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Full-Text Articles in Neuroscience and Neurobiology
Enhanced Nicotine Self-Administration And Suppressed Dopaminergic Systems In A Rat Model Of Diabetes, Laura O'Dell
Enhanced Nicotine Self-Administration And Suppressed Dopaminergic Systems In A Rat Model Of Diabetes, Laura O'Dell
Departmental Papers (Psych)
Patients with diabetes display a heightened propensity to use tobacco; however, it is unclear whether they experience enhanced rewarding effects of nicotine. Thus, this study examined the reinforcing effects of nicotine in a rodent model of diabetes involving administration of streptozotocin (STZ), a drug that is toxic to pancreatic insulin-producing cells. The first study compared STZ- and vehicle-treated rats that had 23-hour access to intravenous self-administration (IVSA) of nicotine or saline and concomitant access to food and water. In order to examine the contribution of dopamine to our behavioral effects, dopamine transporter (DAT), D1 and D2 receptor levels were compared …
A Mechanistic Hypothesis Of The Factors That Enhance Vulnerability To Nicotine Use In Females, Laura O'Dell
A Mechanistic Hypothesis Of The Factors That Enhance Vulnerability To Nicotine Use In Females, Laura O'Dell
Departmental Papers (Psych)
Women are particularly more vulnerable to tobacco use than men. This review proposes a unifying hypothesis that females experience greater rewarding effects of nicotine and more intense stress produced by withdrawal than males. We also provide a neural framework whereby estrogen promotes greater rewarding effects of nicotine in females via enhanced dopamine release in the nucleus accumbens (NAcc). During withdrawal, we suggest that corticotropin-releasing factor (CRF) stress systems are sensitized and promote a greater suppression of dopamine release in the NAcc of females versus males. Taken together, females display enhanced nicotine reward via estrogen and amplified effects of withdrawal via …
Behavioral, Biochemical, And Molecular Indices Of Stress Are Enhanced In Female Versus Male Rats Experiencing Nicotine Withdrawal, Laura O'Dell
Departmental Papers (Psych)
Stress is a major factor that promotes tobacco use and relapse during withdrawal. Although women are more vulnerable to tobacco use than men, the manner in which stress contributes to tobacco use in women versus men is unclear.Thus, the goal of this study was to compare behavioral and biological indices of stress in male and female rats during nicotine withdrawal. Since the effects of nicotine withdrawal are age-dependent, this study also included adolescent rats. An initial study was conducted to provide comparable nicotine doses across age and sex during nicotine exposure and withdrawal. Rats received sham surgery or an osmotic …
Effect Of Nicotine On Body Composition, Laura O'Dell
Effect Of Nicotine On Body Composition, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
The Effects Of Opioids And Opioid Analogs On Animal And Human Endocrine Systems, Laura O'Dell
The Effects Of Opioids And Opioid Analogs On Animal And Human Endocrine Systems, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Nicotine Withdrawal Produces Fewer Decreases In Extracellular Levels Of Dopamine In The Nucleus Accumbens Of Adolescent Versus Adult Rats., Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Protracted Withdrawal From Alcohol And Drugs Of Abuse Impairs Long-Term Potentiation Of Intrinsic Excitability In The Juxtacapsular Bed Nucleus Of The Stria Terminalis, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Alcohol Self-Administration Acutely Stimulates The Hypothalamic-Pituitary-Adrenal (Hpa) Axis, But Alcohol Dependence Leads To A Dampened Neuroendocrine State, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
A Psychobiological Framework Of The Substrates That Mediate Nicotine Use During Adolescence, Laura O'Dell
A Psychobiological Framework Of The Substrates That Mediate Nicotine Use During Adolescence, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Female Rats Display Dose-Dependent Differences To The Rewarding And Aversive Effects Of Nicotine In An Age-, Hormone-, And Sex-Dependent Manner., Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Rodent Models Of Nicotine Reward: What Do They Tell Us About Tobacco Abuse In Humans?, Laura O'Dell
Rodent Models Of Nicotine Reward: What Do They Tell Us About Tobacco Abuse In Humans?, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Impact Of Serotonin 2c Receptor Null Mutation On Physiology And Behavior Associated With Nigrostriatal Dopamine Pathway Function., Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell
Cellular And Behavioral Interactions Of Gabapentin With Alcohol Dependence, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell
Crf1 Receptor Antagonists Attenuate Escalated Cocaine Self-Administration In Rats, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell
Enhanced Vulnerability To The Rewarding Effects Of Nicotine During The Adolescent Period Of Development, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Crf–Crf1 System Activation Mediates Withdrawal-Induced Increases In Nicotine Self-Administration In Nicotine-Dependent Rats., Laura O'Dell
Crf–Crf1 System Activation Mediates Withdrawal-Induced Increases In Nicotine Self-Administration In Nicotine-Dependent Rats., Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Adolescent Nicotine Exposure Produces Less Affective Measures Of Withdrawal Relative To Adult Nicotine Exposure In Male Rats, Laura O'Dell
Adolescent Nicotine Exposure Produces Less Affective Measures Of Withdrawal Relative To Adult Nicotine Exposure In Male Rats, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Viral Vector-Induced Amygdala Npy Overexpression Reverses Increased Alcohol Intake Caused By Repeated Deprivations In Wistar Rats, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
“Nicotine Deprivation Effect” In Rats With Intermittent 23-Hour Access To Intravenous Nicotine Self-Administration, Laura O'Dell
“Nicotine Deprivation Effect” In Rats With Intermittent 23-Hour Access To Intravenous Nicotine Self-Administration, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Behavioral And Neurochemical Responses To Cocaine In Periadolescent And Adult Rats, Laura O'Dell
Behavioral And Neurochemical Responses To Cocaine In Periadolescent And Adult Rats, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Corticotropin-Releasing Factor Within The Central Nucleus Of The Amygdala Mediates Enhanced Ethanol Self-Administration In Ethanol-Dependent Rats During Withdrawal., Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Biphasic Alterations In Serotonin1b (5-Ht1b) Receptor Function During Abstinence From Extended Cocaine Self-Administration, Laura O'Dell
Biphasic Alterations In Serotonin1b (5-Ht1b) Receptor Function During Abstinence From Extended Cocaine Self-Administration, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Extended Access To Nicotine Self-Administration Leads To Dependence: Circadian Measures, Withdrawal Measures, And Extinction Behavior In Rats, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Unlimited Access To Heroin Self-Administration: Independent Motivational Markers Of Opiate Dependence, Laura O'Dell
Unlimited Access To Heroin Self-Administration: Independent Motivational Markers Of Opiate Dependence, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Diminished Nicotine Withdrawal In Adolescent Rats: Implications For Vulnerability To Addiction, Laura O'Dell
Diminished Nicotine Withdrawal In Adolescent Rats: Implications For Vulnerability To Addiction, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Stress Enhancement Of Craving During Sobriety: A Risk For Relapse, Laura O'Dell
Stress Enhancement Of Craving During Sobriety: A Risk For Relapse, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Epipregnanolone And A Novel Synthetic Neuroactive Steroid Reduce Reduce Alcohol Self-Administration In Rats., Laura O'Dell
Epipregnanolone And A Novel Synthetic Neuroactive Steroid Reduce Reduce Alcohol Self-Administration In Rats., Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Ethanol-Induced Increases In Neuroactive Steroids In The Rat Brain And Plasma Are Absent In Adrenalectomized And Gonadectomized Rats, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Nicotine Withdrawal In Adolescent And Adult Rats, Laura O'Dell
Nicotine Withdrawal In Adolescent And Adult Rats, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.