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Articles 4531 - 4560 of 5800

Full-Text Articles in Neuroscience and Neurobiology

Differences In Prefrontal Cortex Activation And Deactivation During Strategic Episodic Verbal Memory Encoding In Mild Cognitive Impairment, Joana B. Balardin, Marcelo C. Batistuzzo, Maria Da Graca Moraes Martin, Joao R. Sato, Jerusa Smid, Claudia Porto, Cary R. Savage, Ricardo Nitrini, Edson Amaro Jr., Eliane C. Miotto Jan 2015

Differences In Prefrontal Cortex Activation And Deactivation During Strategic Episodic Verbal Memory Encoding In Mild Cognitive Impairment, Joana B. Balardin, Marcelo C. Batistuzzo, Maria Da Graca Moraes Martin, Joao R. Sato, Jerusa Smid, Claudia Porto, Cary R. Savage, Ricardo Nitrini, Edson Amaro Jr., Eliane C. Miotto

Center for Brain, Biology, and Behavior: Faculty Publications

In this study we examined differences in fMRI activation and deactivation patterns during episodic verbal memory encoding between individuals with MCI (n = 18) and healthy controls (HCs) (n = 17). Participants were scanned in two different sessions during the application of self-initiated or directed instructions to apply semantic strategies at encoding of word lists. MCI participants showed reduced free recall scores when using self-initiated encoding strategies that were increased to baseline controls' level after directed instructions were provided. During directed strategic encoding, greater recruitment of frontoparietal regions was observed in both MCI and control groups; group differences …

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Correlations Between Sensory Encoding And Central Morphology Of Muscle Proprioceptors In The Rat, Hanna Marie Gabriel Jan 2015

Correlations Between Sensory Encoding And Central Morphology Of Muscle Proprioceptors In The Rat, Hanna Marie Gabriel

Browse all Theses and Dissertations

Until now, observations regarding the central morphology and organization of Ia, group II and Ib Golgi tendon organ afferents have been confined to the cat model. As the use of rodents in the study of the development and organization of segmental spinal cord circuitry increases, a complete account of the peripheral encoding and central connectivity of rodent muscle proprioceptors is necessary. The data presented in this study establish the central morphology and spatial distribution of 12 (4 of each class) functionally phenotyped muscle proprioceptor afferents in the rat by intracellular labeling with Neurobiotin. Each afferent type showed a characteristic central …

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What, If Anything, Is Colored?: Color Perceptions - Color Judgments - Without Color, Olivia Ziegler Jan 2015

What, If Anything, Is Colored?: Color Perceptions - Color Judgments - Without Color, Olivia Ziegler

Philosophy Honors Papers

No abstract provided.

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The Effects Of Molecular Chaperones On Tau Fibril Assembly, Ahmed Omran Jan 2015

The Effects Of Molecular Chaperones On Tau Fibril Assembly, Ahmed Omran

Electronic Theses and Dissertations

The accumulation of microtubule-associated protein tau into fibrillar aggregates is the hallmark of Alzheimer’s disease and other neurodegenerative disorders, collectively referred to as tauopathies. Fibrils can propagate from one cell to the next and spread throughout the brain. However, a study shows that only small aggregates can be taken up by cultured neuronal cells. The mechanisms that lead to the breakage of fibrils into smaller fragments remain unknown. In yeast, the AAA+ chaperone HSP104 processes the reactivation of protein aggregates and is responsible for fragmentation of fibrils. This study focused on investigating the effects of molecular chaperones on tau fibrils …

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Orbitofrontal 18f-Dopa Uptake And Movement Preparation In Parkinson’S Disease, Lucio Marinelli, Arnoldo Piccardo, Laura Mori, Silvia Morbelli, Nicola Girtler, Antonio Castaldi, Agnese Picco, Carlo Trompetto, Maria Felice Ghilardi, Giovanni Abbruzzese, Flavio Nobili Jan 2015

Orbitofrontal 18f-Dopa Uptake And Movement Preparation In Parkinson’S Disease, Lucio Marinelli, Arnoldo Piccardo, Laura Mori, Silvia Morbelli, Nicola Girtler, Antonio Castaldi, Agnese Picco, Carlo Trompetto, Maria Felice Ghilardi, Giovanni Abbruzzese, Flavio Nobili

Publications and Research

In Parkinson’s disease (PD) degeneration of mesocortical dopaminergic projections may determine cognitive and behavioral symptoms. Choice reaction time task is related to attention, working memory, and goal-directed behavior. Such paradigm involves frontal cortical circuits receiving mesocortical dopamine which are affected early in PD. The aim of this study is to characterize the role of dopamine on the cognitive processes that precede movement in a reaction time paradigm in PD.We enrolled 16 newly diagnosed and untreated patientswith PDwithout cognitive impairment or depression and 10 control subjectswith essential tremor. They performed multiple-choice reaction time task with the right upper limb and brain …

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Pcdh19 Expression In Normal And Regenerating Adult Zebrafish Retinas, Kristin N. Forkapa Ms. Jan 2015

Pcdh19 Expression In Normal And Regenerating Adult Zebrafish Retinas, Kristin N. Forkapa Ms.

Williams Honors College, Honors Research Projects

My Honors Research Project will test the function of the N-cadherin molecule on the zebrafish optic nerve regeneration. N-cadherin is a member of the cadherin superfamily. Cadherins are cell adhesion molecules important for animal development and maintenance of adult structures. Unlike mammals, fish and amphibians have the ability to regenerate their optic nerve after damages. Molecular mechanisms underlying the optic nerve regeneration are still under intense investigation. Studies in Dr. Liu’s laboratory showed that expression of several cadherins, including N-cadherin, was greatly increased during adult zebrafish optic nerve regeneration, suggesting that cadherins may be involved in the optic nerve regeneration …

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Targeting Methylglyoxal And Ppar Gamma To Alleviate Neuropathic Pain Associated With Type 2 Diabetes, Ryan B. Griggs Jan 2015

Targeting Methylglyoxal And Ppar Gamma To Alleviate Neuropathic Pain Associated With Type 2 Diabetes, Ryan B. Griggs

Theses and Dissertations--Physiology

Neuropathic pain affects up to 50% of the 29 million diabetic patients in the United States. Neuropathic pain in diabetes manifests as a disease of the peripheral and central nervous systems. The prevalence of type 2 diabetes is far greater than type 1 (90%), yet the overwhelming focus on type 1 models this has left the mechanisms of pain in type 2 diabetes largely unknown. Therefore I aimed to improve the current mechanistic understanding of pain associated with type 2 diabetes using two preclinical rodent models: Zucker Diabetic Fatty rats and db/db mice. In addition, I highlight the translational importance …

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Examining Oxytocin As A Potential Pharmacotherapy For Methamphetamine Addiction, Brittney M. Cox Jan 2015

Examining Oxytocin As A Potential Pharmacotherapy For Methamphetamine Addiction, Brittney M. Cox

MUSC Theses and Dissertations

Human and animal studies suggest that females differ in their motivation to use methamphetamine (meth), and have increased propensity to relapse. However, addiction pharmacotherapies have primarily only been tested in males, which may not accurately predict treatment outcomes in females. Evidence suggests that oxytocin, an endogenous peptide well known for its role in social behaviors and childbirth, is a promising addiction pharmacotherapy. This dissertation first examines sex differences in the effect of oxytocin to decrease meth and sucrose seeking. Our data indicate that systemic oxytocin decreased responding for meth differentially in males and females on a progressive ratio schedule of …

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The Effect Of Adolescent Alcohol On Dopaminergic And Gabaergic Neurotransmission In The Adult Prefrontal Cortex, Samuel W. Centanni Jan 2015

The Effect Of Adolescent Alcohol On Dopaminergic And Gabaergic Neurotransmission In The Adult Prefrontal Cortex, Samuel W. Centanni

MUSC Theses and Dissertations

The prefrontal cortex (PFC) is thought to play an important role in cognitive processes that are negatively impacted by alcohol exposure. Compared to other brain regions, the neuronal connections of the PFC undergo a critical period of reorganization and refinement during adolescence that coincides with improvements in cognitive control and decision-making. Environmental insults that occur during this period may be particularly damaging to the PFC, resulting in aberrant neurodevelopment along with long-lasting effects on cognitive functioning that negatively impacts decision-making and behavioral control. Experimentation with alcohol typically begins during adolescence when it is often consumed in excessive binge-like episodes resulting …

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Calciumsignalextract: A Matlab Gui To Automatically Extract The Activity Of Multiple Cells From Calcium Imaging Data, Stephan Meyer Zum Alten Borgloh Jan 2015

Calciumsignalextract: A Matlab Gui To Automatically Extract The Activity Of Multiple Cells From Calcium Imaging Data, Stephan Meyer Zum Alten Borgloh

Gilbert Laboratory

A Matlab GUI that automatically segments fluorescence image stacks into ROIs based on differential morphology and fluorescence activity of the individual cells. The time course data of each ROI gets extracted and plotted. External data from behavioral experiments and sensory stimuli can be integrated to compare for task and stimulus dependent neuronal events

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Oral Care Practice Guidelines For The Care-Dependent Hospitalized Adult Outside Of The Intensive Care Unit Setting, Cynthia Susan Drapal Jan 2015

Oral Care Practice Guidelines For The Care-Dependent Hospitalized Adult Outside Of The Intensive Care Unit Setting, Cynthia Susan Drapal

Walden Dissertations and Doctoral Studies

Many nurses lack evidence-based knowledge to deliver appropriate oral care, view oral care in the care-dependent patient as a comfort measure, and give it a low clinical priority. An estimated 44%-65% of hospitalized care-dependent patients do not receive adequate oral care, an intervention that can prevent aspiration pneumonia or pneumonitis. The purpose of this project was to develop a policy for use of an oral assessment tool and evidence-based guidelines for oral care in hospitalized care-dependent adults outside of the intensive care unit setting at a regional health system in the Southeast United States. The project used the theoretical foundations …

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Cortisol Levels And Voltage Conditions Of College Students, Adriana Steffens Jan 2015

Cortisol Levels And Voltage Conditions Of College Students, Adriana Steffens

Walden Dissertations and Doctoral Studies

There is a limited research base on low voltage brain conditions, which are characterized by electrical activity being measured at below 20 microvolts. The purpose of this study was to examine the relationship between saliva cortisol levels and voltage using an EGG in a college student population. Illuminating this relationship is important to inform how low voltage conditions can affect daily memory and cognitive functioning of undergraduate college students that may be a result of stress. The college student population may be vulnerable to the low voltage condition because of stress from the transition between teenage and adult life and …

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Feel The Noise: Relating Individual Differences In Auditory Imagery To The Structure And Function Of Sensorimotor Systems, Cesar F. Lima, Nadine Lavan, Samuel Evans, Zarinah Agnew, Andrea R. Halpern, Pradheep Shanmugalingam, Sophie Meekings, Dana Boebinger, Markus Ostarek, Carolyn Mcgettigan, Jane E. Warren, Sophie K. Scott Jan 2015

Feel The Noise: Relating Individual Differences In Auditory Imagery To The Structure And Function Of Sensorimotor Systems, Cesar F. Lima, Nadine Lavan, Samuel Evans, Zarinah Agnew, Andrea R. Halpern, Pradheep Shanmugalingam, Sophie Meekings, Dana Boebinger, Markus Ostarek, Carolyn Mcgettigan, Jane E. Warren, Sophie K. Scott

Faculty Journal Articles

Humans can generate mental auditory images of voices or songs, sometimes perceiving them almost as vividly as perceptual experiences. The functional networks supporting auditory imagery have been described, but less is known about the systems associated with interindividual differences in auditory imagery. Combining voxel-based morphometry and fMRI, we examined the structural basis of interindividual differences in how auditory images are subjectively perceived, and explored associations between auditory imagery, sensory-based processing, and visual imagery. Vividness of auditory imagery correlated with gray matter volume in the supplementary motor area (SMA), parietal cortex, medial superior frontal gyrus, and middle frontal gyrus. An analysis …

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Signals From The 4th Dimension: Role Of Extracellular Matrix Signaling In Synaptic Plasticity Mediating Addiction, Alexander C. W. Smith Jan 2015

Signals From The 4th Dimension: Role Of Extracellular Matrix Signaling In Synaptic Plasticity Mediating Addiction, Alexander C. W. Smith

MUSC Theses and Dissertations

Chronic cocaine abuse causes maladaptive neuroadaptations that underlie vulnerability to relapse, even after protracted abstinence. A great deal of work has examined mechanisms of neuroplasticity by which these occur. However, the majority of experimentation has focused on intracellular signaling cascades, while the extracellular compartment has been largely ignored. In the past decade, work has emerged in the learning and memory literature that indicates that extracellular matrix remodeling and signaling is required for adaptive forms of neuroplasticity (e.g. learning and memory), although it has not been thoroughly examined in models of maladaptive neuroplasticity. Throughout this dissertation a drug self-administration, extinction and …

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Familiarity Differentially Affects Right Hemisphere Contributions To Processing Metaphors And Literals, V. T. Lai, Wessel Van Dam, L. L. Conant, J. R. Binder, Rutvik Desai Jan 2015

Familiarity Differentially Affects Right Hemisphere Contributions To Processing Metaphors And Literals, V. T. Lai, Wessel Van Dam, L. L. Conant, J. R. Binder, Rutvik Desai

Faculty Publications

The role of the two hemispheres in processing metaphoric language is controversial. While some studies have reported a special role of the right hemisphere (RH) in processing metaphors, others indicate no difference in laterality relative to literal language. Some studies have found a role of the RH for novel/unfamiliar metaphors, but not conventional/familiar metaphors. It is not clear, however, whether the role of the RH is specific to metaphor novelty, or whether it reflects processing, reinterpretation or reanalysis of novel/unfamiliar language in general. Here we used functional magnetic resonance imaging (fMRI) to examine the effects of familiarity in both metaphoric …

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Experimental-Computational Analysis Of Vigilance Dynamics For Applications In Sleep And Epilepsy, Farid Yaghouby Jan 2015

Experimental-Computational Analysis Of Vigilance Dynamics For Applications In Sleep And Epilepsy, Farid Yaghouby

Theses and Dissertations--Biomedical Engineering

Epilepsy is a neurological disorder characterized by recurrent seizures. Sleep problems can cooccur with epilepsy, and adversely affect seizure diagnosis and treatment. In fact, the relationship between sleep and seizures in individuals with epilepsy is a complex one. Seizures disturb sleep and sleep deprivation aggravates seizures. Antiepileptic drugs may also impair sleep quality at the cost of controlling seizures. In general, particular vigilance states may inhibit or facilitate seizure generation, and changes in vigilance state can affect the predictability of seizures. A clear understanding of sleep-seizure interactions will therefore benefit epilepsy care providers and improve quality of life in patients. …

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Role Of Alpha Oscillations In Reweighting Multiple Attributes During Choice, Samuel I. Dunham Jan 2015

Role Of Alpha Oscillations In Reweighting Multiple Attributes During Choice, Samuel I. Dunham

CMC Senior Theses

In our everyday lives, we must often weigh the different attributes of items in order to select the item that best fits our current goals, allowing us to make optimal decisions. Construal Level Theory proposes a psychological mechanism for re-weighting attributes, utilizing selective attention as the process by which we implement self-control. It has been hypothesized that switching attention between attributes is facilitated by the suppression of cortical oscillations over posterior brain regions within the alpha (8-12 Hz) frequency range. To test this idea, we re-examined previously collected whole-brain electroencephalography (EEG) data from a dietary choice experiment in which participants …

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Elucidating The Role Of Endogenous Electric Fields In Regulating The Astrocytic Response To Injury In The Mammalian Central Nervous System, Matthew L. Baer Jan 2015

Elucidating The Role Of Endogenous Electric Fields In Regulating The Astrocytic Response To Injury In The Mammalian Central Nervous System, Matthew L. Baer

Theses and Dissertations

Endogenous bioelectric fields guide morphogenesis during embryonic development and regeneration by directly regulating the cellular functions responsible for these phenomena. Although this role has been extensively explored in many peripheral tissues, the ability of electric fields to regulate wound repair and stimulate regeneration in the mammalian central nervous system (CNS) has not been convincingly established. This dissertation explores the role of electric fields in regulating the injury response and controlling the regenerative potential of the mammalian CNS. We place particular emphasis on their influence on astrocytes, as specific differences in their injury-induced behaviors have been associated with differences in the …

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Gliopathy Of Demyelinating And Non-Demyelinating Strains Of Mouse Hepatitis Virus, Lawrence Charles Kenyon, Kaushiki Biswas, Kenneth Shindler, Manasi Nabar, Marjorie Stout, Susan T. Hingley, Judith B. Grinspan, Jayasri Das Sarma Jan 2015

Gliopathy Of Demyelinating And Non-Demyelinating Strains Of Mouse Hepatitis Virus, Lawrence Charles Kenyon, Kaushiki Biswas, Kenneth Shindler, Manasi Nabar, Marjorie Stout, Susan T. Hingley, Judith B. Grinspan, Jayasri Das Sarma

PCOM Scholarly Works

Demyelination in the central nervous system induced by neurovirulent strains of Mouse Hepatitis Virus (MHV) is mediated by the viral spike glycoprotein, but it is not clear whether the mechanism of this disease pathology involves direct viral infection of oligodendrocytes. Detailed studies of glial cell tropism of MHV are presented, demonstrating that direct MHV infection of oligodendrocytes differs between demyelinating (RSA59) and non-demyelinating (RSMHV2) viral strains both in vitro and in vivo. Our results indicate that direct injury of mature oligodendrocytes is an important mechanism of virus-induced demyelination. In vivo, RSA59 infection was identified in spinal cord gray and white …

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Structural Organization Of The Connections Between Neurons Of The Paraventricular And Lateral Hypothalamic Regions In The Adult Male Rat, Berenise De Haro Jan 2015

Structural Organization Of The Connections Between Neurons Of The Paraventricular And Lateral Hypothalamic Regions In The Adult Male Rat, Berenise De Haro

Open Access Theses & Dissertations

The hypothalamus is a major integrator of homeostatic signals in the brain; within the hypothalamus, there are sub-regions with specific roles in regulating energy balance. For example, the lateral hypothalamic area (LHA) has been classically associated with feeding behaviors, and contains two major orexigenic cell populations expressing the neuropeptides melanin concentrating hormone (MCH) or hypocretin 1/orexin A (H/O). Similarly, the paraventricular nucleus of the hypothalamus (PVH) integrates information to mediate neuroendocrine and autonomic responses related to ingestive behaviors. The PVH has also been implicated directly in the control of feeding. However, the precise structural and functional interactions between these two …

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Separating The Signal From The Noise In Electrocorticographic (Ecog) Signals : Novel Analytic Methods And Their Application To Experimental And Theoretical Neuroscience, William Grey Coon Jan 2015

Separating The Signal From The Noise In Electrocorticographic (Ecog) Signals : Novel Analytic Methods And Their Application To Experimental And Theoretical Neuroscience, William Grey Coon

Legacy Theses & Dissertations (2009 - 2024)

Measurements are comprised of two parts: signal, that is, the true quantity one wishes to measure, and noise, that is, measurement fluctuations that are unrelated to the true signal.

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A Novel Method For Studying Gene Regulatory Elements In Vivo Reveals Essential Roles For Intron Splicing In Neurofilament Gene Expression, Chen Wang Jan 2015

A Novel Method For Studying Gene Regulatory Elements In Vivo Reveals Essential Roles For Intron Splicing In Neurofilament Gene Expression, Chen Wang

Legacy Theses & Dissertations (2009 - 2024)

Axon outgrowth requires coordinated expression of critical cytoskeletal genes in response to extracellular cues. The spatial and temporal expression of these genes is regulated transcriptionally and posttranscriptionally. Such regulation is largely mediated through the activity of cis-regulatory elements within the cytoskeletal DNAs and RNAs, which recruit specific sets of trans-factors such as DNA- and RNA-binding proteins, as well as microRNAs. To identify the functionally active cis-elements, characterize their dynamically changing sets of trans-factors, and investigate the association between the two sets of regulators in the context of an intact developing nervous system, one needs to combine appropriate in vivo strategies …

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Nosh-Aspirin (Nbs-1120), A Dual Nitric Oxide And Hydrogen Sulfide-Releasing Hybrid, Reduces Inflammatory Pain, Miriam D. Fonseca, Fernando Q. Cunha, Khosrow Kashfi, Thiago M. Cunha Jan 2015

Nosh-Aspirin (Nbs-1120), A Dual Nitric Oxide And Hydrogen Sulfide-Releasing Hybrid, Reduces Inflammatory Pain, Miriam D. Fonseca, Fernando Q. Cunha, Khosrow Kashfi, Thiago M. Cunha

Publications and Research

The development of nitric oxide (NO)- and hydrogen sulfide (H2S)-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) has generated more potent anti-inflammatory drugs with increased safety profiles. A new hybrid molecule incorporating both NO and H2S donors into aspirin (NOSH-aspirin) was recently developed. In the present study, the antinociceptive activity of this novel molecule was compared with aspirin in different models of inflammatory pain. It was found that NOSH-aspirin inhibits acetic acid-induced writhing response and carrageenan (Cg)-induced inflammatory hyperalgesia in a dosedependent (5–150 lmol/kg, v.o.) manner, which was superior to the effect of the same doses of aspirin. NOSH-aspirin’s antinociceptive effect was also …

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Biological Basis Of Motherhood And Effect Of Stress On Maternal Psychophysiology, Erin Loree Minnick 15 Jan 2015

Biological Basis Of Motherhood And Effect Of Stress On Maternal Psychophysiology, Erin Loree Minnick 15

Honor Scholar Theses

No abstract provided.

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Characterization Of The Trans-Plasma Membrane Electron Transport System In The Myelin Membrane, Afshan Sohail Jan 2015

Characterization Of The Trans-Plasma Membrane Electron Transport System In The Myelin Membrane, Afshan Sohail

Theses and Dissertations (Comprehensive)

Myelination is the key feature of evolution in the nervous system of vertebrates. Myelin is the protrusion of glial cells. More specifically, "oligodendrocytes" in the central nervous system (CNS), and "Schwann" cells in the peripheral nervous system (PNS) form myelin membranes. Myelin remarkably, enhances the propagation of nerve impulses. However, myelin restricts the access of extracellular metabolites to the axons. A pathology called "demyelination" is associated with myelin. The myelin sheath is not only an insulator, but it is itself metabolically active. In this study it is hypothesized that the ratio of NAD(P)+/NAD(P)H and the glycolytic pathway of …

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Influence Of Planning Resources On Gait Control In Parkinson’S Disease, Frederico P. Faria Jan 2015

Influence Of Planning Resources On Gait Control In Parkinson’S Disease, Frederico P. Faria

Theses and Dissertations (Comprehensive)

Movement disturbances in individuals with Parkinson’s disease (PD) have been associated with difficulties to plan complex actions. Performance of simple and complex actions overloads resources for individuals with Parkinson’s disease (PD). However, it is unclear if central resources required to plan gait adjustments while walking exacerbate gait disturbances of patients with PD. More specifically, it is unclear how gait impairments, sensory processing, and the dopaminergic system influence the load on processing resources (e.g. cognitive load) during the planning of step modifications. In order to investigate the relative influence of these factors on cognitive load and its impact on gait control, …

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Clique Topology Reveals Intrinsic Geometric Structure In Neural Correlations, Chad Giusti, Eva Pastalkova, Carina Curto, Vladimir Itskov Jan 2015

Clique Topology Reveals Intrinsic Geometric Structure In Neural Correlations, Chad Giusti, Eva Pastalkova, Carina Curto, Vladimir Itskov

Department of Mathematics: Faculty Publications

Detecting meaningful structure in neural activity and connectivity data is challenging in the presence of hidden nonlinearities, where traditional eigenvalue-based methods may be misleading. We introduce a novel approach to matrix analysis, called clique topology, that extracts features of the data invariant under nonlinear monotone transformations. These features can be used to detect both random and geometric structure, and depend only on the relative ordering of matrix entries. We then analyzed the activity of pyramidal neurons in rat hippocampus, recorded while the animal was exploring a 2D environment, and confirmed that our method is able to detect geometric organization using …

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Effect Of Somatostatin On Voltage-Gated Calcium Influx In Isolated Neonatal Rat Carotid Body Type I Cells, Eric J. Dunn Jan 2015

Effect Of Somatostatin On Voltage-Gated Calcium Influx In Isolated Neonatal Rat Carotid Body Type I Cells, Eric J. Dunn

Browse all Theses and Dissertations

Somatostatin (SST) is a neuropeptide hormone that regulates the release of secondary hormones. Evidence suggests SST plays a neuromodulatory role due to its distribution throughout the central nervous system. Interestingly, SST has been suggested to affect the carotid body, the small peripheral chemoreceptors that regulate breathing. It has been shown that the peripheral chemoreflex sensitivity to CO2 and hypoxia is reduced by SST in humans (Pedersen et al., 1999; Pandit et al., 2014). SST has also been found to inhibit whole cell Ca2+ currents recorded from adult rat carotid body type I cells (e Silva & Lewis, 1995), but the …

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An Epigenetic Hypothesis For The Genomic Memory Of Pain, Sebastian Alvarado, Maral Tajerian, Matthew Suderman, Ziv Machnes, Stephanie Pierfelice, Magali Millecamps, Laura S. Stone, Moshe Szyf Jan 2015

An Epigenetic Hypothesis For The Genomic Memory Of Pain, Sebastian Alvarado, Maral Tajerian, Matthew Suderman, Ziv Machnes, Stephanie Pierfelice, Magali Millecamps, Laura S. Stone, Moshe Szyf

Publications and Research

Chronic pain is accompanied with long-term sensory, affective and cognitive disturbances. What are the mechanisms that mediate the long-term consequences of painful experiences and embed them in the genome? We hypothesize that alterations in DNA methylation, an enzymatic covalent modification of cytosine bases in DNA,serve as a “genomic” memory of pain in the adult cortex. DNA methylation is an epigenetic mechanism for long-term regulation of gene expression. Neuronal plasticity at the neuroanatomical, functional, morphological, physiological and molecular levels has been demonstrated throughout the neuroaxis in response to persistent pain, including in the adult prefrontal cortex (PFC). We have previously reported …

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Characterization Of Calbindin Positive Interneurons Within The Ventral Horn Of The Mouse Spinal Cord, Taylor L. Floyd, David R. Ladle Jan 2015

Characterization Of Calbindin Positive Interneurons Within The Ventral Horn Of The Mouse Spinal Cord, Taylor L. Floyd, David R. Ladle

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

Sensory-motor circuits in the spinal cord integrate sensory feedback from muscles and modulate locomotor behavior. Although we know how the sensory-motor system generally works, the main issue lies in identifying all neurons involved and understanding their interrelationships. Many interneurons contribute to sensory-motor circuits and have been well studied. For example, Renshaw cells (RC) are inhibitory interneurons that prevent motor neurons from over-activity. A distinguishing feature of RCs is that they are the only interneurons within the ventral-most region of the spinal cord expressing the calcium binding protein calbindin (CB). Recent studies have found other subpopulations of ventral horn interneurons outside …

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