Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
- Keyword
-
- Ketosis (4)
- Exercise training (2)
- Fatty acid oxidation (2)
- Lipid metabolism (2)
- AMPK (1)
-
- Beta-hydroxybutyrate (1)
- Cardiac hypertrophy (1)
- Chronic exercise (1)
- Exercise adaptation (1)
- Exercise metabolism (1)
- Exercise physiology (1)
- Glucose intolerance (1)
- Glucose metabolism (1)
- Glycogen (1)
- Heart failure (1)
- Hyperlipidemia (1)
- Hypoxia (1)
- Insulin (1)
- Ischemia (1)
- Ketone bodies (1)
- Ketone body metabolism (1)
- Lipid accumulation (1)
- Metabolic remodeling (1)
- Metabolism (1)
- Mitochondrial biogenesis (1)
- MnSOD (1)
- Nutritional ketosis (1)
- OSCP (1)
- ROS (1)
- Reperfusion (1)
Articles 1 - 7 of 7
Full-Text Articles in Exercise Physiology
Sex- And Age-Specific Differences In Mice Fed A Ketogenic Diet, Kenyon W. Sprankle, Mya Knappenberger, Erica J. Locke, Jack Thompson, Madison Vinovrski, Kaylin Knapsack, Stephen C. Kolwicz Jr.
Sex- And Age-Specific Differences In Mice Fed A Ketogenic Diet, Kenyon W. Sprankle, Mya Knappenberger, Erica J. Locke, Jack Thompson, Madison Vinovrski, Kaylin Knapsack, Stephen C. Kolwicz Jr.
Health Sciences Faculty Publications
The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that results in the elevation of serum ketone bodies, known as ketosis. This metabolic consequence has been suggested as a method for treating neurological conditions, improving exercise performance, and facilitating weight loss for overweight individuals. However, since most research primarily uses male populations, little is known about the potential sex differences during the consumption of the KD. In addition, the effects of the KD on aging are relatively unexplored. Therefore, the purpose of this study was to explore sex- and age-specific differences in mice fed the KD. Male and female C57BL/6N …
The Effects Of Exercise Training On Glucose Homeostasis And Muscle Metabolism In Type 1 Diabetic Female Mice, Caitlin O'Neill, Erica J. Locke, Darren A. Sipf, Jack Thompson, Erin Drebushenko, Nate Berger, Brooke Segich, Stephen C. Kolwicz Jr.
The Effects Of Exercise Training On Glucose Homeostasis And Muscle Metabolism In Type 1 Diabetic Female Mice, Caitlin O'Neill, Erica J. Locke, Darren A. Sipf, Jack Thompson, Erin Drebushenko, Nate Berger, Brooke Segich, Stephen C. Kolwicz Jr.
Health Sciences Faculty Publications
Although exercise training is an important recommendation for the management of type 1 diabetes (T1D), most of the available research studies predominantly focus on male subjects. Given the importance of sex as a biological variable, additional studies are required to improve the knowledge gap regarding sex differences in T1D research. Therefore, the purpose of this study was to examine the role of exercise training in mediating changes in glucose homeostasis and skeletal muscle metabolism in T1D female mice. Female mice were injected with streptozotocin (STZ) to induce T1D. Two weeks after STZ injection, control (CON) and STZ mice were exercise …
Sex Differences In Endurance Exercise Capacity And Skeletal Muscle Lipid Metabolism In Mice, Lola Holcomb, Patrick Rowe, Caitlin O'Neill, Elizabeth Dewitt, Stephen C. Kolwicz Jr.
Sex Differences In Endurance Exercise Capacity And Skeletal Muscle Lipid Metabolism In Mice, Lola Holcomb, Patrick Rowe, Caitlin O'Neill, Elizabeth Dewitt, Stephen C. Kolwicz Jr.
Health Sciences Faculty Publications
Previous studies suggest that sex differences in lipid metabolism exist with females demonstrating a higher utilization of lipids during exercise, which is mediated partly by increased utilization of muscle triglycerides. However, whether these changes in lipid metabolism contribute directly to endurance exercise performance is unclear. Therefore, the objective of this study was to investigate the contribution of exercise substrate metabolism to sex differences in endurance exercise capacity (EEC) in mice. Male and female C57BL/6-NCrl mice were subjected to an EEC test until exhaustion on a motorized treadmill. The treadmill was set at a 10% incline, and the speed gradually increased …
Ketone Body Metabolism In The Ischemic Heart, Stephen C. Kolwicz Jr.
Ketone Body Metabolism In The Ischemic Heart, Stephen C. Kolwicz Jr.
Health Sciences Faculty Publications
Ketone bodies have been identified as an important, alternative fuel source in heart failure. In addition, the use of ketone bodies as a fuel source has been suggested to be a potential ergogenic aid for endurance exercise performance. These findings have certainly renewed interest in the use of ketogenic diets and exogenous supplementation in an effort to improve overall health and disease. However, given the prevalence of ischemic heart disease and myocardial infarctions, these strategies may not be ideal for individuals with coronary artery disease. Although research studies have clearly defined changes in fatty acid and glucose metabolism during ischemia …
The Effects Of Fasting Or Ketogenic Diet On Endurance Exercise Performance And Metabolism In Female Mice, Lola Holcomb, Caitlin O'Neill, Elizabeth Dewitt, Stephen C. Kolwicz Jr.
The Effects Of Fasting Or Ketogenic Diet On Endurance Exercise Performance And Metabolism In Female Mice, Lola Holcomb, Caitlin O'Neill, Elizabeth Dewitt, Stephen C. Kolwicz Jr.
Health Sciences Faculty Publications
The promotion of ketone body (KB) metabolism via ketosis has been suggested as a strategy to increase exercise performance. However, studies in humans and animals have yielded inconsistent results. The purpose of the current study was to examine the effects of ketosis, achieved via fasting or a short-term ketogenic diet (KD), on endurance exercise performance in female mice. After 8 h of fasting, serum KB significantly increased and serum glucose significantly decreased in fasted compared to fed mice. When subjected to an endurance exercise capacity (EEC) test on a motorized treadmill, both fed and fasted mice showed similar EEC performance. …
An "Exercise" In Cardiac Metabolism, Stephen C. Kolwicz Jr.
An "Exercise" In Cardiac Metabolism, Stephen C. Kolwicz Jr.
Health Sciences Faculty Publications
Research has demonstrated that the high capacity requirements of the heart are satisfied by a preference for oxidation of fatty acids. However, it is well known that a stressed heart, as in pathological hypertrophy, deviates from its inherent profile and relies heavily on glucose metabolism, primarily achieved by an acceleration in glycolysis. Moreover, it has been suggested that the chronically lipid overloaded heart augments fatty acid oxidation and triglyceride synthesis to an even greater degree and, thus, develops a lipotoxic phenotype. In comparison, classic studies in exercise physiology have provided a basis for the acute metabolic changes that occur during …
Amp-Activated Protein Kinase Controls Exercise Training - And Aicar-Induced Increases In Sirt3 And Mnsod, Josef Brandauer, Marianne A. Andersen, Holti Kellezi, Steve Risis, Christian Frozig, Sara G. Vienberg, Jonas T. Treebak
Amp-Activated Protein Kinase Controls Exercise Training - And Aicar-Induced Increases In Sirt3 And Mnsod, Josef Brandauer, Marianne A. Andersen, Holti Kellezi, Steve Risis, Christian Frozig, Sara G. Vienberg, Jonas T. Treebak
Health Sciences Faculty Publications
The mitochondrial protein deacetylase sirtuin (SIRT) 3 may mediate exercise training-induced increases in mitochondrial biogenesis and improvements in reactive oxygen species (ROS) handling. We determined the requirement of AMP-activated protein kinase (AMPK) for exercise training-induced increases in skeletal muscle abundance of SIRT3 and other mitochondrial proteins. Exercise training for 6.5 weeks increased SIRT3 (p < 0.01) and superoxide dismutase 2 (MnSOD; p < 0.05) protein abundance in quadriceps muscle of wild-type (WT; n = 13–15), but not AMPK α2 kinase dead (KD; n = 12–13) mice. We also observed a strong trend for increased MnSOD abundance in exercise-trained skeletal muscle of healthy humans (p = 0.051; n = 6). To further elucidate a role for …