Human and Clinical Nutrition Commons^™

What Kigali’S Open‑Air Markets Reveal About Achieving Food And Nutrition Security: The Role Of African Indigenous Crops, Eugene Baraka, Mary S. Willis, Brice A. Ishimwe

Department of Nutrition and Health Sciences: Faculty Publications

Background: Household dietary diversity in Rwanda remains low and significantly contributes to the double burden of malnutrition. Rwanda has one of the highest under five stunting rates globally, and malnutrition remains one of the most pressing public health issues; therefore, factors that shape food and nutrition security are of utmost concern. Globally, the variety of foods available in open-air markets has been shown to affect dietary diversity. Furthermore, the consumption of indigenous foods can contribute to a diverse diet and improve nutrition status. At present, there are limited data on foods available for purchase in open-air markets in Africa. …

The Crucial Role Of Sestrins In Oxidative Stress Response And Disease: An Analysis Of Phosphorylation Mutation S110a In Hsesn2, Julianne Fay

Honors Program: Senior Projects (Public)

Sestrins are highly conserved proteins which are induced under environmentally stressful conditions to adjust the cell’s response to such disturbances. This protein possesses two domains critical for its dual function in reducing reactive oxygen species (ROS) and regulating the mTORC1 complex. Sestrins may use diverse transcription factors, such as Nrf2, peroxiredoxin reductase activity, and a catalytic cysteine to regenerate oxidized species; however this was confirmed to be through a mechanism likely different than AhpD, for which there was distance sequence similarity. Furthermore, Sestrins are important regulators of TORC1 and AMPK, which are crucial energy sensors able to control cellular metabolism …

Potential Effectiveness Of Registered Dietitian Nutritionists In Healthy Behavior Interventions For Managing Type 2 Diabetes In Older Adults: A Systematic Review, Laurel Dobrow, Isabella Estrada, Nasira Burkholder-Cooley, John Miklavcic

Food Science Faculty Articles and Research

Purpose: A systematic review was conducted to assess how the involvement of a registered dietitian nutritionist (RDN) in healthy behavior interventions (HBIs) potentially affects outcomes in older adults with type 2 diabetes (T2D).

Methods: Literature was searched for primary research published between 2016 and 2020 on HBI involving a RDN affecting outcomes in older adults with T2D. Evaluations of hemoglobin A1c (HbA1c), blood glucose, blood pressure, cholesterol, anthropometry, body composition, medication usage, healthcare cost, and self-efficacy and/or adherence to healthy behaviors outcomes were selected for inclusion. All the literature included were summarized, evaluated for certainty of evidence criteria, and assessed …

Preliminary Evidence That Lectins In Infant Soy Formula Apparently Bind Bovine Milk Exosomes And Prevent Their Absorption In Healthy Adults, Ezra Mutai, Alice Kah Hui Ngu, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Background: Milk exosomes and their microRNA (miR) cargos are bioavailable. The content of exosomes and miRs is negligible in infant formulas compared to human milk, and dietary depletion of exosomes led to changes in bacterial communities and impaired gut health in juvenile mice. Adverse effects of formula feeding may be compounded by using soy formulas due to exosome binding by abundant lectins in that matrix. The purpose of this study was to assess the bioavailability of milk exosomes and their miR cargos added to soy formula in adults, as well as the potential role of soy lectins in exosome …

Omega-6 And Omega-3 Fatty Acid-Derived Oxylipins From The Lipoxygenase Pathway In Maternal And Umbilical Cord Plasma At Delivery And Their Relationship With Infant Growth, Maranda Thompson, Arzu Ulu, Ana G. Yuil-Valdes, Maheswari Mukherjee, Melissa K. Thoene, Matthew Van Ormer, Rebecca Slotkowski, Elizabeth Lyden, Ann Anderson-Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan

Department of Nutrition and Health Sciences: Faculty Publications

Omega-3 and omega-6 fatty acids are important for neonatal development and health. One mechanism by which omega-3 and omega-6 fatty acids exert their effects is through their metabolism into oxylipins and specialized pro-resolving mediators. However, the influence of oxylipins on fetal growth is not well understood. Therefore, the objective of this study was to identify oxylipins present in maternal and umbilical cord plasma and investigate their relationship with infant growth. Liquid chromatography–tandem mass spectrometry was used to quantify oxylipin levels in plasma collected at the time of delivery. Spearman’s correlations highlighted significant correlations between metabolite levels and infant growth. They …

Scavenger Receptors In Host Defense: From Functional Aspects To Mode Of Action, Qamar Taban, Peerzada Tajamul Mumtaz, Khalid Z. Masoodi, Ehtishamul Haq, Syed Mudasir Ahmad

Department of Nutrition and Health Sciences: Faculty Publications

Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain. They are functionally diverse as they are involved in various disorders and biological pathways and their major function in innate immunity and homeostasis. Numerous scavenger receptors have been discovered so far and are apportioned in various classes (A-L). Scavenger receptors are documented as pattern recognition receptors and known to act in coordination with other co-receptors such as Toll-like receptors in generating the immune responses against a repertoire of ligands such as microbial pathogens, non-self, intracellular …

Development Of Balanced Budget Bites And Feasibility Evaluation, Holly Hansen, Kendra Kattelmann, Kathryn Morrison, Becky Jensen, Hailey Millner, Addison Reimer, Jen Sip, Brittany Canfield, Cydney Chamberlain

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

Objective: Balanced Budget Bites was created to educate individuals of Feeding Brookings about different cooking techniques, food safety, meal planning, budgeting, and financial resources in the Brookings, SD area while highlighting lower-cost food items. Participants and Recruitment: The target audience of Balanced Budget Bites were individuals that participated in Feeding Brookings that were recruited for four weeks via a flyer and a posting of the flyer on Feeding Brookings’ Facebook page. Method and Implementation: Participants of Feeding Brookings completed a pre-survey before taking Balanced Budget Bites to assess their skills, confidence, and knowledge related to nutrition and finance. The online …

“Many People Have No Idea”: A Qualitative Analysis Of Healthcare Barriers Among Yazidi Refugees In The Midwestern United States, Falah N. Rashoka, Megan S. Kelley, Jeong‑Kyun Choi, Marc A. Garcia, Weiwen Chai, Hazim N. Rashawka

Department of Nutrition and Health Sciences: Faculty Publications

Background: The COVID-19 pandemic has shed new light on inequities in healthcare access faced by immigrant and refugee communities. To address ongoing disparities, there is an urgent need for ecological approaches to better understand the barriers that hinder and resources that facilitate access to healthcare. This study investigates barriers to healthcare system access faced by Yazidi refugees in the Midwestern United States.

Methods: Informed by the Interpretative Phenomenological Approach, three focus group meetings with a community advisory board were conducted between September 2019 and January 2020. The nine-member focus group included social workers, healthcare providers, and members of the Yazidi …

Barriers To Summer Food Service Program (Sfsp) Implementation Before And After Covid-19: A Qualitative, Collective Case Study, Masoomeh Hajizadeh Oghaz, Falah N. Rashoka, Megan S. Kelley

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: SFSP, as a federal food assistance program, could ensure that children have sufficient nutritious food during summer. According to a 2016 USDA report, only 0.4–0.6% of eligible children participated in this program in Nebraska, which makes for one of the lowest SFSP participation rates in the U.S. This study aims to better understand how the COVID-19 pandemic has impacted SFSP implementation in urban and rural settings across the state.

Conclusions: Insights from this study may inform the development of policies that expand food access to vulnerable families. On the organizational level, this includes providing participating kids and their parents …

Maximal Strength Training Increases Metabolic Energy Expenditure In Sedentary Adults Classified As Obese, Robert E. Anderson Iii

Theses and Dissertations--Nutrition and Food Systems

Background: Metabolic adaptations reduce resting and non-resting energy expenditure to account for approximately 120 kcal/day. Weight loss promotes greater skeletal muscle efficiency, reducing the energy cost of physical activity and is correlated with declines in skeletal muscle glucose oxidation. Maximal Strength Training (MST) has the potential to upregulate glucose utilization and may offset these metabolic adaptations. Objective: To determine if MST offsets markers of metabolic adaptation by increasing resting and non-resting energy expenditure in sedentary individuals classified as obese. Methods: Five (5) participants (2 females, 3 males), ages 18-35 years, with obesity (BMI 30–45 kg/m2) were enrolled in an 8-week …

Aims: Action Against Infirmity And Malnutrition In Seniors, Maeve Lorraine Mary O'Connell

Theses

Aim: The primary aim of this thesis was to investigate the relationship between nutrition and frailty in Irish older adults. The nutritional status, dietary quality and perceived barriers/motivators to nutrition were also examined, and a frailty intervention protocol was designed. Methods: Cross-sectional study in Irish community-dwelling adults aged ≥65 years. Nutritional status, dietary intake, functional mobility and food choice motivators/healthy eating barriers were assessed using the Mini Nutritional Assessment – Short Form (MNA-SF), a food frequency questionnaire (FFQ), the Timed Up and Go (TUG) test and a custom designed 2-item questionnaire, respectively. Frailty was defined as three or more of …

Mothers' Perceptions Of Their Children's Weight: Opportunity For Health Promotion In Kuwait, Abdullah Al-Taiar, Nawal Alqaoud, Reem Sharaf-Alddin, Muge Akpinar-Elci

Community & Environmental Health Faculty Publications

Background: Mothers’ perceptions of their children’s weight remain mostly unknown in oil-rich countries of the Middle East.

Aims: To compare maternal perceptions of their children’s weight with actual body weight.

Methods: We used the Kuwait nutritional surveillance data for 5 consecutive years (2015-2019) (N = 5119), which were collected through face-to-face interviews with mothers of children aged 2-5 years attending vaccination centres.

Results: Of the 5119 mothers in the study, 163 (3.18%) and 332 (6.48%) had obese or overweight children, respectively. Among 4624 mothers who had normal weight children, 1350 (29.20%) perceived their children’s weight as …

Nutritional Status In Critical Care Of Covid-19 Patients, Dolph Lewis Davis Iii

Theses and Dissertations--Nutrition and Food Systems

Critical care nutrition is a poorly researched, and such a sudden pandemic event requiring manipulation of nutritional status via propofol-induced sedation for mechanical ventilation is potentially impactful on patient outcomes. This paper seeks to provide context to the impact of critical care protocols on the nutritional status of obese patients suffering from COVID-19.

The Short- And Long-Term Effects On The Microbiome Of Infants Who Are Exposed To Opioids In Utero, Dawson Brown-Ezell

Undergraduate Honors Theses

Introduction: The gut microbiome is believed to have a significant impact on health throughout the lifespan, and the influence of infant nutrition and other environmental factors are of particular interest in its development. The aim of this research project was to learn more about the microbiome and short chain fatty acid (SCFA) composition of toddlers of differing weights, considering birth history, environment, and diet. In East Tennessee, opioid misuse is a growing issue, and a number of participants in this study were exposed in utero. We also hoped to identify related effects on infant’s SCFA composition. Finally, it is known …

Nutrition Education And The Effects On Athletic Performance In Collegiate Athletes With Low Energy Availability, Karleigh Sudenga

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

Current research suggests that collegiate athletes lack nutritional knowledge needed for optimal athletic performance. The absence of basic nutritional knowledge in college athletes puts them at an increased risk for RED-S and its sports performance consequences. The objective of this narrative review is to evaluate the literature on low energy availability in collegiate athletes and determine if nutrition education can improve athletic performance. Multiple studies concluded that nutrition education may improve dietary intake in collegiate athletes, while there was one contradicting study that found that athletes improved nutritional knowledge but did not improve dietary intake. 3 studies found that low …

Narrative Review Of The Relationship Between Depression And Low Blood Folate And Vitamin B12 Levels, Jennifer Sip

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

Depression is a common psychological mood disorder that impacts more than 16 million adults in the United States. It can impact several areas of a person’s life including physical activity, diet and daily activities. The role of nutrition in depression therapy has been researched for several years, with folate and vitamin B12 being the main highlights. Folate and vitamin B12 play a vital role in the development of the central nervous system and conversion of homocysteine to methionine. Past research has found inconsistent findings regarding the relationship between folate, vitamin B12 and their role in depression. This article dives into …

Association Of Diet Qualitymeasured By Three A Priori-Defined Dietary Patterns With Gut Microbiota And Intestinal Permeability Among Obese Individuals, Sarah Eaton, Heather Rasmussen, Weiwen Chai

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: The human gastrointestinal tract (GI)may play a critical role in the prevention of obesity and metabolic diseases. Considering the importance of a healthy diet for optimal health, this study examined associations of diet quality assessed by three a priori-defined dietary patterns (Healthy Eating Index 2010 [HEI-2010],Mediterranean Eating Pattern for Americans [MEPA], and Dietary Approaches to Stop Hypertension [DASH] with gut microbiota, short-chain fatty acids (SCFA) and intestinal permeabilitymarkers in adult obese participants.

Conclusions: Blautia abundance and inversely associated with intestinal permeability markers such as urinary 24-h sucralose levels suggesting diet quality may have positive impact on the human GI …

Intracellular Fate Of Bovine Milk Exosomes In Murine Bone Marrow-Derived Macrophages, Afsana Khanam, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Milk exosomes (MEs) and their microRNA cargos constitute novel bioactive food compounds, and bovine MEs (BMEs) are being considered for use in drug delivery. The internalization of MEs by macrophages and degradation in lysosomes (in all cells) limit biological activities. Here, we determined whether BMEs internalized by murine bone marrow-derived macrophages (BMDMs) retrofuse with the intralumenal membrane in the multivesicular body (MVB) for subsequent release into the extracellular space or whether BMEs are destined for degradation in lysosomes.

Conclusions: The retrofusion of BME-derived intralumenal MVBs and secretion of BME into the extracellular space is quantitatively minor in BMDMs. The majority …

Genetically Altered Bovine Milk Exosomes (Bmes) Evade Elimination Bymurine Bone Marrow-Derived Macrophages (Bmdms), Alice Ngu, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: To develop BMEs that evade elimination by BMDMs.

Conclusions: The elimination of BMEs UNL1 and UNL2 is significantly reduced compared unmodified BMEs in BMDM cultures. This is of great importance when using BMEs for delivering therapeutics.

Γ-Glutamyl Valine, Found In Dry Edible Beans, Is Anti-Diabetic In Db/Db Mice, Bikram Upadhyaya, Kaustav Majumder, Regis Moreau

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: Dietary γ -glutamyl peptides (γ -GPs) found in dry edible beans exhibit biological activities (antioxidant, anti-inflammatory) with potential benefits against chronic metabolic disorders. γ -GPs are responsible for the desirable Kokumi flavor through allosteric activation of the Calcium Sensing Receptor (CaSR) present in multiple mammalian tissues. In this study, we investigated the metabolic effects of γ -glutamyl valine (γ -EV) in diabetic obese mice.

Conclusions: γ -EV improved the diabetic condition of db/db mice via modulation of glucose and lipid metabolism.

The Impact Of Covid-19 On Perceived Barriers And Facilitators To The Healthfulness Of Communities With Low-Income, Elder Varela, Jamie Zeldman, Alison Kuch, Yanli Wang, Mohammad Shushari, Elizabeth L. Hall, Jade Mcnamara, Jesse Stabile Morrell, Terezie Tolar-Peterson, Onikia Brown, Melissa D. Olfert, Lisa Franzen-Castle, Tandalayo Kidd, Sarah Colby, Geoffrey Greene, Karla P. Shelnutt

Department of Nutrition and Health Sciences: Faculty Publications

Background: The COVID-19 pandemic brought new challenges affecting the wellbeing of individuals in communities with low income. Understanding where people live and how those environments can facilitate or hinder living a healthy lifestyle is essential for developing interventions that target behavior change and health promotion. Objective: This study compares Extension Nutrition Educators’ (NEs) perceptions of the barriers and facilitators impacting the healthfulness of the environment of communities with low income in eleven states before and during the COVID-19 pandemic.

Associations Between Atherogenic Markers And Hearing Loss: National Health And Nutrition Examination Survey: 2011-2012, 2015-2016, Anna Anya Rombakh

All Master's Theses

Importance Hearing loss (HL) is a major public health problem that has been previously found to be associated with abnormal atherogenic markers.

Objective To investigate the associations between such atherogenic markers and the degree of HL using continuous NHANES data from cycle years 2011-2012 and 2015-2016.

Design, Study, and Participants This observational study used data from two National Health and Nutrition Examination Survey (NHANES) cycle years 2011-2012 and 2015-2016. NHANES continuously conducts data collection via home interviews and physical exams completed in their Mobile Examination Centers. NHANES participants ages 20-69 who partook in audiometry, anthropometric and laboratory testing were included. …

Psychosocial Influences On And Behavioral Characteristics Of Young Adult Food Addiction, Rachel A. Wattick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction. Research on food addiction has increased in recent years, but there are few studies focusing on college-attending young adults, who may be at risk of developing food addiction due to the stress of the college environment. Additionally, causes and characteristics of food addiction are under-explored.

Aim. This dissertation aims to 1) determine the impact of adverse childhood experiences (ACEs) and other early life influences on the development of food addiction in college-attending young adults and 2) determine the psychosocial and behavioral characteristics of young adults with food addiction.

Methods. A sequential explanatory mixed-methods design was used for aims 1 …

Implementation Of An Inpatient To Outpatient Communication Pathway To Improve Outcomes In High-Risk Oncology Patients., Kimberly Procaccino Mba, Rd, Ldn, Janine Gilboy Rd, Ldn, Jennifer Brennan Rd, Cso, Erin Levine Rd, Cso, Ldn, Amanda Stone, Alyse Wittman

Clinical Nutrition Service

No abstract provided.

Comparing Retrospective Psu Measurements With The Leep-Covid 2020 Study To Ascertain Similarities In Calories Per Kilogram Of Body Weight For Ventilator-Dependent Covid-19 Patients, Kimberly Cephas

Clinical Nutrition Service

No abstract provided.

Navigating The Perfect Storm: Staffing Crisis During The Pandemic, Melissa Faura Rd, Ldn, Ann Flickinger Ms, Rd, Ldn, Kimberly Procaccino Mba, Rd, Ldn

Clinical Nutrition Service

No abstract provided.

The Role Of Ovarian Hormones In Appetite-Regulation: Examining The Post-Exercise Appetite Response In Pre- Vs Post-Menopausal Females, Jessica A.L. Tucker

Theses and Dissertations (Comprehensive)

INTRODUCTION: Appetite fluctuates across the menstrual cycle, suggesting ovarian hormones are involved in the regulation of appetite hormones and energy intake. Exercise is another regulator of appetite with higher intensity exercise generating a greater and more consistent suppression. Considering there is limited evidence investigating the role of ovarian hormones in appetite regulation, menopause represents a stage of life where ovarian function declines, thus providing an opportunity to further explore the role of ovarian hormones in the appetite-regulatory response to exercise. PURPOSE: To examine the role of ovarian hormones on appetite-regulating hormones in pre- and post-menopausal females following a …

Nutritional Status Of Children Living Within Institution-Based Care: A Retrospective Analysis With Funnel Plots And Control Charts For Programme Monitoring, Emily Delacey, Evan Hilberg, Elizabeth Allen, Michael Quiring, Cally J. Tann, Nora Ellen Groce, James Vilus, Ethan A. Bergman, Merzel Demasu-Ay, Hang T. Dam, Marko Kerac

All Faculty Scholarship for the College of Education and Professional Studies

Objectives The aim of this study is to fill a key information gap on the nutrition-related epidemiology of orphaned and vulnerable children living within institution-based care (IBC) across six countries.

Design A retrospective analysis with Shewhart control charts and funnel plots to explore intersite and over time variations in nutritional status.

Setting We conducted a retrospective analysis of records from Holt International’s Child Nutrition Programme from 35 sites in six countries; Mongolia, India, Ethiopia, Vietnam, China and the Philippines.

Participants Deidentified health records from Holt International’s online nutrition screening database included records from 2926 children, 0–18 years old. Data were …

Descriptive Study Of A Healthy Weight Management Program For Overweight Or Obese Children And Youth, Chad Roberts, Pam Kasyan-Howe, Kristin Domville, Lisa Schubert

Fall 2021 Virtual OTD Capstone Symposium

The rise in obesity among children and youth in the last 20 years is a public health concern. The prevalence of childhood obesity has multiplied worldwide in the last four decades (“The Heavy Burden of Obesity and the Economics of Prevention,” 2019). Obesity is a complex chronic disease in which abnormal or excessive accumulation of body fat impairs health (Wharton et al., 2020). Childhood obesity can profoundly affect children's physical health, social and emotional well-being, and self-esteem (Rankin et al., 2016 & Purnell et al., 2018). The problem is a lack of an occupation-based evaluation tool utilized to link occupational …

Mechanical Overload-Induced Muscle-Derived Extracellular Vesicles Promote Adipose Tissue Lipolysis, Ivan J. Vechetti Jr, Bailey D. Peck, Yuan Wen, R Grace Walton, Taylor R. Valentino, Alexander P. Alimov, Cory M. Dungan, Douglas W. Van Pelt, Ferdinand Von Walden, Bjorn Alkner, Charlotte A. Peterson, John J. Mccarthy

Department of Nutrition and Health Sciences: Faculty Publications

How regular physical activity is able to improve health remains poorly understood. The release of factors from skeletal muscle following exercise has been proposed as a possible mechanism mediating such systemic benefits. We describe a mechanism wherein skeletal muscle, in response to a hypertrophic stimulus induced by mechanical overload (MOV), released extracellular vesicles (EVs) containing muscle-specific miR-1 that were preferentially taken up by epidydimal white adipose tissue (eWAT). In eWAT, miR-1 promoted adrenergic signaling and lipolysis by targeting Tfap2α, a known repressor of Adrβ3 expression. Inhibiting EV release prevented the MOV-induced increase in eWAT miR-1 abundance and expression of …