Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
The Respiratory Manifestations In Patients With Primary Sjögren?S Syndrome: Is Interstitial Lung Disease Related To Disease Activity?, Özlem Özdemi̇r Işik, Ayten Yazici, Ayşe Çefle
The Respiratory Manifestations In Patients With Primary Sjögren?S Syndrome: Is Interstitial Lung Disease Related To Disease Activity?, Özlem Özdemi̇r Işik, Ayten Yazici, Ayşe Çefle
Turkish Journal of Medical Sciences
Background/aim: Sjögren?s syndrome is a systemic, autoimmune disease and can affect many organs and systems. In this study, we aimed to evaluate the respiratory manifestations, and the association between interstitial lung disease (ILD) and disease activity in primary SS (pSS) patients. Materials and methods: The study design was retrospective cross-sectional, and 151 patients followed up with a diagnosis of pSS between 2004 and 2019 were included in the study. Demographic and clinical data, laboratory results, chest radiographs and thorax computed tomography (CT) results were obtained from patient files and hospital imaging system. Thorax CT was requested from all patients with …
Interstitial Lung Disease In Patients With Systemic Lupus Erythematosus: A Cohort Study, Naci̇ Şenkal, Esen Kiyan, Ali̇ Aslan Demi̇r, Yasemi̇n Yalçinkaya, Ahmet Gül, Murat İnanç, Mahdume Lale Öçal, Bahar Artim Esen
Interstitial Lung Disease In Patients With Systemic Lupus Erythematosus: A Cohort Study, Naci̇ Şenkal, Esen Kiyan, Ali̇ Aslan Demi̇r, Yasemi̇n Yalçinkaya, Ahmet Gül, Murat İnanç, Mahdume Lale Öçal, Bahar Artim Esen
Turkish Journal of Medical Sciences
Background/aim: Systemic lupus erythematosus (SLE) is an autoimmune disease with a variety of organ/system involvement. Respiratory system involvement is common in these patients and usually manifests itself by disorders of the lung parenchyma, pleura, pulmonary vasculature or diaphragm. In this study, we sought to determine the frequency of interstitial lung disease (ILD) in patients with SLE and associated risk factors. Materials and methods: Three hundred randomly chosen patients with SLE were included. Chest x-ray (CXR), lung spirometry and carbon monoxide diffusion test (DLCO) were performed. High-resolution thorax computed tomography (HRCT) was performed for a definite diagnosis of ILD. Results: Of …
Pleuroparenchymal Fibroelastosis In Systemic Sclerosis-Associated Interstitial Lung Disease, Alper Sari, Ömer Önder, Berkan Armağan, Ertuğrul Çağri Bölek, Bayram Fari̇soğullari, Emre Bi̇lgi̇n, Gözde Kübra Yardimci, Orhan Maci̇t Ariyürek, Ali̇ Akdoğan
Pleuroparenchymal Fibroelastosis In Systemic Sclerosis-Associated Interstitial Lung Disease, Alper Sari, Ömer Önder, Berkan Armağan, Ertuğrul Çağri Bölek, Bayram Fari̇soğullari, Emre Bi̇lgi̇n, Gözde Kübra Yardimci, Orhan Maci̇t Ariyürek, Ali̇ Akdoğan
Turkish Journal of Medical Sciences
Background/aim: To explore the frequency and clinical associations of radiologic pleuroparenchymal fibroelastosis (PPFE) in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). Materials and methods: In this single-center retrospective study, high resolution computed tomography (HRCT) images of 105 patients with SSc-ILD were examined for the presence of PPFE. Demographic, clinical, laboratory, and pulmonary function test (PFT) data of patients with and without PPFE were compared. Results: PPFE was detected in 19 (18.1%) patients (`definite PPFE' in 13 and `consistent with PPFE' in 6 patients). Patients with PPFE had higher age and longer disease duration than PPFE (-) patients (p < 0.05 for both). Radiologic usual interstitial pneumoniae (UIP) pattern was more frequent (26.3% vs. 4.7%, p = 0.01) and median force vital capacity (FVC) was lower in patients with PPFE (64% vs. 82%, p = 0.005). Spontaneous pneumothorax developed in one patient with PPFE. More deaths occured in PPFE (+) group during follow-up (31% vs. 11%, p = 0.04). Conclusion: PPFE on HRCT is not uncommon in SSc-ILD and is associated with radiologic UIP pattern and worse lung functions. Further studies are needed to elucidate the prognostic value of PPFE in SSc-ILD.