Medicine and Health Sciences Commons^™

Reducing The Public Health Impact Of Bovine Tuberculosis By Controlling Disease Transmission Between Cattle And White-Tailed Deer In Northwestern Minnesota, Barbara Knust

Michigan Bovine Tuberculosis Bibliography and Database

Bovine tuberculosis, caused by infection with Mycobacterium bovis, is a re-emerging zoonotic disease. It has staged a comeback by establishing infections in wildlife and cattle, creating the potential for human disease in locations where it was thought to be under control. In northwestern Minnesota, infected cattle and white-tailed deer were first discovered in 2005. A major bovine tuberculosis eradication campaign is underway in the state, with multiple efforts employed to control M. bovis infection in both cattle and deer populations. In order to effectively eradicate bovine tuberculosis in Minnesota, there is a need for better understanding of the factors …

Effects Of Shielding Adenoviral Vectors With Polyethylene Glycol On Vector-Specific And Vaccine-Mediated Immune Responses, Eric A. Weaver, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Many individuals have been previously exposed to human adenovirus serotype 5 (Ad5). This prior immunity has long been known to hinder its use for gene therapy and as a gene-based vaccine. Given these immunogenicity problems, we have tested whether polyethylene glycol (PEG) can blunt immune effects against Ad5 during systemic and mucosal vaccination. Ad5 vectors were covalently modified with 5-, 20-, and 35-kDa linear PEG polymers and evaluated for their ability to produce immune responses against transgene antigen products and the vector itself. We show that shielding Ad5 with different-sized PEGs generally reduces transduction and primary antibody responses by the …

Ecological Niche Of The 2003 West Nile Virus Epidemic In The Northern Great Plains Of The United States, Michael Wimberly, Michael B. Hildreth, Stephen P. Boyte, Erik Lindquist, Lon Kightlinger

Public Health Resources

Background: The incidence of West Nile virus (WNv) has remained high in the northern Great Plains compared to the rest of the United States. However, the reasons for the sustained high risk of WNv transmission in this region have not been determined. To assess the environmental drivers of WNv in the northern Great Plains, we analyzed the county-level spatial pattern of human cases during the 2003 epidemic across a seven-state region.
Methodology/Principal Findings: County-level data on WNv cases were examined using spatial cluster analysis, and were used to fit statistical models with weather, climate, and land use variables as predictors. …

How Does A Riverine Setting Affect The Lifestyle Of Shellmound Builders In Brazil?, Sabine Eggers, C. C. Petronilho, K. Brandt, C. Jericó-Daminello, J. Filippini, Karl Reinhard

Karl Reinhard Publications

The contact of inland and coastal prehistoric groups in Brazil is believed to have been restricted to regions with no geographical barrier, as is the case in the Ribeira de Iguape valley. The inland osteological collection from the riverine shellmound Moraes (5800–4500 BP) represents a unique opportunity to test this assumption for this region. Despite cultural similarities between riverine and coastal shellmounds, important ecological and site distribution differences are expected to impact on lifestyle. The purpose of this study is thus to document and interpret health and lifestyle indicators in Moraes in comparison to coastal shellmound groups. Specifically we test …

Antibody Responses Of Cervids (Cervus Elaphus) Following Experimental Mycobacterium Bovis Infection And The Implications For Immunodiagnosis, Noel P. Harrington, Om P. Surujballi, John F. Prescott, J. Robert Duncan, W. Ray Waters, Konstantin Lyashchenko, Rena Greenwald

Michigan Bovine Tuberculosis Bibliography and Database

Captive and free-ranging wildlife animals are implicated in the maintenance and transmission of bovine tuberculosis and therefore pose a significant obstacle to eradication of the disease from domestic livestock. The current antemortem diagnostic method, the intradermal tuberculin skin test, is impractical for routine use with many wild animals. Antibody-based assays are particularly attractive because the animals are handled only once and immediate processing of the sample is not required. This report characterizes the antibody responses of red deer-elk hybrids (Cervus elaphus) against Mycobacterium bovis and subsequently evaluates the diagnostic performance of select antigens in a rapid-test format. Sequential …

Toward Using National Cancer Surveillance Data For Preventing And Controlling Cervical And Other Human Papillomavirus-Associated Cancers In The Us, Mona Saraiya, Faruque Ahmed, Mary White, Herschel Lawson, Elizabeth R. Unger, Christie Eheman

Public Health Resources

This supplement, known as the ABHACUS (Assessing the Burden of HPV-Associated Cancers in the United States) supplement, contains 22 articles. Together, these articles provide a comprehensive snapshot of data related to the occurrence and control of multiple cancers that have been associated with the human papillomavirus (HPV). These analyses highlight the burden of HPV associated cancers in the US population as a whole and among vulnerable population subgroups. We anticipate that these findings will be an important resource for enhancing existing strategies for the prevention and control of HPV associated cancers.

HPV is estimated to be responsible for 5.2% of …

Short-Term Memory, Working Memory, And Executive Functioning In Preschoolers: Longitudinal Predictors Of Mathematical Achievement At Age 7 Years, Rebecca Bull, Kimberly A. Espy, Sandra A. Wiebe

Developmental Cognitive Neuroscience Laboratory: Faculty and Staff Publications

This study examined whether measures of short-term memory, working memory, and executive functioning in preschool children predict later proficiency in academic achievement at 7 years of age (third year of primary school). Children were tested in preschool (M age = 4 years, 6 months) on a battery of cognitive measures, and mathematics and reading outcomes (from standardized, norm-referenced school-based assessments) were taken on entry to primary school, and at the end of the first adn third year of primary school. Growth curve analyses examined predictors of math and reading achievement across the duration of the study and revealed that better …

Intraretinal Signaling By Ganglion Cell Photoreceptors To Dopaminergic Amacrine Neurons, Dao-Qi Zhang, Kwoon Y. Wong, Patricia J. Sollars, David M. Berson, Gary E. Pickard, Douglas G. Mcmahon

School of Veterinary and Biomedical Sciences: Faculty Publications

Retinal dopaminergic amacrine neurons (DA neurons) play a central role in reconfiguring retinal function according to prevailing illumination conditions, yet the mechanisms by which light regulates their activity are poorly understood. We investigated the means by which sustained light responses are evoked in DA neurons. Sustained light responses were driven by cationic currents and persisted in vitro and in vivo in the presence of L-AP4, a blocker of retinal ON-bipolar cells. Several characteristics of these L-AP4-resistant light responses suggested that they were driven by melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), including long latencies, marked poststimulus persistence, and a peak …

Questions And Answers: Keeping Herds Free From Bovine Tuberculosis And Protecting The Food Supply

Michigan Bovine Tuberculosis Bibliography and Database

Questions:
What can I do to keep my herd bovine tuberculosis (TB)-free?
How can I make sure that the animals I buy come from a TB-free herd?
How can I make sure that the animals I buy have not been exposed to a TB-infected herd?
Are new animals introduced to my stockyard a threat?
How do I protect calves from disease exposure?
If there is a TB outbreak in my area, are there any additional biosecurity measures, above and beyond best practices that I should take to reduce the chance of my cows getting the disease?
What biosecurity measures can …

Β-Funaltrexamine Inhibits Inducible Nitric-Oxide Synthase Expression In Human Astroglial Cells, Randall L. Davis, Daniel J. Buck, Neda Saffarian, Shekhar Mohan, Udaya Desilva, Samodha C. Fernando, Craig W. Stevens

Samodha C. Fernando Publications

The inducible isoform of nitric-oxide synthase (iNOS) is involved in neuropathogenesis associated with infection and disease in the brain. Hence, there is considerable interest in the identification of therapeutic interventions to prevent iNOS-mediated pathology. Astroglia are a major site of iNOS expression during neuropathogenesis. To mimic a key component of neuroinflammation, human A172 astroglial cells were exposed in vitro to a cytokine mixture containing interferon γ, tumor necrosis factor α, and interleukin-1β, resulting in significant iNOS expression. Next, we assessed the effects of the mu opioid receptor antagonist, β-funaltrexamine (β-FNA), on cytokine induced iNOS expression in human astroglia. β-FNA dose-dependently …

Cancer In American Indian And Alaska Native Young Adults (Ages 20–44 Years): Us, 1999–2004, Hannah K. Weir, Melissa Jim, Loraine D. Marrett, Temeika L. Fairley

Public Health Resources

BACKGROUND. An examination of cancer incidence patterns in American Indians and Alaska Native (AI/AN) young adults may provide insight into their present and future cancer burden.

METHODS. To reduce racial misclassification, incidence data were linked with the Indian Health Service (IHS) patient services database. Age-adjusted cancer incidence rates per 100,000 (AAR) and corresponding rate ratios (RR) for young adults (ages 20-44 years) were compared across IHS regions and for selected cancers within Contract Health Service Delivery Area counties by race (AI/AN vs non-Hispanic whites [NHW]) and sex.

RESULTS. The all-sites cancer incidence rate was lower for AI/ANs …

Punishing My Parents: Juveniles’ Perspectives On Parental Responsibility, Eve M. Brank, Jodi Lane

Department of Psychology: Faculty Publications

Interviews of 147 juveniles in postadjudication residential facilities revealed that the juveniles generally did not believe their parents were responsible for the illegal activities of the juvenile. A vast majority of juveniles said that their parents were not responsible at all and also said that if they had known that their parents would also be punished for their crimes, they would have been less likely to commit the crimes. No patterns emerged for these questions based on the demographic or social characteristics of the juveniles. Implications of the juveniles’ perspective are considered, focusing particularly on the juveniles’ lack of willingness …

Incidence Of Cancers Of The Oral Cavity And Pharynx Among American Indians And Alaska Natives, 1999–2004, Marsha E. Reichman, Janet J. Kelly, Carol L. Kosary, Steven S. Coughlin, Melissa Jim, Anne P. Lanier

Public Health Resources

BACKGROUND. Previous studies identified disparities in incidence rates of cancers of the oral cavity and pharynx between American Indians/Alaska Natives (AI/AN) and non-Hispanic whites (NHW) and differences between various AI/AN populations. Reporting among AI/AN has been hampered by: 1) heterogeneity among various anatomic sites of oral cavity and pharyngeal cancers obscuring unique patterns of individual anatomic sites; 2) race misclassification and under-reporting of AI/AN; and 3) sparseness of data needed to identify regional variations.

METHODS. To improve race classification of AI/AN, data from US central cancer registries were linked with Indian Health Service (IHS) records. AI/AN incidence data …

Gastric Cancer Among American Indians And Alaska Natives In The United States, 1999–2004, Charles Wiggins, David G. Perdue, Jeffrey A. Henderson, Michael G. Bruce, Anne P. Lanier, Janet J. Kelly, Brenda F. Seals, David K. Espey

Public Health Resources

BACKGROUND. Gastric cancer incidence rates for American Indians and Alaska Natives (AI/ANs) historically have exceeded those for non-Hispanic whites (NHWs). Previous reports may have underestimated the true burden of gastric cancer in AI/AN populations because of misclassification of AI/AN race in cancer registries.

METHODS. Population-based cancer registry data from 1999 through 2004 were used to describe gastric cancer incidence in AI/ANs and NHWs in the US. To address misclassification of race, registry data were linked with Indian Health Service administrative records, and analyses were restricted to residents of Contract Health Service Delivery Areas (CHSDA). Disease patterns were assessed …

Questions And Answers: Bovine Tuberculosis Signs And Symptoms

Michigan Bovine Tuberculosis Bibliography and Database

Questions:

What is bovine tuberculosis (TB)?
What animals and species can it affect?
What are the symptoms of TB?
What should I do if my animals show these symptoms?
How does TB get into cattle herds?
Are dairies more susceptible to TB?
How does APHIS test for TB?
How many animals in the United States are tested for TB each year?
Typically, when are animals tested for TB?
Does wildlife spread TB to commercial cattle? W
hat is the risk of TB transmission from local wildlife?
How is TB being managed in wildlife?
How can I find out if the …

Hugo Who? G. F. Arnold’S Alternative Early Approach To Psychology And Law, Brian H. Bornstein, Steven D. Penrod

Department of Psychology: Faculty Publications

Hugo Münsterberg is widely regarded as the founder of the discipline of psychology and law, and the publication of his book On the Witness Stand (1908) is considered the signal event in its founding. However, numerous other researchers were conducting and publishing research on psycholegal topics in the late 1800s and early 1900s, and at least one other book on psychology and law— G. F. Arnold’s Psychology Applied to Legal Evidence and Other Constructions of Law (1906)—appeared prior to the publication of Münsterberg’s work. The present paper contrasts these two seminal publications, focusing on their relevance to the “basic-versus-applied” debate …

Regulation Of The Bioavailability Of Thioredoxin In The Lens By A Specific Thioredoxin-Binding Protein (Tbp-2), Namal P.M. Liyanage, M. Rohan Fernando, Marjorie F. Lou

School of Veterinary and Biomedical Sciences: Faculty Publications

Thioredoxin (TRx) is known to control redox homeostasis in cells. In recent years, a specific TRx binding protein called thioredoxin binding protein-2 (TBP-2) was found in other cell types and it appeared to negatively regulate TRx bioavailability and thereby control TRx biological function. In view of the sensitivity of lens transparency to redox status, proper regulation of TRx bioavailability is of the utmost importance. This study was conducted to examine the presence and function of TBP-2 in human lens epithelial cells (HLE B3). We cloned human lens TBP-2 from a human cDNA library (GenBank accession number AY 594328) and showed …

Distinct Functions Of Autoreactive Memory And Effector Cd4+ T Cells In Experimental Autoimmune Encephalomyelitis, Wassim Elyaman, Pia Kivisäkk, Jay Reddy, Tanuja Chitnis, Khadir Raddassi, Jaime Imitola, Elizabeth Bradshaw, Vijay K. Kuchroo, Hideo Yagita, Mohamed H. Sayegh, Samia J. Khoury

Jay Reddy Publications

The persistence of human autoimmune diseases is thought to be mediated predominantly by memory T cells. We investigated the phenotype and migration of memory versus effector T cells in vivo in experimental autoimmune encephalomyelitis (EAE). We found that memory CD4⁺ T cells up-regulated the activation marker CD44 as well as CXCR3 and ICOS, proliferated more and produced more interferon-γ and less interleukin-17 compared to effector T cells. Moreover, adoptive transfer of memory T cells into T cell receptor (TCR)αβ^-/- recipients induced more severe disease than did effector CD4⁺ T cells with marked central nervous system inflammation and …

Distinguishing Civil And Criminal Institutional Deprivations Of Liberty: An Analysis Of Expressive Functions, Marc W. Pearce

Department of Psychology: Dissertations, Theses, and Student Research

A basic function of the criminal justice system is to impose legal punishment through deprivations of liberty. Because deprivations of liberty that flow from civil institutions are not punitive, the distinction between civil and criminal institutional deprivations of liberty arguably hinges on the concept of punishment. Punishment, in turn, may be distinguished from non-punitive sanctions based on its unique expressive function; that is, punishment is defined in part by the special feelings of resentment and judgments of disapproval that it expresses. These feelings and judgments have been labeled “condemnation.” This dissertation explores whether condemnation can be translated into an empirical …

Temperament, Parenting, And Prosocial Behaviors: Applying A New Interactive Theory Of Prosocial Development, Meredith Mcginley

Department of Psychology: Dissertations, Theses, and Student Research

The primary purpose of the current study was to examine whether theoretically based interactions between dimensions of children’s temperament and maternal socialization predicted children’s and early adolescents’ prosocial (i.e, helping) behaviors. A new theory was derived by examining how an existing interactive model of early moral development, Kochanska’s (1993) theory of early conscience internalization, would apply to the prediction of prosocial behaviors. Aspects of child temperament and maternal socialization were thought to operate in a different manner from Kochanska’s theory. Unlike early conscience internalization, fearful temperament and parental punishment do not appear to promote prosocial behavior. Moreover, it was thought …

Anxiety And Emotion Dysregulation In Daily Life: An Experience-Sampling Comparison Of Social Phobia And Generalized Anxiety Disorder Analogue Groups, Nathan Alan Miller

Department of Psychology: Dissertations, Theses, and Student Research

Recent research suggests the presence of both common and disorder-specific emotion regulation deficits across the anxiety disorders (Turk et al., 2005), including those that may be uniquely characteristic of social phobia (SP; Kashdan & Breen, 2008; Kashdan & Steger, 2006; Turk et al., 2005). The purpose of the present study was to replicate and expand upon this growing literature in important directions. The initial portion of this study involved administration of relevant self-report symptom, emotion, and emotion regulation survey measures to a large undergraduate sample (N = 784). Scores on several symptom measures were used to create a SP analogue …

Comparison Of The Contributions Of Heat-Labile Enterotoxin And Heat-Stable Enterotoxin B To The Virulence Of Enterotoxigenic Escherichia Coli In F4ac Receptor-Positive Young Pigs, Joseph Erume, Emil M. Berberov, Stephen D. Kachman, Michael A. Scott, You Zhou, David H. Francis, Rodney A. Moxley

School of Veterinary and Biomedical Sciences: Faculty Publications

In swine, the most common and severe enterotoxigenic Escherichia coli (ETEC) infections are caused by strains that express K88 (F4)⁺ fimbriae, heat-labile enterotoxin (LT), heat-stable enterotoxin b (STb), and enteroaggregative E. coli heat-stable toxin 1. Previous studies based on a design that involved enterotoxin genes cloned into a nontoxigenic fimbriated strain have suggested that LT but not STb plays an important role in dehydrating diarrheal disease in piglets study, we compared these two toxins in terms of importance for piglets >1 week old with a study design that involved construction of isogenic single- and double-deletion mutants and inoculation of …

Alcohol And Other Drugs, National Institute On Alcohol Abuse And Alcoholism

Public Health Resources

Addictive disorders represent a major health issue both in the United States and worldwide. Because alcohol and drug dependence are likely to co-occur, exploring how alcohol addiction may relate to and interact with other addictions is important. Current research is exploring the underlying causes of addiction, and why alcohol and other drug use disorders co-occur so frequently, as well as how behavioral and drug therapies can best treat these disorders. There is no “magic bullet” for treating addiction—no treatment will work for everyone in every situation. More research is needed to identify effective treatments for different populations, especially youth, older …

Assessment Of Risk Associated With The Minnesota Proposed Plan For Split-State Status For Mycobacterium Bovis (Bovine Tuberculosis)

Michigan Bovine Tuberculosis Bibliography and Database

In July 2005, a Minnesota beef herd tested positive for Mycobacterium bovis (M. bovis) and was officially declared infected with bovine tuberculosis (TB). This was the first infected herd identified since Minnesota’s Accredited Free (AF) status was obtained in 1976. Subsequent testing identified infection in white-tailed deer and several cattle herds adjacent to this index herd. In February 2008, Minnesota declared its 11th infected cattle herd, resulting in the downgrade of the entire State’s TB status to Modified Accredited (MA).
In an effort to minimize the impact of MA status to the State and producers, Minnesota initiated the …

Transmembrane Domain Length Of Viral K+ Channels Is A Signal For Mitochondria Targeting, Jorg Balss, Panagiotis Papatheodorou, Mario Mehmel, Dirk Baumeister, Brigitte Hertel, Nicolas Delaroque, Frank C. Chatelain, Daniel L. Minor Jr., James L. Van Etten, Joachim Rassow, Anna Moroni, Gerhard Thiel

James Van Etten Publications

K⁺ channels operate in the plasma membrane and in membranes of organelles including mitochondria. The mechanisms and topogenic information for their differential synthesis and targeting is unknown. This article describes 2 similar viral K⁺ channels that are differentially sorted; one protein (Kesv) is imported by the Tom complex into the mitochondria, the other (Kcv) to the plasma membrane. By creating chimeras we discovered that mitochondrial sorting of Kesv depends on a hierarchical combination of N- and C-terminal signals. Crucial is the length of the second transmembrane domain; extending its C terminus by >2 hydrophobic amino acids redirects Kesv …

Supracutaneous Vibrotactile Perception Threshold At Various Non-Glabrous Body Loci, Miriam Bikah, M. Susan Hallbeck, John H. Flowers

Department of Psychology: Faculty Publications

Researchers at the University of Nebraska–Lincoln are currently designing a wearable/portable neutron detector. As an alerting mechanism, the device will transmit vibration to the wearer’s skin in the presence of hazardous levels of neutron radiation. The present study was designed to help in the ergonomically correct body placement of the neutron detection device while providing numerical values for vibratory thresholds at the surface of various non-glabrous body loci. The aim of the study was to investigate the underlying effects of locus stimulated, amount of subcutaneous fat around a specific body site and gender on low frequency vibration thresholds. Thirty-six participants, …

Exploiting A Research Underclass In Phase 1 Clinical Trials, Carl Elliott, Roberto Abadie

Department of Sociology: Faculty Publications

In November 1996, the Wall Street Journal reported that Eli Lilly was paying homeless alcoholics from a local shelter to participate in safety testing of new drugs at its trial site in Indianapolis.1 “These individuals want to help society,” asserted Lilly’s director of clinical pharmacology. The subjects, however, said they took part for easy money and free room and board. Although Lilly reportedly offered the lowest per diem in the business, it managed to attract poor subjects from all over the country.1 The medical director of the local Homeless Initiative Program said Lilly had created a “shadow economy” of paid …

Recombinant Mycobacteria Overexpressing D-Alanine Ligase Gene And Uses Therefore: United States Patent No. Us 7,371,571 B2, Raul G. Barletta, Zhengyu Feng

School of Veterinary and Biomedical Sciences: Faculty Publications

Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic mycobateria are provided. These strains overproduce enzymes involved in the synthesis and incorporation of D-alanine into mycobacterial peptidoglycan, the backbone of the mycobacterial cell wall. These overproducing strains may be used as reference strains in in vitro screening methods to identify antimycobacterial agents.

Tendinopathy Discrimination By Use Of Spatial Frequency Parameters In Ultrasound B-Mode Images, Gregory R. Bashford, Nicholas Tomsen, Shruti Arya, Judith M. Burnfield, Kornelia Kulig

Biomedical Imaging and Biosignal Analysis Laboratory

The structural characteristics of a healthy tendon are related to the anisotropic speckle patterns observed in ultrasonic images. This speckle orientation is disrupted upon damage to the tendon structure as observed in patients with tendinopathy. Quantification of the structural appearance of tendon shows promise in creating a tool for diagnosing, prognosing, or measuring changes in tendon organization over time. The current work describes a first step taken towards this goal—classification of Achilles tendon images into tendinopathy and control categories. Eight spatial frequency parameters were extracted from regions of interest on tendon images, filtered and classified using linear discriminant analysis. Resulting …

Clozapine And Olanzapine Exhibit An Intrinsic Anxiolytic Property In Two Conditioned Fear Paradigms: Contrast With Haloperidol And Chlordiazepoxide, Alexa Mead, Ming Li, Shitij Kapur

Department of Psychology: Faculty Publications

Psychotic fear and anxiety disturbances are seen at a relatively high frequency in patients with schizophrenia. Atypical anti-psychotics are believed to show superior efficacy in reducing these symptoms. However, clinical and preclinical evidence regarding their anxiolytic efficacy has been mixed. In this study, we evaluated the possible anxiolytic property of two atypicals, clozapine and olanzapine, and compared them with typical haloperidol and chlordiazepoxide (a prototype of sedative-anxiolytic drug) in two preclinical models of fear. In Experiment 1, we used a fear-induced passive avoidance and conditioned place aversion paradigm and examined the effects of clozapine (20 mg/kg, sc), haloperidol (0.05 mg/kg, …