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Articles 2761 - 2790 of 3580
Full-Text Articles in Pharmacology
Statistical Optimization Of Furosemide Tablet Formulation Using Hadamard Matrix(ออพติไมเซชันเซิงสถิติของตำรับยาเม็ดฟูโรซีโมด์โดยใชัมาทริกซ..., Pienkit Dangprasirt
Statistical Optimization Of Furosemide Tablet Formulation Using Hadamard Matrix(ออพติไมเซชันเซิงสถิติของตำรับยาเม็ดฟูโรซีโมด์โดยใชัมาทริกซ..., Pienkit Dangprasirt
The Thai Journal of Pharmaceutical Sciences
Different formulations of furosemide tablets were prepared by varying compression force, manufacturing process, amounts of disintegrant and lubricant. An Hadamard matrix H[8] was employed as a statistical experimental design for constructing the furosemi...
Antipeptic Ulcer Activity Of Turmeric (Curcuma Longa L.)(ฤทธิ์ของขมิ้นชันในการต้านการเกิดแผลในกระเพาะอาหารหนูขาว), Uraiwanpermpipat, Anchalee Chuthaputti, Niyada Kiatying-Angsulee
Antipeptic Ulcer Activity Of Turmeric (Curcuma Longa L.)(ฤทธิ์ของขมิ้นชันในการต้านการเกิดแผลในกระเพาะอาหารหนูขาว), Uraiwanpermpipat, Anchalee Chuthaputti, Niyada Kiatying-Angsulee
The Thai Journal of Pharmaceutical Sciences
The protective effect of turmeric (Curcuma longa L.) against experimentally - induced gastric ulcer was evaluated in Wistar rats, using hydrochloric acid and aspirin as ulcerogenic agents and hypothermic restraint model. Various preparations and extracts...
Subacute Toxicity Of Traditional Medicinal Benjakul(พิษกึ่งเฉียบพลันของยาแผนโบราณเบญจกูล), Pranee Chavalittumrong, Aimmanas Attawish, Pat Rugsamon, Pranee Chuntapet
Subacute Toxicity Of Traditional Medicinal Benjakul(พิษกึ่งเฉียบพลันของยาแผนโบราณเบญจกูล), Pranee Chavalittumrong, Aimmanas Attawish, Pat Rugsamon, Pranee Chuntapet
The Thai Journal of Pharmaceutical Sciences
Benjakul, a Thai traditional medicine, is composed of five constituents, namely Zingiber officinale rhizomes, Piper retrofractum fruits, Plumbago indica root, Piper sarmentosum and Piper sp. locally called Sa-Karn, at different ratios on traditional exam...
Constituents Of Artocarpus Gomezianus Leaves, Benjaporn Kingroungpet, Thatree Phadungcharoen, Nijsiri Ruangrungsi, Toshikazu Sekine
Constituents Of Artocarpus Gomezianus Leaves, Benjaporn Kingroungpet, Thatree Phadungcharoen, Nijsiri Ruangrungsi, Toshikazu Sekine
The Thai Journal of Pharmaceutical Sciences
Examination of the ethanol extract from the leaves of Artocarpus gomezianus (Moraceae) revealed the presence of a long chain hydrocarbon, 1-dotriacontanol, a steroid; (3-sitosterol, two triterpenoids; lupeol-3-acetate and simiarenol, and phenolic glycosi...
Production Technique And Pharmaceutical Application Of Microspheres.Part Ii. Other Production Techniques / Comparion And Application(เทคนิคการผลิตไมโครสเฟียร์และการประยุกต์ท..., ธวัชชัย แพชมัด, กาญจน์พิมล ฤทธิเดช
Production Technique And Pharmaceutical Application Of Microspheres.Part Ii. Other Production Techniques / Comparion And Application(เทคนิคการผลิตไมโครสเฟียร์และการประยุกต์ท..., ธวัชชัย แพชมัด, กาญจน์พิมล ฤทธิเดช
The Thai Journal of Pharmaceutical Sciences
Microsphere can also be prepared by other techniques: chemical and thermal crosslinking, spray drying, meltable dispersion, polymerization and coacervation. Advantage and disadvantage of each preparation technique are compared. The appearance and morphol...
Comparative Quality Investigation Of Three Locally-Manufactured Medicines In Thailand(การเปรียบเทียบคุณภาพยาสามชนิดที่ผลิตขี้นในประเทศไทย), Jinda Wangboonskul, Voravich Kitiwongsoonthorn, Sumon Sakolchai, Chanchai Charupash, Kanokwan Jarukumjorn, Supawadee Chieawchanwatana, Natthida Weerapreeyakul, Wirat Ruengsitagoon, Unchalee Tattawasart
Comparative Quality Investigation Of Three Locally-Manufactured Medicines In Thailand(การเปรียบเทียบคุณภาพยาสามชนิดที่ผลิตขี้นในประเทศไทย), Jinda Wangboonskul, Voravich Kitiwongsoonthorn, Sumon Sakolchai, Chanchai Charupash, Kanokwan Jarukumjorn, Supawadee Chieawchanwatana, Natthida Weerapreeyakul, Wirat Ruengsitagoon, Unchalee Tattawasart
The Thai Journal of Pharmaceutical Sciences
Locally-manufactured medicines of 3 selected drugs have been investigated for their pharmaceutical quality and comparison has been made between GMP-approved and non-GMP approved factories. In this study, aluminium hydroxide suspension, ampicillin capsule...
Food Additive - Drug Interaction Induced Mutagens And Possible Prevention(การเกิดสารก่อกลายพันธุ์จากอันตรกิริยาระหว่างสารเจือปน ในอาหา..., Kaew Kansadalampai, Suyanee Suharitdamrong
Food Additive - Drug Interaction Induced Mutagens And Possible Prevention(การเกิดสารก่อกลายพันธุ์จากอันตรกิริยาระหว่างสารเจือปน ในอาหา..., Kaew Kansadalampai, Suyanee Suharitdamrong
The Thai Journal of Pharmaceutical Sciences
Twenty-seven of drug preparations were treated with sodium nitrite and the products were tested for mutagenicity on Salmonella typhimurium test system (Ames test). Using Ames spot test, it was suggested that eleven preparations were mutagenic; then, they...
นิพนธ์ปฏิทัคน์: บทบาทของเพศต่อการศึกษาทางเภสัชจลนศาสตร์ และเภสัชพลศาสตร์, ศรีสมบัติ นวนพรัตน์สกุล
นิพนธ์ปฏิทัคน์: บทบาทของเพศต่อการศึกษาทางเภสัชจลนศาสตร์ และเภสัชพลศาสตร์, ศรีสมบัติ นวนพรัตน์สกุล
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Application Of Freeze-Drying Technique In Preparing Indomethacin-Lactose Solid Dispersion(การใช้เทคนิคการทำให้แห้งแบบเยือกแข็งในการเตรียม อินโดเม..., Pienkit Dangprasirt, Sansanee Pongwai, Wasan Limpongsanurak, Chockchai Tregitwatana
Application Of Freeze-Drying Technique In Preparing Indomethacin-Lactose Solid Dispersion(การใช้เทคนิคการทำให้แห้งแบบเยือกแข็งในการเตรียม อินโดเม..., Pienkit Dangprasirt, Sansanee Pongwai, Wasan Limpongsanurak, Chockchai Tregitwatana
The Thai Journal of Pharmaceutical Sciences
Indomethacin (ID) solid dispersions were prepared by coprecipitation method using lactose as a water-soluble carrier. Two techniques, simple evaporation and freeze-drying techniques, were used to prepare 1:1 and 1:5 indomethacindactose coprecipitates. Di...
Study Of Antiemetic Activity Of Morinda Citrifolia L. Fruits(การศึกษาฤทธิ์ต้านอาเจียนของผลยอ), Anchalee Chuthaputti, Puntarika Na, Uraiwan Permpipat, Yenchit Techadamrongsin
Study Of Antiemetic Activity Of Morinda Citrifolia L. Fruits(การศึกษาฤทธิ์ต้านอาเจียนของผลยอ), Anchalee Chuthaputti, Puntarika Na, Uraiwan Permpipat, Yenchit Techadamrongsin
The Thai Journal of Pharmaceutical Sciences
Morinda citrifolia L. or ‘ Yor’ is one of sixty six medicinal plants selected for the primary health care in Thailand. According to Thai traditional medicine, infusion or decoction of roasted or grilled mature, unripe fruits has been used to relieve ...
บทความพิเศษ แนวคิดปัจจุบันเรื่องการ,ประเมินความเสี่ยงจากพิษ ของสารเกาะเกี่ยว (Bound Residues) ในอา..., อรรัตน์ สมาธิวัฒน์, พาลาภ สิงหเสนี
บทความพิเศษ แนวคิดปัจจุบันเรื่องการ,ประเมินความเสี่ยงจากพิษ ของสารเกาะเกี่ยว (Bound Residues) ในอา..., อรรัตน์ สมาธิวัฒน์, พาลาภ สิงหเสนี
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Effect Of Clinacanthus Nutans On Human Cell-Mediated Immune Response In Vitro(การศึกษาฤทธิ์ของสารสกัดจากพญายอต่อการตอบสนอง ทางภูมิคุ้มกัน..., Busarawan Sriwanthana, Pranee Chavalittumrong, Laor Chompuk
Effect Of Clinacanthus Nutans On Human Cell-Mediated Immune Response In Vitro(การศึกษาฤทธิ์ของสารสกัดจากพญายอต่อการตอบสนอง ทางภูมิคุ้มกัน..., Busarawan Sriwanthana, Pranee Chavalittumrong, Laor Chompuk
The Thai Journal of Pharmaceutical Sciences
The extract of Clinacanthus nutans has been used for the treatment against a variety of symptoms from either infectious or non-infectious agents. Less has been known for its activity on the immune system. Human immunocompetent cells were used to study th...
Key Words Index, Authors Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A
Key Words Index, Authors Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Characterization Of Central Serotonergic Alterations In Male Rats Following Prenatal Exposure To Fluoxetine, Theresa M. Cabrera
Characterization Of Central Serotonergic Alterations In Male Rats Following Prenatal Exposure To Fluoxetine, Theresa M. Cabrera
Dissertations
No abstract provided.
Comparative Pharmacologic Studies On Synthetic And Recombinant Inhibitors Of Thrombin, Demetra D. Callas
Comparative Pharmacologic Studies On Synthetic And Recombinant Inhibitors Of Thrombin, Demetra D. Callas
Dissertations
No abstract provided.
Pharmacologic Studies On Synthetic Analogues Of Heparin With Selective Affinity To Endogenous Serine Protease Inhibitors, Walter P. Jeske
Pharmacologic Studies On Synthetic Analogues Of Heparin With Selective Affinity To Endogenous Serine Protease Inhibitors, Walter P. Jeske
Dissertations
No abstract provided.
Relationships Between The Expression Of Genes Involved In The Regulation Of Apoptosis And Cell Death Induced By Nitrogen Mustard In Human Colon Carcinoma Cell Lines, Greggory Bernard Herbert
Relationships Between The Expression Of Genes Involved In The Regulation Of Apoptosis And Cell Death Induced By Nitrogen Mustard In Human Colon Carcinoma Cell Lines, Greggory Bernard Herbert
Dissertations
No abstract provided.
An Update On Hyperlipidemia And Its Management, R A. Memon, A H. Gilani
An Update On Hyperlipidemia And Its Management, R A. Memon, A H. Gilani
Department of Biological & Biomedical Sciences
No abstract provided.
Maturational Changes In Cerebrovascular Ca2+ In Hypoxia, Shelley D. Zurcher
Maturational Changes In Cerebrovascular Ca2+ In Hypoxia, Shelley D. Zurcher
Loma Linda University Electronic Theses, Dissertations & Projects
The clinical consequences of hypoxic cerebrovascular insults in the neonate, can be severe. It would therefore be valuable to understand the mechanisms of hypoxia-induced cerebrovasodilation. These studies were done in ovine middle cerebral and common carotid arteries to help elucidate the mechanisms through which calcium handling is involved in hypoxic cerebral vasodilation, comparing newborns and adults. The present studies demonstrate that calcium sensitivity (measured by the pD2) and the maximum contractile response to calcium increased with maturation. In addition, hypoxia depressed the maximum response to calcium and this effect was greater in adult than in newborn arteries. These results suggest …
Persistent Oral Dyskinesias Induced By Long-Term Haloperidol Treatment Is Dissociated From Changes In Neostriatal B(Max) And Mrna Content For Dopamine D(2) Receptors, Nuoyu Huang
Electronic Theses and Dissertations
Due to the presumed associations of dopamine (DA) receptor supersensitivity phenomena in both long-term neuroleptic-treated tardive dyskinetic rats and neonatal 6-hydroxydopamine (n6-OHDA)-lesioned rats, we studied the influence of haloperidol on n6-OHDA-lesioned rats. At 3 days after birth rats received 6-OHDA-HBr (200 $\mu$g, bilateral intracerebroventricularly; desipramine pretreatment, 20 mg/kg, 1h) or vehicle. Two months later haloperidol (1.5/kg/day $\times$ 2 days/week for 4 weeks, then 1.5 mg/kg/day, every day for 10 months) was added to the drinking water. Spontaneous oral activity of intact and n6-OHDA-lesioned rats receiving haloperidol was reached and maintained at significantly higher levels after 15 weeks of haloperidol treatment. …
Indomethacin Reduces Splenic Red Pulp Macrophage Populations In Female New Zealand White Rabbits, Thane S. Thurmond
Indomethacin Reduces Splenic Red Pulp Macrophage Populations In Female New Zealand White Rabbits, Thane S. Thurmond
Electronic Theses and Dissertations
In an effort to elucidate the mechanism by which indomethacin (IN) attenuates the stimulatory effect of estradiol (E$\sb2$) on rabbit splenic red pulp macrophages (RPM), thirty-nine female New Zealand White rabbits were divided into 10 groups: ovariectomized (OVX), OVX/IN at 0.1 and 5.0 mg/kg body weight (bw)/day; sham OVX (SOVX), SOVX/IN at 0.1 and 5.0 mg/kg bw/day; OVX/25 mg E2, OVX/25 mg E$\sb2$/IN at 0.1 and 5.0 mg/kg bw/day; intact Control. Quantitative changes in RPM population in response to the treatments were measured using a 0 to 4 histologic grading scale. Estradiol treatment resulted in increased RPM grade when compared …
Altered Platelet Activating Factor Metabolism In Insulin Dependent Diabetes Mellitus, R A. Memon, S A. Saeed, A Jabbar, A Jafri, A H. Gilani, S Saleem, H Akbani
Altered Platelet Activating Factor Metabolism In Insulin Dependent Diabetes Mellitus, R A. Memon, S A. Saeed, A Jabbar, A Jafri, A H. Gilani, S Saleem, H Akbani
Department of Biological & Biomedical Sciences
Diabetes mellitus is associated with several abnormalities of platelet function. Recent studies have shown that the blood level of platelet activating factor (PAF), a potent inducer of platelet aggregation, is elevated in insulin dependent diabetes mellitus (IDDM) and remains unchanged in non-insulin dependent diabetes mellitus (NIDDM) patients. However, the mechanism of this increase in PAF levels has not been determined. In this study we have measured the activity of plasma PAF acetylhydrolase (an enzyme that regulates PAF levels) and lipoprotein levels in control subjects and diabetic patients. The data presented show that plasma PAF acetylhydrolase activity is significantly decreased in …
Phase Ii Trial Of Murine Monoclonal Antibody D612 Combined With Recombinant Human Monocyte Colony-Stimulating Factor (Rhm-Csf) In Patients With Metastatic Gastrointestinal Cancer, Mansoor Saleh, Michael Khazaeli, Richard Wheeler, Pat Bucy, Tiepe Liu, Michael Everson, David Mun, Jeff Schlom
Phase Ii Trial Of Murine Monoclonal Antibody D612 Combined With Recombinant Human Monocyte Colony-Stimulating Factor (Rhm-Csf) In Patients With Metastatic Gastrointestinal Cancer, Mansoor Saleh, Michael Khazaeli, Richard Wheeler, Pat Bucy, Tiepe Liu, Michael Everson, David Mun, Jeff Schlom
Haematology and Oncology, East Africa
In a Phase II study, 14 patients with metastatic gastrointestinal cancer received the mAb D612 (40 mg/m2, days 4, 7, and 11) in combination with recombinant human monocyte colony-stimulating factor [(rhM-CSF) 80 ug/kg/days 1-14]. The combined treatment was well tolerated and resulted in characteristic biological activity associated with each of the agents. Thus, 10 of 14 patients experienced D612-associated secretory diarrhea, which responded to the prostaglandin inhibitor Indomethacin in 5 of 7 patients. rhM-CSF therapy was associated with peripheral mono- cytosis (peak absolute monocyte count, 1444 ±394/mm3) and thrombocytopenia (nadir count, 78 ±10/nim '). Monocyte surface marker analysis revealed a …
Development Of A Stable Topical Indomethacin Solution, Panida Vayumhasuwan, Saranya Tharasawaeng
Development Of A Stable Topical Indomethacin Solution, Panida Vayumhasuwan, Saranya Tharasawaeng
The Thai Journal of Pharmaceutical Sciences
Each topical indomethacin solution formulated was composed of ethanol, propylene glycol, a surfactant and water. The surfactants studied were polysorbate 80, pluronic F127 and pluronic F68. Predicted shelf lives at an average laboratory room temperature (33 ℃) of the formulations containing 5% polysorbate 80, 5% pluronic F127 and 5% pluronic F68 were 8.23, 7.43 and 5.06 years, respectively. From a statistical point of view, first order rate constants predicted by the Arrhenius equation were not different from those actually obtained at ambient temperature.
Cd16+ Monocytes In Patients With Cancer: Spontaneous Elevation And Pharmacologic Induction By Recombinant Human Macrophage Colony- Stimulating Factor, Mansoor Saleh, Goldman Samuel, Lobuglio Albert, Beall Arthur, Sabio Hernan, Mccord Melissa, Minasian Lori, Alpaugh Katherine, Weiner Louis, Munn David
Cd16+ Monocytes In Patients With Cancer: Spontaneous Elevation And Pharmacologic Induction By Recombinant Human Macrophage Colony- Stimulating Factor, Mansoor Saleh, Goldman Samuel, Lobuglio Albert, Beall Arthur, Sabio Hernan, Mccord Melissa, Minasian Lori, Alpaugh Katherine, Weiner Louis, Munn David
Haematology and Oncology, East Africa
The small subset of circulating monocytes that express the maturation- associated CD16 antigen has recently been reported to be elevated in patients with bacterial sepsis. We now show that this novel CD16+ monocyte population is also spontaneously expanded in patients with cancer. We studied 14 patients with metastatic gastrointestinal carcinoma enrolled in a clinical trial of recombinant human macrophage colony-stimulating factor (rhMCSF) plus monoclonal antibody D612. We found that before any cytokine treatment, 12 of 14 patients constitutively displayed significant elevations in both the percentage and the absolute number of CD16+ monocytes, as compared with both normal subjects and ill …
การเรียนการสอนเภสัชจลนศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, เพ็ญศรี ทองนพเนื้อ
การเรียนการสอนเภสัชจลนศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, เพ็ญศรี ทองนพเนื้อ
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Comparison Of Piroxicam Flux From Gel Preparations Through Polydimethylsiloxane Membrane And Pig Skin, Panida Vayumhasuwan, Busaba Polpakdee
Comparison Of Piroxicam Flux From Gel Preparations Through Polydimethylsiloxane Membrane And Pig Skin, Panida Vayumhasuwan, Busaba Polpakdee
The Thai Journal of Pharmaceutical Sciences
In vitro permeation behaviors of a synthetic membrane, Silastic™, and a biological membrane, newborn pig skin, were characterized using piroxicam as a model drug. Experiments had been carried out using modified Franz diffusion cells. Various gel bases containing 2% piroxicam were prepared to study the in vitro permeation of the drug. Gelling agents studied were Pluronic F127, Carbopol 940, hydroxypropyl methylcellulose and hydroxyethyl cellulose. Piroxicam fluxes from the four gel bases through SilasticT were correlated with the fluxes through pig skin with the r2 of 0.96. The Carbopol 940 gel base yielded the highest flux. It was, therefore, used for …
การเรียนการสอนเภสัชจลนศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, เพ็ญศรี ทองนพเนื้อ
การเรียนการสอนเภสัชจลนศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, เพ็ญศรี ทองนพเนื้อ
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Comparison Of Piroxicam Flux From Gel Preparations Through Polydimethylsiloxane Membrane And Pig Skin, Panida Vayumhasuwan, Busaba Polpakdee
Comparison Of Piroxicam Flux From Gel Preparations Through Polydimethylsiloxane Membrane And Pig Skin, Panida Vayumhasuwan, Busaba Polpakdee
The Thai Journal of Pharmaceutical Sciences
In vitro permeation behaviors of a synthetic membrane, Silastic™, and a biological membrane, newborn pig skin, were characterized using piroxicam as a model drug. Experiments had been carried out using modified Franz diffusion cells. Various gel bases containing 2% piroxicam were prepared to study the in vitro permeation of the drug. Gelling agents studied were Pluronic F127, Carbopol 940, hydroxypropyl methylcellulose and hydroxyethyl cellulose. Piroxicam fluxes from the four gel bases through SilasticT were correlated with the fluxes through pig skin with the r2 of 0.96. The Carbopol 940 gel base yielded the highest flux. It was, therefore, used for …
Development Of A Stable Topical Indomethacin Solution, Panida Vayumhasuwan, Saranya Tharasawaeng
Development Of A Stable Topical Indomethacin Solution, Panida Vayumhasuwan, Saranya Tharasawaeng
The Thai Journal of Pharmaceutical Sciences
Each topical indomethacin solution formulated was composed of ethanol, propylene glycol, a surfactant and water. The surfactants studied were polysorbate 80, pluronic F127 and pluronic F68. Predicted shelf lives at an average laboratory room temperature (33 ℃) of the formulations containing 5% polysorbate 80, 5% pluronic F127 and 5% pluronic F68 were 8.23, 7.43 and 5.06 years, respectively. From a statistical point of view, first order rate constants predicted by the Arrhenius equation were not different from those actually obtained at ambient temperature.