Exercise Physiology Commons^™

The Effects Of High Intensity Interval-Based Kettlebells And Battle Rope Training On Grip Strength And Body Composition In College-Aged Adults, Jeffrey Quednow, Tim Sedlak, Joseph Meier, Jeffrey Janot, Saori Braun

International Journal of Exercise Science

International Journal of Exercise Science 8(2) : 124-133, 2015. The aim of this current study is to evaluate the changes in body composition and hand grip strength following high intensity interval training (HIIT) utilizing kettlebells and battle ropes. We hypothesize results will show that our HIIT protocol will improve grip strength and body composition. Subjects in the experimental and control group consist of 13 college-aged students (9 females; 4 males). Subjects in both groups complete a pre-test and post-test consisting of height, weight, grip strength via handgrip dynamometers and body composition via skinfold calipers. The experimental group completes a 5-week …

Activity Profile Differences Between Sub-Elite Futsal Teams, Sera Dogramaci, Mark Watsford, Aron Murphy

International Journal of Exercise Science

International Journal of Exercise Science 8(2) : 112-123, 2015. Whilst there are a range of studies examining the differences in match demands between levels of competition, there is an absence of the analysis these differences between teams within the same level of competition. The study used notational analysis to identify performance indicators that differentiated between sub-elite futsal teams from Brazil, Spain and Australia during regular season matches. Based on world rankings, Spanish and Brazilian futsal was deemed to be superior to Australian futsal. The Australian players spent a significantly greater time engaged in high intensity activity than the Spanish players …

Effects Of A Smart-Phone Application On Psychological, Physiological, And Performance Variables In College-Aged Individuals While Running, Martin J. Moran, John M. Coons

International Journal of Exercise Science

International Journal of Exercise Science 8(2) : 104-111, 2015. The purpose of this study was to determine the effects of auditory exergaming through the use of a smart-phone app called Zombies, Run! on psychological, physiological, and performance variables in college-aged individuals while running. Participants included both males (n = 10) and females (n = 10). Participants ran three 15 minute trials, after which they completed motivational questionnaires regarding inspiration, enjoyment, confidence, and anxiety levels. The first run got the participants accustomed to the application. The second and third were randomly counterbalanced either using the application again or running with no …

Co-Ingestion Of Carbohydrate With Branched-Chain Amino Acids Or L-Leucine Does Not Preferentially Increase Serum Igf-1 And Expression Of Myogenic-Related Genes In Response To A Single Bout Of Resistance Exercise, Rui Li, Maria Pontes Ferreira, Matthew B. Cooke, Paul La Bounty, Bill Campbell, Mike Greenwood, Darren S. Willoughby, Richard B. Kreider

Nutrition and Food Science Faculty Research Publications

This study determined if the co-ingestion of carbohydrate (CHO) with branched-chain amino acids (BCAA) or L-leucine (LEU) preferentially affected serum IGF-1 and the expression of myogenic-related genes in response to resistance exercise (RE). Forty one, college-age males were randomly assigned to 1 of 4 groups: CHO, CHO-BCAA, CHO-LEU, or placebo (PLC). Resistance exercise consisted of 4 sets of leg press and leg extension at 80% 1RM. Supplements were ingested peri-exercise, and venous blood and muscle biopsies were obtained pre-exercise (PRE), and at 30, 120, and 360 min post-exercise. Serum IGF-1 was determined with ELISA, and skeletal muscle mRNA expression of …

Amp-Activated Protein Kinase Controls Exercise Training - And Aicar-Induced Increases In Sirt3 And Mnsod, Josef Brandauer, Marianne A. Andersen, Holti Kellezi, Steve Risis, Christian Frozig, Sara G. Vienberg, Jonas T. Treebak

Health Sciences Faculty Publications

The mitochondrial protein deacetylase sirtuin (SIRT) 3 may mediate exercise training-induced increases in mitochondrial biogenesis and improvements in reactive oxygen species (ROS) handling. We determined the requirement of AMP-activated protein kinase (AMPK) for exercise training-induced increases in skeletal muscle abundance of SIRT3 and other mitochondrial proteins. Exercise training for 6.5 weeks increased SIRT3 (p < 0.01) and superoxide dismutase 2 (MnSOD; p < 0.05) protein abundance in quadriceps muscle of wild-type (WT; n = 13–15), but not AMPK α2 kinase dead (KD; n = 12–13) mice. We also observed a strong trend for increased MnSOD abundance in exercise-trained skeletal muscle of healthy humans (p = 0.051; n = 6). To further elucidate a role for …

Reduced Regional Cerebral White Matter Perfusion In Middle-Aged Hispanic Adults, Evan P. Pasha, Takashi Tarumi, Mitzi M. Gonzales, Miriam E. Pearman, Andrean P. Haley, Hirofumi Tanaka

International Journal of Exercise Science: Conference Proceedings

Background: Hispanics are at least 1.5 times more likely at any age past 55 years to have mild cognitive impairment and manifest dementia symptoms 7 years earlier than non-Hispanic Caucasians. Regional cerebral hypoperfusion has been implicated as an initial event in the pathogenesis of dementia. Aim: To compare cerebral perfusion in brain regions known to be susceptible to vascular related hypoperfusion in Hispanic and non-Hispanic Caucasian adults. Methods: Apparently healthy middle-aged Hispanic (n=16) and non-Hispanic Caucasian (n=16) subjects were matched across age, gender, years of education, and cognitive status. Arterial spin labeled perfusion magnetic resonance imaging (ASL-MRI) estimated cerebral blood …

High-Density Lipoprotein Antioxidant Responses To High-Intensity Interval And Steady-State Moderate-Intensity Exercise, Zacharias Papadakis, Jeffrey S. Forsse, Annie A. Bane, Taylor Kyle, Li Qian, Flor Elisa Morales Marroquín, Peter W. Grandjean

International Journal of Exercise Science: Conference Proceedings

High-intensity interval exercise (HIIE) may impart health benefits beyond what is acquired through moderate-intensity steady state exercise (SSE). Paraoxonase 1 (PON1), an antioxidant associated with high-density lipoprotein (HDL), may be altered with exercise; however, it is unclear whether HIIE provides a greater stimulus for increasing PON1 antioxidant activity than a comparable or greater amount of SSE. PURPOSE: Determine the influence of HIIE on PON1 concentration and activity relative to a comparable amount of moderate-intensity SSE and a dose that is half that of SSE. METHODS: Seventeen male participants (age 27.8 + 6.4 yr; weight 80.6 + 9.0 kg; BMI 25.1 …

The Effects Of Physical Activity On Markers Of Hepatic Inflammation During Weight-Loss, Andrew Seija, Kaylee E. Poole, Kevin Eck, Matthew Harris, Tayler N. Nick, Joshua S. Wooten

International Journal of Exercise Science: Conference Proceedings

Non-alcoholic fatty liver disease (NAFLD) represents a continuum that begins with accumulation of lipid in hepatic cells progressing to hepatic steatosis with inflammation (steatohepatitis), fibrosis, and cirrhosis. Weight-loss using dietary modification and physical activity are common strategies used for the treatment of NAFLD; however, it remains to be determined the effects of physical activity on hepatic inflammation during weight-loss. The purpose of this study was to determine the therapeutic role of physical activity on plasma and hepatic inflammatory markers during weight-loss. Male C57BL/6 mice were fed either a low-fat (LFD; 10% kcal fat) or high-fat (HFD; 60% kcal fat) diet …

The Effects Of Physical Activity On Hepatic Lipid Metabolism During Weight-Loss, Kaylee Poole, Andrew Seija, Kevin Eck, Matthew Harris, Tayler Nick, Joshua S. Wooten

International Journal of Exercise Science: Conference Proceedings

Non-alcoholic fatty liver disease (NAFLD) develops as a result of physical inactivity and overnutrition. Changing dietary behaviors and increasing physical activity are common strategies used for weight-loss; however, it remains unclear what additional benefits are provided by incorporating physical activity in a weight-loss program for the treatment of NAFLD. The purpose of this study was to determine how physical activity reduces hepatic steatosis and changes the expression of hepatic lipogenic genes during weight-loss. Male C57BL/6 mice were fed either a low-fat (LFD; 10% kcal fat) or high-fat (HFD; 60% kcal fat) diet for 10-weeks. Following 10-weeks, the HFD group was …

Effects Of Fish Oil Supplementation On Post-Resistance Exercise Muscle Soreness In Untrained Females, Grant M. Tinsley, Joshua J. Gann, Stefan R. Huber, Paul M. La Bounty, Rodney G. Bowden, Thomas L. Andre, Paul M. Gordon, Peter W. Grandjean

International Journal of Exercise Science: Conference Proceedings

The anti-inflammatory properties of omega-3 fatty acids contained in fish oil may help alleviate symptoms of delayed onset of muscle soreness (DOMS) and improve recovery from exercise.

PURPOSE: To examine the effects of fish oil supplementation on the time-course of post-resistance exercise muscle soreness in young untrained females.

METHODS: Seventeen non-resistance trained females (age 23.6 ± 3.0 y, % fat 27.4 ± 3.2, weight 60.2 ± 9.6 kg) were randomized into one of two groups: fish oil (6 g/d; 5:1 EPA:DHA) or placebo (6 g/d corn/soy oil). After consuming the supplements for one week, participants underwent a single bout of …

Controlled Cold Water And Water Slushy Ingestion, And Heat Performance In Subjects Of Average Fitness, Samantha N. Cantu, Christopher M. Hearon, Matthew V. Bliss, Ryan Fiddler

International Journal of Exercise Science: Conference Proceedings

Fluid ingestion is known to improve exercise performance and could lead to a heat sink effect, if cold enough. While research has been conducted on the influence of hydration in exercise performance, little has been done which consider beverages’ temperature during controlled consumption. PURPOSE: To examine the effect of controlled consumption of water at different temperatures on heat performance in subjects of average fitness. METHODS: Fifteen males, ages 18-29, with no prior heat illness were recruited. Subjects were tested for body composition and peak oxygen consumption (VO_2peak) prior to testing. All subjects underwent three experimental trials [cold …

Effect Of Nitric Oxide Bioavailability On Cutaneous Microvascular Function In Healthy Young African Americans, Kiyoung Kim

International Journal of Exercise Science: Conference Proceedings

We have recently demonstrated impaired microcirculatory function in healthy young African Americans (AAs) as indexed by attenuated cutaneous vasodilation during local heating. The mechanisms resulting in this impairment are multifactorial; however, recent evidence suggests that decreased nitric oxide (NO) bioavailability is a primary contributor. PURPOSE: To expand our previous findings and determine if this reduced microvascular vasodilatory response in AAs is related to a decrease in NO bioavailability. We hypothesized that NO dependent cutaneous vasodilation in response to local heating is lower in healthy young AAs relative to age / sex / body mass matched Caucasians (CA). METHOD: To date …

3-Nitrotyrosine And Soluble Vascular And Intracellular Adhesion Molecule Responses To High-Intensity Interval And Steady-State Moderate-Intensity Exercise, Jeffrey S. Forsse, Zacharias Papadakis, Annie A. Bane, J. Kyle Taylor, Li Qian, Flor Elisa Morales Marroquín, Peter W. Grandjean

International Journal of Exercise Science: Conference Proceedings

Vascular endothelium may respond differently to high-intensity interval exercise (HIIE) when compared to moderate-intensity steady state exercise (SSE). We hypothesized that greater sympathetic stimulation of soluble vascular adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) and greater oxidative and nitrative stress on the vascular endothelium may transiently result from HIIE. PURPOSE: Determine the influence of HIIE on sVCAM-1, sICAM-1 and 3-nitrotyrosine (NT), a marker of nitric oxide-dependent reactive nitrogen species and nitrative stress, relative to a comparable amount of moderate-intensity SSE and a dose that is half that of SSE. METHODS: Seventeen male participants (age 27.8 + 6.4 yr; weight …

The Positive Effects Of Acute Resistance Exercise On Blood Lipid Profiles In College-Aged Men, Farzana F. Alam, Jin K. Park, Neil A. Schwarz, Ashley P. Lamar, Yunsuk Koh

International Journal of Exercise Science: Conference Proceedings

Low- to moderate-intensity exercise has been widely recommended for people at any age to improve cardiovascular health due to its positive effects on blood lipids and lipoproteins. Recently, many people have been participating in not only low- to moderate-intensity, but high-intensity exercise as well in order to improve their cardiovascular health. However, it is unclear whether high-intensity exercise, particularly resistance exercise, can positively influence blood lipids and lipoproteins. Purpose: The current study examined the effects of low- and high-intensity of resistance exercise on changes in blood lipids and lipoproteins. Methods: In a randomized, cross-over design, 10 healthy recreationally resistance-trained (at …

Changes In Creatine Phosphokinase Isoenzymes After Varying Levels Of Resistance Exercise, Ashley Lamar, Yunsuk Koh, Jin K. Park, Farzana Alam

International Journal of Exercise Science: Conference Proceedings

Creatine phosphokinase (CK) isoenzymes are found in various tissues, such as skeletal muscle (CK-MM), cardiac muscle (CK-MB), and the brain (CK-BB). Elevated CK isoenzymes indicate damage or injury to specific tissue. Using CK isoenzymes as a marker in order to indicate muscle damage as a result of different degrees of resistance exercise has not been clearly examined. Purpose: To determine the changes in CK isoenzymes following resistance exercise at different intensities. Methods: Ten healthy recreationally resistance-trained (at least 3 - 6 days per week for a minimum of one year) men participated in the study. The participants performed …

Leg Lean Mass Adaptations Following Short-Term Barbell Training In Women, Jacob A. Mota, Matt S. Stock, Kendra D. Olinghouse, Alexander S. Drusch, Brennan J. Thompson

International Journal of Exercise Science: Conference Proceedings

Participation in a resistance training program results in both neural adaptations and increases in lean body mass, the latter of which is considered a slow process. The majority of previous investigations that have examined the time course associated with muscular adaptations have utilized exercise machines or single-joint movements. Furthermore, the adaptations associated with resistance training in women are not as well understood as those for men. The purpose of this investigation was to examine the effects of a four week resistance training intervention on changes in leg lean mass in untrained, college-aged women. Thirty-five women (mean ± SD age = …

Changes In Arterial Stiffness And Blood Pressure During Various Vascular Reactivity Tests, Jisok Lim, Miriam Pearman, Mohammed Alkatan, Daniel Machin, Wonil Park, Hirofumi Tanaka

International Journal of Exercise Science: Conference Proceedings

Increased arterial stiffness is an independent prognosis marker of elevated cardiovascular risks. However, some investigators have questioned the utility of arterial stiffness above and beyond the traditional blood pressure (BP) measurement as the change in arterial stiffness is often accompanied by the corresponding change in BP. Although the associations between chronic levels of arterial stiffness and BP have been fairly well studied, it is not clear if and how much arterial stiffness is influenced by acute changes in BP. PURPOSE: We determined magnitudes of BP-dependence of arterial stiffness during acute BP perturbations. METHODS: Thirty apparently healthy subjects (46±4 …

Passive Hyperthermia Therapy Similarly Reduces Arterial Blood Pressure In Obese Type 2 Diabetic And Healthy Individuals, Eric Rivas

International Journal of Exercise Science: Conference Proceedings

Diabetes which is associated with impaired glycemic control, can damage macro and microvasculature, and impair vascular relaxation (i.e., endothelial dysfunction). The high thermal conductance of hot water will cause thermoregulatory adjustments that increase cardiac output, heart rate and stroke volume while reducing central venous pressure. This project tested the hypothesis that an acute bout of hot water hyperthermia will reduce arterial blood pressure during and following the exposure, but the response will be attenuated in obese type 2 diabetics. Eleven obese type 2 diabetics (T2D) (50.1 ± 12 y, 45 ± 7.1% fat mass, 7.5 ± 1.8% HbA1C) and nine …

The Effects Of Ammonia Inhalants On Anaerobic Performance Following A Simulated American Football Game, Joseph R. Secrest, Eric J. Jones, Mark Faries, Christopher M. Hearon

International Journal of Exercise Science: Conference Proceedings

Ammonia inhalants (AI) are anecdotally referred to as ergogenic aids in the realm of aggressive team/lifting sports. However, the efficacy of AI usage has yet to be established or reported to our knowledge. Therefore, the purpose of this study was to establish the effects of AI’s on anaerobic performance following a simulated American football game (SAFG) in a climate controlled setting (35.8 °C, 27.5% RH). METHODS: Ten apparently healthy anaerobically trained college-aged males participated dressed in American football apparel, excluding the helmet. Each subject participated in two trials, 136 minutes each, separated by a minimum of 48 hours (AI or …

Pre-Prandial Vinegar Ingestion Improves Two-Hour Glucose Control In Older, Type Ii Diabetics More Than Post-Prandial Walking, Sarah J. Taylor, Matthew J. Garver, Anna E. Ciufo, Taylor G. Flowers, Chase M. Harbach, Austin A. Ray, Cory M. Scheadler

International Journal of Exercise Science: Conference Proceedings

Background: Exercise engagement benefits diabetic patients through an insulin-like effect on muscle. Literature indicates that vinegar consumption may lower blood glucose levels. It is not currently clarified whether a relative amount of vinegar ingestion or a walking bout is more effective at controlling glucose in older, Type II diabetics during the acute phase following a meal. Purpose: The aim was to directly compare the impact of preferred-pace walking (15 min, postprandial) versus ingestion of a relative quantity of vinegar (0.3 g/kg) on two-hour glucose control. Methods: The two arms of the trial were completed in a randomized, …

Role Of High-Intensity Resistance Exercise In Vascular Inflammation In Recreationally Trained Men, Jin K. Park, Neil Schwarz, Darryn Willoughby, Yunsuk Koh

International Journal of Exercise Science: Conference Proceedings

Soluble intracellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) are known as vascular inflammatory markers and play a key role in the development of atherosclerosis. Although low to moderate intensity exercise may positively influence inflammatory markers, the role of high-intensity resistance exercise in sICAM-1 and sVCAM-1 has not been fully examined. The current study examined the effects of resistance exercise at different intensities (low vs. high) on acute responses of sICAM-1 and sVCAM-1. In a randomized, cross-over design, 10 recreationally trained (resistance-trained 3 to 6 days per week for at least one year) college-aged men performed a …

Thermoregulatory Dysfunction In Multiple Sclerosis Patients During Moderate Exercise In A Thermoneutral Environment, Mu Huang, Nathan Morris, Ollie Jay, Scott Davis

International Journal of Exercise Science: Conference Proceedings

Impairments in sudomotor function during passive heat stress have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, little is known regarding exercise induced increases in core body temperature on thermoregulatory mechanisms in MS. Thus, the aim of this study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared to healthy controls (CN) during moderate exercise. Thermoregulatory function in five patients diagnosed with relapsing-remitting MS and five mass-matched healthy controls were compared during a single bout of cycling exercise (fixed workload of 70 Watts) for 30-60 minutes …

Influence Of Decompression Rate On Hemodynamic Compensation To Continuous Lower Body Negative Pressure, Edward J. St. John Jr., William H. Cooke

International Journal of Exercise Science: Conference Proceedings

We applied lower body negative pressure (LBNP) continuously, at three decompression rates, in an attempt to simulate uncontrolled hemorrhage as might be experienced by victims of traumatic injury. The purpose of our study was to determine whether hemodynamic compensations to simulated hemorrhage depend more on the magnitude, or the rate of change in pressure applied. Forty five (45) young, healthy subjects participated. We recorded the electrocardiogram, beat-to-beat arterial pressure (finger photoplethysmography), and measured cardiac output (inert gas rebreathing to calculate stroke volume) during continuous LBNP applied at three different decompression rates (n = 15 subjects for each rate; slow = …

Lower Extremity Proprioception And Physical Performance Testing: A Correlation Study, Danielle Aguilar, Erin Drozd, Clara Borja, Dr.Jason Winchester, Dr. Chad Jackson

International Journal of Exercise Science: Conference Proceedings

Proprioception is a function of the somatosensory system which has implications for activities of daily living, athletic endeavors, and risk of injury. It has been suggested that athletes who sustain injuries may have decreased proprioception and a corresponding increase in the risk of re-injury. Interventions for injury prevention and/or recovery may include, but are not limited to, emphasis on proprioceptive ability via joint position awareness. The purpose of this investigation was to determine if a correlation exists between proprioceptive ability and other components of physical performance such as lower body muscular power and change of direction. It was hypothesized that …

Comparison Of Multiple Sets And Single Set Of Resistance Training On Muscle Strength And Power, Junyoung Hong

International Journal of Exercise Science: Conference Proceedings

Studies have been conducted to investigate the effects of different resistance training modalities on muscle strength and power in order to improve physical performance, yet to date findings have been inconclusive. Optimal resistance programs for muscular responses to high and low volume resistance training still need to be explored. The purpose of this study was to compare the effects of multiple sets (70% of 1RM, 3 sets/10 reps) and a single set (50-100% of 1RM, 1 set/up to 8 reps) of resistance training on muscular strength and power in healthy male college students. A total of 19 students were randomly …

The Effects Of Deep Water Running And Cold Water Immersion On Muscle Soreness, Todd J. Castleberry, Vic Benezra, Sarah Deemer, Tara Niemann, Janie Foreman

International Journal of Exercise Science: Conference Proceedings

Delayed onset muscle soreness (DOMS) is caused from any type of activity that places unaccustomed loads on a muscle. Athletes are consistently pursuing methods to help decrease soreness. The purpose of this study is to evaluate the effects of deep water running (DWR) and cold water immersion (CWI) on perceived muscle soreness and creatine kinase (CK) activity. Healthy participants (males=2, females =12; mean ± SD, 22.8 + 4.9 yrs; 38.0 + 7.8 yrs VO_2max; 113.6 + 27.3 lbs 1RM) completed five days of data collection. Seven days following a 1 repetition maximum (1RM), participants completed an eccentric exercise …

Acute Flavanol Supplementation Improves The Attenuated Cerebral Vasodilatory Capacity In Young African Americans, Jordan C. Patik, Chansol Hurr, Michelle L. Harrison, R. Matthew Brothers

International Journal of Exercise Science: Conference Proceedings

African Americans (AA) have increased risk for cerebral vascular disease including stroke, Alzheimer’s disease, or dementia relative to Caucasian Americans (CA). Our recent study found that AA have attenuated cerebral vasodilatory response to rebreathing-induced hypercapnia when compared with CA. Thus, we hypothesized that acute flavanol intake restores blunted cerebral responses in AA. Fourteen healthy college-aged AA and 14 age- and sex-matched CA participants were studied. A four-parameter logistic regression was used for curve fitting the responses of cerebral vascular conductance (%CVCi) relative to changes in end-tidal carbon dioxide concentration. In AA, there were significant improvements in total range of changes …

Wrist Immobilization: Does Elbow And Shoulder Overcompensation Occur When Performing Drinking And Hammering Tasks?, Virginia P. Stofer, Scott P. Mclean, Jimmy Smith

International Journal of Exercise Science: Conference Proceedings

Wrist orthoses, which immobilize or reduce motion at the wrist, may cause difficulties in performing daily tasks as they may affect other nearby joints and muscles of the upper extremity. Previous studies have generally focused on compensatory shoulder movements, not elbow movements, when wearing wrist orthoses. The purpose this study was to determine whether wrist immobilization results in compensatory movements of both the elbow and shoulder. Specifically, this study examined joint movement of the elbow and shoulder joints when performing a drinking and hammering task while wearing a wrist orthosis. Informed consent was received from all participants prior to participation …

A Comparative Study On The Energy Cost Of Pushing The Hope Haven Kidchair And Free Wheelchair Mission Gen 2 Wheelchair, Elisa J. Hamm, Benjamin M. Jonah, Karen Rispin

International Journal of Exercise Science: Conference Proceedings

Introduction: Wheelchair skills tests can be used to assess the mobility provided by different types of wheelchairs [1]. A repeated measures study design in which participants complete skills in one type of wheelchair and then another minimizes individual variation [2]. Free Wheelchair Mission Generation 2 (FWM-2) and Hope Haven KidChair (H-KC) offer two pediatric-sized wheelchairs designed for use in low-resource settings. We hypothesize that four simple skills tests will be able to distinguish some strengths and weaknesses of the mobility provided by these two wheelchairs. Methods: This study was done in partnership with a host organization at a …

Attenuated Cerebral Vasodilatory Capacity In Response To Hypercapnia In Young Obese Individuals, Janée D. Terwoord, Chansol Hurr, R. Matthew Brothers

International Journal of Exercise Science: Conference Proceedings

Obese individuals are at a greater risk for the development of a variety of cardio and cerebral vascular diseases including hypertension, atherosclerosis, coronary artery disease and stroke. Furthermore, obesity is associated with cognitive impairment and is a risk factor for dementia and Alzheimer’s disease. The exact mechanisms of this elevated risk are not fully characterized; however, impaired microvascular function is believed to be a contributor. This study tested the hypothesis that the cerebral vasodilatory capacity in response to hypercapnia is reduced in obese individuals relative to age and sex matched lean counterparts. Cerebral blood velocity (CBFV) was measured using transcranial …