Medicine and Health Sciences Commons^™

Investigation Of The Relationship Between Triglyceride Glucose Index And Metabolic And Hematological Parameters In Obese Individuals, Özge Baş Aksu, Feri̇de Özkara, Rifat Emral, Volkan Genç, Demet Çorapçioğlu, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: This research examined the association between the triglyceride-glucose (TyG) index and metabolic, hepatic, and hematologic variables in a population of severely obese subjects, with a focus on the assessment of glycemic control.

Materials and methods: This retrospective study included 315 adult patients with a body mass index (BMI) ≥ 35 kg/m² who were evaluated for bariatric surgery. Participants were grouped according to HbA1c levels: those with HbA1c ≥ 6.5% and those with HbA1c < 6.5%. TyG, atherogenic index of plasma (AIP), fibrosis-4 (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI), and hematological inflammation markers were assessed and compared between groups. To investigate associations, correlation and regression analyses were conducted.

Results: Individuals with HbA1c ≥ 6.5% had significantly higher TyG, AIP, APRI, and FIB-4 values than those with lower HbA1c. The TyG index showed a strong …

The Role Of The Hemoglobin-Albumin-Lymphocyte-Platelet (Halp) Score In Deep Neck Infections And Its Relationship With Clinical Parameters, Ayşe Seçi̇l Kayali Di̇nç, Nagi̇han Gülhan Yaşar, Agah Yeni̇çeri̇, Çeti̇n Şahutoğlu, İbrahi̇m Sevi̇m, Meli̇h Çayönü

Turkish Journal of Medical Sciences

Background/aim: Deep neck infections (DNI) are suppurative infections of the cervical spaces, which may lead to life-threatening complications. The HALP score is a laboratory parameter reflecting a patient’s nutritional and inflammatory status. The aim of this study was to compare the HALP scores of patients with DNI with those of a control group. A secondary objective was to investigate the potential relationship between the HALP score and clinical parameters, and to assess its role in determining disease severity.

Materials and methods: The study retrospectively included patients who were hospitalized and treated for DNI. Data were extracted from the hospital’s electronic …

Health Impacts And Medical Assistance After Libyan Flood Disaster: Emergency Medical Teams’ Responses, Hakan Güner, Okan Maden, Muhammed Saltuk Deni̇z, Kerem Dost Bi̇lmez, Şükrü Yorulmaz, Mehmet Enes Gökler

Turkish Journal of Medical Sciences

Background/aim: Floods are the most frequent natural disasters and pose direct and indirect health risks, some well-documented and others poorly understood. Epidemiological studies help bridge these gaps and guide effective public health responses.In September 2023, Storm Daniel caused severe flooding in Libya, damaging infrastructure, including healthcare facilities. The disaster affected 250,000 people, displaced 48,000, and claimed 15,000 lives, making it the second deadliest natural disaster of the year. This study aims to assess the characteristics of flood-affected patients to improve disaster preparedness.

Materials and methods: This descriptive study examined disaster victims who visited three clinics established as part of an …

Erratum To " Evaluation Of Clinical Features And Treatment Modality Of Pediatric Patients With Steven Johnson Syndrome/Toxic Epidermal Necrolysis: A Single-Center Experience " [ Turkish Journal Of Medical Sciences 55 2 461 469], Funda Ayteki̇n Güveni̇r

Turkish Journal of Medical Sciences

In the original article, the ORCID of one of the co-authors, Hatice Irmak ÇELİK, was incorrectly reported by the corresponding author. At the request of the authors, the ORCID has been corrected to reflect the accurate information. This correction does not affect the content or conclusions of the article. The authors apologize for this oversight.

Link to the original article: https://doi.org/10.55730/1300-0144.5990

Nitrate And Nitrite Levels In Cattle Feed, Drinking Water, Rumen Content, And Blood Methemoglobin Levels In Burdur Province Of Türkiye, Reyda Kiyici, Hasan Altan Akkan, Mehmet Karaca, Esra Zeybek, Bayram Kudret Karaayvaz, Fi̇rdevs Mor Savaş, Yahya Öztürk, Asim Kart, Ramazan Yildiz, Murat Bayezi̇t

Turkish Journal of Veterinary & Animal Sciences

This study was conducted to determine the risk factors associated with nitrate/nitrite poisoning in cattle in the Burdur region. Feed and water samples were collected from 10 different farms randomly selected from 9 districts. A total of 33 feed samples, 13 water samples, 21 rumen contents, and 20 blood samples were collected for analysis. Nitrate and nitrite levels in feed, drinking water, and rumen fluid, as well as methemoglobin levels in blood samples, were determined using a spectrophotometric method. The average nitrate and nitrite levels in feed samples were 3.06 mg/kg and 3.54 mg/kg, respectively. The mean nitrate and nitrite …

Quadratus Lumborum Block For Total Abdominal Hysterectomy: A Double-Blind, Randomized, Controlled Trial, Nada Pejcic, Marija Kutlesic, Ivan Velickovic, Vladimir Milic, Slavisa Kovacevic, Radmilo Jankovic, Dejan Mitic, Radomir Mitic, Nenad Zornic

Turkish Journal of Medical Sciences

Background/aim: The Quadratus lumborum block (QLB) is an interfascial block recommended for multimodal pain therapy after cesarean section in patients who cannot receive intrathecal morphine. We wanted to investigate whether QLB contributes to better analgesia after total abdominal hysterectomy (TAH). The study was registered on the website ClinicalTrials.gov (registration number NCT05765318).

Materials and methods: Patients scheduled for TAH were randomized into two groups of 30 members each. The treatment group received QLB, while the control group did not undergo any block. The primary outcome was the amount of morphine during the first 12 postoperative h. Secondary outcomes included the total …

A Comparison Of Turp, Holep, And Rfa For Nonneurogenic Luts In Men, Turgay Ebi̇loğlu, Özgür Çinar, Selçuk Sarikaya, Adem Emrah Coğuplugi̇l, Bahadir Topuz, Cengi̇z Kara, Selahatti̇n Bedi̇r

Turkish Journal of Medical Sciences

Background/aim: The effect of transurethral resection of the prostate (TURP) for nonneurogenic male lower urinary tract symptoms (LUTS) is well known. However, recent advancements have come into use, so studies have been done to compare these new techniques to the gold standard TURP technique. The aim of this study was to compare the results of TURP, holmium laser enucleation of the prostate (HoLEP), and radiofrequency ablation (RFA) in men.

Materials and methods: The patients who had the TURP procedure were defined as group 1 (G1), those who had HoLEP were in group 2 (G2), and those who had RFA were …

Survival Of Patients With 2014 Figo Stage Iiic High-Grade Serous Ovarian Cancer Who Treated With Platin-Based Adjuvant Chemotherapy, Mehmet Ünsal, Meltem Yücesoy, Okan Oktar, Yeşi̇m Uçar, Gülşah Ti̇ryaki̇ Güner, Okan Ayteki̇n, A.Alp Tokalioğlu, Hande Esra Koca Yildirim, Fati̇h Kiliç, Burak Ersak, Caner Çakir, Di̇lek Yüksel, Çi̇ğdem Kiliç, Sevgi̇ Koç, Günsu Ki̇myon Cömert, Özlem Moraloğlu Teki̇n, Yaprak Engi̇n Üstün, Taner Turan

Turkish Journal of Medical Sciences

Background/aim: Epithelial ovarian cancer is the second most prevalent type of gynecological cancer. We aimed to investigate prognostic factors related to survival in patient with 2014 FIGO stage IIIC high-grade serous ovarian cancer (HGSOC).

Materials and methods: Two hundred fifty eight patients were evaluated retrospectively. The absence of a visible tumor was determined as maximum cytoreduction, and a residual tumor size of 1 cm or less was determined as optimal cytoreduction. Patients who underwent cytoreduction followed by a combination of platinum and taxane adjuvant chemotherapy were included. Exclusion criteria for the study were patients taking neoadjuvant chemotherapy and those with …

Acute Effects Of Virtual Reality-Based Relaxation And Exergaming On Primary Dysmenorrhea Symptoms, Muhammed Şeref Yildirim, Merve Çoğ, Büşra Mehder Akbaş, Si̇nem Salar, Hi̇lal Kekli̇cek

Turkish Journal of Medical Sciences

Background/aim: Primary dysmenorrhea (PD) is a menstrual disorder with significant physical and psychological impacts. Physical activity and relaxation techniques are proven methods for managing PD. Advances in virtual reality (VR) suggest that immersive relaxation and exergaming could provide new avenues for symptom relief. This study aimed to investigate the acute effects of VR-based interventions on PD symptoms and compare them with a control group receiving Jacobson’s Relaxation

Materials and methods: A randomized, controlled, single-blind trial was conducted with 43 female participants aged 18–30 years with regular menstrual cycles and PD. Participants were allocated to three groups: (I) immersive VR relaxation, …

A Prospective Study For The Examination Of Peripheral Blood Smear Samples In Pediatric Population Using Artificial Intelligence, Eli̇f Habi̇be Akteki̇n, Mert Burkay Çöteli̇, Ayşe Erbay, Nalan Yazici

Turkish Journal of Medical Sciences

Background/aim: Peripheral blood smear (PBS) and bone marrow aspiration are gold standards of manual microscopy diagnostics for blood cell disorders. Nowadays, data-driven artificial intelligence (AI) techniques open new perspectives in digital hematology. This study proposes an AI learning technique for the classification of blood cells over PBS samples while increasing the sensitivity and specificity rates of the experts as a decision support system of a prediagnostic tool.

Materials and methods: The methodology of this study comprises three steps for the creation of an effective learning technique for blood cell disorders. First is the digitization of PBS samples in 100x optical-digital …

Comparison Of Total Oxidative State, Total Antioxidative State , Serum Paraoxonase Activity, And Thiol Levels Before And After 6 Months Of Treatment In Patients With Multiple Sclerosis Who Have Been Recently Started On New Therapy Agents, Emel Başar, Hasan Bayindir, Hati̇ce Ferhan Kömürcü, Ebru Bi̇lge Di̇ri̇k, Ömer Anlar, Özcan Erel

Turkish Journal of Medical Sciences

Background/aim: The objective of this study was to establish the oxidative stress determiners as a total oxidative state (TOS), total antioxidative state (TAS), paraoxonase (PON) activity, oxidative stress index (OSI), and thiol/disulfide levels before and after 6 months of immunomodulator therapy in patients who were diagnosed according to the revised McDonald Criteria.

Materials and methods: Thirty-nine patients were included in our study who were diagnosed according to the revised McDonald Criteria, approved to participate in the study, and had been treated in the neurology inpatient clinic or presented in the neurology outpatient clinic of Ankara Yıldırım Beyazıt University Atatürk Training …

Can Mac-2 Binding Protein Glycosylation Isomer Serve As A Biomarker For Predicting Pulmonary Arterial Pressure And Pulmonary Hypertension In Systemic Sclerosis?, Ridvan Mercan, Di̇lara Bulut Gökten, Sonat Pinar Kara, Nesli̇han Meli̇k Üzüm, Savaş Güzel

Turkish Journal of Medical Sciences

Background/aim: This study aimed to explore the role of Mac-2 binding protein glycosylation isomer (M2BPGi) serum levels as a biomarker that could contribute to understanding organ involvement and the overall disease process in systemic sclerosis (SSc).

Materials and methods: The cross-sectional study examined 108 patients with SSc. Seventy-two people were included in the control group. Demographic and clinical characteristics of the patients, laboratory and radiological findings, pulmonary function tests and echocardiography results, and presence of pulmonary hypertension (PHT) based on echocardiographic evaluation were recorded. Venous blood samples of 5 mL were collected from individuals. Human M2BPGi levels in the samples …

Evaluation Of Treatment Compliance In Gout Patients: A Patient-Centered Study, Murat Buğra Görgülü, Riza Can Kardaş, Di̇lara Koç Şeramet, Ridvan Mercan, Mehmet Engi̇n Tezcan, Hami̇t Küçük, Abdurrahman Tufan, Berna Göker, Mehmet Aki̇f Öztürk

Turkish Journal of Medical Sciences

Background/aim: Most studies on unsuccessful gout treatment suggest that knowledge gaps and inadequate physician interventions are major contributors. However, there is a lack of research on the extent to which patients, educated by knowledgeable and experienced physicians, adhere to these recommendations.

Materials and methods: This study evaluated patients seen in university rheumatology clinics who were adequately informed about diet, target serum uric acid levels, and gout by rheumatologists. We assessed their compliance with treatment, clinical and laboratory findings, and disease status a median of seven years after treatment initiation. A total of 302 gout patients who began treatment in tertiary …

Cytopathological Evaluation Of Pericardial Effusions: 192 Cases In A Tertiary-Level Healthcare Centre, Ayşegül Aksoy Altinboğa, Nur Kivrak

Turkish Journal of Medical Sciences

Background/aim: There are many different benign and malignant etiologies of pericardial effusions (PEs), which can compress the heart and large vessels emerging from the heart and cause significant clinical findings. The aim of this study was to cytologically examine the underlying diseases causing PEs and to conduct detailed evaluations of underlying cancers in cases of malignant PE, both within the whole study population and according to sex.

Materials and methods: All PE samples obtained between 2019 and 2024 were reevaluated and categorized as nondiagnostic, negative for malignancy (NFM), atypia of undetermined significance (AUS), suspicious for malignancy (SFM), or malignant according …

Procedural And Patient-Related Factors Play Differential Roles In The Postdural Puncture Headache, Ece Yanik, Doğa Vuralli, Tuğba Tunç

Turkish Journal of Medical Sciences

Background/aim: The incidence of postdural puncture headache varies depending on the multifactorial nature of the risk factors. Patient-related and procedure-related risk factors are still controversial. In this prospective observational study, we aimed to evaluate the risk factors for postdural puncture headache, the effect of previous headache features on the development of postdural puncture headache, and the risk factors for the immediate or delayed postdural puncture headache.

Materials and methods: We prospectively analyzed 116 patients who underwent lumbar puncture for diagnostic or therapeutic purposes. All clinical and laboratory findings, previous headache history, and the features and information related to the lumbar …

Differentiation Of Multinodular And Vacuolating Neuronal Tumor And Dysembryoplastic Neuroepithelial Tumor Based On Mri, Burcu Gül, Bora Korkmazer, Ahmet Kürşat Karaman, Esra Koçhan Kizilkiliç, Mahmut Esat Aykan, Çi̇ğdem Özkara, Ni̇l Çomunoğlu, Ci̇han İşler, Serdar Arslan, Osman Kizilkiliç

Turkish Journal of Medical Sciences

Background/aim: To compare the MRI findings and clinical features of multinodular and vacuolating neuronal tumor (MVNT) and dysembryoplastic neuroepithelial tumor (DNET), and reveal the distinguishing features of these tumors from each other.

Materials and methods: Patients with a suspected magnetic resonance imaging (MRI)-based diagnosis of MVNT between 2018 and 2022 were collected from the hospital database. In addition, patients diagnosed with DNET on histopathological examination and who had MRIs in the same time period were included in the study. The MRI findings and clinical features were evaluated for each patient.

Results: There were 21 patients in the MVNT group and …

Comparison Of The Effectiveness Of Different Scoring Systems And Biochemical Markers Indetermining The Severity And Complications Of Acute Pancreatitis, Ahmet Ali̇ Aktaş, Deni̇z Siğirli, Pinar Taşar, Sadik Ayhan Kiliçturgay

Turkish Journal of Medical Sciences

Background and study aim: The aim of the study is to demonstrate the effectiveness of different scoring systems and inflammatorymarkers in predicting the severity, local complications, pancreatic necrosis, and mortality of acute pancreatitis (AP).

Materials and methods: The data of 357 patients whom the severity of pancreatitis was classified according to the Revised AtlantaClassification System diagnosed with AP were retrospectively examined. Also The APACHE II, BISAP, mCTSI, and Ranson scores ofall patients were calculated. After determining the cut-off values for scoring systems and inflammatory markers with ROC analysis,comparison for AP severity, local complication, necrosis, and mortality.

Results: In the study, …

Evaluation Of Clinical Features And Treatment Modality Of Pediatric Patients With Steven Johnson Syndrome/Toxic Epidermal Necrolysis: A Single-Center Experience, Funda Ayteki̇n Güveni̇r, Vi̇ldan Seli̇n Çayhan, Selman Kürşat Balci, Ragip Dere, Hati̇ce Irmak Çeli̇k, Serhat Emeksi̇z, Ahmet Selmanoğlu, Zeynep Şengül Emeksi̇z, Emrah Şenel, Emi̇ne Di̇bek Misirlioğlu

Turkish Journal of Medical Sciences

Background/aim: Steven Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but life-threatening severe cutaneous drug hypersensitivity reactions. The aim of our study was to evaluate the clinical features of pediatric patients diagnosed with SJS, TEN or SJS/TEN overlap and to examine treatment modalities.

Materials and methods: Patients aged 0–18 years who were followed up with SJS, TEN or SJS/TEN overlap at Ankara Bilkent City Hospital between August 2019 and January 2024 were retrospectively analyzed.

Results: Twelve patients who met the inclusion criteria were included in the study. Five of the patients had SJS, four had SJS/TEN overlap, and …

Does Dexmedetomidine Infusion Reduce The Postoperative Analgesic Need In Lumbar Disc Surgery?, Si̇bel Çatalca, Özlem Özmete, Numan Berk, Soner Çi̇vi̇, Emre Durdağ, Caner İncekaş, Nesri̇n Bozdoğan Özyilkan

Turkish Journal of Medical Sciences

Background/aim: Patients experience moderate-to-severe pain, especially in the first days after lumbar disc surgery. Poorly controlled pain in the postoperative period negatively affects patient outcomes. Dexmedetomidine is a highly selective α2 adrenoceptor agonist with demonstrated analgesic efficacy. However, conflicting results have been reported in the current literature regarding the efficacy of dexmedetomidine in this surgery. In this study, we tested the hypothesis that dexmedetomidine safely improves pain scores and reduces opioid consumption in lumbar microdiscectomy.

Materials and methods: Medical records of patients who underwent lumbar microdiscectomy with general anesthesia between January 2023 and October 2023 were retrospectively reviewed. Patients who …

Cardiac Surgery Dilemmas: Evaluating Outcomes Of Sternotomy Versus Thoracotomy, Muhammet Fethi̇ Sağlam, Emrah Uguz, Kemal Eşref Erdogan, Hüseyi̇n Ünsal Erçeli̇k, Murat Yücel, Mete Hidiroglu, Erol Şener

Turkish Journal of Medical Sciences

Background/aim: This retrospective study aimed to compare the clinical outcomes, including reoperation rates, mortality, and valve size measurements, in patients undergoing sternotomy and thoracotomy for cardiac surgery, particularly focusing on tricuspid valve replacements. The study sought to highlight differences in surgical approaches and their impact on patient outcomes.

Materials and methods: A total of 107 patients were included, with 82 undergoing sternotomy and 25 undergoing thoracotomy. Preoperative right ventricular function parameters (mean pulmonary artery pressure, tissue Doppler imaging, and tricuspid annular plane systolic excursion), valve sizes, and other clinical data were recorded. Statistical analyses were performed to assess differences in …

The Impact Of Parenting Style, Temperament And Character On Problematic Internet And Smartphone Use Among Non-Clinical Female Adolescents, Sadetti̇n Burak Açikel, Nur Çeti̇n

Turkish Journal of Medical Sciences

Background/aim: It is known that various temperament and character dimensions, and parenting styles could be associated with problematic internet and smartphone use. This study aimed to examine the association between temperament, character, and parenting styles and problematic smartphone and internet use in nonclinical female teenagers.

Materials and methods: 244 nonclinical female adolescent were included the study. Young’s Internet Addiction Test Short Form, Smartphone Addiction Scale, Junior Temperament and Character Inventory and Parenting Style Scale were used for collecting data.

Results: Problematic smartphone use was significantly negatively correlated with cooperativeness character type, strictness/supervision, and acceptance/involvement subscales of the parenting style scale. …

Benzyl Alcohol Improves Ang Ii-Induced Vascular And Renal Injury, Qi Hua, Zhenyu Gu

Turkish Journal of Medical Sciences

Background/aim: The etiology of hypertension in pediatric populations is complex and multifactorial, with metabolic abnormalitiesplaying a fundamental role in the pathogenesis of the condition. This study investigates the therapeutic effects of Benzyl alcohol (BA),identified through metabolomics analysis of pediatric hypertension serum, on Angiotensin II (Ang II)-induced vascular and renalinjury in murine models.

Materials and methods: Male C57BL/6 mice were used to establish a vascular remodeling model by continuous 4-week Ang II infusionusing a subcutaneous osmotic pump. Bioinformatics was used to identify target metabolites. The tail artery, common carotid arterydiastolic, and systolic pressures in mice were determined with a blood pressure …

Comparative Vasorelaxant Effects Of Atorvastatin And Rosuvastatin In Rat Aorta:Investigating The Role Of Perivascular Adipose Tissue, Deni̇z Kaleli̇ Durman, Meryem Aras, Gülsüm Ruveyda Aktaş, Bi̇rsel Sönmez Uydeş Doğan

Turkish Journal of Medical Sciences

Background/aim: Statins are known to display pleiotropic effects on the vascular system, beyond their lipid-lowering properties. Studieson isolated vascular preparations have demonstrated their acute relaxant effects on vascular tone. Considering the increased evidence inregard to the contribution of perivascular adipose tissue (PVAT) in the regulation of vascular homeostasis, we aimed to investigate thepossible modulatory role of PVAT in the vascular effects of atorvastatin and rosuvastatin in isolated rat aorta.

Materials and methods: Thoracic aortas isolated from young male Wistar rats were divided into two groups: rings with intact PVAT(+) and rings without PVAT (-), and then mounted in an isolated …

The Effects Of Liraglutide On Expressions Of Insulin Secretion And Beta Cell Survive Associated Gpcr Genes In Pancreatic Beta Cells, Meli̇kenur Türkol, Türker Bi̇lgen

Turkish Journal of Medical Sciences

Background/aim: Liraglutide as a long-acting glucagon-like peptide drug has anti-hyperglycemic and antiobesity effects. G protein-coupled receptors (GPCRs) are well- known drug target molecules that conduct critical signaling pathways related with diseases. Research has confirmed the role of many GPCRs genes in the regulation of pancreatic beta cell functions and insulin secretion. Liraglutide dependent expressional changes in GPCR genes may let us determine new drug targets.

Materials and methods: Therefore, we investigated the changes in expression of GPR75, GPR56, GLP1R, M3R, and CB1R genes, which are the GPCR family members, in response to liraglutide treatment in the NIT-1 mouse pancreatic beta …

Epstein Barr Virus Associated Venous Thromboembolism, Yeli̇z Çi̇çek, Ali̇ Mert

Turkish Journal of Medical Sciences

No abstract provided.

Effects Of Workload And Distance Traveled On Psychological Resilience And Values Among Emergency Healthcare Workers, Rami̇z Yazici, Efe Demi̇r Bala, Ayşe Fethi̇ye Basa Kalafat, Eyüp Sari, Hüseyi̇n Mutlu, Hakan Güner, Hi̇lmi̇ Kaya, Rabi̇a Bi̇rsen Tapkan, Utku Murat Kalafat, Serkan Doğan

Turkish Journal of Medical Sciences

Background/aim: Emergency medical services (EMS) personnel face significant challenges in their daily work, which can lead to burnout and affect their mental well-being. This study aimed to investigate how workload and distance traveled, as specific aspects of EMS work, influence the psychological resilience and values of EMS personnel. The Connor–Davidson Resilience Scale (CD-RISC) and Spiritual and Humanistic Value Scale (SHVS) were utilized to assess psychological resilience and values, respectively.

Materials and methods: A cross-sectional study was conducted among EMS personnel in Ankara, Türkiye, utilizing a questionnaire survey distributed between 23 and 30 May 2024. The study was approved by the …

Paradigm Shift In Obesity Treatment: An Extensive Review Of Current Pipeline Agents, Ecesu Çeti̇n, Brian Pedersen, Mehmet Furkan Burak

Turkish Journal of Medical Sciences

Obesity is a multifaceted disease that poses a significant public health challenge. Recent discoveries in understanding the biological pathways that regulate satiety and metabolism have led to a shift in the treatment paradigm for obesity. Thus, the gap between pharmacological and surgical interventions has diminished. The latest approved anti-obesity medications are achieving weight loss comparable to surgery. These GLP-1 analog-based therapies not only cause substantial weight loss but also improve obesity-associated comorbidities. However, there are still unmet needs in obesity care, and treatment options with alternative pathways are necessary. Whether achieved through lifestyle changes or medication, weight loss often leads …

Navigating Pregnancy With Cardiovascular Disease: Pathophysiology, Risk Stratification, And Maternal–Fetal Outcomes, Osman Türkmen, Serra Akar İnan

Turkish Journal of Medical Sciences

Pregnancy induces significant cardiovascular changes, including increases in heart rate, blood volume, and cardiac output, which may exacerbate existing heart conditions or unmask previously undiagnosed heart diseases.. This review outlines the types of cardiovascular diseases that affect pregnant women, organized by the modified World Health Organization risk classification. It covers key areas, including how pregnancy impacts the heart, common maternal and fetal complications, and effective management strategies. The review emphasizes the importance of preconception counseling, risk assessment, and continuous monitoring to ensure the best maternal and fetal outcomes. It also highlights practical guidelines for healthcare providers and discusses the latest …

Antifungal Prophylaxis In High-Risk Patients With Hematologic Malignancy:A Comparison Of Practice With Guidelines In Türkiye, Özlem Güzel Tunçcan, Seçki̇n Çağirgan, Hakan Özdoğu, Si̇nem Ci̇vri̇z Bozdağ, Fi̇li̇z Vural, Mustafa Pehli̇van, Hüseyi̇n Saffet Beköz, Yasemi̇n Esen, Tuba Koç, Petek Gi̇li̇k, Esi̇n Şenol

Turkish Journal of Medical Sciences

Background/aim: Primary antifungal prophylaxis (AFP) is recommended by guidelines as the gold standard for patients with hematologic malignancies. This study aimed to investigate the level of knowledge and translation of guideline recommendations into real-life setting among physicians in Türkiye.Materials and methods: In this prospective, observational study, the physicians’ knowledge of ΑFP guideline recommendations in patients with acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) undergoing first remission-induction (Group I), and graft-versus-host-disease (GvHD) after allogeneic stem cell transplant (Group II), was compared with clinical practice via 11-item multiple-choice questionnaire evaluating the timing and patients in whom AFP was initiated, with AFP …

Thoracic Disc Herniations: Diagnosis, Surgical Techniques, And Complication Insights, Mehmet Deni̇zhan Yurtluk, Aydin Si̇nan Apaydin, Hakan Kina, Khoi Than

Turkish Journal of Medical Sciences

Abstract: Thoracic disc herniations (TDHs) are rare conditions, comprising 0.1% to 5% of all reported herniation cases, and affecting up to 1 in 1,000,000 individuals. The mid to lower thoracic spine, particularly between the T11 and T12 vertebrae, is most frequently affected and often associated with trauma. Conditions like Scheuermann’s disease can predispose patients to TDHs. This study explores the clinical manifestations, diagnostic methods, surgical techniques, and complications associated with TDHs. Diagnosis relies on magnetic resonance imaging and computed tomography myelography to identify the level and nature of the herniation. Various surgical approaches, including posterolateral, lateral, and anterior, have been …