Pharmacology Commons^™

เทคโนโลยีทางเภสัชกรรม ตอนที่ 1, ไกรสีห์ อัมพรายน์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Methyl Salicylate Preparations Sontaining Herbal Extracts For Relief Of Local Skin Inflammation. Formulation And In Vivo Evalauation Of Gel And Ointment Dosage Forms In Mice, Parkpoom Tengamnuay, Withaya Janthasoot, Veeraya Rattanachaipipat, Wallapa Rattanachaipipat

The Thai Journal of Pharmaceutical Sciences

Topical methyl salicylate (MS) ointments or analgesic balms have long been used for treatment of minor skin irritations and muscle pains. The products generally contain 15- 50% w/w of MS in an appropriate ointment base. Their pain-relieving action is mainly a result of the counterirritant and rubefacient effects of MS and menthol contained in these preparations. This study attempted to modify the conventional MS ointment in order to enhance its efficacy by including some herbal ingredients with known antiinflammatory/antiedema activities in the formulation. Aescin, chamomile and aloe vera gel extracts were the three natural ingredients selected for inclusion. The modified …

เทคโนโลยีทางเภสัชกรรม ตอนที่ 2, ไกรสีห์ อัมพรายน์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Spray Dried Rice Starch For Direct Compression.(แป้งข้าวเจ้าชนิดพ่นแห้งสำหรับใช้ในการตอกยาเม็ดโดยตรง), Ampol Mitrevej, Nuttanan Sinchaipanid, Surachai Palanuphap

The Thai Journal of Pharmaceutical Sciences

A direct compression filler (SDRS) was prepared by spray drying rice starch. Scanning electron microscope revealed that a particle of SDRS was made up entirely of aggregates of rice starch grains, and the shape of SDRS was extremely spherical. Because of...

Phospholipid Microemulsions: Ii. Electronphotomicrographs Of Systems Containing Butanol As A Co-Surfactant.(ฟอสโฟไลปีดไมโครอิมัลชัน: Ii. ภาพถ่ายจากกล้องจุลทรรศน..., Wanchai Sutananta

The Thai Journal of Pharmaceutical Sciences

The electronphotomicrographs of phospholipid microemulsions containing butanol as a co-surfactant were presented. Various structures were found. For example, a definite oil core or a hard sphere type microemulsion was found in a sample containing isoprop...

Subject Index, Author Index(ดัชนีคำสำคัญ, ดัชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

เทคโนโลยีทางเภสัชกรรม ตอนที่ 1, ไกรสีห์ อัมพรายน์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

The Application Of Powdered Sugar-Tapioca Starch Granules Prepared By Fluidized Bed Granulation Technique In Direct Tableting Process, Poj Kulvanich, Detpon Prechagoon

The Thai Journal of Pharmaceutical Sciences

This report is concerned with the production of granules from powdered sugar-tapioca starch mixtures by fluidized bed granulation technique. The application of such granules as direct compression vehicles in manufacture of tablets products was demonstrated. The mixtures of powdered sugar-tapioca starch in the ratio of 1:1 were employed to prepare the granules using polyvinylpyrrolidone and gelatin as the granulating agents. Successful granulation of sugar-starch mixtures in a fluidized bed granulator were attained to have porous, irregular shape granules with narrow size distribution and low density. The physical properties of granular products using two binders were different. The finished granules were …

พิษของยาสมุนไพรตีสาร (แก้ปิตตะสมุฏฐาน), ปราณี ชวลิตธำรง, เอมมนัส อัตตวิชญ์, พัช รักษามั่น, ปราณี จันทเพ็ชร

The Thai Journal of Pharmaceutical Sciences

ยาแผนโบราณตรีสารประกอบด้วยสมุนไพร 3 ชนิดคือ รากเจตมูลเพลิงแดง รากช้าพลู และเถาสะค้านในอัตราส่วนที่ต่างกันแล้วแต่สมุฎฐาน (ปิตตะ วาตะ หรือเสมหะ) จากการศึกษาพิษเฉียบพลันของสารสกัดด้วย 50% เอธานอลของสมุนไพรที่เป็นส่วนผสมของยาแผนโบราณตรีสารในหนูถีบจักรพบว่า สารสกัด เจตมูลเพลิงแดงเมื่อให้ทางปาก และฉีดเข้าใต้ผิวหนัง มีค่า LD เทียบเท่าผงยาแห้งเท่ากับ 23.2 และ 17.8 ก./กก. ตามลำดับ ส่วนสารสกัดสะค้านและสารสกัดข้าพลูเมื่อให้ทางปากหรือฉีดเข้าใต้ผิวหนัง มีค่า LD มากกว่า 40.0 ก./กก. และจากการศึกษาพิษกึ่งเฉียบพลันของยาแผนโบราณตรีสารแก้ปิตตะสมุฏฐาน(สำหรับรักษาอาการป่วยด้วยธาตุไฟในฤดูหนาว)ซึ่งประกอบด้วยรากเจตมูลเพลิงแดง 12 ส่วน รากช้าพลู 4 ส่วน และเถ้าสะค้าน 8 ส่วน ในหนูขาวพันธุ์วิสตาร์ โดยป้อนยาในขนาด 0.36, 2.88 และ 23.04 ก./กก./วัน เป็นระยะเวลา 10 วันหรือคิดเป็น 1, 8 และ 64 เท่าของขนาดที่ใช้ในคน พบว่าในหนูทั้งสองเพศทุกกลุ่มที่ได้รับยามีการเจริญเติบโต และค่าทางโลหิตวิทยาคือค่า ฮีมาโตคริต ค่าจำนวนเม็ดเลือดขาว ค่าจำนวนเกล็ดเลือด ไม่แตกต่างจากกลุ่มควบคุม ส่วนค่าทางชีวเคมีของหนูขาวทุกกลุ่มที่ได้รับยาพบว่ามีค่าครีอาตินินสูงกว่ากลุ่มควบคุมอย่างมีนัยสำคัญ จากการตรวจพยาธิสภาพภายนอกของ อวัยวะต่าง และจุลพยาธิวิทยาของตับ และไต ไม่พบความผิดปกติที่เกิดจากยาตรีสารแก้ปิตตะสมุฏฐาน

Flavonoidal Constituents And Pharmacological Activities Of Glycyrrhiza Species, Shi-Shan Jia, Gui-Fen Qiu, Yuichi Fujii, Fumio Ikegam, Isamu Marakoshi

The Thai Journal of Pharmaceutical Sciences

This review deals with the similarities and differences of flavonoidal constituents isolated from the different parts of several Glycvrrhiza species (licorice plant), including the root and rhizome and the aerial part, with their chemotaxonomic character...

Corydaldine From Stephania Pierrei, Kittisak Likhitwitayawuid, Nijsiri Ruangrungsi

The Thai Journal of Pharmaceutical Sciences

Corydaldine [1] was isolated from the tubers of Stephania pierrei Diels. The complete 3H and unambiguous 13c NMR assignments of 1 were obtained through extensive NMR studies.

Antimicrobial Activity Of Cephalosporins Against Pathogenic Gram-Negative Bacilli(ฤทธิ์ต้านจุลชีพของ Cephalosporins ที่มีต่อเชื้อก่อโรครูปแท่งแกรมลบ), Mali Wirotesangthong, Pintip Pongpech

The Thai Journal of Pharmaceutical Sciences

Antimicrobial activity of cephalosporins against 241 gram-negative bacterial strains isolated from clinical specimens at Siriraj Hospital was determined. The majority (83.3-100%) of all strains of E. coll, Vibrio spp., Proteus spp. and Salmonella spp. we...

Theophylline Sustained Release Tablets Prepared From Theophylline Granules Coated With Ethylcellulose Using Fluidized Bed Technique(ยาเม็ดธืโอฟิลินชนิดออกฤทธิ์นานซึ่งเตรียม..., Poj Kulvanich, Sudarat Eiamtrakarn

The Thai Journal of Pharmaceutical Sciences

Theophylline granular cores were prepared from different fillers (microcrystalline cellulose, corn starch, dibasic calcium phosphate and lactose) by wet granulation. The theophylline granules were then coated with ethylcellulose using fluidized bed coati...

การอบรม Effective Drug Management And Rational Drug Use, พัชรินทร์ สุวรรณกูฏ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

1h And 13c Nmr Assignments Of Eleutherol, Kittisak Likhitwitayawuid, Nijsiri Ruangrungsi, Rawiwun Kaewamatawong

The Thai Journal of Pharmaceutical Sciences

Complete ]H and unequivocal 13c NMR assignments of eleutherol [1] were obtained through extensive NMR studies, including homonuclear COSY, NOE difference, HETCOR and HMBC experiments.

In Situ Regulation Of Cytosolic Phospolipase A₂, Beverly A. Rzigalinski

Theses and Dissertations in Biomedical Sciences

The 85 kDa cytosolic phospholipase A₂ (cPLA₂) is an agonist-responsive effector for intracellular signal transduction through the arachidonate cascade. In vitro studies have demonstrated that this enzyme is regulated by sub-micromolar calcium and is specific for arachidonate as the sn-2 fatty acyl group of phospholipid substrates. However, very little data is available regarding in situ mechanisms which govern the activity of cPLA₂. The primarily objective of these studies was to develop an in situ system for the study of cPLA₂, and investigate mobilization of arachidonate during signal transduction events.

Dimethylsulfoxide differentiation of the …

Cerebral Microcirculatory Effects Of Maturation, Scott R. Elliott

Loma Linda University Electronic Theses, Dissertations & Projects

The present studies demonstrate that in the second (2B) and fourth (4B) branches of newborn and adult sheep middle cerebral arteries, 5-HT2 serotonergic receptors mediate contractile responses to serotonin and that alpha-1 adrenergic receptors mediate contractile responses to norepinephrine. In addition, tissue sensitivity to 5-HT and NE decreases significantly with maturation, but does not vary with branch order. These age-related changes were associated with a decrease in affinity and maximum response in 2B and 4B segments of 5-HT and NE contracted arteries, respectively. Norepinephrine and 5-HT occupancy at the pD₂ rose significantly in 2B segments, but did not change …

Antithrombotic Activity Of Clove Oil, Shaikh A. Saeed, A H. Gilani

Department of Biological & Biomedical Sciences

Clove oil inhibited human platelet aggregation induced by arachidonic acid (AA), platelet-activating factor (PAF) or collagen. Clove oil was a more effective inhibitor for aggregation induced by AA and PAF (IC50:4 and 6 microM respectively) than collagen (IC50: 132 microM). The in vivo experiments in rabbits showed that clove oil (50-100 mg/kg) afforded 100% protection against PAF (11 mg/kg, i.v.) and 70% protection against AA (2.0 mg/kg, i.v.)-induced thrombosis and shock due to pulmonary platelet thrombosis. It also inhibited thromboxane-A2 and 12-HETE production by human platelets incubated with [C14] AA. These results are indicative that clove oil is inhibitory of …

Denervation Supersensitivity Of The Rat Vas Deferens: A Role For Protein Kinase C, Sonny T. Abraham

Electronic Theses and Dissertations

A role for protein kinase C (PKC) in the denervation-induced supersensitivity of the rat vas deferens was investigated. Chronic, surgical denervation of the rat vas deferens (up to 8 days) resulted in tissues that produced enhanced contractile responses to norepinephrine (NE) in isolated organ baths. Single challenges of NE (10 $\mu$M) produced 0.6 $\pm$ 0.1 g of maximal tension in the control vas whereas in the paired, denervated tissue 2.2 $\pm$ 0.3 g of tension was recorded (n = 6). Cumulative concentration-effect curves to NE produced in the denervated vas deferens were shifted 18-fold to the left of the control …

Differential Role Of The Endothelium In Regulating Microvascular Blood Flow, Tao Tang

Electronic Theses and Dissertations

The vascular endothelial cell (EC) plays an important role in regulating vascular tone and local blood flow by sensing chemical and mechanical stimuli on the vascular wall and releasing a host of vasoactive substances upon activations of endogenous or exogenous vasoactive substances. The central hypothesis is that local control of blood now and autoregulatory behavior in the microcirculation is distinctive at different levels of the vasculature and is dependent on the cellular activities of the EC and its interaction with the local environment. The in vivo as well as the ex vivo, flow-controlled preparations of the hamster cheek pouch were …

Characterization Of The Vasoactivity Of Tachykinins In Isolated Rat Kidney: Functional Studies And In Vitro Receptor Autoradiography, Yuejin Chen

Electronic Theses and Dissertations

Although tachykinins have potent vascular actions, their effect on renal resistance blood vessels is currently unknown. The vasoactive properties of tachykinins and related analogs were assessed in isolated perfused rat kidney. At a basal perfusion pressure (PP) of 75 $\pm$ 6 mm Hg (n = 5), bolus injections of substance P (SP) had no significant vasoactive effect. Following a sustained increase in baseline PP (134 $\pm$ 10 mm Hg) produced by phenylephrine (1 $\mu$M), SP evoked a dose-dependent increase in PP. The largest dose of SP increased PP by 60 $\pm$ 5 mm Hg. The vasoconstrictor response to SP was …

Possible Presence Of Calcium Channel Blocker(S) In Rubia Cordifolia: An Indigenous Medicinal Plant, A H. Gilani, K H. Janbaz, M Zaman, A Lateef, A Suria, H R. Ahmed

Department of Biological & Biomedical Sciences

Crude extract of Rubia cordifolia (RC) was tested in isolated tissue preparations for its possible calcium channel antagonistic activity. RC suppressed the spontaneous contractions of guinea-pig atria, rabbit jejunum and rat uterus in a concentration dependent manner (0.1-3 mg/ml). In rabbit aorta, it inhibited norepinephrine (10 microM) and KCl (80 mM) induced contractions. Replacement of physiological salt solution with calcium free solution abolished the spontaneous movements of rabbit jejunum. However, addition of calcium (25 micrograms/ml) in the tissue bath restored the spontaneous movements. When the tissues were pretreated with plant extract (1 mg/ml) or verapamil (0.5 microgram/ml), addition of calcium …

Hepatoprotective Effects Of Artemisia Scoparia Against Carbon Tetrachloride: An Environmental Contaminant, A H. Gilani, K H. Janbaz

Department of Biological & Biomedical Sciences

The hepatoprotective activity of crude extract of artemisia scoparia (aerial parts) was investigated against experimentally produced hepatic damage using carbon tetrachloride (CCl4) as a model hepatotoxin. CCl4 at the dose of 1.5 ml/kg, produced liver damage in rats as manifested by the rise in serum levels of AST and ALT to 395 +/- 110 and 258 +/- 61 IU/l (mean +/- SEM; n = 10) respectively, compared to control values of 106 +/- 15 and 26 +/- 04. Pretreatment of rats with plant extract (150 mg/kg) significantly lowered (P < 0.01), the respective serum GOT and GPT levels to 93 +/- 05 and 27 +/- 03 IU/l, indicating hepatoprotective action. Pentobarbital sodium (75 mg/kg)-induced sleeping time in mice was found to be 140.8 +/- 1.5 min (n = 10) which was similar (P > 0.05) to that obtained in the group of animals pretreated with …

The Interaction Of O6-Benzylguanine And Streptozotocin In The Inactivation Of O6-Methylguanine Dna Methyltransferase And The Reversal Of 1,3 Bis (2-Chloroethyl)-1-Nitrosourea Resistance, Upendra Kumar Marathi

Master's Theses

No abstract provided.

Dopaminergic Modulation Of Basal Forebrain Cholinergic Neurons, Mary Elizabeth Muench

Master's Theses

No abstract provided.

Role Of The Pharmacist In Support Of The Who Revised Drug Strategy(บทบาทของเภสัชกรในการสนับสนุนแผนงานด้านยาขององค์การอนามัยโลก), นิยดา เกียรติยิ่งอังศุลี

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

บรรณาธิการแถลง, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Jsps-Nrct Core University Exchange System On Pharmaceutical Sciences, Second Joint Seminar, Recent Advances On Pharmaceutics And Pharmaceutical Technology, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Scanning Electron Micrograph And Antimicrobial Activity Of Streptomyces Species N28-1 And N97-1(ภาพอิเล็กตรอนสแคนนิงและฤทธิ์การยับยั้งจุลชีพของเชื้อ S..., Penphun Naenna, Nuttada Virochsaengaroon, Somboon Tanasupawat

The Thai Journal of Pharmaceutical Sciences

Two strains of Streptomyces species N28-1 and N97-1 are morphologically studied with scanning electron microscope. The antimicrobial pattern of them are determined. Strain N28-1 inhibited gram-positive bacteria, mycoplasma and mycobacteria while strain N...

ยาฉีดเภสัชภัณฑ์รังสี Tc-99m Human Serum Albumin, สง ยุตยาจาร, ศึริศักดี้ ดำรงพิศุทธิกุล, พ.ท.หญิงสุเนตรา ดำรงพิศุทธิกุล

The Thai Journal of Pharmaceutical Sciences

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