Medicine and Health Sciences Commons^™

Meeting Report: The Role Of Environmental Lighting And Circadian Disruption In Cancer And Other Diseases, Richard G. Stevens, David E. Blask, George C. Brainard, Johnni Hansen, Steven W. Lockley, Ignacio Provencio, Mark S. Rea, Leslie Reinlib

Department of Neurology Faculty Papers

Light, including artificial light, has a range of effects on human physiology and behavior and can therefore alter human physiology when inappropriately timed. One example of potential light-induced disruption is the effect of light on circadian organization, including the production of several hormone rhythms. Changes in light-dark exposure (e.g., by nonday occupation or transmeridian travel) shift the timing of the circadian system such that internal rhythms can become desynchronized from both the external environment and internally with each other, impairing our ability to sleep and wake at the appropriate times and compromising physiologic and metabolic processes. Light can also have …

Comparison Of Contrast Enhanced Color Doppler Targeted Biopsy To Conventional Systematic Biology: Impact On Gleason Score, M. Mitterberger, G. M. Pinggera, W. Horninger, G. Bartsch, H. Strasser, G. Schafer, A. Brunner, Ethan J. Halpern, J. Gradl, L. Pallwein, F. Frauscher

Department of Radiology Faculty Papers

Purpose: Prostate cancer grading with Gleason score is an important prognostic factor. This prospective randomized study compares ultrasound systematic biopsy vs contrast enhanced color Doppler targeted biopsy for the impact on Gleason score findings.

Materials and Methods: We examined 690 men (mean age 56 years, range 41 to 77) with a serum total prostate specific antigen of 1.25 ng/ml or greater, a free-to-total prostate specific antigen ratio less than 18% and/or a suspicious digital rectal examination. Contrast enhanced color Doppler targeted biopsies with a limited number of cores (5 or less) were performed in hypervascular areas of the peripheral zone …

Endothelial Stomatal And Fenestral Diaphragms In Normal Vessels And Angiogenesis, R. V. Stan

Dartmouth Scholarship

Vascular endothelium lines the entire cardiovascular system where performs a series of vital functions including the control of microvascular permeability, coagulation inflammation, vascular tone as well as the formation of new vessels via vasculogenesis and angiogenesis in normal and disease states. Normal endothelium consists of heterogeneous populations of cells differentiated according to the vascular bed and segment of the vascular tree where they occur. One of the cardinal features is the expression of specific subcellular structures such as plasmalemmal vesicles or caveolae, transendothelial channels, vesiculo-vacuolar organelles, endothelial pockets and fenestrae, whose presence define several endothelial morphological types. A less explored …

Impact Of Acceptance And Commitment Therapy Versus Education On Stigma Toward People With Psychological Disorders, Akihiko Masuda, Steven C. Hayes, Lindsay B. Fletcher, Paul J. Seignourel, Kara Bunting, Scott A. Herbst, Michael P. Twohig, Jason Lillis

Psychology Faculty Publications

Acceptance and commitment therapy (ACT) has previously been shown to alter stigmatizing attitudes and to be relatively useful for psychologically inflexible participants. The present study is the first to bring those two findings together by comparing ACT to an education intervention for reducing stigma toward people with psychological disorders, and examining whether results differ for psychologically inflexible versus flexible individuals. A sample of college students (N=95) was randomly assigned to a 2¹/₂ h ACT or educational workshop. Measures were taken before and after the workshop and at a 1-month follow-up. ACT reduced mental health stigma …

Compounds Of Use In The Treatment Of Epilepsy, Seizure, And Electroconvulsive Disorders, Peter A. Crooks, Aimee K. Bence, David Robert Worthern

Pharmaceutical Sciences Faculty Patents

The present invention provides pharmaceutical preparations and the uses thereof for preventing and/or treating seizures and other electroconvulsive disorders by administering a pharmaceutically effective amount of a therapeutic compound . . .

To view the rest of this abstract, please download this patent.

Formation Of Native Prions From Minimal Components In Vitro, Nathan R. Deleault, Brent T. Harris, Judy R. Rees, Surachai Supattapone

Dartmouth Scholarship

The conformational change of a host protein, PrPC, into a disease-associated isoform, PrPSc, appears to play a critical role in the pathogenesis of prion diseases such as Creutzfeldt–Jakob disease and scrapie. However, the fundamental mechanism by which infectious prions are produced in neurons remains unknown. To investigate the mechanism of prion formation biochemically, we conducted a series of experiments using the protein misfolding cyclic amplification (PMCA) technique with a preparation containing only native PrPC and copurified lipid molecules. These experiments showed that successful PMCA propagation of PrPScmolecules in a purified system requires accessory polyanion molecules. In addition, we found that …

Azithromycin In The Extremely Low Birth Weight Infant For The Prevention Of Bronchopulmonary Dysplasia: A Pilot Study, Hubert O. Ballard, Michael I. Anstead, Lori A. Shook

Pediatrics Faculty Publications

BACKGROUND: Azithromycin reduces the severity of illness in patients with inflammatory lung disease such as cystic fibrosis and diffuse panbronchiolitis. Bronchopulmonary dysplasia (BPD) is a pulmonary disorder which causes significant morbidity and mortality in premature infants. BPD is pathologically characterized by inflammation, fibrosis and impaired alveolar development. The purpose of this study was to obtain pilot data on the effectiveness and safety of prophylactic azithromycin in reducing the incidence and severity of BPD in an extremely low birth weight (< or = 1000 grams) population.

METHODS: Infants < or = 1000 g birth weight admitted to the University of Kentucky Neonatal Intensive Care Unit (level III, regional referral center) from 9/1/02-6/30/03 were eligible for this pilot study. The pilot study was double-blinded, randomized, and placebo-controlled. Infants were randomized to treatment or placebo within 12 hours of beginning mechanical ventilation (IMV) and within 72 hours of birth. The treatment group received azithromycin 10 mg/kg/day for 7 days followed by 5 mg/kg/day for the duration of the study. Azithromycin or placebo was continued until the infant no longer required IMV or supplemental oxygen, to a maximum of 6 weeks. Primary endpoints were incidence of BPD as defined by oxygen requirement at 36 weeks gestation, post-natal steroid use, days of IMV, and mortality. Data was analyzed by intention to treat using Chi-square and ANOVA.

RESULTS: A total of 43 extremely premature infants were enrolled in this pilot study. Mean gestational age and …

Ada News - 06/04/2007, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Session 1 - Rationalizing The Home Front: The Cold War, The Nevada Test Site, And Radiation Exposure, Leisl A. Carr

International Symposium on Technology and Society

Beginning in 1953, radiation exposure and its effects became a hotly contested issue between the government, members of communities surrounding the Nevada Test Site (NTS), and researchers within the national scientific community. The Atomic Energy Commission (AEC), concerned about maintaining a continental testing facility and aware that atomic testing would impact communities surrounding the NTS, sent representatives to areas potentially affected by fallout to instruct and reassure the affected public. How government officials perceived neighboring communities and how these communities perceived these representatives of the government often determined public responses to the atomic testing program. The story of radiation monitors …

Exclusive Breastfeeding Practices In Rural Haitian Women, Susan B. Roman

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

An Evaluation Of Personal Protective Equipment Used With Local Public Health Employees, Aimee E. Eberly

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

Is Chronic Wasting Disease (Cwd) In Deer And Elk Affecting Public Health?, Steven C. Nattrass

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

Language Use And Sexual Communication Among Xhosa Speakers In Cape Town, South Africa, Demetria Cain

UCHC Graduate School Masters Theses 2003 - 2010

No abstract provided.

Holistic Nursing: Preface, Noreen Frisch

Nursing Faculty Publications

Evidence is all the rage in nursing these days, and the evidence-based practice (EBP) movement seems well-nigh unstoppable. Anyway, who would want to stop progress toward clinical care based on proven best practices? Many years ago, the nurse-scientist Dr. Norma Matheny reminded us how difficult it is to get any intervention/activity out of nursing practice once nurses are used to performing the activity. Nurses seem to be trapped in “we've always done it this way” kind of thinking, even when new knowledge shows a practice to be obsolete (or, worse, dangerous). Then, there is the equally daunting challenge of getting …

Dentalgram - Vol. 21, No. 06, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• The class of 2007: 182 dental, dental hygiene, IDP, and advanced education program graduates
• Students receive numerous awards and honors
• SD surgical site for Nobel Biocare World Conference
• NASDAD receives $25,000 matching grant from the Kellogg Foundation
• Surgery Center named Koppel Special Care Dentistry Center
• SD completes fifth year of community-based dental partnership program
• Little Tucker get his grill on
• Over 2,000 children visit dental booth during Children's Day Fair
• Orthodontic department sponsors Easter egg hunt
• LLUSD host booth during LLU Employee Benefits Fair
• The School host Employee Appreciation Day
• CDA winners
• Report from Sir Run Run …

Maine State Employee Survey On Disability, Commission On Disability And Employment, Department Of Financial And Administrative Services Bureau Of Human Resources, Muskie School Of Public Service University Of Southern Maine

Disability & Aging

The Executive Order regarding Maine State Government as a Model Employer of people with disabilities was signed on February 24, 2006. The order included several action steps, including a survey of State employees to ascertain the prevalence of workers with disabilities in State employment.

Maine’s Bureau of Human Resources and the Commission on Disability and Employment were named to oversee this survey. The University of Southern Maine’s Muskie School of Public Service administered the survey and analyzed results. Each of these three organizations are members of an Executive Order Working Group designed to overall all action steps under the Executive …

Darwinism And The Meaning Of Life, Arthur Falk

Center for the Study of Ethics in Society Papers

Papers presented for the Center of the Study of Ethics in Society Western Michigan University.

La Vie À L’Endroit De Rachid Boudjedra : Entre Subjectivité Et Folie, Sonia Zlitni Fitouri

Présence Francophone: Revue internationale de langue et de littérature

In this study of Rachid Boudjedra’s La vie à l’endroit, I will show how the Algerian writer endeavours to put “en abyme” three types of madness (joyful, fatal, hallucinatory); these generate one another in a cause and effect relationship and distance themselves from the delirious discourse of his first novels in order to give an account of a period of terror which struck Algeria under the Muslim fundamentalist threat. We will also show how the character-narrator faces all this madness by setting up his subj bj ectivity as a shield against what he calls “external fear and inner fear”, and …

Animal Research: A Moral Science, Bernard E. Rollin

Experimentation Collection

No abstract provided.

Cetacean Brains: How Aquatic Are They?, Lori Marino

Anatomy Collection

The adaptation of cetaceans to a fully aquatic lifestyle represents one of the most dramatic transformations in mammalian evolutionary history. Two of the most salient features of modern cetaceans are their fully aquatic lifestyle and their large brains. This review article will offer an overview of comparative neuroanatomical research on aquatic mammals, including analyses of odontocete cetacean, sirenian, pinniped, and fossil archaeocete brains. In particular, the question of whether a relationship exists between being fully aquatic and having a large brain is addressed. It has been hypothesized that the large, well‐developed cetacean brain is a direct product of adaptation to …

Flight Physician - June, 2007, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twenty page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Alcohol Slows Interhemispheric Transmission, Increases The Flash-Lag Effect, And Prolongs Masking: Evidence For A Slowing Of Neural Processing And Transmission., Sarah A Khan, Brian Timney

Brain and Mind Institute Researchers' Publications

While the alcohol literature is extensive, relatively little addresses the relationship between physiological effects and behavioural changes. Using the visual system as a model, we examined alcohol's influence on neural temporal processing as a potential means for alcohol's effects. We did this by using tasks that provided a measure of processing speed: Poffenberger paradigm, flash-lag, and backward masking. After moderate alcohol, participants showed longer interhemispheric transmission times, larger flash-lags, and prolonged masking. Our data are consistent with the view that alcohol slows neural processing, and provide support for a reduction in processing efficiency underlying alcohol-induced changes in temporal visual processing.

Perceiving The Relationship Between Discrete And Continuous Data: A Comparison Of Sonified Data Display Formats, Carina M. Mccormick, John H. Flowers

Department of Psychology: Faculty Publications

This study compared the effectiveness of two auditory display designs for conveying the relationship between discrete and continuous data. Participants judged the relationship between simulated data representing “sea temperature,” (a continuous variable) and “storm occurrence” (a categorical variable) by rating the strength of covariation between these variables and qualitatively describing the relationship for one of two types of auditory displays. One format integrated the representation of storms and sea temperature into a single pitch-varying “stream” by signaling storms occurrence by momentary amplitude and timbre changes. The other format presented the storm occurrence information as atonal percussive events separate from the …

Congenital Diseases And A New York State Regulation. Help Is Here., Preeti Gupta Dds, Stuart L. Segelnick Dds, Milton Palat Dds

Individual Scholarship

Knowledge of a little known New York State regulation and its insurance implications can be used to provide dental benefits to people who have congenital diseases or anomalies. An explanation of the regulation is provided, and some of the more common congenital diseases that may affect the dentition, such as amelogenesis imperfecta, dentinogenesis imperfecta, ectodermal dysplasia, cleft lip/palate and trisomy 21, are reviewed.

The Physiological Consequences Of Bed Rest, Kristin J. Stuempfle, Daniel G. Drury

Health Sciences Faculty Publications

Bed rest often is used to treat a wide variety of medical conditions. However, bed rest results in profound deconditioning of the body. Bed rest reduces the hydrostatic pressure gradient within the cardiovascular system, reduces muscle force production, virtually eliminates compression on the bones, and lowers total energy expenditure. This review focuses on the deconditioning that occurs in the cardiovascular, muscular, and skeletal systems following bed rest. Reduction in plasma volume reduces cardiac preload, stroke volume, cardiac output, and ultimately, maximal oxygen consumption. Skeletal muscle volume, muscle cross sectional area, and fiber cross sectional area decrease, which results in diminished …

Global Stability Results Of An Sis Age-Structured Epidemic Model With Vertical Transmission, M. El-Doma

Applications and Applied Mathematics: An International Journal (AAM)

An SIS age-structured epidemic model for a vertically as well as horizontally transmitted disease is investigated when the fertility, mortality and cure rates depend on age and the force of infection of proportionate mixing assumption type. We determine the steady states and prove the global stability for the endemic equilibriums.

Adolescents’ Perceptions Of Their Roles In Decision-Making In The Oral Cleft Clinic, Rebecca Ann Hague

Masters Theses

Background: The literature suggests adolescents have the cognitive abilities equivalent to an adult for health related decisions. Adolescents should participate in treatment planning at a level equivalent to their cognitive abilities and the extent they desire. Little is known regarding adolescents' perceived and desired level of involvement in decision making in an oral cleft clinic.

Purpose: To describe adolescents' perceptions of their roles and desired level of involvement in decision-making in an oral cleft clinic.

Methods: Four adolescents completed a questionnaire and participated in focus groups.

Results: Participants reported that they perceive they are involved in decision-making processes, are knowledgeable …

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link Newsletter, Vol. 3, Iss. 5, June 2007

Public Health Link

This issue highlights the newly created joint public health and law programs between Thomas Jefferson University and Widener University as well as an article written by Dr. James Plumb on poverty reduction and health.

Adherence To Recommendations For Follow-Up To Abnormal Pap Tests, Katherine S. Eggleston, Ann L. Coker, Kathryn J. Luchok, Tamra E. Meyer

CRVAW Faculty Journal Articles

OBJECTIVE: To evaluate whether timely adherence rates differ by race among women with abnormal Pap tests participating in a cost-free or reduced-cost program.

METHODS: Eligible subjects included women aged 47-64 years who received a referral for follow-up care after an abnormal Pap test from 1999 to 2002 in South Carolina (n=330). Adherence was measured as days to receipt of follow-up care after an abnormal Pap test. Cox proportional hazards modeling was used to estimate risk factors associated with time to adherence within 60 and 365 days by race.

RESULTS: African-American and non-Hispanic white women had similar adherence to follow-up. Among …

Intraoperative Analgesia For Day-Care Surgery: Practice Trends, Aliya Ahmed, Shemila Abbasi, Chandar Prakash, Subhash Chandar

Department of Anaesthesia

Our objective was to determine the trends of providing intraoperative analgesia for day-care surgery among the various anaesthesiologists at our university hospital. All patients having surgical procedures under general anaesthesia in the Surgical Day Care Unit (SDC) of the Hospital were included. The study was done over two months and 142 patients were enrolled during the study period. Of these 45% received pethidine for intraoperative analgesia, 24% pethidine and ketorolac, 6% pethidine and paracetamol suppositories, 18% received fentanyl, 2% tramadol and 5% received other analgesic combinations. Of the 22% patients who received pethidine intraoperatively needed rescue analgesia in recovery room, …