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Articles 1 - 3 of 3
Full-Text Articles in Medicinal Chemistry and Pharmaceutics
Shedding Light On Ester Drug Metabolism: Investigating Carboxylesterases In Live Cells With Fluorogenic Chemical Tools, Carolyn J. Karns
Shedding Light On Ester Drug Metabolism: Investigating Carboxylesterases In Live Cells With Fluorogenic Chemical Tools, Carolyn J. Karns
Masters Theses
No abstract provided.
Development Of A Chemical Biology Approach To Uncover The Influence Of Sequence Variations On Ces1 Activity In Live Cells, Samuel James Knebel
Development Of A Chemical Biology Approach To Uncover The Influence Of Sequence Variations On Ces1 Activity In Live Cells, Samuel James Knebel
Masters Theses
Drug metabolism is the biochemical process of modifying drugs to detoxify and remove them through enzymatic transformations. These biotransformation’s occur primarily in the liver and are critical to understanding how pharmaceutical compounds are chemically altered inside the human body. Human carboxylesterases (CESs) catalyze the hydrolysis of esters, amides, thioesters, and carbamates. CES-mediated hydrolysis plays an important role in the metabolism of many drugs including the first FDA approved antiviral treatment for COVID-19, remdesivir (Veklury), the seizure control medication rufinamide (Banzel), and the flu antiviral drug oseltamivir (Tamiflu). CES activity is known to be influenced by a variety of factors including …
Medicinal Properties Of Cyperus Species (Sedge Family, Cyperaceae), Lata Maishaya Udari
Medicinal Properties Of Cyperus Species (Sedge Family, Cyperaceae), Lata Maishaya Udari
Masters Theses
The grasses that yield therapeutically important products are among the least studied in the Cyperaceae family. Herb-based medicine from ancient times have played a vital role in ailments of various disease and nowadays it has been a particular area of interest in medicine. Phytochemicals are inherent compounds derived from plants that are biologically active, non-nutritive chemicals that act as a defensive or prophylactic medicine in humans. Their extracts have proven to show inhibition properties against different microbes. Despite the prevalence of Cyperus species and their traditional use in medicine, the chemical components responsible for their attributes remain largely unknown. This …