Open Access. Powered by Scholars. Published by Universities.®
Medicinal Chemistry and Pharmaceutics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Medicinal Chemistry and Pharmaceutics
Inhibition Of Amyloid-Β Aggregation And Caspase-3 Activation By The Ginkgo Biloba Extract Egb761, Yuan Luo, Julie V. Smith, Vijaykumar Paramasivam, Adam Burdick, Kenneth J. Curry, Justin P. Buford, Ikhlas Khan, William J. Netzer, Huaxi Xu, Peter Butko
Inhibition Of Amyloid-Β Aggregation And Caspase-3 Activation By The Ginkgo Biloba Extract Egb761, Yuan Luo, Julie V. Smith, Vijaykumar Paramasivam, Adam Burdick, Kenneth J. Curry, Justin P. Buford, Ikhlas Khan, William J. Netzer, Huaxi Xu, Peter Butko
Faculty Publications
Standardized extract from the leaves of the Ginkgo biloba tree, labeled EGb761, has been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementias and Alzheimer's disease (AD). Substantial experimental evidence indicates that EGb761 protects against neuronal damage from a variety of insults, but its cellular and molecular mechanisms remain unknown. Using a neuroblastoma cell line stably expressing an AD-associated double mutation, we report that EGb761 inhibits formation of amyloid-β (Aβ) fibrils, which are the diagnostic, and possibly causative, feature of AD. The decreased Aβ fibrillogenesis in the presence of EGb761 was observed …
Oxidation-Reduction Characteristics Of Chlorophenols In An Aprotic Medium, Cecil A. Sorrells, Ali U. Shaikh, Victor M. Samokyszyn
Oxidation-Reduction Characteristics Of Chlorophenols In An Aprotic Medium, Cecil A. Sorrells, Ali U. Shaikh, Victor M. Samokyszyn
Journal of the Arkansas Academy of Science
Eighteen chlorophenols, containing from one to five chlorine atoms on the benzene ring at various positions, have been studied by cyclic voltammetric methods to evaluate their oxidation-reduction characteristics in an aprotic medium. The compounds were dissolved in dimethylsulfoxide containing 0.10 M tetrabutylammonium perchlorate as the supporting electrolyte and were then both oxidized and reduced on a glassy carbon electrode. The results indicate that phenols oxidize in a one-step process to phenoxium ion which dimerizes to quinone ether. The ether can be reduced back to phenol in a two-step reduction process. The oxidation potential of the chlorophenols varies with the number …