Success Of This Emerging Nosocomial Pathogen, Sreedhar R Nallapareddy, Kavindra V Singh, Pablo C Okhuysen, Barbara E Murray

Faculty, Staff and Student Publications

Enterococcus faecium recently evolved from a generally avirulent commensal into a multidrug-resistant health care-associated pathogen causing difficult-to-treat infections, but little is known about the factors responsible for this change. We previously showed that some E. faecium strains express a cell wall-anchored collagen adhesin, Acm. Here we analyzed 90 E. faecium isolates (99% acm(+)) and found that the Acm protein was detected predominantly in clinically derived isolates, while the acm gene was present as a transposon-interrupted pseudogene in 12 of 47 isolates of nonclinical origin. A highly significant association between clinical (versus fecal or food) origin and collagen adherence (P

Contribution Of The Collagen Adhesin Acm To Pathogenesis Of Enterococcus Faecium In Experimental Endocarditis, Sreedhar R Nallapareddy, Kavindra V Singh, Barbara E Murray

Faculty, Staff and Student Publications

Enterococcus faecium is a multidrug-resistant opportunist causing difficult-to-treat nosocomial infections, including endocarditis, but there are no reports experimentally demonstrating E. faecium virulence determinants. Our previous studies showed that some clinical E. faecium isolates produce a cell wall-anchored collagen adhesin, Acm, and that an isogenic acm deletion mutant of the endocarditis-derived strain TX0082 lost collagen adherence. In this study, we show with a rat endocarditis model that TX0082 Deltaacm::cat is highly attenuated versus wild-type TX0082, both in established (72 h) vegetations (P < 0.0001) and for valve colonization 1 and 3 hours after infection (P or=50-fold reduction relative to an Acm producer) were found in three of these five nonadherent isolates, including the sequenced strain TX0016, by quantitative reverse transcription-PCR, indicating that acm transcription is downregulated in vitro in these isolates. However, examination of TX0016 cells obtained directly from infected rat vegetations by flow cytometry showed that Acm was present on 40% of cells grown during infection. Finally, we demonstrated a significant reduction in E. faecium collagen adherence by affinity-purified anti-Acm antibodies from E. faecium endocarditis patient sera, suggesting that Acm may be a potential immunotarget for strategies to control this emerging pathogen.

Evidence That Α2-Antiplasmin Becomes Covalently Ligated To Plasma Fibrinogen In The Circulation: A New Role For Plasma Factor Xiii In Fibrinolysis Regulation, Michael W. Mosesson, Kevin R. Siebenlist, Irene Hernandez, K. N. Lee, V. J. Christiansen, P. A. Mckee

Biomedical Sciences Faculty Research and Publications

Background:

Plasma alpha₂-antiplasmin (α₂AP) is a rapid and effective inhibitor of the fibrinolytic enzyme plasmin. Congenital α₂AP deficiency results in a severe hemorrhagic disorder due to accelerated fibrinolysis. It is well established that in the presence of thrombin-activated factor XIII (FXIIIa), α₂AP becomes covalently ligated to the distal α chains of fibrin or fibrinogen at lysine 303 (two potential sites per molecule). Some time ago we showed that α₂AP is covalently linked to plasma fibrinogen . That singular observation led to our hypothesis that native plasma factor XIII (FXIII), …