Medicine and Health Sciences Commons^™

The Impact Of Co-Active Coaching On Physically Inactive 12 To 14 Year Olds In Ontario, Paul Gorczynski, Jennifer Irwin, Don Morrow

Donald Morrow

No abstract provided.

Life Coaching As An Intervention For Individuals With Obesity, Courtney Newnham-Kanas, Jennifer Irwin, Don Morrow

Donald Morrow

No abstract provided.

Ssrn As An Initial Revolution In Academic Knowledge Aggregation And Dissemination, David Bray, Sascha Vitzthum, Benn Konsynski

Sascha Vitzthum

Within this paper we consider our results of using the Social Science Research Network (SSRN) over a period of 18 months to distribute our working papers to the research community. Our experiences have been quite positive, with SSRN serving as a platform both to inform our colleagues about our research as well as inform us about related research (through email and telephoned conversations of colleagues who discovered our paper on SSRN). We then discuss potential future directions for SSRN to consider, and how SSRN might well represent an initial revolution in 21st century academic knowledge aggregation and dissemination. Our paper …

Evaluations Of The Effectiveness Of A Web-Based Graduate Epidemiology Course, Molly A. Rose, Anthony J. Frisby, Michael D. Hamlin, Susan S. Jones

Anthony J Frisby, PhD

An online epidemiology course was developed, implemented, and evaluated for graduate nursing students through the collaborative efforts of nursing faculty and information, education, and instructional design staff of the library at a health sciences university. This epidemiology course is a core curriculum course for graduate nursing students. The course was piloted with 14 students (one student in Romania); the initial online offering ran concurrently with a traditional classroom section. Extensive evaluation data were collected and analyzed to compare the effectiveness of the classroom and distance-learning formats. Areas of evaluation included objective measures, such as midterm and final examination scores and …

Health Policy Newsletter Goes On-Line!, Anthony J. Frisby

Anthony J Frisby, PhD

No abstract available.

Incentives For Orphan Drug Research And Development In The United States, Rosa Rodriguez-Monguio, Enrique Seoane-Vazquez, Sheryl Szeinbach, Jay Visaria

Rosa Rodriguez-Monguio

Background The Orphan Drug Act (1983) established several incentives to encourage the development of orphan drugs (ODs) to treat rare diseases and conditions. This study analyzed the characteristics of OD designations, approvals, sponsors, and evaluated the effective patent and market exclusivity life of orphan new molecular entities (NMEs) approved in the US between 1983 and 2007. Methods Primary data sources were the FDA Orange Book, the FDA Office of Orphan Drugs Development, and the US Patent and Trademark Office. Data included all orphan designations and approvals listed by the FDA and all NMEs approved by the FDA during the study …

Physicians' Experiences With Brca1/2 Testing In Community Settings., Nancy L. Keating, Kathryn A. Stoeckert, Meredith M. Regan, Lisa Digianni, Judy E. Garber

Kathryn Sabella

Gender Specific Differences In The Pros And Cons Of Smoking Among Current Smokers In Eastern Kentucky: Implications For Future Smoking Cessation Interventions, Dana A. Hazen, David M. Mannino, Richard Clayton

David M. Mannino

This study investigated gender differences in the perceived “pros” and “cons” of smoking using the constructs of decisional balance (DB) and stage of change from the Transtheoretical Model. The population distribution for stage of change among a population-based, cross-sectional survey of 155 current smokers over 40 years was: precontemplation (22.6%), contemplation (41.9%), preparation (35.5%). Results of stepwise regression models indicated significant gender differences in DB were in the preparation stage of change; scores on the DB measure increased 3.94 points (95% CI: 1.94, 5.93) for male smokers. Interventions targeting the “pros” and “cons” of smoking may need to be gender …

Rural Realities – Populations And Workforce…Does Anybody Care?, Janie Smith

Janie Smith

No abstract provided.

Career Development For Transition-Aged Youth With Emotional Disturbances: Exemplary Practices Of Florida Mental Health And Substance Abuse Agencies, Mason G. Haber, Troy Loker, Nicole Deschenes, Hewitt B. Clark

Mason G. Haber

Though an emerging literature on career development practices for transition-age youth with emotional disturbances (TAY w/ED) exists, this literature has not been systematically reviewed. In addition, efforts by publicly-funded sites in Florida to implement such programs have not been comprehensively described. The current project is designed to advance these aims to provide a basis for expanded implementation of career development programs for TAY w/ED in the state.

Challenges, Benefits And Weaknesses Of Intermediate Care: Results From Five Uk Case Study Sites, Emma Regan, Graham Martin, Jon Glasby, Graham Hewitt, Susan Nancarrow, Hilda Parker

Susan Nancarrow

The authors explore the views of practitioners and managers on the implementation of intermediate care for elderly people across England, including their perceptions of the challenges involved in its implementation, and their assessment of the main benefits and weaknesses of provision. Qualitative data were collected in five case study sites (English primary care trusts) via semistructured interviews (n = 61) and focus group discussions (n = 21) during 2003 to 2004. Interviewees included senior managers, intermediate care service managers, clinicians and health and social care staff involved in the delivery of intermediate care. The data were analysed thematically …

Improved Feed Protein Fractionation Schemes For Formulating Rations With The Cornell Net Carbohydrate And Protein System, Cristina Lanzas, G A. Broderick, D G. Fox

Cristina Lanzas

Adequate predictions of rumen-degradable protein (RDP) and rumen-undegradable protein (RUP) supplies are necessary to optimize performance while minimizing losses of excess nitrogen (N). The objectives of this study were to evaluate the original Cornell Net Carbohydrate Protein System (CNCPS) protein fractionation scheme and to develop and evaluate alternatives designed to improve its adequacy in predicting RDP and RUP. The CNCPS version 5 fractionates CP into 5 fractions based on solubility in protein precipitant agents, buffers, and detergent solutions: A represents the soluble nonprotein N, B1 is the soluble true protein, B2 represents protein with intermediate rates of degradation, B3 is …

Obstructive Lung Disease Models: What Is Valid, Jill M. Ferdinands, David M. Mannino

David M. Mannino

Use of disease simulation models has led to scrutiny of model methods and demand for evidence that models credibly simulate health outcomes. We sought to describe recent obstructive lung disease simulation models and their validation. Medline and EMBASE were used to identify obstructive lung disease simulation models published from January 2000 to June 2006. Publications were reviewed to assess model attributes and four types of validation: first-order (verification/debugging), second-order (comparison with studies used in model development), third-order (comparison with studies not used in model development), and predictive validity. Six asthma and seven chronic obstructive pulmonary disease models were identified. Seven …

Preschool Parent-Pediatrician Consultations And Predictive Referral Patterns For Problematic Behaviors, John Fanton, Brittany Macdonald, Elizabeth Harvey

Elizabeth (Lisa) Harvey

Objective—The present study examined parents’ reports of the frequency, nature, and outcome of pediatrician consultation and interventions about significant preschool behavior problems. Method—Parents were asked whether they consulted or not with their pediatric providers about disruptive behavioral problems during a longitudinal study of preschool children. Results—Eighty 4-year-old children had parents who had consulted with their pediatricians versus 90 children whose parents did not. Children who eventually met criteria for Attention Deficit/ Hyperactivity Disorder (ADHD) or Oppositional Defiant Disorder (ODD) two years later, received different pediatric interventions at age 4 than children who did not have a diagnosis, χ2 (2) = …

Individuals' Use Of Care While Uninsured: Effects Of Time Since Episode Inception And Episode Length, Carole Gresenz, J. Rogowski, Jose Escarce

Carole Roan Gresenz

No abstract provided.

Permissive Underfeeding In Trauma Patients, L. Current, Jane Gervasio, J. Ash, L. Bortenschlager, T. Pohlman

Jane M. Gervasio

Abstract from the ASHP Midyear Clinical Meeting, Orlando, FL, December 6-11, 2008.

The Differentiation Of Hepatocyte-Like Cells From Monkey Embryonic Stem Cells., Xiaocui Ma, Jian Wu, M Zern

jian duan wu

Embryonic stem cells (ESC) hold great potential for the treatment of liver diseases. Here, we report the differentiation of rhesus macaque ESC along a hepatocyte lineage. The undifferentiated monkey ESC line, ORMES-6, was cultured in an optimal culture condition in an effort to differentiate them into hepatocyte-like cells in vitro. The functional efficacy of the differentiated hepatic cells was evaluated using RT-PCR for the expression of hepatocyte specific genes, and Western blot analysis and immunocytochemistry for hepatic proteins such as alpha-fetoprotein (AFP), albumin and alpha1-antitrypsin (alpha1-AT). Functional assays were performed using the periodic acid schiff (PAS) reaction and ELISA. The …

Hoping For A Miracle: Supporting Patients In Transplantation And Cardiac Assist Programs, Katrina Bramstedt

Katrina A. Bramstedt

Purpose of review: Palliative medicine is often viewed as a medical specialty reserved for end of life care. This review focuses on the role that palliative care can play in transplant and cardiac assist device programs, along the continuum of a patient's disease course. Recent findings: In general, transplant and cardiac assist programs do not incorporate palliative medicine during the treatment course, but rather reserve it for when the patient is approaching death and is no longer a candidate for transplant or device therapy. There is a new shift, however, to viewing the practice of aggressive medicine and palliative medicine …

Towards Self-Organizing, Smart Business Networks: Let’S Create ‘Life’ From Inert Information, David Bray, Benn Konsynski

David A. Bray

We review three different theories that can inform how researchers can determine the performance of smart business networks, to include: (1) the Theory of Evolution, (2) the Knowledge-Based Theory of the Firm, and (3) research insights into computers and cognition. We suggest that each of these theories demonstrate that to be generally perceived as smart, an organism needs to be self-organizing, communicative, and tool-making. Consequentially, to determine the performance of a smart business network, we suggest that researchers need to determine the degree to which it is self-organizing, communicative, and tool-making. We then relate these findings to the Internet and …

Feeding Intolerance Of Patients Placed In Pentobarbital-Induced Coma At Methodist Hospital, J. Egel, J. Mcgehee, D. Stillabower, N. Ponton, Jane Gervasio

Jane M. Gervasio

Abstract from the ASHP Midyear Clinical Meeting, Orlando, FL, December 6-11, 2008.

Fluoranthene, But Not Benzo[A]Pyrene, Interacts With Hypoxia Resulting In Pericardial Effusion And Lordosis In Developing Zebrafish, Cole W. Matson, Alicia R. Timme-Laragy, Richard T. Di Giulio

Alicia R. Timme-Laragy

Previous research has documented several PAHs that interact synergistically, causing severe teratogenicity in developing fish embryos. The coexposure of CYP1A inhibitors (e.g. FL or ANF) with AHR agonists (e.g. BaP or BNF) results in a synergistic increase in toxicity. As with chemical CYP1A inhibitors, it has also been shown that CYP1A morpholinos exacerbate BNF-induced embryotoxicity. We hypothesized that a hypoxia-induced reduction in CYP1A activity in BNF or BaP-exposed zebrafish embryos would similarly enhance pericardial effusion and other developmental abnormalities. BaP, BNF, ANF, and FL exposures, both individually and as BaP+FL or BNF+ANF combinations, were performed under hypoxia and normoxia. CYP1A …

Social Policy, Imperiled Communities, And Hiv/Aids Transmission In Prisons: A Call For Zero Tolerance, Louis F. Graham, Henrie Treadwell, Kisha Braithwaite

Louis F Graham

HIV/AIDS and African-American male imprisonment contribute to the destruction of African-American communities. African-American men and HIV/AIDS are disproportionately represented throughout all sectors of the criminal justice industry, including the juvenile justice system. The criminal justice system contributes to unacceptably high African-American male imprisonment rates and HIV prevalence directly via the ‘war on drugs’ and lax enforcement of institutional policy among other things, and indirectly through perpetuation of economic hardship which further exacerbates imprisonment rates, thus closing the loop of a vicious cycle of revolving prison doors and HIV contraction. This article briefly introduces surrounding socio-political issues that contextualizes the ensuing …

Technical Analysis: The Interface Of Rational And Irrational Decision Making, William Marty Martin

William Marty Martin

No abstract provided.

A Hybrid Model For Prediction Of Peptide Binding To Mhc Molecules, P. Zhang, V. Brusic, K. Basford

Ping Zhang

We propose a hybrid classification system for predicting peptide binding to major histocompatibility complex (MHC) molecules. This system combines Support Vector Machine (SVM) and Stabilized Matrix Method (SMM). Its performance was assessed using ROC analysis, and compared with the individual component methods using statistical tests. The preliminary test on four HLA alleles provided encouraging evidence for the hybrid model. The datasets used for the experiments are publicly accessible and have been benchmarked by other researchers.

© Copyright Springer-Verlag Berlin Heidelberg, 2009

Access the published version at www.springerlink.com/.

Fitness And Action Monitoring: Evidence For Improved Cognitive Flexibility In Young Adults, Jason R. Themanson, Matthew B. Pontifex, Charles H. Hillman

Jason R. Themanson, Ph.D

To improve behavior, one must detect errors and initiate subsequent corrective adaptations. This action monitoring process has been widely studied, but little is known about how one may improve this aspect of cognition. To examine the relationship between cardiorespiratory fitness and action monitoring, we recorded the error-related negativity (ERN), an event-related brain potential believed to index action monitoring, as well as post-error behavioral indices of action monitoring from healthy young adults (18–25 years) who varied in cardiorespiratory fitness. These measures were collected during the execution of flanker tasks emphasizing response accuracy or speed to better assess the specificity of any …

Finding Recurrent Regions Of Copy Number Variation: A Review, Oscar M. Rueda, Ramon Diaz-Uriarte

Ramon Diaz-Uriarte

Copy number alterations (CNA) in genomic DNA are linked to a variety of human diseases. Although many methods have been developed to analyze data from a single subject, disease-critical genes are more likely to be found in regions that are common or recurrent among diseased subjects. Unfortunately, finding recurrent CNA regions remains a challenge. We review existing methods for the identification of recurrent CNA regions. Methods differ in their working definition of ``recurrent region'', the type of input data, the statistical and computational methods used to identify recurrence, and the biological considerations they incorporate (which play a role in the …

Family Sources Of Educational Gender Inequality In Rural China: A Critical Assessment, Emily C. Hannum, Peggy A. Kong, Yuping Zhang

Emily C. Hannum

Regressing Scalar Outcomes On Image Predictors Via Functional Principal Component Regression, Philip T. Reiss

Philip T. Reiss

No abstract provided.

Application Of Two Machine Learning Algorithms To Genetic Association Studies In The Presence Of Covariates, Bareng As Nonyane, Andrea S. Foulkes

Andrea S Foulkes

Background - Population-based investigations aimed at uncovering genotype-trait associations often involve high-dimensional genetic polymorphism data as well as information on multiple environmental and clinical parameters. Machine learning (ML) algorithms offer a straightforward analytic approach for selecting subsets of these inputs that are most predictive of a pre-defined trait. The performance of these algorithms, however, in the presence of covariates is not well characterized. Methods and Results - In this manuscript, we investigate two approaches: Random Forests (RFs) and Multivariate Adaptive Regression Splines (MARS). Through multiple simulation studies, the performance under several underlying models is evaluated. An application to a cohort …

Gene Set Enrichment Analysis For Non-Monotone Association And Multiple Experimental Categories, Rongheng Lin, Shuangshuang Dai, Richard D. Irwin, Alexandra N. Heinloth, Gary A. Boorman, Leping Li

Rongheng Lin

Background Recently, microarray data analyses using functional pathway information, e.g., gene set enrichment analysis (GSEA) and significance analysis of function and expression (SAFE), have gained recognition as a way to identify biological pathways/processes associated with a phenotypic endpoint. In these analyses, a local statistic is used to assess the association between the expression level of a gene and the value of a phenotypic endpoint. Then these gene-specific local statistics are combined to evaluate association for pre-selected sets of genes. Commonly used local statistics include t-statistics for binary phenotypes and correlation coefficients that assume a linear or monotone relationship between a …