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Neuroscience and Neurobiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Social behavior (8)
- Meadow vole (5)
- Partner preference (5)
- Attention (4)
- Cognitive stimulation (4)
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- FMRI (4)
- Oxytocin (4)
- Prairie vole (4)
- Sociality (4)
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- Zebrafish (4)
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- Functional MRI (3)
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- Rodent (3)
- Violence (3)
- Academic achievement (2)
- Adolescent (2)
- Anxiety behavior (2)
- Axon guidance (2)
- COVID-19 pandemic (2)
- Change detection (2)
- Childhood adversity (2)
- Cognitive development (2)
- Concordance (2)
- Cortical thickness (2)
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Articles 1 - 30 of 92
Full-Text Articles in Neuroscience and Neurobiology
Differentiating Between Us & Them: Reduced In-Group Bias As A Novel Mechanism Linking Childhood Violence Exposure With Internalizing Psychopathology, Steven W. Kasparek, Maya L. Rosen, Lucy A. Lurie, Mina Cikara, Kelly Sambrook, Dario Cvencek, Andrew N. Meltzoff, Katie A. Mclaughlin
Differentiating Between Us & Them: Reduced In-Group Bias As A Novel Mechanism Linking Childhood Violence Exposure With Internalizing Psychopathology, Steven W. Kasparek, Maya L. Rosen, Lucy A. Lurie, Mina Cikara, Kelly Sambrook, Dario Cvencek, Andrew N. Meltzoff, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Strong in-group bonds, facilitated by implicit favoritism for in-group members (i.e., in-group bias), promote mental health across development. Yet, we know little about how the development of in-group bias is shaped by early-life experiences. Childhood violence exposure is known to alter social information processing biases. Violence exposure may also influence social categorization processes, including in-group biases, in ways that influence risk for psychopathology. We examined associations of childhood violence exposure with psychopathology and behavioral and neural indices of implicit and explicit bias for novel groups in children followed longitudinally across three time points from age 5 to 10 years old …
Functional Network Reconfiguration Supporting Memory-Guided Attention, Kylie Isenburg, Thomas M. Morin, Maya L. Rosen, David C. Somers, Chantal E. Stern
Functional Network Reconfiguration Supporting Memory-Guided Attention, Kylie Isenburg, Thomas M. Morin, Maya L. Rosen, David C. Somers, Chantal E. Stern
Neuroscience: Faculty Publications
Studies have identified several brain regions whose activations facilitate attentional deployment via long-term memories. We analyzed task-based functional connectivity at the network and node-specific level to characterize large-scale communication between brain regions underlying long-term memory guided attention. We predicted default mode, cognitive control, and dorsal attention subnetworks would contribute differentially to long-term memory guided attention, such that network-level connectivity would shift based on attentional demands, requiring contribution of memory-specific nodes within default mode and cognitive control subnetworks. We expected that these nodes would increase connectivity with one another and with dorsal attention subnetworks during long-term memory guided attention. Additionally, we …
Rhythms In Barriers And Fluids: Circadian Clock Regulation In The Aging Neurovascular Unit, Lea Skapetze, Sharon Owino, Eng H. Lo, Ken Arai, Martha Merrow, Mary Harrington
Rhythms In Barriers And Fluids: Circadian Clock Regulation In The Aging Neurovascular Unit, Lea Skapetze, Sharon Owino, Eng H. Lo, Ken Arai, Martha Merrow, Mary Harrington
Neuroscience: Faculty Publications
The neurovascular unit is where two very distinct physiological systems meet: The central nervous system (CNS) and the blood. The permeability of the barriers separating these systems is regulated by time, including both the 24 h circadian clock and the longer processes of aging. An endogenous circadian rhythm regulates the transport of molecules across the blood-brain barrier and the circulation of the cerebrospinal fluid and the glymphatic system. These fluid dynamics change with time of day, and with age, and especially in the context of neurodegeneration. Factors may differ depending on brain region, as can be highlighted by consideration of …
Childhood Trauma And Brain Structure In Children And Adolescents, Matthew Peverill, Maya L. Rosen, Lucy A. Lurie, Kelly A. Sambrook, Margaret A. Sheridan, Katie A. Mclaughlin
Childhood Trauma And Brain Structure In Children And Adolescents, Matthew Peverill, Maya L. Rosen, Lucy A. Lurie, Kelly A. Sambrook, Margaret A. Sheridan, Katie A. Mclaughlin
Neuroscience: Faculty Publications
The dimensional model of adversity proposes that experiences of threat and deprivation have distinct neurodevelopmental consequences. We examined these dimensions, separately and jointly, with brain structure in a sample of 149 youth aged 8–17—half recruited based on exposure to threat-related experiences. We predicted that greater threat would be uniquely associated with reduced cortical thickness and surface area in brain regions associated with salience processing including ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), and insula, and that deprivation experiences would be uniquely associated with reductions in cortical thickness and surface area in frontoparietal areas associated with cognitive control. As predicted, …
Input From Torus Longitudinalis Drives Binocularity And Spatial Summation In Zebrafish Optic Tectum, Alexander L. Tesmer, Nicholas P. Fields, Estuardo Robles
Input From Torus Longitudinalis Drives Binocularity And Spatial Summation In Zebrafish Optic Tectum, Alexander L. Tesmer, Nicholas P. Fields, Estuardo Robles
Neuroscience: Faculty Publications
Background: A continued effort in neuroscience aims to understand the way brain circuits consisting of diverse neuronal types generate complex behavior following sensory input. A common feature of vertebrate visual systems is that lower-order and higher-order visual areas are reciprocally connected. Feedforward projections confer visual responsiveness to higher-order visual neurons while feedback projections likely serve to modulate responses of lower-order visual neurons in a context-dependent manner. Optic tectum is the largest first-order visual brain area in zebrafish and is reciprocally connected with the torus longitudinalis (TL), a second-order visual brain area that does not receive retinal input. A functional role …
Maternal Mental Health Mediates The Effects Of Pandemic-Related Stressors On Adolescent Psychopathology During Covid-19, Liliana J. Lengua, Stephanie F. Thompson, Stephanie Gyuri Kim, Maya L. Rosen, Alexandra Rodman, Steven Kasparek, Makeda Mayes, Maureen Zalewski, Andrew Meltzoff, Kate A. Mclaughlin
Maternal Mental Health Mediates The Effects Of Pandemic-Related Stressors On Adolescent Psychopathology During Covid-19, Liliana J. Lengua, Stephanie F. Thompson, Stephanie Gyuri Kim, Maya L. Rosen, Alexandra Rodman, Steven Kasparek, Makeda Mayes, Maureen Zalewski, Andrew Meltzoff, Kate A. Mclaughlin
Neuroscience: Faculty Publications
Background: This study examined whether COVID-19-related maternal mental health changes contributed to changes in adolescent psychopathology. Methods: A community sample of 226 adolescents (12 years old before COVID-19) and their mothers were asked to complete COVID-19 surveys early in the pandemic (April–May 2020, adolescents 14 years) and approximately 6 months later (November 2020–January 2021). Surveys assessed pandemic-related stressors (health, financial, social, school, environment) and mental health. Results: Lower pre-pandemic family income-to-needs ratio was associated with higher pre-pandemic maternal mental health symptoms (anxiety, depression) and adolescent internalizing and externalizing problems, and with experiencing more pandemic-related stressors. Pandemic-related stressors predicted increases in …
Early-Childhood Temperament Moderates The Prospective Associations Of Coping With Adolescent Internalizing And Externalizing Symptoms, Michele R. Smith, Krystal H. Parrish, Lisa Shimomaeda, Maureen Zalewski, Maya L. Rosen, Alexandra Rodman, Steven Kasparek, Makeda Mayes, Andrew N. Meltzoff, Katie A. Mclaughlin, Liliana J. Lengua
Early-Childhood Temperament Moderates The Prospective Associations Of Coping With Adolescent Internalizing And Externalizing Symptoms, Michele R. Smith, Krystal H. Parrish, Lisa Shimomaeda, Maureen Zalewski, Maya L. Rosen, Alexandra Rodman, Steven Kasparek, Makeda Mayes, Andrew N. Meltzoff, Katie A. Mclaughlin, Liliana J. Lengua
Neuroscience: Faculty Publications
While appraisal and coping are known to impact adolescent psychopathology, more vulnerable or resilient responses to stress may depend on individual temperament. This study examined early life temperament as a moderator of the prospective relations of pre-adolescent appraisal and coping with adolescent psychopathology. The sample included 226 (62% female, 14–15 years) adolescents with assessments starting at 3 years of age. Adolescents were predominately White (12% Black 9% Asian, 11% Latinx, 4% Multiracial, and 65% White). Observed early-childhood temperament (fear, frustration, executive control, and delay ability) were tested as moderators of pre-adolescent coping (active and avoidant) and appraisal (threat, positive) on …
Exposure To Violence As An Environmental Pathway Linking Low Socioeconomic Status With Altered Neural Processing Of Threat And Adolescent Psychopathology, David G. Weissman, Maya L. Rosen, Natalie L. Colich, Kelly A. Sambrook, Liliana J. Lengua, Margaret A. Sheridan, Katie A. Mclaughlin
Exposure To Violence As An Environmental Pathway Linking Low Socioeconomic Status With Altered Neural Processing Of Threat And Adolescent Psychopathology, David G. Weissman, Maya L. Rosen, Natalie L. Colich, Kelly A. Sambrook, Liliana J. Lengua, Margaret A. Sheridan, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Low childhood socioeconomic status (SES) is associated with increased risk for psychopathology, in part because of heightened exposure to environmental adversity. Adverse experiences can be characterized along dimensions, including threat and deprivation, that contribute to psychopathology via distinct mechanisms. The current study investigated a neural mechanism through which threat and deprivation may contribute to socioeconomic disparities in psychopathology. Participants were 177 youths (83 girls) aged 10–13 years recruited from a cohort followed since the age of 3 years. SES was assessed using the income-to-needs ratio at the age of 3 years. At the age of 10–13 years, retrospective and current …
A Genetic Labeling System To Study Dendritic Spine Development In Zebrafish Models Of Neurodevelopmental Disorders, Elisabeth C. Demarco, George R. Stoner, Estuardo Robles
A Genetic Labeling System To Study Dendritic Spine Development In Zebrafish Models Of Neurodevelopmental Disorders, Elisabeth C. Demarco, George R. Stoner, Estuardo Robles
Neuroscience: Faculty Publications
Dendritic spines are the principal site of excitatory synapse formation in the human brain. Several neurodevelopmental disorders cause spines to develop abnormally, resulting in altered spine number and morphology. Although spine development has been thoroughly characterized in the mammalian brain, spines are not unique to mammals. We have developed a genetic system in zebrafish to enable high-resolution in vivo imaging of spine dynamics during larval development. Although spiny neurons are rare in the larval zebrafish, pyramidal neurons (PyrNs) of the zebrafish tectum form an apical dendrite containing a dense array of dendritic spines. To characterize dendritic spine development, we performed …
Assessing The Degree Of Ecological Validity Of Your Study: Introducing The Multidimensional Assessment Of Research In Context (Marc) Tool, Sandra Naumann, Michelle L. Byrne, Alethia De La Fuente, Anita Harrewijn, Tehila Nugiel, Maya Rosen, Nienke Van Atteveldt, Pawel J. Matusz
Assessing The Degree Of Ecological Validity Of Your Study: Introducing The Multidimensional Assessment Of Research In Context (Marc) Tool, Sandra Naumann, Michelle L. Byrne, Alethia De La Fuente, Anita Harrewijn, Tehila Nugiel, Maya Rosen, Nienke Van Atteveldt, Pawel J. Matusz
Neuroscience: Faculty Publications
In cognitive neurosciences, fundamental principles of mental processes and functional brain organization have been established with highly controlled tasks and testing environments. Recent technical advances allowed the investigation of these functions and their brain mechanisms in naturalistic settings. The diversity in those approaches have been recently (Matusz, P. J., Dikker, S., Huth, A. G., & Perrodin, C. (2019). Are we ready for real-world neuroscience? Journal of Cognitive Neuroscience, 31(3), 327–338. doi:10.1162/jocn_e_01276) classified via a three-category cycle, including controlled laboratory, partially naturalistic laboratory, and naturalistic real-world research. Based on this model, we developed the Multidimensional Assessment of Research in Context (MARC) …
The Ubiquitin Ligase Siah2 Is A Female-Specific Regulator Of Circadian Rhythms And Metabolism, Tsedey Mekbib, Ting Chung Suen, Aisha Rollins-Hairston, Kiandra Smith, Ariel Armstrong, Cloe Gray, Sharon Owino, Kenkichi Baba, Julie E. Baggs, J. Christopher Ehlen, Gianluca Tosini, Jason P. Debruyne
The Ubiquitin Ligase Siah2 Is A Female-Specific Regulator Of Circadian Rhythms And Metabolism, Tsedey Mekbib, Ting Chung Suen, Aisha Rollins-Hairston, Kiandra Smith, Ariel Armstrong, Cloe Gray, Sharon Owino, Kenkichi Baba, Julie E. Baggs, J. Christopher Ehlen, Gianluca Tosini, Jason P. Debruyne
Neuroscience: Faculty Publications
Circadian clocks enable organisms to predict and align their behaviors and physiologies to constant daily day-night environmental cycle. Because the ubiquitin ligase Siah2 has been identified as a potential regulator of circadian clock function in cultured cells, we have used SIAH2-deficient mice to examine its function in vivo. Our experiments demonstrate a striking and unexpected sexually dimorphic effect of SIAH2-deficiency on the regulation of rhythmically expressed genes in the liver. The absence of SIAH2 in females, but not in males, altered the expression of core circadian clock genes and drastically remodeled the rhythmic transcriptome in the liver by increasing the …
Stress-Related Psychopathology During The Covid-19 Pandemic, Katie A. Mclaughlin, Maya L. Rosen, Steven W. Kasparek, Alexandra M. Rodman
Stress-Related Psychopathology During The Covid-19 Pandemic, Katie A. Mclaughlin, Maya L. Rosen, Steven W. Kasparek, Alexandra M. Rodman
Neuroscience: Faculty Publications
The COVID-19 pandemic has introduced widespread societal changes that have required ongoing adaptation. Unsurprisingly, stress-related psychopathology has increased during the pandemic, in both children and adults. We review these patterns through the lens of several leading conceptual models of the link between stress and psychopathology. Some of these models focus on characteristics of environmental stressors—including cumulative risk, specific stressor types, and stress sensitization approaches. Understanding the specific aspects of environmental stressors that are most likely to lead to psychopathology can shed light on who may be in most need of clinical intervention. Other models center on factors that can buffer …
Mice Lacking Full Length Adgrb1 (Bai1) Exhibit Social Deficits, Increased Seizure Susceptibility, And Altered Brain Development, Fu Hung Shiu, Jennifer C. Wong, Takahiro Yamamoto, Trisha Lala, Ryan H. Purcell, Sharon Owino, Dan Zhu, Erwin G. Van Meir, Randy A. Hall, Andrew Escayg
Mice Lacking Full Length Adgrb1 (Bai1) Exhibit Social Deficits, Increased Seizure Susceptibility, And Altered Brain Development, Fu Hung Shiu, Jennifer C. Wong, Takahiro Yamamoto, Trisha Lala, Ryan H. Purcell, Sharon Owino, Dan Zhu, Erwin G. Van Meir, Randy A. Hall, Andrew Escayg
Neuroscience: Faculty Publications
The adhesion G protein-coupled receptor BAI1/ADGRB1 plays an important role in suppressing angiogenesis, mediating phagocytosis, and acting as a brain tumor suppressor. BAI1 is also a critical regulator of dendritic spine and excitatory synapse development and interacts with several autism-relevant proteins. However, little is known about the relationship between altered BAI1 function and clinically relevant phenotypes. Therefore, we studied the effect of reduced expression of full length Bai1 on behavior, seizure susceptibility, and brain morphology in Adgrb1 mutant mice. We compared homozygous (Adgrb1−/−), heterozygous (Adgrb1+/−), and wild-type (WT) littermates using a battery of tests to assess social behavior, anxiety, repetitive …
Emerging Roles For The Orphan Gpcrs, Gpr37 And Gpr37 L1, In Stroke Pathophysiology, Sabra Mouhi, Breona Martin, Sharon Owino
Emerging Roles For The Orphan Gpcrs, Gpr37 And Gpr37 L1, In Stroke Pathophysiology, Sabra Mouhi, Breona Martin, Sharon Owino
Neuroscience: Faculty Publications
Recent studies have shed light on the diverse and complex roles of G-protein coupled receptors (GPCRs) in the pathophysiology of stroke. These receptors constitute a large family of seven transmembrane-spanning proteins that play an intricate role in cellular communication mechanisms which drive both tissue injury and repair following ischemic stroke. Orphan GPCRs represent a unique sub-class of GPCRs for which no natural ligands have been found. Interestingly, the majority of these receptors are expressed within the central nervous system where they represent a largely untapped resource for the treatment of neurological diseases. The focus of this review will thus be …
Contributions Of Emotion Regulation And Brain Structure And Function To Adolescent Internalizing Problems And Stress Vulnerability During The Covid-19 Pandemic: A Longitudinal Study, David G. Weissman, Alexandra M. Rodman, Maya L. Rosen, Steven Kasparek, Makeda Mayes, Margaret A. Sheridan, Lilliana J. Lengua, Andrew N. Meltzoff, Katie A. Mclaughlin
Contributions Of Emotion Regulation And Brain Structure And Function To Adolescent Internalizing Problems And Stress Vulnerability During The Covid-19 Pandemic: A Longitudinal Study, David G. Weissman, Alexandra M. Rodman, Maya L. Rosen, Steven Kasparek, Makeda Mayes, Margaret A. Sheridan, Lilliana J. Lengua, Andrew N. Meltzoff, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Background: Adolescence is a period of increased vulnerability for internalizing problems, particularly following stressful life events. We examined how emotion regulation and brain structure and function were associated with internalizing problems during the COVID-19 pandemic and moderated the association between pandemic-related stressors and internalizing problems. Methods: Data are from a longitudinal sample (N = 145, age range, 10–15 years) strategically assessed at 3 crucial time points: before the COVID-19 pandemic, early during the stay-at-home order period, and again 6 months later. We examined associations of amygdala and hippocampal volume and amygdala activation during an emotional processing task before the pandemic, …
Neural Mechanisms Underlying The Income-Achievement Gap: The Role Of The Ventral Visual Stream, Maya L. Rosen, Lucy A. Lurie, Kelly A. Sambrook, Andrew N. Meltzoff, Katie A. Mclaughlin
Neural Mechanisms Underlying The Income-Achievement Gap: The Role Of The Ventral Visual Stream, Maya L. Rosen, Lucy A. Lurie, Kelly A. Sambrook, Andrew N. Meltzoff, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Children from low-socioeconomic status (SES) households on average exhibit lower academic achievement than their higher-SES peers. We investigated a novel hypothesis that differences in early-developing sensory networks—specifically the ventral visual stream (VVS), which is involved in processing visual stimuli—contribute to SES-related disparities in executive functions (EF) and academic outcomes. We used fMRI to investigate SES-related differences in neural function in children (6–8 years, n = 62) during two attentional tasks involving attention to visual information: cued attention and memory-guided attention. Recruitment of VVS during both tasks was associated with EF and academic achievement, and SES-related differences in VVS activation during …
Social Selectivity And Social Motivation In Voles, Annaliese K. Beery, Sarah A. Lopez, Katrina L. Blandino, Nicole S. Lee, Natalie S. Bourdon
Social Selectivity And Social Motivation In Voles, Annaliese K. Beery, Sarah A. Lopez, Katrina L. Blandino, Nicole S. Lee, Natalie S. Bourdon
Neuroscience: Faculty Publications
Selective relationships are fundamental to humans and many other animals, but relationships between mates, family members, or peers may be mediated differently. We examined connections between social reward and social selectivity, aggression, and oxytocin receptor signaling pathways in rodents that naturally form enduring, selective relationships with mates and peers (monogamous prairie voles) or peers (group-living meadow voles). Female prairie and meadow voles worked harder to access familiar versus unfamiliar individuals, regardless of sex, and huddled extensively with familiar subjects. Male prairie voles displayed strongly selective huddling preferences for familiar animals, but only worked harder to repeatedly access females versus males, …
Brain Parcellation Selection: An Overlooked Decision Point With Meaningful Effects On Individual Differences In Resting-State Functional Connectivity, Nessa V. Bryce, John C. Flournoy, João F. Guassi Moreira, Maya L. Rosen, Kelly A. Sambook, Patrick Mair, Katie A. Mclaughlin
Brain Parcellation Selection: An Overlooked Decision Point With Meaningful Effects On Individual Differences In Resting-State Functional Connectivity, Nessa V. Bryce, John C. Flournoy, João F. Guassi Moreira, Maya L. Rosen, Kelly A. Sambook, Patrick Mair, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Over the past decade extensive research has examined the segregation of the human brain into large-scale functional networks. The resulting network maps, i.e. parcellations, are now commonly used for the a priori identification of functional networks. However, the use of these parcellations, particularly in developmental and clinical samples, hinges on four fundamental assumptions: (1) the various parcellations are equally able to recover the networks of interest; (2) adult-derived parcellations well represent the networks in children's brains; (3) network properties, such as within-network connectivity, are reliably measured across parcellations; and (4) parcellation selection does not impact the results with regard to …
Distress Tolerance As A Mechanism Linking Violence Exposure To Problematic Alcohol Use In Adolescence, Charlotte Heleniak, China R. Bolden, Connor J. Mccabe, Hilary K. Lambert, Maya L. Rosen, Kevin M. King, Kathryn C. Monahan, Katie A. Mclaughlin
Distress Tolerance As A Mechanism Linking Violence Exposure To Problematic Alcohol Use In Adolescence, Charlotte Heleniak, China R. Bolden, Connor J. Mccabe, Hilary K. Lambert, Maya L. Rosen, Kevin M. King, Kathryn C. Monahan, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Adolescents exposed to violence are at elevated risk of developing most forms of psychopathology, including depression, anxiety, and alcohol abuse. Prior research has identified emotional reactivity and difficulties with emotion regulation as core mechanisms linking violence exposure with psychopathology. Scant research has examined behavioral responses to distress as a mechanism in this association. This study examined the association of violence exposure with distress tolerance—the ability to persist in the face of distress—and whether lower distress tolerance linked violence exposure with subsequent increases in depression, anxiety, and alcohol abuse problems during adolescence. Data were collected prospectively in a sample of 287 …
Gpr37 Modulates Progenitor Cell Dynamics In A Mouse Model Of Ischemic Stroke, Sharon Owino, Michelle M. Giddens, Jessie G. Jiang, Trang Kimberly T. Nguyen, Fu Hung Shiu, Trisha Lala, Marla Gearing, Myles R. Mccrary, Xiaohuan Gu, Ling Wei, Shan P. Yu, Randy A. Hall
Gpr37 Modulates Progenitor Cell Dynamics In A Mouse Model Of Ischemic Stroke, Sharon Owino, Michelle M. Giddens, Jessie G. Jiang, Trang Kimberly T. Nguyen, Fu Hung Shiu, Trisha Lala, Marla Gearing, Myles R. Mccrary, Xiaohuan Gu, Ling Wei, Shan P. Yu, Randy A. Hall
Neuroscience: Faculty Publications
The generation of neural stem and progenitor cells following injury is critical for the function of the central nervous system, but the molecular mechanisms modulating this response remain largely unknown. We have previously identified the G protein-coupled receptor 37 (GPR37) as a modulator of ischemic damage in a mouse model of stroke. Here we demonstrate that GPR37 functions as a critical negative regulator of progenitor cell dynamics and gliosis following ischemic injury. In the central nervous system, GPR37 is enriched in mature oligodendrocytes, but following injury we have found that its expression is dramatically increased within a population of Sox2-positive …
Promoting Youth Mental Health During The Covid-19 Pandemic: A Longitudinal Study, Maya L. Rosen, Alexandra M. Rodman, Steven W. Kasparek, Makeda Mayes, Malila M. Freeman, Liliana J. Lengua, Andrew N. Meltzoff, Katie A. Mclaughlin
Promoting Youth Mental Health During The Covid-19 Pandemic: A Longitudinal Study, Maya L. Rosen, Alexandra M. Rodman, Steven W. Kasparek, Makeda Mayes, Malila M. Freeman, Liliana J. Lengua, Andrew N. Meltzoff, Katie A. Mclaughlin
Neuroscience: Faculty Publications
The COVID-19 pandemic has introduced novel stressors into the lives of youth. Identifying factors that protect against the onset of psychopathology in the face of these stressors is critical. We examine a wide range of factors that may protect youth from developing psychopathology during the pandemic. We assessed pandemic-related stressors, internalizing and externalizing psychopathology, and potential protective factors by combining two longitudinal samples of children and adolescents (N = 224, 7-10 and 13-15 years) assessed prior to the pandemic, during the stay-at-home orders, and six months later. We evaluated how family behaviors during the stay-at-home orders were related to changes …
Comparative Assessment Of Familiarity/Novelty Preferences In Rodents, Annaliese K. Beery, Katharine L. Shambaugh
Comparative Assessment Of Familiarity/Novelty Preferences In Rodents, Annaliese K. Beery, Katharine L. Shambaugh
Neuroscience: Faculty Publications
Sociality—i.e., life in social groups—has evolved many times in rodents, and there is considerable variation in the nature of these groups. While many species-typical behaviors have been described in field settings, the use of consistent behavioral assays in the laboratory provides key data for comparisons across species. The preference for interaction with familiar or novel individuals is an important dimension of social behavior. Familiarity preference, in particular, may be associated with more closed, less flexible social groups. The dimension from selectivity to gregariousness has been used as a factor in classification of social group types. Laboratory tests of social choice …
Mechanisms Linking Socioeconomic Status And Academic Achievement In Early Childhood: Cognitive Stimulation And Language, Lucy A. Lurie, Mckenzie P. Hagen, Katie A. Mclaughlin, Margaret A. Sheridan, Andrew N. Meltzoff, Maya L. Rosen
Mechanisms Linking Socioeconomic Status And Academic Achievement In Early Childhood: Cognitive Stimulation And Language, Lucy A. Lurie, Mckenzie P. Hagen, Katie A. Mclaughlin, Margaret A. Sheridan, Andrew N. Meltzoff, Maya L. Rosen
Neuroscience: Faculty Publications
There is a strong positive association between childhood socioeconomic status (SES) and academic achievement. This disparity may, in part, be explained by differences in early environmental experiences and language development. Cognitive stimulation—including language exposure, access to learning materials, caregiver involvement in children's learning, and variety of experiences—varies by SES and may link SES to language development. Childhood language development in turn is associated with academic achievement. In the current longitudinal study of 101 children (60–75 months), SES was positively associated with cognitive stimulation and performance on language measures. Cognitive stimulation mediated the association between SES and children's language. Furthermore, children's …
Pyramidal Neurons Of The Zebrafish Tectum Receive Highly Convergent Input From Torus Longitudinalis, Elisabeth Demarco, Alexander L. Tesmer, Bruna Hech, Koichi Kawakami, Estuardo Robles
Pyramidal Neurons Of The Zebrafish Tectum Receive Highly Convergent Input From Torus Longitudinalis, Elisabeth Demarco, Alexander L. Tesmer, Bruna Hech, Koichi Kawakami, Estuardo Robles
Neuroscience: Faculty Publications
The torus longitudinalis (TL) is a midbrain structure unique to ray finned fish. Although previously implicated in orienting behaviors elicited by changes in ambient lighting, the role of TL in visual processing is not well-understood. TL is reciprocally connected to tectum and is the only known source of synaptic input to the stratum marginalis (SM) layer of tectal neuropil. Conversely, tectal pyramidal neurons (PyrNs) are the only identified tectal neuron population that forms a dendrite in SM. In this study we describe a zebrafish gal4 transgenic that labels TL neurons that project to SM. We demonstrate that the axonal TL …
The Zebrafish Visual System Transmits Dimming Information Via Multiple Segregated Pathways, Estuardo Robles, Nicholas P. Fields, Herwig Baier
The Zebrafish Visual System Transmits Dimming Information Via Multiple Segregated Pathways, Estuardo Robles, Nicholas P. Fields, Herwig Baier
Neuroscience: Faculty Publications
Vertebrate retinas contain circuits specialized to encode light level decrements. This information is transmitted to the brain by dimming-sensitive OFF retinal ganglion cells (OFF-RGCs) that respond to light decrements with increased firing. It is known that OFF-RGCs with distinct photosensitivity profiles form parallel visual channels to the vertebrate brain, yet how these channels are processed by first- and higher order brain areas has not been well characterized in any species. To address this question in the larval zebrafish visual system, we examined the visual response properties of a genetically identified population of tectal neurons with a defined axonal projection to …
Biological Aging In Childhood And Adolescence Following Experiences Of Threat And Deprivation: A Systematic Review And Meta-Analysis, Natalie L. Colich, Maya L. Rosen, Eileen S. Williams, Katie A. Mclaughlin
Biological Aging In Childhood And Adolescence Following Experiences Of Threat And Deprivation: A Systematic Review And Meta-Analysis, Natalie L. Colich, Maya L. Rosen, Eileen S. Williams, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Life history theory argues that exposure to early life adversity (ELA) accelerates development, although existing evidence for this varies. We present a meta-analysis and systematic review testing the hypothesis that ELA involving threat (e.g., violence exposure) will be associated with accelerated biological aging across multiple metrics, whereas exposure to deprivation (e.g., neglect, institutional rearing) and low-socioeconomic status (SES) will not. We meta-analyze 54 studies (n = 116,010) examining associations of ELA with pubertal timing and cellular aging (telomere length and DNA methylation age), systematically review 25 studies (n = 3,253) examining ELA and neural markers of accelerated development (cortical thickness …
Cognitive Stimulation As A Mechanism Linking Socioeconomic Status With Executive Function: A Longitudinal Investigation, Maya L. Rosen, Mckenzie P. Hagen, Lucy A. Lurie, Zoe E. Miles, Margaret A. Sheridan, Andrew N. Meltzoff, Katie A. Mclaughlin
Cognitive Stimulation As A Mechanism Linking Socioeconomic Status With Executive Function: A Longitudinal Investigation, Maya L. Rosen, Mckenzie P. Hagen, Lucy A. Lurie, Zoe E. Miles, Margaret A. Sheridan, Andrew N. Meltzoff, Katie A. Mclaughlin
Neuroscience: Faculty Publications
Executive functions (EF), including working memory, inhibition, and cognitive flexibility, vary as a function of socioeconomic status (SES), with children from economically disadvantaged backgrounds having poorer performance than their higher SES peers. Using observational methods, we investigated cognitive stimulation in the home as a mechanism linking SES with EF. In a sample of 101 children aged 60–75 months, cognitive stimulation fully mediated SES-related differences in EF. Critically, cognitive stimulation was positively associated with the development of inhibition and cognitive flexibility across an 18-month follow-up period. Furthermore, EF at T1 explained SES-related differences in academic achievement at T2. Early cognitive stimulation—a …
Deconstructing Circadian Disruption: Assessing The Contribution Of Reduced Peripheral Oscillator Amplitude On Obesity And Glucose Intolerance In Mice, Vincent Van Der Vinne, Blanca Martin Burgos, Mary E. Harrington, David R. Weaver
Deconstructing Circadian Disruption: Assessing The Contribution Of Reduced Peripheral Oscillator Amplitude On Obesity And Glucose Intolerance In Mice, Vincent Van Der Vinne, Blanca Martin Burgos, Mary E. Harrington, David R. Weaver
Psychology: Faculty Publications
Disturbing the circadian regulation of physiology by disruption of the rhythmic environment is associated with adverse health outcomes but the underlying mechanisms are unknown. Here, the response of central and peripheral circadian clocks to an advance or delay of the light-dark cycle was determined in mice. This identified transient damping of peripheral clocks as a consequence of an advanced light-dark cycle. Similar depression of peripheral rhythm amplitude was observed in mice exposed to repeated phase shifts. To assess the metabolic consequences of such peripheral amplitude depression in isolation, temporally chimeric mice lacking a functional central clock (Vgat-Cre+ Bmal1fl/fl) were housed …
Quantitative Proteomics Reveal An Altered Pattern Of Protein Expression In Brain Tissue From Mice Lacking Gpr37 And Gpr37l1, Trang Kimberly Thu Nguyen, Eric B. Dammer, Sharon A. Owino, Michelle M. Giddens, Nora S. Madaras, Duc M. Duong, Nicholas T. Seyfried, Randy A. Hall
Quantitative Proteomics Reveal An Altered Pattern Of Protein Expression In Brain Tissue From Mice Lacking Gpr37 And Gpr37l1, Trang Kimberly Thu Nguyen, Eric B. Dammer, Sharon A. Owino, Michelle M. Giddens, Nora S. Madaras, Duc M. Duong, Nicholas T. Seyfried, Randy A. Hall
Neuroscience: Faculty Publications
GPR37 and GPR37L1 are glia-enriched G protein-coupled receptors that have been implicated in several neurological and neurodegenerative diseases. To gain insight into the potential molecular mechanisms by which GPR37 and GPR37L1 regulate cellular physiology, proteomic analyses of whole mouse brain tissue from wild-type (WT) versus GPR37/GPR37L1 double knockout (DKO) mice were performed in order to identify proteins regulated by the absence versus presence of these receptors (data are available via ProteomeXchange with identifier PXD015202). These analyses revealed a number of proteins that were significantly increased or decreased by the absence of GPR37 and GPR37L1. One of the most decreased proteins …
Characterizing The Diverse Cells That Associate With The Developing Commissures Of The Zebrafish Forebrain, Jake Schnabl, M.P.H Litz, Caitlin Schneider, N. Penkofflidbeck, Sarah Bashiruddin, M. S. Schwartz, Kristin Alligood, Michael Barresi
Characterizing The Diverse Cells That Associate With The Developing Commissures Of The Zebrafish Forebrain, Jake Schnabl, M.P.H Litz, Caitlin Schneider, N. Penkofflidbeck, Sarah Bashiruddin, M. S. Schwartz, Kristin Alligood, Michael Barresi
Zebrafish Forebrain Cellular Characterization
During embryonic development of bilateral organisms, neurons send axons across the midline at specific points to connect the two halves of the nervous system with a commissure. Little is known about the cells at the midline that facilitate this tightly regulated process. We exploit the con served process of vertebrate embryonic development in the zebrafish model system to elucidate the identity of cells at the midline that may facilitate postoptic (POC) and anterior commissure (AC) development. We have discovered that three differentgfap+ astroglial cell morphologies persist in contact with pathfinding axons throughout commissure formation. Similarly, olig2+ progenitor cells occupy delineated …