Medicinal Chemistry and Pharmaceutics Commons^™

Inhibition Of Amyloid-Β Aggregation And Caspase-3 Activation By The Ginkgo Biloba Extract Egb761, Yuan Luo, Julie V. Smith, Vijaykumar Paramasivam, Adam Burdick, Kenneth J. Curry, Justin P. Buford, Ikhlas Khan, William J. Netzer, Huaxi Xu, Peter Butko

Faculty Publications

Standardized extract from the leaves of the Ginkgo biloba tree, labeled EGb761, has been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementias and Alzheimer's disease (AD). Substantial experimental evidence indicates that EGb761 protects against neuronal damage from a variety of insults, but its cellular and molecular mechanisms remain unknown. Using a neuroblastoma cell line stably expressing an AD-associated double mutation, we report that EGb761 inhibits formation of amyloid-β (Aβ) fibrils, which are the diagnostic, and possibly causative, feature of AD. The decreased Aβ fibrillogenesis in the presence of EGb761 was observed …

Oxidation-Reduction Characteristics Of Chlorophenols In An Aprotic Medium, Cecil A. Sorrells, Ali U. Shaikh, Victor M. Samokyszyn

Journal of the Arkansas Academy of Science

Eighteen chlorophenols, containing from one to five chlorine atoms on the benzene ring at various positions, have been studied by cyclic voltammetric methods to evaluate their oxidation-reduction characteristics in an aprotic medium. The compounds were dissolved in dimethylsulfoxide containing 0.10 M tetrabutylammonium perchlorate as the supporting electrolyte and were then both oxidized and reduced on a glassy carbon electrode. The results indicate that phenols oxidize in a one-step process to phenoxium ion which dimerizes to quinone ether. The ether can be reduced back to phenol in a two-step reduction process. The oxidation potential of the chlorophenols varies with the number …

Growing Lavender In Western Australia, Aileen Reid

Bulletins 4000 -

Lavender oil is an essential oil, derived from plants (genus Lavendulai primarily by steam distillation of the flowers. There are several types of lavender oil. The 'true' lavender oil, and the most highly prized, comes from Lavendula augustifolia; it is primarily used in the fragrance and perfume industry. World production is about 200 tonnes per year. Spike lavender oil, derived from Lavendula latifolia, has a world production of about 150-200 tonnes per year. Lavandin oil is derived from hybrids of L. augustifolia x L. latifolia that yield much higher than L. augustifolia but the oil is lower quality, hence it …

Trans-Resveratrol Inhibits Calcium Influx In Thrombin-Stimulated Human Platelets, Yuliya Dobrydneva, Roy L. Williams, Peter F. Blackmore

Chemistry & Biochemistry Faculty Publications

1 The phytoestrogenic compound trans-resveratrol (trans-3,5,4'-trihydroxystilbene) is found in appreciable quantities in grape skins and wine. It has been shown that both products rich in trans-resveratrol and pure trans-resveratrol inhibit platelet aggregation both in vivo and in vitro. However the mechanism of this action still remains unknown.

2 An essential component of the aggregation process in platelets is an increase in intracellular free Ca²⁺ ([Ca²⁺]_i). Ca²⁺ must enter the cell from the external media through specific and tightly regulated Ca²⁺ channels in the plasma membrane. The objective …

The Effect Of 48 Hr Glucose Administration On The Hepatic P-450 System, John N. Buchholz

Loma Linda University Electronic Theses, Dissertations & Projects

The administration of glucose for 48 hrs to mice resulted in a shift of the dose response curve of phenobarbital, an indication that glucose administration significantly sensitized the animals to the effects of the drug. Glucose administration produced a reduction in the catalytic activity of hepatic microscopical P-450 as measured by the in vitro conversion of p-Nitrocellulose to p-Nitrophenol.

The administration of glucose to rats for 48 hrs resulted in prolonged anesthesia after the administration of pentobarbital. The spectral binding of hexobarbital and methadone to hepatic microsomal P-450 was found to be significantly reduced following glucose administration. The changes in …

Cattle Fertility Not Harmed By Pour-On Insecticides, D J. Barker

Journal of the Department of Agriculture, Western Australia, Series 4

Pour-on insecticides have been a feature of lice and fly control on cattle for many years and in many countries, but it seems that only in Western Australia have they been suspected of lowering fertility.

Frequent reports of this effect have been received by the Department of Agriculture since the first pour-on insecticide was marketed in W.A. in the late 1960's, culminating in the research work reported below.

The work clears pour-ons as a cause of reduced fertility in herds.

Emergency Chlorination Of Farm Water Supplies, H C. Hughes

Journal of the Department of Agriculture, Western Australia, Series 4

TOWARDS the end of summer (and especially in a drought) the risk of water in dams, soaks, wells or tanks becoming polluted is increased.

Bore water is much less likely to be affected unless the bore is poorly sited near a farm building, such as a shearing or milking shed, a pig pen, or a septic tank system.

Marker Dyes In Antibiotics, K Needham, N. Ingleton

Journal of the Department of Agriculture, Western Australia, Series 4

'For some years the presence of penicillin in milk has been a serious problem for the dairy industry.

When cows are treated for mastitis with antibiotics some residue finds its way into the milk.

Unless the milk from treated cows is withheld for at least 72 hours after treatment this residue enters the bulk milk supply.

List Of Registered Stock Foods : 1963-64, H G. Cariss

Journal of the Department of Agriculture, Western Australia, Series 4

All foods for stock sold in Western Australia are required by the Feeding Stuffs Act, 1928-1951, to be registered annually with the Department of Agriculture.

A list of stock foods which have now been registered with the Department of Agriculture for the current registration year appears here.

Drugs For Worm Control. 1. Sheep Drenching Trials With Mk 360, M R. Gardiner, J. Craig

Journal of the Department of Agriculture, Western Australia, Series 4

DRENCHING sheep with drugs designed to eliminate parasites has become an established practice in the higher rainfall districts of Western Australia.

has been tested in many trials, and their is little doubt that drenching sheep clinically affected with worms—the so-called "tactical" drench—is valuable and necessary.

However, there is usually less general acceptance of the value of "strategic" drenching— the prevention of clinical parasitism by giving the drug at certain specific times, pre-determined by a knowledge of the numerical rise and fall of the various parasites within the animal body.

The Effect Of Drugs On Experimental Renal Hypertension In The Dog., J. J. Prusmack

Electronic Theses and Dissertations

No abstract provided.