Medicine and Health Sciences Commons^™

Neural Substrates Of Sound–Touch Synesthesia After A Thalamic Lesion, Michael S. Beauchamp, Tony Ro

Publications and Research

Neural plasticity induced by stroke can mediate positive outcomes, such as recovery of function, but can also result in the formation of abnormal connections with negative consequences for perception and cognition. In three experiments using blood-oxygen level dependent (BOLD) functional magnetic resonance imaging, we examined the neural substrates of acquired auditory-tactile synesthesia, in which certain sounds can produce an intense somatosensory tingling sensation in a patient with a thalamic lesion. Compared with nine normal controls, the first experiment showed that the patient had a threefold greater BOLD response to sounds in the parietal operculum, the location of secondary somatosensory cortex. …

Gender Specific Differences In The Pros And Cons Of Smoking Among Current Smokers In Eastern Kentucky: Implications For Future Smoking Cessation Interventions, Dana A. Hazen, David M. Mannino, Richard Clayton

Preventive Medicine and Environmental Health Faculty Publications

This study investigated gender differences in the perceived “pros” and “cons” of smoking using the constructs of decisional balance (DB) and stage of change from the Transtheoretical Model. The population distribution for stage of change among a population-based, cross-sectional survey of 155 current smokers over 40 years was: precontemplation (22.6%), contemplation (41.9%), preparation (35.5%). Results of stepwise regression models indicated significant gender differences in DB were in the preparation stage of change; scores on the DB measure increased 3.94 points (95% CI: 1.94, 5.93) for male smokers. Interventions targeting the “pros” and “cons” of smoking may need to be gender …

Ada News - 12/08/2008, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Bullying Of Medical Students In Pakistan: A Cross-Sectional Questionnaire Survey., Syed Ahmer, Abdul Wahab Yousafzai, Naila Bhutto, Sumira Alam, Amanullah Khan Sarangzai, Arshad Iqbal

Department of Psychiatry

Background: Several studies from other countries have shown that bullying, harassment, abuse or belittlement are a regular phenomenon faced not only by medical students, but also junior doctors, doctors undertaking research and other healthcare professionals. While research has been carried out on bullying experienced by psychiatrists and psychiatry trainees in Pakistan no such research has been conducted on medical students in this country. Methodology/Principal Findings: We conducted a cross-sectional questionnaire survey on final year medical students in six medical colleges of Pakistan. The response rate was 63%. Fifty-two percent of respondents reported that they had faced bullying or harassment …

Today - December 8, 2008, Loma Linda University

TODAY

Inside this issue:

-- Loma Linda University Medical Center plastic surgeon gains national recognition
-- Spiritual care workshop planned for LLU students, faculty
-- BALL, BHPSA, BSA hold 25th annual spiritual retreat
-- Campus community internal newsletter available online
-- Center for Spiritual Life & Wholeness begins new television program on LLBN
-- Medical help wanted by Scheer Memorial Hospital in Nepal
-- Savannah Edwards receives philanthropy award
-- Compassion Alive: ‘La Escuelita’ gets a facelift
-- GIS Day 2008
-- INNERWEAVE: The Wholeness Story
-- Whirlwind of activities hits Loma Linda University Children’s Hospital
-- East Campus celebrates grand …

Scan-Rescan And Intra-Observer Variability Of Magnetic Resonance Imaging Of Carotid Atherosclerosis At 1.5 T And 3.0 T, Arvin Vidal, Yves Bureau, Trevor Wade, J David Spence, Brian K Rutt, Aaron Fenster, Grace Parraga

Medical Biophysics Publications

Carotid atherosclerosis measurements for eight subjects at baseline and 14 +/- 2 days later were examined using 1.5 T and 3.0 T magnetic resonance imaging (MRI). A single observer blinded to field strength, subject and timepoint manually segmented carotid artery wall and lumen boundaries in randomized images in five measurement trials. Mean increases in the signal-to-noise ratios (SNR) for T1-weighted images acquired at 3.0 T compared to 1.5 T were 90% (scan) and 80% (rescan). Despite significantly improved SNR and contrast-to-noise ratios (CNR) for images acquired at 3.0 T, vessel wall volume (VWV) intra-observer variability was not significantly different using …

Glypican-1 Modulates The Angiogenic And Metastatic Potential Of Human And Mouse Cancer Cells, Takuma Aikawa, Chery A. Whipple, Martha E. Lopez, Jason Gunn, Alison Young, Arthur D. Lander, Murray Korc

Dartmouth Scholarship

Cells isolated from many types of human cancers express heparin-binding growth factors (HBGFs) that drive tumor growth, metastasis, and angiogenesis. The heparan sulfate proteoglycan glypican-1 (GPC1) is a coreceptor for HBGFs. Here we show that both cancer cell–derived and host-derived GPC1 are crucial for efficient growth, metastasis, and angiogenesis of human and mouse cancer cells. Thus downregulation of GPC1 in the human pancreatic cancer cell line PANC-1, using antisense approaches, resulted in prolonged doubling times and decreased anchorage-independent growth in vitro as well as attenuated tumor growth, angiogenesis, and metastasis when these cells were transplanted into athymic mice. Moreover, athymic …

Designing An International Friendship Model For Children, Charlotte Martins

Theses and Graduate Projects

In 2006 this writer traveled to Windhoek, Namibia to take the course Walking the Truth; Culture, Gender and HIV/AID,S in Sub-Saharan Africa. As part of that class each student was assigned to work with an organization or individual whose mission was working with HIV/AIDS patients or there families. It was from this experience that the project was born. The purpose of this project is to design a friendship model that links children of middle school age from different cultures and different nations together through letter writing.

Firearms And Children: A Public Health Issue, Janet M. Benz

Theses and Graduate Projects

This is the time for nurses as individuals and collectively as a profession to realize their obligation to society in regards to the injury and death caused by firearms. Not one population or single community is immune from gun violence in America; it is an epidemic that does not discriminate. There are monumental implications for both nurses in practice and leadership to make a difference when it comes to changing policy from a public health perspective to reduce gun violence and save lives. In this project, Margaret Newman's (1994) theory of Health as Expanding consciousness is applied to the role …

Supporting Charge Nurses In Their Leadership Development: A Framework For Education, Sonja Rivers

Theses and Graduate Projects

This project examines the complex and multifaceted role of the charge nurse in the acute care setting and compares the charge nurse's role to that of a front line leader. Charge nurse competencies are identified and leadership skills and behaviors necessary for the charge nurse to function effectively in the role are explored including those related to emotional intelligence. A conceptual framework for education is developed using Botatzis' Theory of Self-Directed Learning, and Swanson's middle range theory of caring, Nursing as Informed Caring for the Well-Being of others.

Achieving Cultural Competence Through The Use Of Community Health Workers: Open Cities Health Center's Approach, Dorii Gbolo

Theses and Graduate Projects

The purpose of this project is to identify objectives necessary for incorporating a Community Health Worker (CHW) program within an urban Federally Qualified Community Clinic setting, for the purpose of enhancing the culturally specific care provided by the clinic. CHWs offer our current fragmented and complex health care system an opportunity to improve the health of underserved populations in our country. The use of CHWs dates back to the 1960's as an attempt to expand health care to the underserved residing in poor communities.

If one is poor, an immigrant, or just different from the norms of our society receiving …

How One's Cultural View Of Obesity Affects Care Giving, Marietta Kramper Farris

Theses and Graduate Projects

As the United States faces the challenge of obesity it is important to understand the cultural aspects of caring for these patients. Leininger's Transcultural Nursing Theory is used as a framework for the development of an educational program for health care professionals. The obese patients receiving care should be able to count on their care givers to appreciate the biases, stigmatization and discrimination of the culture in which they live. A review of the history of cultural views of obesity and thinness is used as a starting point. An in-depth review of related research is presented to detail bias, stigmatization, …

Supporting Lactation: Beyond Nutrition, Desiree' M. Bertilrud

Theses and Graduate Projects

Breastfeeding provides nutritional, health, immunological, psychological, economical and environmental benefits. Despite the abundance of scientific evidence and public health campaigns, the United States fails to meet national goals for breast feeding rates. Numerous barriers to lactation are identified and explored. However, by far, returning to work has the greatest impact on the duration of breastfeeding. Employers and organizations who support breastfeeding are the recipients of a multitude of benefits. The purpose of this project is to identify the strategic steps to establish a lactation room in an outpatient clinic setting for employees to support maternal-child relationships, foster employee satisfaction, and …

Teaching The Teacher Program To Assist Nurse Managers To Educate Nursing Staff In Ecuadorian Hospitals, Sheri P. Palmer, Sondra Heaston

Faculty Publications

Continuing education for hospital staff nurses is a concern worldwide. Current research shows that continuing education among nurses can positively affect patient outcomes (O’Brien, T., Freemantle, N., Oxman, A, et al., 2002. Interactive continuing education workshops or conferences can improve professional practice and patient outcomes. Journal of Evidence Based Nursing. 26 (5)). Seeing a need for improved patient outcomes among hospitals in Ecuador, we conducted a teaching the teacher program to assist nurse managers to carry-out continuing education in their hospital system. This teaching the teacher program was established through the collaboration between one College of Nursing in Utah, USA …

Season Of Birth And Risk For Schizophrenia, Seth Roberts

Theses and Dissertations

Background: Schizophrenia is a chronic, debilitating mental disorder characterized by positive (e.g., hallucinations, delusions) and negative (e.g., catatonia, flat affect) signs and symptoms. Many studies suggest that individuals born in winter or spring months are at increased risk for schizophrenia. Study Objectives: 1) To determine whether season of birth affects risk for schizophrenia in the Irish Study of High Density Schizophrenia Families (ISHDSF). 2) To examine, by computer simulation, power to detect genetic associations with schizophrenia under a variety of conditions and using different analytic strategies. 3) To test whether specific genes are associated with schizophrenia in the Irish Case …

The Ability Of Children With Language Impairment To Understand Emotion Conveyed By Prosody In A Narrative Passage, Chelsea Celeste Voorhees

Theses and Dissertations

Several recent studies indicate that children with Language Impairment (LI) have difficulty recognizing and inferring meaning from emotional prosody. The present study is a replication investigating the ability of children with LI to recognize emotion conveyed by prosody in an orally presented narrative passage. Twenty-two children with LI and twenty-two age matched peers ranging from age 7;0 to 10;11 (M= 9.11, SD= 2.54) were selected to participate. Participants listened to recordings of a seven sentence passage read by actors to express happiness, anger, sadness, and fear. The children's task was to identify which emotion the speaker portrayed. Scores obtained from …

Fetal And Early Neonatal Death: Do The Determinants Vary?, Ashley Carter

Theses and Dissertations

Purpose: To compare the determinants and distribution of fetal and early neonatal deaths in the Commonwealth of Virginia. Background: Much attention is devoted to reducing the infant mortality rate which was declining up until 2002. The recent rise was parsed and found to stem from an increase in deaths during the early neonatal period. Fetal deaths are not well understood and are not routinely included when evaluating infant mortality. Methods: Using data collected from 2001 to 2006 fetal death and linked infant birth and death certificates by the Virginia Department of Health, crude mortality rates and leading causes of death …

Effect Of Metro Living On Oral Cancers In Virginia: 2001-2005, Preeti Sastry

Theses and Dissertations

Background: Forty percent of all head and neck cancers occur in the oral cavity. According to ICD-O (International classification of diseases for oncology) C00-C14 includes cancers of the lip, oral cavity and pharynx. Studies have indicated that increased population density or Metro living have increased oral cancer incidence. The objectives of this study are to look at the distribution of Oral and Oro pharyngeal Cancers in Virginia from 2001-2005 The study aims to determine if there is an association between metro living (beale code 3) and advanced Oral Cancers. This study is also being done to determine if Metro living …

Do Black Msm Have More Idu And Hiv Positive Partners Compared To White Men Having Sex With Men ?, Shankar Krishnappa

Theses and Dissertations

Objectives: This study estimates the proportion of intravenous drug use (IDU) partners and HIV positive sexual partners among black and white and examine the association between repeat HIV testing and sex with high risk partners. Methods: A cross-sectional study of MSM was conducted by using pooled data from counseling, Testing, Referral services in Virginia, USA 2002-2007. Results: We obtained a sample of 19679 MSM out of which 10924(56%) and 6739(34%) were white and black MSM respectively. The proportion of IDU partners and HIV positive partners were among white MSM (5% and 11%) and black MSM (3% and 9%) respectively. Age …

Medicare Managed Care Penetration And Prevalence Of Older Adult Disability, Christine Moe

Theses and Dissertations

OBJECTIVE: To investigate the relationship between Medicare Managed Care (MMC) penetration and percentage of disability in older adults (individuals age 65 and older). Considering disability as an indicator of one or more unsuccessfully managed chronic diseases, this study investigates the assumption that managed care improves coordination of care, as well as access to preventive care. If managed care’s mandate is being met, then it should be evidenced in decreased prevalence of older adult disability. METHOD: Taking an ecological approach, this study used data from the Agency for Healthcare Research and Quality (AHRQ, 2003) to compare the percentage of older adult …

Mesenteric Panniculitis With Pedal Edema In A 33-Year-Old Pakistani Man: A Case Report And Literature Review., Abdul M Zafar, Muhamad A Rauf, Tabish Chawla, Gule Khanda

Department of Radiology

Introduction:Mesenteric panniculitis is a rare pathology of unknown etiology characterized by inflammation and fibrosis in the mesentery. Its protean clinical and radiological manifestations make it a diagnostic challenge. There is no established treatment available for its management. The clinical outcome is inconsistent, with the prognosis ranging from complete resolution without any treatment to rapid progression culminating in death. Case Presentation: A 33-year-old Pakistani man presented with vague abdominal pain, an ill-defined epigastric mass and bilateral pedal edema. A detailed review of his history and laboratory investigations did not point to any diagnosis. The Patient underwent an exploratory laparotomy based …

Effects Of Shielding Adenoviral Vectors With Polyethylene Glycol On Vector-Specific And Vaccine-Mediated Immune Responses, Eric A. Weaver, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Many individuals have been previously exposed to human adenovirus serotype 5 (Ad5). This prior immunity has long been known to hinder its use for gene therapy and as a gene-based vaccine. Given these immunogenicity problems, we have tested whether polyethylene glycol (PEG) can blunt immune effects against Ad5 during systemic and mucosal vaccination. Ad5 vectors were covalently modified with 5-, 20-, and 35-kDa linear PEG polymers and evaluated for their ability to produce immune responses against transgene antigen products and the vector itself. We show that shielding Ad5 with different-sized PEGs generally reduces transduction and primary antibody responses by the …

Psychometrically Equivalent Thai Monosyllabic Word Recognition Materials Spoken By Male And Female Talkers, Chela Williams

Theses and Dissertations

The purpose of this study was to develop, digitally record, evaluate, and psychometrically equate a set of Thai monosyllabic word lists to use in the measurement of word recognition ability. A native male and female talker from Thailand, who were judged to have a standard Thai dialect, participated as talkers in digitally recording familiar Thai monosyllabic words. Twenty native Thai participants were used as subjects to determine the percentage of correct word recognition for each word at 10 intensity levels ranging from --5 to 40 dB HL in 5 dB increments. The 200 words with the highest raw scores were …

The Relationship Among Emotion Understanding, Language, And Social Behavior In Children With Language Impairment, Lara Lynn Goldie

Theses and Dissertations

This study examines the influence of emotion understanding, language, and working memory on reticence and prosocial behavior in children with language impairment (LI). The Comprehensive Assessment of Spoken Language (CASL; Carrow-Woolfolk, 1999) and The Universal Nonverbal Intelligence Test (UNIT; Bracken & McCallum, 2003) were administered to 39 children with LI and 39 typical age-matched peers. A nonword repetition task and two tasks measuring emotion understanding were also administered. Each of the participant's classroom teachers completed The Teacher Behavioral Rating Scale (TBRS; Hart & Robinson, 1996). Structural equation modeling was used to estimate models of the data using a maximum likelihood …

Identification And Characterization Of Sigma(S), A Novel Component Of The Staphylococcus Aureus Stress And Virulence Responses, Lindsey N. Shaw, Catharina Lindholm, Tomasz K. Prajsnar, Halie K. Miller, Melanie C. Brown, Ewa Golonka, George C. Stewart, Andrej Tarkowski, Jan Potempa

Molecular Biosciences Faculty Publications

S. aureus is a highly successful pathogen that is speculated to be the most common cause of human disease. The progression of disease in S. aureus is subject to multi-factorial regulation, in response to the environments encountered during growth. This adaptive nature is thought to be central to pathogenesis, and is the result of multiple regulatory mechanisms employed in gene regulation. In this work we describe the existence of a novel S. aureus regulator, an as yet uncharacterized ECF-sigma factor (sigma(S)), that appears to be an important component of the stress and pathogenic responses of this organism. Using biochemical approaches …

Fatal Transfusion Related Acute Lung Injury Following Coronary Artery By-Pass Surgery: A Case Report., Fauzia Ahmad Bawany, Hasanat Sharif

Section of Cardiothoracic Surgery

Background:Transfusion related acute lung injury (TRALI) is a potentially fatal Acute Lung Injury following transfusion of blood components. Hypotheses implicate donor-derived anti-human leukocyte antigen or granulocyte antibodies reacting with recipients' leukocytes, releasing inflammatory mediators. Lack of agreement on underlying cellular and molecular mechanisms renders improving transfusion safety difficult and expensive.

Case Presentation:

Literature search has not revealed any case of TRALI from Pakistan. We report the case of fatal TRALI in a 68 year old male who received blood products after coronary artery by-pass surgery.

Conclusion:

This article aims to create awareness about this complication and suggests that post …

Students Campaign For Clean Water, Jessica Block ‘09

News and Events (Discontinued Series)

No abstract provided.

Abcb6 Is A Porphyrin Transporter With A Novel Trafficking Signal That Is Conserved In Other Abc Transporters, Yu Fukuda

Theses and Dissertations (ETD)

The ATP-binding cassette (ABC) transporters play an important role as a barrier to protect cells from the accumulation of toxic xenobiotics and metabolites due to their ability to translocate a wide array of compounds across lipid bilayers. However, many ABC transporters, especially the ones localized in the intracellular organelles, are involved in critical biological processes such as antigen presentation. The core unit of ABC transporters contains two functional domains: the membrane spanning domain (MSD) and the nucleotide binding domain. The full transporters contain two of these units in tandem in a single polypeptide, whereas the half transporters only contain one …

Imaging Activity Of Neuronal Populations With New Long-Wavelength Voltage-Sensitive Dyes, Joseph P. Wuskell, Leslie M. Loew

UCHC Articles - Research

We have assessed the utility of five new long-wavelength fluorescent voltage-sensitive dyes (VSD) for imaging the activity of populations of neurons in mouse brain slices. Although all the five were capable of detecting activity resulting from activation of the Schaffer collateral-CA1 pyramidal cell synapse, they differed significantly in their properties, most notably in the signal-to-noise ratio of the changes in dye fluorescence associated with neuronal activity. Two of these dyes, Di-2-ANBDQPQ and Di-1-APEFEQPQ, should prove particularly useful for imaging activity in brain tissue and for combining VSD imaging with the control of neuronal activity via light-activated proteins such as channelrhodopsin-2 …

Development Of Unicef Latin America/Caribbean (Lac) Well-Being Indicators, Mark Edberg

Prevention and Community Health Faculty Publications

No abstract provided.