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Articles 301 - 329 of 329
Full-Text Articles in Medicine and Health Sciences
Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü
Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü
Turkish Journal of Medical Sciences
Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement …
Could Lactate Clearance Be A Marker Of Mortality In Pediatric Intensive Care Unit?, Özlem Saraç Sandal, Gökhan Ceylan, Ferhat Sari, Gülhan Atakul, Mustafa Çolak, Sevgi̇ Topal, Eki̇n Soydan, Ünal Utku Karaarslan, Hasan Ağin
Could Lactate Clearance Be A Marker Of Mortality In Pediatric Intensive Care Unit?, Özlem Saraç Sandal, Gökhan Ceylan, Ferhat Sari, Gülhan Atakul, Mustafa Çolak, Sevgi̇ Topal, Eki̇n Soydan, Ünal Utku Karaarslan, Hasan Ağin
Turkish Journal of Medical Sciences
Background/aim: Hyperlactatemia is a common finding in critically ill patients and has significant prognostic implications. However, a single lactate measurement has not been correlated to mortality consistently. In this study, we aimed to correlate the clinical efficacy of lactate clearance for the prediction of mortality in pediatric intensive care unit patients. Materials and methods: This retrospective observational study was performed in the pediatric intensive care unit in patients with lactate level >3 mmol/lt. Initial, 6th h, and 24th h lactate levels were recorded and lactate clearance was calculated using these values (lactate level at admission - level 6 h later …
Can Surfactants Affect Mortality And Morbidity In Term Infants With Respiratory Failure?, Senem Alkan Özdemi̇r, Özlem Yilman, Şebnem Çalkavur, Tüli̇n Gökmen Yildirim
Can Surfactants Affect Mortality And Morbidity In Term Infants With Respiratory Failure?, Senem Alkan Özdemi̇r, Özlem Yilman, Şebnem Çalkavur, Tüli̇n Gökmen Yildirim
Turkish Journal of Medical Sciences
Background/aim: We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration. Materials and methods: In this retrospective study infants hospitalized in the 4th level neonatal intensive care unit during January 2019 and December 2021 and administered surfactant due to respiratory distress were included. Term infants given surfactant due to respiratory failure were included in the study through the data recording system. The number of surfactant doses, indications for administration, mortality, duration of hospitalization, intubation time, and inotrope use were …
The Effect Of Comprehensive Multidisciplinary Pulmonary Rehabilitation On 5-Year Survival In Copd: Does Maintaining A Home Exercise Program Improve Survival?, Seher Satar, Mustafa Engi̇n Şahi̇n, Pinar Ergün
The Effect Of Comprehensive Multidisciplinary Pulmonary Rehabilitation On 5-Year Survival In Copd: Does Maintaining A Home Exercise Program Improve Survival?, Seher Satar, Mustafa Engi̇n Şahi̇n, Pinar Ergün
Turkish Journal of Medical Sciences
Background/aim: Chronic Obstructive Pulmonary Disease (COPD) is one of the most common causes of death worldwide. Therefore, optimizing medical therapy in the comprehensive management of the disease, as well as including pulmonary rehabilitation (PR) in the treatment, is essential. The goal of our study was to determine the impact of PR on the survival of COPD patients. Materials and methods: Between 2007-2015, 509 COPD patients who completed the PR constituted the PR group, while 167 patients who applied but could not complete it after the initial evaluations formed the control group. In the PR group, dyspnea perception, exercise capacity, muscle …
Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman
Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman
Turkish Journal of Medical Sciences
Background/aim: Infertility is a global problem that brings about serious sexual and social consequences that strain the health sector and society. The expansion of CAG and GGC repeats in androgen receptor (AR) gene (Ensembl number ENSG00000169083) may lead to reduced fertility. Our objective was to determine the association of CAG and GGC repeats with altered sperm parameters in male infertile subjects. Materials and methods: This was a cross-sectional study conducted at Aga Khan University, Karachi, Pakistan. A total of 376 males were recruited, out of which group A (N = 208) and group B (N = 168) were comprised of …
Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci
Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci
Turkish Journal of Medical Sciences
Background/aim: Intravesical BCG treatment fails inexplicably in 30%-45% of patients for high-grade nonmuscle-invasive bladder cancer (NMIBC). We aimed to investigate the role of PD-1/PD-L1 interaction on BCG failure of high-grade NMIBC and to identify biomarkers for predicting BCG responsive cases. Materials and methods: Thirty BCG responsive and 29 nonresponsive NMIBCs were included in the study. Expressions of PDL1(SP-263), MSH2, MSH6, PMS2, and MLH1 were evaluated on pre- and post-BCG transurethral resection (TUR-B) specimens by immunohistochemistry. PD-L1(SP-263) expression was categorised as negative/low, high. DNA mismatch repair protein (MMR) expressions were classified as 'reduced' if ≤30% of nuclei stained, 'preserved' if >30% …
Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu
Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: Nicotine acts as an agonist of nicotinic acetylcholine receptors (nAChR). These receptors belong to a superfamily of ligand-gated ion channels. We previously demonstrated that nicotine increased electrical field stimulation (EFS)-induced contractile or relaxation responses, possibly by facilitating neurotransmitter release from nerve terminals in various rabbit tissues. Studies have shown that there is an interaction between the endocannabinoid and nicotinic systems. This study aimed to investigate the interaction between nicotine and the endocannabinoid system in the rabbit urine bladder and also investigate the enhancing effect of nicotine on EFS-induced contractile responses in rabbit isolated bladder smooth muscle and its interaction …
Favorable Efficacy Of Adalimumab Treatment In Experimental Acute Pancreatitis Model, Başak Çakir Güney, Alpaslan Tanoğlu, Murat Yeni̇çeri̇, Zafer Çirak, Ayşe Gökçen Sade, Yeşi̇m Önal Taştan, Zeli̇ha Seri̇ndağ, Mustafa Kaplan
Favorable Efficacy Of Adalimumab Treatment In Experimental Acute Pancreatitis Model, Başak Çakir Güney, Alpaslan Tanoğlu, Murat Yeni̇çeri̇, Zafer Çirak, Ayşe Gökçen Sade, Yeşi̇m Önal Taştan, Zeli̇ha Seri̇ndağ, Mustafa Kaplan
Turkish Journal of Medical Sciences
Background/aim: Acute pancreatitis is a clinical picture with a wide range of symptoms from mild inflammation to multiorgan failure and death. The aim of this study is to investigate the effects of Adalimumab (ADA) on inflammation and apoptosis in a cerulein-induced acute pancreatitis model in rats. Material and methods: Experimental cerulein-induced acute pancreatitis model was created by applying 4 intraperitoneal cerulein injections at 1-h intervals. A total of 40 rats, 8 in each group, were randomly distributed into five groups. In the groups that ADA treatment was given, two different doses of ADA were administered 5 mg/kg and 20 mg/kg …
Assessment Of S-Nitrosothiol And Thiol/Disulfide Levels In Acute Coronary Syndrome Patients, Mehmet Murat Yi̇ği̇tbaşi, Abdullah Nabi̇ Aslan, Harun Kundi̇, Mücahi̇t Furkan Erkiliç, Özcan Erel, Haci Ahmet Kasapkara
Assessment Of S-Nitrosothiol And Thiol/Disulfide Levels In Acute Coronary Syndrome Patients, Mehmet Murat Yi̇ği̇tbaşi, Abdullah Nabi̇ Aslan, Harun Kundi̇, Mücahi̇t Furkan Erkiliç, Özcan Erel, Haci Ahmet Kasapkara
Turkish Journal of Medical Sciences
Background/aim: The level of nitric oxide (NO) is important to protect the heart from ischemic damage in acute coronary syndrome (ACS) patients. S-nitrosothiol (SNO) is a molecule that represents the main form of NO storage in the vascular structure. In addition, dynamic thiol/disulfide homeostasis (TDH) is known to play an important role in maintaining the oxidant-antioxidant balance. In this study, our aim is to evaluate the oxidative/nitrosative stress status according to SNO level and TDH in patients with ACS. Materials and methods: The study included 124 patients who were admitted to the emergency service and 124 consecutive individuals who applied …
The Effect Of Topically Administered Lavender Aromatherapy On The Pain Of Insulin Injection In Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial, Hati̇ce Demi̇rağ, Sevi̇lay Hi̇nti̇stan, Enes Bulut
The Effect Of Topically Administered Lavender Aromatherapy On The Pain Of Insulin Injection In Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial, Hati̇ce Demi̇rağ, Sevi̇lay Hi̇nti̇stan, Enes Bulut
Turkish Journal of Medical Sciences
Background/aim: Needle phobia occurs in more than half of diabetic patients due to the pain caused by frequent insulin injections. Therefore, this study evaluated the effect of topically administered lavender aromatherapy on the pain of insulin injections in diabetic patients. Materials and methods: In this double-blind randomized controlled and experimental study, patients who met the study criteria were divided into three groups; topical lavender oil (n = 60), placebo (n = 60), and control (n = 60) groups. The data were collected using the "Patient Information Form", the "Follow-up Form", the "Verbal Category Scale (VCS)", and the "Visual Analogue Scale …
Investigation Of Ceftazidime-Avibactam Susceptibility In Clinical Isolates Of Gram-Negative Bacteria, Ridvan Dumlu, Neval Yurttutan Uyar, Meltem Ayaş, Ni̇lay Aksoy, Nur Öztürk, Ayşe Sesi̇n Kocagöz
Investigation Of Ceftazidime-Avibactam Susceptibility In Clinical Isolates Of Gram-Negative Bacteria, Ridvan Dumlu, Neval Yurttutan Uyar, Meltem Ayaş, Ni̇lay Aksoy, Nur Öztürk, Ayşe Sesi̇n Kocagöz
Turkish Journal of Medical Sciences
Background/aim: Our study investigated the susceptibility rate of ceftazidime-avibactam and the risk factors associated with its resistance by analyzing gram-negative bacteria isolated from various patient samples. Materials and methods: Between March and November 2020, 1119 gram-negative bacteria strains were isolated from patient samples in Acıbadem Healthcare Group hospitals; ceftazidime-avibactam susceptibility results were evaluated using a 10/4µg (Oxoid, UK) disc and evaluated according to Eucast 2020 recommendations. Patient and isolate characteristics that could be risk factors were retrospectively investigated and statistically analyzed using SPSS 25.0. Results: Male patients made up 52% (n = 581) of the study's total patient population, and …
Low Handgrip Strength Is Associated With Diabetic Foot Disease In Geriatric Patients With Type 2 Diabetes, Eren İmre, Neşe Koçakgöl, Erdi̇ İmre
Low Handgrip Strength Is Associated With Diabetic Foot Disease In Geriatric Patients With Type 2 Diabetes, Eren İmre, Neşe Koçakgöl, Erdi̇ İmre
Turkish Journal of Medical Sciences
Background/aim: This study aims to reveal the prevalence of low handgrip strength in older patients with type 2 diabetes who have diabetic foot disease and to assess the association of handgrip strength with diabetic foot disease in older patients with type 2 diabetes. Materials and methods: Eighty-nine geriatric patients with diabetic foot ulcers and 69 patients without diabetic foot ulcers who presented to the endocrinology outpatient clinic between August 2020 and November 2021 were included in the study. The exclusion criteria were the usage of steroids, stroke-induced quadriplegia, myopathy, disability, hemodialysis treatment, type 1 diabetes, patients under 65 years of …
Etiological, Clinical, And Laboratory Evaluation Of Congenital Hypothyroidism And Determination Of Levothyroxine (Lt4) Dose At Treatment Interruption In Differentiating Permanent Vs. Transient Patients, İsmai̇l Dündar, Mehmet Aki̇f Büyükavci, Nurdan Çi̇ftci̇
Etiological, Clinical, And Laboratory Evaluation Of Congenital Hypothyroidism And Determination Of Levothyroxine (Lt4) Dose At Treatment Interruption In Differentiating Permanent Vs. Transient Patients, İsmai̇l Dündar, Mehmet Aki̇f Büyükavci, Nurdan Çi̇ftci̇
Turkish Journal of Medical Sciences
Background/aim: Congenital hypothyroidism (CH) is the most common cause of preventable but irreversible mental retardation in children, although the risk has been widely abolished by national neonatal screening programs. The aim of this study was to determine, (a) the cause of CH, (b) the etiological cause of persistent CH and (c) to investigate the role of laboratory and clinical data in predicting persistent and transient CH. Materials and methods: Patients diagnosed with CH, who started L-thyroxine treatment and were followed up for at least three years were included. Patient data were reviewed retrospectively. Serum thyroid hormones were measured four weeks …
Management Of Recurrent Hemoptysis: A Single-Center Experience, Seda Tural Önür, Sedat Altin, Fatma Tokgöz Akyil, Kaan Kara, Si̇nem Nedi̇me Sökücü, Cengi̇z Özdemi̇r, Mehmet Aki̇f Özgül, Muzaffer Meti̇n, Levent Cansever, Aysun Ölçmen, Nuri̇ Özgür Kiliçkesmez
Management Of Recurrent Hemoptysis: A Single-Center Experience, Seda Tural Önür, Sedat Altin, Fatma Tokgöz Akyil, Kaan Kara, Si̇nem Nedi̇me Sökücü, Cengi̇z Özdemi̇r, Mehmet Aki̇f Özgül, Muzaffer Meti̇n, Levent Cansever, Aysun Ölçmen, Nuri̇ Özgür Kiliçkesmez
Turkish Journal of Medical Sciences
Background/aim: A successful planning methodology for patients with hemoptysis promises overall improvement in patient care. Conducted in a reference center for chest diseases, the present study aims to analyze characteristics and predictors of interventional methods in patients with recurrent hemoptysis. Materials and methods: The present study is a single-center, retrospective observational study. Between 2015 and 2018, 5973 patients with follow-up data until 2021 requiring more than one hospitalization due to recurrent hemoptysis were investigated. Patient characteristics, the amount of hemoptysis, baseline admission parameters, interventional procedures of bronchial artery embolization (BAE), fiberoptic bronchoscopy, rigid bronchoscopy, and surgical resections applied were analyzed …
Causes Of Severe Infections In Patients With Systemic Sclerosis And Associated Factors, Müçteba Enes Yayla, Emi̇ne Uslu Yurteri̇, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Serdar Sezer, Ayşe Bahar Keleşoğlu Di̇nçer, Emi̇ne Gözde Aydemi̇r Gülöksüz, Mehmet Levent Yüksel, Recep Yilmaz, Aşkin Ateş, Tahsi̇n Murat Turğay, Gülay Kinikli
Causes Of Severe Infections In Patients With Systemic Sclerosis And Associated Factors, Müçteba Enes Yayla, Emi̇ne Uslu Yurteri̇, Murat Torğutalp, Di̇dem Şahi̇n Eroğlu, Serdar Sezer, Ayşe Bahar Keleşoğlu Di̇nçer, Emi̇ne Gözde Aydemi̇r Gülöksüz, Mehmet Levent Yüksel, Recep Yilmaz, Aşkin Ateş, Tahsi̇n Murat Turğay, Gülay Kinikli
Turkish Journal of Medical Sciences
Background/aim: Systemic sclerosis (SSc) is a chronic systemic disease characterized by vascular damage, autoimmunity, and fibrosis in the skin and internal organs. In this study, we tried to determine the causes of severe infection in patients with SSc and to reveal the factors associated with severe infection. Materials and methods: We retrospectively examined 214 SSc patients between January 2010 and August 2020. Forty-seven patients with at least one severe infection and 167 patients without severe infection were compared. Results: A total of 76 episodes of severe infections were detected in 47 (22%) patients. Common infections included pneumonia, infected digital ulcer, …
Extremely High Erythrocyte Sedimentation Rate Revisited In Rheumatic Diseases: A Singlecenter Experience, Zehra Özsoy, Emre Bi̇lgi̇n, Melek Seren Aksun, İmdat Eroğlu, Umut Kalyoncu
Extremely High Erythrocyte Sedimentation Rate Revisited In Rheumatic Diseases: A Singlecenter Experience, Zehra Özsoy, Emre Bi̇lgi̇n, Melek Seren Aksun, İmdat Eroğlu, Umut Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: The objectives were to define the distribution of rheumatic diseases in patients with erythrocyte sedimentation rate (ESR) ≥ 100 mm/h and to find variables that can differentiate main study groups from others. Materials and methods: Charts of patients admitted with ESR ≥ 100 mm/h between 2015 and 2020 were reviewed. Patients were divided into four diagnostic groups based on etiology: infection (without a rheumatic diagnosis), oncologic (without a rheumatic diagnosis), rheumatic, and no definitive diagnosis. Patients with the rheumatic diagnosis were divided into three main study groups: those who had been recently diagnosed with a rheumatic disease, those who …
Effect Of Vitamin D On Myocardial Remodeling And Inflammatory Status In Children With Congenital Heart Disease, Sabi̇re Gökalp, Fatma Sedef Tunaoğlu, Fatma Canbeyli̇, Semi̇ha Terlemez, Vi̇ldan Atasayan, Lati̇fe Arzu Aral, Serdar Kula, Ayşe Deni̇z Oğuz
Effect Of Vitamin D On Myocardial Remodeling And Inflammatory Status In Children With Congenital Heart Disease, Sabi̇re Gökalp, Fatma Sedef Tunaoğlu, Fatma Canbeyli̇, Semi̇ha Terlemez, Vi̇ldan Atasayan, Lati̇fe Arzu Aral, Serdar Kula, Ayşe Deni̇z Oğuz
Turkish Journal of Medical Sciences
Background/aim: Vitamin D insufficiency is a common public health problem that is often unrecognized in children with congenital heart disease, and is not generally evaluated at congenital heart disease (CHD) follow-up. Recent studies have suggested that inadequate vitamin D status may have an adverse effect on cardiovascular health. This study investigates the relationship between vitamin D levels and hemodynamic parameters in children with CHD. Methods: Included in the study 40 patients (25 females, 15 males) with CHD, who were evaluated for Ross heart failure score, vitamin D, parathyroid hormone (PTH), calcium, phosphorus, alkaline phosphatase (ALP), whole blood count (WBC) and …
The Relationship Between Morning Blood Pressure Surge And Asymptomatic Episodes Of Paroxysmal Atrial Fibrillation In Patients With Systemic Arterial Hypertension, Ümmü Taş, Sedat Taş, İdi̇l Yavuz
The Relationship Between Morning Blood Pressure Surge And Asymptomatic Episodes Of Paroxysmal Atrial Fibrillation In Patients With Systemic Arterial Hypertension, Ümmü Taş, Sedat Taş, İdi̇l Yavuz
Turkish Journal of Medical Sciences
Background/aim: Hypertension is a known risk factor for developing atrial fibrillation. However, there is limited data to investigate the association between morning blood pressure surge (MBPS) and paroxysmal atrial fibrillation (PAF). We conducted the present study to determine whether there is a relationship between asymptomatic PAF and MBPS and whether MBPS may be a predictor of asymptomatic PAF episodes. Materials and methods: This prospective study comprised 264 adult patients who were newly diagnosed with essential hypertension or were previously diagnosed but not receiving regular antihypertensive therapy. We evaluated the patients in 2 groups according to their 24-h electrocardiography monitoring results: …
Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel
Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: Acute cerebral infarction (ACI) occurs as a result of instant disruption of vascular flow that causes disbalance between oxidative/antioxidative activity. We examined the relationship of serum neuro-oxidative stress parameters with stroke severity and infarct volume in ACI and emphasized the qualitative importance of high-density lipoprotein (HDL) on its relationship with myeloperoxidase (MPO) and paraoxonase-1 (PON1) in the acute period of stroke. Materials and methods: One hundred ACI patients applied within the first 24 h and 50 healthy volunteers were included. The patient group was evaluated with demographic data (including arrival serum biochemical assessment), clinical disability scores, infarct volume, serum …
Ultrasonographic/Regional Muscle Measurements For Diagnosing Sarcopenia In Older Adults With And Without Dementia, Zekeri̇ya Ülger, Gözde Şengül Ayçi̇çek, Özgür Kara, Murat Kara
Ultrasonographic/Regional Muscle Measurements For Diagnosing Sarcopenia In Older Adults With And Without Dementia, Zekeri̇ya Ülger, Gözde Şengül Ayçi̇çek, Özgür Kara, Murat Kara
Turkish Journal of Medical Sciences
Background/aim: Sarcopenia and dementia are growing concerns among older adults that muscle and brain atrophy may cooccur. We aimed to compare the age-related loss of muscle mass by using ultrasound (US), and skeletal muscle mass index (SMI) by bioelectrical impedance analysis in older adults with and without dementia. Materials and methods: A total of 221 older adults aged ≥65 years were included in the study. The diagnosis of sarcopenia was established if low muscle mass according to either SMI or sonographic gastrocnemius (GC) muscle thickness was combined with low grip strength. The diagnosis of dementia was based on the National …
Central Vein Sign: Comparison Of Multiple Sclerosis And Leukoaraiosis, Hüseyi̇n Gökhan Yavaş, Ergi̇n Sağtaş
Central Vein Sign: Comparison Of Multiple Sclerosis And Leukoaraiosis, Hüseyi̇n Gökhan Yavaş, Ergi̇n Sağtaş
Turkish Journal of Medical Sciences
Background/aim: Leukoaraiosis produces white matter lesions (WML) similar to multiple sclerosis (MS) on brain magnetic resonance imaging (MRI), and the distinction between these two conditions is difficult radiologically. This study aimed to investigate the role of the central vein sign (CVS) in susceptibility-weighted imaging (SWI) sequence in distinguishing MS lesions from leukoaraiosis lesions in Turkish population. Materials and methods: In this prospective study, axial SWI and sagittal three-dimensional fluid-attenuated inversion recovery (3DFLAIR) were obtained in 374 consecutive patients. The study consisted of 169 (89 MS patients, 80 patients with leukoaraiosis) patients according to the inclusion and exclusion criteria. Two observers …
Feasibility Of 3d T1w Sequences In Contrast-Material Enhanced Mr Cisternography At 3t, Oktay Algin, Ural Koç, Giyas Ayberk
Feasibility Of 3d T1w Sequences In Contrast-Material Enhanced Mr Cisternography At 3t, Oktay Algin, Ural Koç, Giyas Ayberk
Turkish Journal of Medical Sciences
Background/aim: We investigated the diagnostic values and artifact severities of 3D-T1W sequences in the diagnosis of cerebrospinal fluid (CSF) leakage. Material and methods: We retrospectively reviewed 3-tesla contrast-material enhanced MR cisternography exams of 22 patients with suspected CSF leakage in 4 years. The presence of the artifacts on 3D-T1W data was evaluated using a 4-point scale (0: none; 1: minimal; 2: moderate; 3: prominent). Agreements between CSF leakage results of the 3D-T1W sequences and consensus decisions were evaluated via kappa values. Artifact scores were analyzed by Fisher's exact test. Results: The most compatible techniques with the consensus diagnoses were fat-saturated …
Monitoring Renal Oxygenation Status By Near-Infrared Spectroscopy During Ureterorenoscopy In Children, Sema Şanal Baş, Meryem Onay, Çi̇ğdem Arslan Alici, Umut Alici, Baran Tokar
Monitoring Renal Oxygenation Status By Near-Infrared Spectroscopy During Ureterorenoscopy In Children, Sema Şanal Baş, Meryem Onay, Çi̇ğdem Arslan Alici, Umut Alici, Baran Tokar
Turkish Journal of Medical Sciences
Background/aim: Near-infrared spectroscopy (NIRS) monitoring demonstrates renal blood flow, perfusion, and oxygenation changes. This study aimed to evaluate the effects of pediatric endourological interventions (PEI) on regional oxygen saturation value (rSO2 ) using renal NIRS monitoring. Materials and methods: Patients having bilateral inguinal surgery (group I), cystoscopy (group II), and ureterorenoscopy (group III), 20 patients in each group, were included in the study. NIRS values before induction (T0) and at 5 min (T5), 10 min (T10), 15 min (T15), 20 min (T20), 25 min (T25), 30 min (T30) of the surgical procedure, and at the postextubation (Tend) were determined. The …
The Correlations Between Dynamic Contrast Enhanced Magnetic Resonance Imaging And Immunohistochemical Data In Head And Neck Squamous Cell Carcinomas, Nuri̇ Karabay, Hande Meli̇ke Bülbül, Ersoy Doğan, Ahmet Ömer İki̇z, Gökseni̇l Bülbül, Sülen Sarioğlu
The Correlations Between Dynamic Contrast Enhanced Magnetic Resonance Imaging And Immunohistochemical Data In Head And Neck Squamous Cell Carcinomas, Nuri̇ Karabay, Hande Meli̇ke Bülbül, Ersoy Doğan, Ahmet Ömer İki̇z, Gökseni̇l Bülbül, Sülen Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) can in vivo characterize tumor microvascular environment. The aim of the present study was to reveal the DCE-MRI findings and to determine the correlation between these findings and immunohistochemical data in head and neck squamous cell carcinoma (HNSCC). Materials and methods: Thirty-three patients diagnosed with primary HNSCC were evaluated retrospectively. DCE-MRI was conducted in all cases. CD34, CD105, and ki-67 expressions were analyzed with immunohistochemistry in tissue sections to determine micro-vessel density and proliferative activity. Results: The DCE-MRI is a successful technique in distinguishing tumor tissue from normal tissue. It was determined …
Effectiveness Of Virtual Reality-Based Vestibular Rehabilitation In Patients With Peripheral Vestibular Hypofunction, Yuşa Başoğlu, Mustafa Bülent Şerbetçi̇oğlu, İlayda Çeli̇k, Hasan Demi̇rhan
Effectiveness Of Virtual Reality-Based Vestibular Rehabilitation In Patients With Peripheral Vestibular Hypofunction, Yuşa Başoğlu, Mustafa Bülent Şerbetçi̇oğlu, İlayda Çeli̇k, Hasan Demi̇rhan
Turkish Journal of Medical Sciences
Background/aim: The rehabilitation of classical peripheral vestibular disorders is long and costly. Recently, interactive systems based on virtual reality (VR) technology have reduced the cost of vestibular rehabilitation therapy (VRT) and made the process more enjoyable. This study aims to investigate the effects of VR-based VRT in patients diagnosed with peripheral vestibular hypofunction (PVH). Materials and methods: In this study, a VR-based VRT program that utilized Sony Playstation®4 VR Head Mounted Display was applied to 25 patients (between 18-60) diagnosed with PVH. PVH was diagnosed by evaluating the patients' clinical histories, the findings in the "Micromedical Technologies VisualEyes Spectrum" videonystagmography …
Factors Affecting Patient-Acceptable Symptom States And Treatment Decision In Familial Mediterranean Fever, Derya Yildirim, İbrahi̇m Vasi̇, Erdi̇ Tahta, Riza Can Kardaş, Burcugül Özkiziltaş, Hami̇t Küçük, Mehmet Aki̇f Öztürk, Şemi̇nur Haznedaroğlu, Berna Göker, Abdurrahman Tufan
Factors Affecting Patient-Acceptable Symptom States And Treatment Decision In Familial Mediterranean Fever, Derya Yildirim, İbrahi̇m Vasi̇, Erdi̇ Tahta, Riza Can Kardaş, Burcugül Özkiziltaş, Hami̇t Küçük, Mehmet Aki̇f Öztürk, Şemi̇nur Haznedaroğlu, Berna Göker, Abdurrahman Tufan
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever [FMF] is the most common autoinflammatory disease characterized by inflammatory attacks of fever and polyserositis. Patients' quality of life is significantly affected due to recurrent excruciating pain attacks and complications. This study is performed to evaluate the parameters most affecting patients' satisfaction from treatment. Materials and methods: Three hundred and forty-six consecutive patients diagnosed with FMF were enrolled in this study. Current treatment, acute phase proteins, number, type, and severity of predominant attacks, absenteeism from work/school in the last three months were recorded, and the participants were asked whether they needed additional treatment to evaluate Patient …
Assessment Of Hcv-Rna Test Results And Access Rates To Antiviral Treatment In Patients With Anti-Hcv Positivity-A 10-Year Analysis, Emi̇ne Türkoğlu, Zafer Parlak, Hüseyi̇n Şener Barut
Assessment Of Hcv-Rna Test Results And Access Rates To Antiviral Treatment In Patients With Anti-Hcv Positivity-A 10-Year Analysis, Emi̇ne Türkoğlu, Zafer Parlak, Hüseyi̇n Şener Barut
Turkish Journal of Medical Sciences
Background/aim: Currently, hepatitis C virus (HCV) infection can be cured by direct-acting antivirals (DAAs). In this study, we aimed to find the rate of viremia among patients with a positive anti-HCV test and the rate of antiviral treatment given to viremic patients. We also aimed to reach patients with anti-HCV positivity but not tested for HCV-RNA, and patients, who were diagnosed with HCV-RNA positivity but received no treatment. Materials and methods: In this study, individuals tested for anti-HCV in Tokat Gaziosmanpaşa University Research and Application Hospital in the period between January 2010 and January 2020 were reviewed retrospectively. Anti-HCV positive …
Detection Method Of Intraoperative Awareness: A Randomized Comparative Study, Meltem Bektaş, Türkay Çakan, Pinar Kirdemi̇r, Meli̇s Engi̇n, Hülya Başar
Detection Method Of Intraoperative Awareness: A Randomized Comparative Study, Meltem Bektaş, Türkay Çakan, Pinar Kirdemi̇r, Meli̇s Engi̇n, Hülya Başar
Turkish Journal of Medical Sciences
Background/aim: The incidence of intraoperative awareness varies in a wide range in the literature. The reasons for these different results include the questioning method used and the questioning time. The goal of this study is to compare the effectiveness of different questioning methods and times used in intraoperative awareness research for detecting the incidence. Materials and methods: We recruited patients between the ages of 18-70 years, with normal cognitive functions and able to speak after general anesthesia to the study. The patients were randomly divided into two groups. In Group 1 we applied the modified Brice questionnaire in the first …
Frailty In Community-Dwelling Older Adults: Reliability And Validity Of The Turkish Version Of The Gérontopôle Frailty Screening Tool, Serdar Ceylan, Merve Güner Oytun, Arzu Okyar Baş, Meltem Koca, Burcu Balam Doğu, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Cafer Balci
Frailty In Community-Dwelling Older Adults: Reliability And Validity Of The Turkish Version Of The Gérontopôle Frailty Screening Tool, Serdar Ceylan, Merve Güner Oytun, Arzu Okyar Baş, Meltem Koca, Burcu Balam Doğu, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Cafer Balci
Turkish Journal of Medical Sciences
Background/aim: Recognizing frailty had a great importance in countries with an increasing geriatric population. The study aims to evaluate the reliability and validation of the Gérontopôle frailty screening tool (GFST), which was developed to screen frailty in the community-dwelling older adults, for the Turkish population. Materials and methods: In this crosssectional study, participants who applied to the geriatrics outpatient clinic of a university hospital were included. Comprehensive geriatric assessments of all patients were performed. The validity of the GFST was tested by its concordance with the FRAIL scale. Test-retest and interrater reliability analyses were made. Results: Ninety-six patients were included …