Neuroscience and Neurobiology Commons^™

The Neurological Underpinnings Of Hypnosis And Its Clinical Applications, Raizy Leizerowski

The Science Journal of the Lander College of Arts and Sciences

The brain is so complex that it is almost impossible to select one variable as the reason for a specific observation. This paper will discuss the neurological basis of hypnosis, and how hypnosis has made unique contributions to the refinement and development of cognitive neuroscience. In addition, hypnosis has been proven to cure many psychological and neurologically based diseases. Due to in-depth study of the neurological underpinnings of hypnosis, much advancement has been made in elucidating the relationship between the complex neural circuitry of the brain, its direct correlation to consciousness, and both the efferent and afferent neurological systems. New …

Neurobiology Of Stress, Annaliese K. Beery, Daniela Kaufer

Neuroscience: Faculty Publications

The neurobiology of stress and the neurobiology of social behavior are deeply intertwined. The social environment interacts with stress on almost every front: social interactions can be potent stressors; they can buffer the response to an external stressor; and social behavior often changes in response to stressful life experience. This review explores mechanistic and behavioral links between stress, anxiety, resilience, and social behavior in rodents, with particular attention to different social contexts. We consider variation between several different rodent species and make connections to research on humans and nonhuman primates.

Processing Of Language Switches In Bilingual Individuals With Aphasia: An Event-Related Potential Comparison, Lizette Rodarte

Open Access Theses & Dissertations

Switching between languages, or code-switching, is a common phenomenon in bilingual individuals. In proficient bilinguals, these switches are done with ease and are used for many purposes. Contrary to popular belief, these switches are rule-governed and follow grammatical structure. Bilingual individuals diagnosed with aphasia present with difficulty processing languages and these language switches. With the increase in bilingual individuals, it is likely that the speech-language pathology community will see an increase of bilingual individuals with aphasia on their caseload. For this reason, the purpose of this study is to increase our understanding of the neural processes involved in processing of …

Event Related Potentials In A Two Stimuli Auditory Oddball Task In Concussed College Athletes: A Linguistic Component Replication Study, Christopher Anthony Roosmalen

Open Access Theses & Dissertations

Concussions affect an estimated 1.6 to 3.8 million individuals annually and can result in persistent symptoms and cognitive impairments in attention and memory. Concussions are a rising health concern especially in concussion management. Event Related Potentials (ERP) may more accurately assess cognitive recovery making better return to play decisions. In 2013, Sanchez found no significant difference between concussed athletes and non-concussed individuals in the in amplitude of the P300 ERP component using an auditory oddball task consisting of 2 different consonant, vowel (CV) syllables. Because participants were instructed to maintain a mental and verbal count of the target stimuli, a …

Time Frequency Analysis Of Neural Oscillations In Multi-Attribute Decision-Making, Iris Lieuw

Scripps Senior Theses

In our daily lives, we often make decisions that require the use of self-control, weighing trade-offs between various attributes: for example, selecting a food based on its health rather than its taste. Previous research suggests that re-weighting attributes may rely on selective attention, associated with decreased neural oscillations over posterior brain regions in the alpha (8-12 Hz) frequency range. Here, we utilized the high temporal resolution and whole-brain coverage of electroencephalography (EEG) to test this hypothesis in data collected from hungry human subjects exercising dietary self-control. Prior analysis of this data has found time-locked neural activity associated with each food’s …

Body Sensations: Neurobiology, Learning To Feel, And Sensory Teamwork, Gin Mccollum

Mathematics and Statistics Faculty Publications and Presentations

Most of us must learn to feel, as an artist learns to see in order to draw. All of the physiological processes of feeling and seeing can happen with no awareness at all, when the mind is wandering elsewhere. Essential to the learning process is awareness, prajna. With no awareness, we have unconscious sensations, not conscious perceptions.

The light striking the retina of the eye is the first step in seeing. A great deal more happens in the visual part of the cerebral cortex, at the back of the head, and along the pathways to it. The conscious experience of …

Characterizing The Temporal Dynamics In Functional Connectivity Measured With Fmri, Joshua Swearingen

MUSC Theses and Dissertations

There is a considerable and growing interest in the organization and development of neural function at the scale of the entire brain, particularly from activity observed in fluctuations in the blood oxygen level dependent (BOLD) signal in functional magnetic resonance imaging (fMRI). This activity reliably organizes into sub-networks, whether obtained from subjects at rest or from those involved in various perceptual or cognitive tasks. While these networks have often been identified and studied, the precise dynamics involved in their interactions as well as the relationship between organization found in both resting and task-based activity are not well understood. Here I …

Towards Closed-Loop Deep Brain Stimulation: Behavior Recognition From Human Stn, Soroush Niketeghad

Electronic Theses and Dissertations

Deep brain stimulation (DBS) provides significant therapeutic benefit for movement disorders such as Parkinson’s disease (PD). Current DBS devices lack real-time feedback (thus are open loop) and stimulation parameters are adjusted during scheduled visits with a clinician. A closed-loop DBS system may reduce power consumption and side effects by adjusting stimulation parameters based on patient’s behavior. Thus behavior detection is a major step in designing such systems. Various physiological signals can be used to recognize the behaviors. Subthalamic Nucleus (STN) Local field Potential (LFP) is a great candidate signal for the neural feedback, because it can be recorded from the …

The Effects Of Spinal Manipulative Therapy On Isokinetic Strength And Postactivation Potentiation, Grant D. Sanders

Theses and Dissertations--Kinesiology and Health Promotion

Spinal manipulative therapy (SMT) is a therapeutic procedure employed by various healthcare practitioners for alleviating acute and chronic musculoskeletal complaints. This form of treatment is also delivered to enhance the performance and augment the rehabilitation of athletes. However, despite research findings alleging the strength-modulating effects of SMT alongside numerous professional athletes’ positive anecdotal claims concerning its results, the physiological processes to explain its effects remain largely unexplained. Therefore, the purpose of this work was to investigate the effects of SMT in a college-aged sample population with two experiments.

The first study examined the effect of SMT targeting the lumbosacral region …

The Intranasal Delivery Of Dnsp-11 And Its Effects In Animal Models Of Parkinson's Disease, Mallory J. Stenslik

Theses and Dissertations--Neuroscience

A major challenge in developing disease altering therapeutics for the treatment of Parkinson’s disease (PD) has been the delivery of compounds across the blood-brain barrier (BBB) to the central nervous system (CNS). While direct surgical infusion has been utilized to deliver compounds to the brain that don’t cross the BBB, issues of poor biodistribution in the CNS due in part to properties of the molecules being delivered and/or infusion device protocols have limited the widespread success of this invasive approach. To avoid the issues of surgically delivering compounds to the CNS, numerous studies have examined the use of intranasal administration …

Relationships Between Specific Health-Related Fitness Components And Standardized Academic Achievement Tests, Tona Wilson

Walden Dissertations and Doctoral Studies

In an attempt to meet monetary-driven mandates to improve student achievement test scores, administrators are replacing physical education activities with subject matter classes in many American schools. This practice negates the positive contributions of physical activity to academic performance and student fitness. Guided by self-efficacy theory, this study assessed the impact of optimal versus minimal physical fitness state on student academic achievement. The study sample included 5,416 9th grade students from the same school district who completed a minimum of 5 of the 6 components of the FITNESSGRAM tests, and who also completed the math and English language arts (ELA) …

Temporal Localization Of Insulin-Like Growth Factor 1 (Igf1) Positive Cells In Developing Hypothyroid Brain, Shelby Anne Kline

All Graduate Theses, Dissertations, and Other Capstone Projects

Hypothyroidism has been known to result in numerous neuroanatomical defects in the developing brain. To investigate further into the mechanism in which these defects are obtained, local brain insulin-like growth factor 1 (Igf1) was investigated in relation to the hypothyroid brain. There are many similarities between hypothyroidism and the Igf1 deficient brain. Additionally, TH (thyroid hormone) is known to interact with Igf1. Therefore, the purpose of this study was to investigate the effect of induced congenital hypothyroidism on the temporal expression of Igf1-positive cells in the brain. To investigate the relationship between TH and Igf1 in the brain, we inhibited …

Enhanced Cgmp-Dependent Signaling In Astrocytes: Novel Therapeutic Target In Alzheimer's Disease, Nyema M. Woart

PCOM Biomedical Studies Student Scholarship

Over five million Americans suffer from Alzheimer’s Disease (AD), with an expected 34% increase in the incidence in this disease over the next decade. Unfortunately, there is no cure for AD. Recent studies have indicated that drugs which increase the levels of cyclic guanosine-3’5’-monophosphate (cGMP) may help preserve learning and memory in AD and enhance cognition in the aging brain; however, the mechanism(s) of how cGMP exerts this beneficial effect is unknown. The present findings now suggest that elevation of cGMP in astrocytes depresses inhibitory potassium currents in these cells to stimulate their protective influence on neuronal activity. Cellular currents …

Electrophysiological And Behavioral Working Memory Differences Between Musicians And Non-Musicians, Benjamin P. Richardson

All Master's Theses

The current study examines the P300 brainwave and working memory differences between musicians and non-musicians. Differences in aspects of recorded electrical brain activity have been used to quantify differences in updating processes of working memory possibly related to differences in amount of music experience. The current study is designed to partially replicate and enhance a method previously implemented in research describing how music experience may be associated with differences in visual processing as well auditory working memory and executive function. Behavioral data were collected using six standardized subtest measures of the TOMAL – II, followed by ERP recordings during a …

Introduction To Neuroscience, Charles Keller

Open Educational Resources

Working with a partner from the class, students will choose a topic of interest relevant to the field of neuroscience, explore the relevant literature, write a 5-7 page paper on the topic, and present the results of their research to the class in the form of a 5-10 minute oral presentation.

Dopamine Regulation Of Disengagement In The Basal Ganglia Circuitry, Mabel N. Terminel

Open Access Theses & Dissertations

Evidence suggests that dopamine (DA) is crucial for initiation and termination as well as sustained execution of movement. For the present study, it was hypothesized that DA plays a more important role in initiation and termination of movement than in its sustained production. To test these hypotheses, rats were trained to walk on a treadmill in a continuous and discontinuous (walk 30 secs/stop 15 seconds) fashion for one hour while striatal DA samples were collected using In Vivo Microdialysis (IVMCD). We predicted larger increases during discontinuous compared to continuous walking. It was found that brain dialysate levels of DA consistently …

Restraint Stress Alters Pro-Inflammatory Cytokine Expression And Increases Superoxide Dismutase In The Rat Hypothalamus And Hippocampus, Kristina Isabel Barron

Open Access Theses & Dissertations

The impact of restraint stress on changes in cytokine expression and oxidative stress markers in hippocampal (Hipp) and hypothalamic (Hyp) regions of the brain, were assessed in a rat model. In addition, immune and inflammatory variables were assessed in peripheral blood. Male Wistar rats were acutely (30 min) or repeatedly (30 min/d for 14 consecutive days) exposed to a restraint stress, or maintained as non-stressed controls. At the time of sacrifice, whole blood and brain tissues enriched in Hyp or Hipp regions were collected; blood was collected with EDTA as an anticoagulant and centrifuged to yield plasma. All tissue samples …

Behavioral And Electrophysiologic Performance In Participants With No Brain Damage Responding To Spoken Sentence Length Messages With Pauses Of Different Durations Inserted Withi The Spoken Message: A Pilot Study, Alexandrea Burciaga

Open Access Theses & Dissertations

Aim: The purpose of this pilot study was to examine the behavioral and electrophysiologic performance in two age groups of individuals with no history of brain damage responding to spoken sentence length messages with pauses of different durations inserted within the message with the use of Event-Related Potentials.

Pilot Study: A modified version of the Revised Token Test was used for the experimental task. All participants have not experienced any brain damage. The first group of adult participants consisted of three college age adults; ages 20-30 and the second consisted of three older adults, ages 50-60. Participants were randomly assigned …

Sensorimotor Analysis Of Oxaliplatin Treated Rats, Krystyna Blanka Wieczerzak

Browse all Theses and Dissertations

There is currently no direct evidence that chemotherapy induced peripheral neuropathy (CIPN) necessarily explains the sensorimotor deficits seen in 90% patients treated with oxaliplatin (OX). Some patients develop sensory symptoms without CIPN. Our laboratory reported abnormal signaling from IA afferents in OX treated rats with no evidence of neuropathy. We hypothesized that in the absence of CIPN, the behavioral disability is associated with impaired sensory encoding in OX treated rats. The purpose of this study was to investigate the sensorimotor abilities of OX treated rats. The battery of behavioral tests was designed to address proprioception and sensorimotor integration. In the …

Metabolic Characterization Of Mpnst Cell Lines, Christopher A. Waker

Browse all Theses and Dissertations

Malignant transformation is the process by which cells develop cancer properties. While many causes for malignant transformation are known (i.e. common genetic mutations and/or exposure to toxins or viruses), the basic requirements that allow a cell to stay alive with altered nutrient and energy requirements are just now being studied. In some tumor types malignant cells undergo changes that result in metabolic differences compared to normal cells. These can include defects in mitophagy resulting in an accumulation of dysfunctional mitochondria and/or a metabolic switch resulting in increased glycolysis, termed the Warburg effect. Increased tumor growth and metastasis have also been …

Retinoic Acid Hydroxylase Inhibitors As A Novel Therapy For Alzheimer’S Disease, Isabel M. Makman

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Alzheimer’s Disease (AD) is one of the most prevalent neurodegenerative diseases afflicting the modern world. As no cure for AD has yet been discovered we sought to explore a potential treatment option based on the inhibition of retinoic acid (RA) metabolism, the active metabolite of vitamin A. Beta-amyloid plaques form in the brain and decrease cognitive function in AD patients. In a recent preclinical study RA was shown to decrease these plaques and rescue memory deficits in an Alzheimer’s mouse model[i]. One key limitation is that when RA is administered to humans it induces its own breakdown, making …

Glutamatergic Neurotransmission In The Prefrontal Cortex Mediates The Suppressive Effect Of Intra-Pfc Infusion Of Bdnf On Cocaine-Seeking, Bok Soon Go

MUSC Theses and Dissertations

Infusion of BDNF into the dorsomedial prefrontal cortex (dmPFC) immediately after the last session of cocaine self-administration prevents cocaine-mediated malfunction of synaptic modulation in the dmPFC that mediates relapse to cocaine-seeking through both GluN2A subunit-containing NMDA receptors and GluN2B subunit-containing NMDA receptors (NMDARS). Intra-dmPFC BDNF is known to suppress cocaine-seeking by normalization of cocaine self-administration- induced disturbance of glutamatergic transmission in the nucleus accumbens (NAc) and by prevention of the cocaine self-administration-induced decrease in extracellular signal-regulated kinase (ERK) activity in the dmPFC through activation of tyrosine receptor kinase B (TrkB). Neuronal activity is required for BDNF-induced ERK activation and the …

Influence Of Stress On Substance Use: Age-Associated Variability In Molecular And Behavioral Outcomes, Christina Elizabeth D'Arcy

Open Access Theses & Dissertations

Stress introduces a number of neurological and neurohormonal changes in response to a number of stimuli, and can influence our relationship to rewarding experiences. As such, it holds the potential of promoting vulnerability to addiction to substances such as methamphetamine. While methamphetamine use and abuse has been steadily declining, the fact remains that it and closely related drugs are used in the treatment of conditions such as narcolepsy, weight loss, and attention deficit disorder. In an effort to develop better patient assessment metrics to aid the physician in deciding a course of treatment, we ask the following questions: Do chronic …

Differences In Stress Biomarkers In Women With High And Low Stress Appraisal, Clarissa Sara Gomez

Open Access Theses & Dissertations

Measures of physiological biomarkers have been widely used in the field of stress research to explain how stress negatively impacts health outcomes. Women in particular have been shown to be more at risk for developing physiological and psychological stress-induced conditions (e.g., hypertension, depression) due to hormonal differences (Kirschbaum et al., 1992), but more importantly, because of their appraisal of stressful events (Schamus et al., 2008). Few studies however have examined whether womenâ??s stress appraisal is predictive of stress reactivity, as measured by stress biomarkers, during stressful events. The goal of this study was to examine whether stress appraisal predicted stress …

Electrical Stimulation Uses Sodium Channel Dependent Depolarization To Produce Exocytotic-Like Dopamine Release And Rotational Behavior In Vivo, Alice Elaine Hernandez

Open Access Theses & Dissertations

The goal of this project was to establish Electrical Stimulation (ES) in combination with In Vivo Intracerebral Microdialysis (IVMCD) as a methodology to evoke exocytotic-like dopamine (DA) release. To provide evidence that ES mimics action potential-mediated DA exocytosis, we hypothesized that ES produces depolarization of the membrane potential that is dependent upon sodium (Na+) -channels to produce DA release concomitantly with rotational behavior. To test this, rats received electrode and cannulae implants along the medial forebrain bundle, which contains the DAergic nigrostriatal pathway, and a microdialysis probe at the striatum to undergo IVMCD testing. To begin, steady baseline DA levels …

Rare Pride Campaigns: Evaluating Participatory Communication In Conservation Efforts Throughout Indonesia, Lauren Elizabeth Perez

Open Access Theses & Dissertations

Communication scholars who study international development and social change have found that if facilitators of social change hope to find positive, lasting solutions to complex social and environmental issues, they must incorporate more participatory approaches. However, even the practitioners with the most noble intentions oftentimes fall short of facilitating truly participatory practices because their strategies are the product of linear processes for evaluating the change context. In this study, I apply Lennie and Tacchi's (2014) approach to evaluating communication for development in a case study of Pride Campaigns implemented by managers throughout Indonesia who partnered with the conservation non-governmental organization …

A Structure/Function Analysis Of Nhsl1b In Facial Branchiomotor Neurons, John Ojumu

Theses and Dissertations

The goal of this study was to identify critical regions of a novel gene, Nance-Horan syndrome-like 1b (nhsl1b). It was previously discovered that C-terminal truncation of the Nhsl1b protein in nhsl1b mutants resulted in a loss of migration in the facial motor neurons of the hindbrain (Walsh et al. 2011). As nhsl1b expresses many isoforms, multiple targets were investigated in order to determine which transcript bears the largest impact on the motor neurons. Using confocal microscopy to observe immunostained embryos, we examined a mutation in an nhsl1b transcript that encodes a WHD, a domain that is known to …

Role Of Sox11 During Vertebrate Ocular Morphogenesis And Retinal Neurogenesis, Lakshmi Shashidharan Pillai

Theses and Dissertations--Biology

Microphthalmia, anophthalmia, and coloboma (MAC) are distinct abnormalities demonstrating a continuum of developmental eye defects that contribute to 15-20% of blindness and severe vision deficiencies in children worldwide. The genetic etiology of MAC is large, complex and encompasses the whole developmental biology of the eye. Understanding how the eye develops will aid in identifying genes and developmental pathways involved in MAC. Although investigation of the genetic architecture of congenital anomalies is growing exponentially, much work remains to be accomplished to understand the complex, genetically heterogeneous congenital anomalies, which significantly impact childhood vision.

With an interest in elucidating the mechanisms that …

Dual Functions For Insulinoma-Associated 1 In Retinal Development, Marie A. Forbes-Osborne

Theses and Dissertations--Biology

Proper visual system function requires tightly controlled proliferation of a pool of relatively homogeneous retinal progenitor cells, followed by the stepwise specification and differentiation of multiple distinct cell types. These retinal cells, both neuronal and glial, must be generated in the correct numbers, and the correct laminar location to permit the formation of synaptic connections between individual cell types. After synapses are made, constant signaling is required as part of normal retinal function, and to maintain cellular identity and connectivity. These processes rely on both extrinsic and intrinsic signaling, with regulation of gene expression by cascades of transcription factors having …

White Matter Differences Between Multiple System Atrophy (Parkinsonian Type) And Parkinson’S Disease: A Diffusion Tensor Image Study, L. Ji, Yingying Wang, Nanjing Medical University, J. Shi

Department of Special Education and Communication Disorders: Faculty Publications

The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson’s disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for the first time to investigate three groups (15 MSA-P, 20 PD patients and 20 controls) with diffusion tensor imaging data. By TBSS, we performed pairwise comparisons of fractional anisotropy (FA), mean diffusivity, radial diffusivity (RD) and axial diffusivity maps. The clusters with significant differences between MSA-P and PD were used as ROIs for further analyses. FA/RD …