Neuroscience and Neurobiology Commons^™

Rapid And Objective Assessment Of Neural Function In Autism Spectrum Disorder Using Transient Visual Evoked Potentials, Paige M. Siper, Vance Zemon, James Gordon, Julia George-Jones, Stacey Lurie, Jessica Zweifach, Teresa Tavassoli, A. Ting Wang, Jesslyn Jamison, Joseph D. Buxbaum, Alexander Kolevzon

Publications and Research

Objective There is a critical need to identify biomarkers and objective outcome measures that can be used to understand underlying neural mechanisms in autism spectrum disorder (ASD). Visual evoked potentials (VEPs) offer a noninvasive technique to evaluate the functional integrity of neural mechanisms, specifically visual pathways, while probing for disease pathophysiology.

Methods Transient VEPs (tVEPs) were obtained from 96 unmedicated children, including 37 children with ASD, 36 typically developing (TD) children, and 23 unaffected siblings (SIBS). A conventional contrast-reversing checkerboard condition was compared to a novel short-duration condition, which was developed to enable objective data collection from severely affected populations …

In-Vivo Imaging Of Magnetic Fields Induced By Transcranial Direct Current Stimulation (Tdcs) In Human Brain Using Mri, Mayank V. Jog, Robert X. Smith, Kay Jann, Walter Dunn, Belen Lafon, Dennis Truong, Allan Wu, Lucas C. Parra, Marom Bikson, Danny J. J. Wang

Publications and Research

Transcranial direct current stimulation (tDCS) is an emerging non-invasive neuromodulation technique that applies mA currents at the scalp to modulate cortical excitability. Here, we present a novel magnetic resonance imaging (MRI) technique, which detects magnetic fields induced by tDCS currents. This technique is based on Ampere’s law and exploits the linear relationship between direct current and induced magnetic fields. Following validation on a phantom with a known path of electric current and induced magnetic field, the proposed MRI technique was applied to a human limb (to demonstrate invivo feasibility using simple biological tissue) and human heads (to demonstrate feasibility in …

Insects: Still Looking Like Zombies, Christopher S. Hill

Animal Sentience

In arguing that insect brains are capable of sentience, Klein & Barron rely heavily on Bjorn Merker’s claim that activity in the human mid-brain is sufficient for conscious experience. I criticize Merker’s claim by pointing out that the behaviors supported by midbrain activity are much more primitive than the ones that appear to depend on consciousness. I raise a similar objection to Klein & Barron’s contention that insect behaviors are similar to behaviors that manifest consciousness in human beings. The similarity is weak. I also respond to the related view that integrative activity in mid-brain structures is sufficient to explain …

Adult Neurogenesis In Avian Auditory Cortex, Caudomedial Nidopallium (Ncm): Lateralization And Effects Of Statins, Shuk C. Tsoi

Dissertations, Theses, and Capstone Projects

In the first part of this paper, we investigated the basic relationship between learning, memory and adult neurogenesis using zebra finches. We found that in the auditory cortex, the left hemisphere had more new neurons than the right hemisphere. This lateralization was correlated with song learning and memory. In the second part, we used juvenile zebra finches as a model organism to study the effects of Lipitor on learning, memory and neurogenesis. We found that Lipitor impaired song learning and memory storage. Lipitor treatments also changed the morphology of new neurons and size of old neurons, suggesting statins may affect …

Examining Relationships Between Basic Emotion Perception And Musical Training In The Prosodic, Facial, And Lexical Channels Of Communication And In Music, Jamie Twaite

Dissertations, Theses, and Capstone Projects

Research has suggested that intensive musical training may result in transfer effects from musical to non-musical domains. There is considerable research on perceptual and cognitive transfer effects associated with music, but, comparatively, fewer studies examined relationships between musical training and emotion processing. Preliminary findings, though equivocal, suggested that musical training is associated with enhanced perception of emotional prosody, consistent with a growing body of research demonstrating relationships between music and speech. In addition, few studies directly examined the relationship between musical training and the perception of emotions expressed in music, and no studies directly evaluated this relationship in the facial …

Cognitive Dissonance Or Contrast?, Thomas R. Zentall

Animal Sentience

According to Festinger (1957), cognitive dissonance occurs when one’s behavior or belief is inconsistent with another belief and one modifies one of the beliefs in an attempt to reduce the dissonance. In nonhuman animals, we have examined a version of human cognitive dissonance theory called justification of effort, according to which the value of reward following more difficult tasks increases, presumably to justify (to oneself or to others) performing the more difficult task. We have examined the justification of effort effect in animals and found a pattern similar to the one in humans but we propose a simpler underlying …

Motor Experience Reprograms Development Of A Genetically-Altered Bilateral Corticospinal Motor Circuit, Najet Serradj, John H. Martin

Publications and Research

Evidence suggests that motor experience plays a role in shaping development of the corticospinal system and voluntary motor control, which is a key motor function of the system. Here we used a mouse model with conditional forebrain deletion of the gene for EphA4 (Emx1-Cre:EphA4tm2Kldr), which regulates development of the laterality of corticospinal tract (CST). We combined study of Emx1-Cre:EphA4tm2Kldr with unilateral forelimb constraint during development to expand our understanding of experience-dependent CST development from both basic and translational perspectives. This mouse develops dense ipsilateral CST projections, a bilateral motor cortex motor representation, and bilateral motor phenotypes. Together these phenotypes can …

Structural Dichotomy Of The Mind; The Role Of Sexual Neuromodulators, Ion G. Motofei, David L. Rowland

Journal of Mind and Medical Sciences

The mind (mental function) and sexuality represent two distinct environmental functions, but which are supported within the brain by a common (somatic-autonomic) neurobiological substrate. As a consequence, mental function takes on autonomic characteristics from the sexual-autonomic system (like autonomy, duality), while sexual function takes on features from mental functioning (such as lateralization). In this paper we discuss the lateralized action of two classes of sexual neuromodulators: hormones and pheromones. This process of lateralization is assimilated with the structural dichotomy of the mind.

A relatively similar process but related to informational dichotomy of the mind will be presented in a forthcoming …

Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic And Ca2+-Handling Deficits In Alzheimer's Disease Models, Erez Eitan, Emmette R. Hutchison, Krisztina Marosi, James Comotto, Maja Mustapic, Saket M. Nigam, Caitlin Suire, Chinmoyee Maharana, Gregory A. Jicha, Dong Liu, Vasiliki Machairaki, Kenneth W. Witwer, Dimitrios Kapogiannis, Mark P. Mattson

Sanders-Brown Center on Aging Faculty Publications

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder in which aggregation-prone neurotoxic amyloid β-peptide (Aβ) accumulates in the brain. Extracellular vesicles (EVs), including exosomes, are small 50–150 nm membrane vesicles that have recently been implicated in the prion-like spread of self-aggregating proteins. Here we report that EVs isolated from AD patient cerebrospinal fluid and plasma, from the plasma of two AD mouse models, and from the medium of neural cells expressing familial AD presenilin 1 mutations, destabilize neuronal Ca²⁺ homeostasis, impair mitochondrial function, and sensitize neurons to excitotoxicity. EVs contain a relatively low amount of Aβ but have an …

Commentaries On Deepak Chopra And Menas Kafatos’ Book, “You Are The Universe”; 2017, Harmony Books., Shelli Joye

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

No abstract provided.

Commentaries On Deepak Chopra And Menas Kafatos’ Book, “You Are The Universe”; 2017, Harmony Books., Ervin Laszlo

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

No abstract provided.

From The Handbook Of The Laszlo Institute Of New Paradigm Research And The Intelligence Of The Cosmos , Inner Traditions, September 2017, Ervin Laszlo

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

No abstract provided.

The Pribram – Bohm Hypothesis Part Ii: The Physiology Of Consciousness, Shelli R. Joye

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

A physiology of consciousness is elaborated, based upon implications of the Pribram-Bohm hypothesis (developed in Part I of this series). The model presented here is in sharp contrast to the prevailing conviction among neuroscientists that consciousness will eventually be discovered to be a physiological epiphenomenon of neuronal electrical impulses firing in the brain. In contrast, the Pribram-Bohm theory holds that consciousness, inherent in what Bohm views cosmologically as “the Whole,” manifests as a dynamic conscious energy resonance bridging the explicate space-time domain with the nonlocal, transcendent flux domain termed the “implicate order.” Presented in Part I, the Pribram-Bohm hypothesis posits …

Commentaries On Deepak Chopra And Menas Kafatos’ Book, “You Are The Universe”; 2017, Harmony Books., Allan Combs

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

No abstract provided.

Commentaries On Deepak Chopra And Menas Kafatos’ Book, “You Are The Universe”; 2017, Harmony Books., Jim Smith

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

No abstract provided.

Integral In-Dwelling: A Prepositional Theology Of Religions, Bruce Alderman

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

The concept of generalized co-presence is a central one in the gram- mar of Bhaskar’s metaRealist metaphysics. As a term denoting the radical relationality and mutual indwelling of beings in the cosmos, generalized co- presence finds analogues in the holographic principle of Morin’s Complex Thought, Wilber’s nondual inflection of holarchy, as well as multiple religious archetypes of divine interindependence. In this paper, I will explore the potential of this concept for framing a “deep participatory,” Complex Integral Realist model of interreligious relationship that can amplify the integrative potential of the metaRealist, Integral, and participatory approaches to this topic that have …

Growth And Happiness In The Human Personality, Rien Havens, Allan Combs

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

This paper explores stages and styles of meaning making in a population at Kegan’s (1982) developmental levels 3 through 5. It is a qualitative study of the relationship between adult personality development and how individuals speak about meaning and well-being in their lives. Nineteen participants ranging widely in age and socioeconomic class were selected informally through connections with the researchers, and snowball sampling. They were chosen from an original group of 50, based on informal interviews suggesting that they had achieved Kegan’s developmental levels of “Socialized Mind” (stage 3), or especially “Self-Authoring Mind” (stage 4) or “Self-Transforming Mind” (stage 5). …

Consciousness: Where We Are At, Imants Barušs

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

It is useful every couple of years to take a bird’s eye view of consciousness studies and reflect on what we see. When I look, I still see two streams, one of which is the social and political framework for the study of consciousness, and the other of which is the substance of what we know about consciousness. The former is still largely defined by the extent to which the scientific study of consciousness has been freed from a materialist agenda. The latter includes recent research into the clarity of cognitive functioning in the absence of sufficient neurological support for …

Why Consciousness Matters: Insights From A New Generation, Kathleen Noble

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

The University of Washington-Bothell is home to a transdisciplinary and integral minor in consciousness that is the first and only such program at a public research university. This study reports a content analysis of reflection essays submitted by 122 students who completed at least four of the five courses that comprise the minor between 2012 and 2016. Results indicate that students derived significant benefits from this approach to the study of consciousness, including a deep appreciation for the depth and breadth of the mind and the need to release their understanding of consciousness from the constraints of scientific materialism. They …

Commentaries On Deepak Chopra And Menas Kafatos’ Book, “You Are The Universe”; 2017, Harmony Books., Stanley Krippner

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

No abstract provided.

Commentaries On Deepak Chopra And Menas Kafatos’ Book, “You Are The Universe”; 2017, Harmony Books., Joe Subbiondo

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

No abstract provided.

Commentaries On Deepak Chopra And Menas Kafatos’ Book, “You Are The Universe”; 2017, Harmony Books., Simon Senzon

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

No abstract provided.

Reduced Efficacy Of Anti-AΒ Immunotherapy In A Mouse Model Of Amyloid Deposition And Vascular Cognitive Impairment Comorbidity, Erica M. Weekman, Tiffany L. Sudduth, Carly N. Caverly, Timothy J. Kopper, Oliver W. Phillips, David K. Powell, Donna M. Wilcock

Sanders-Brown Center on Aging Faculty Publications

Vascular cognitive impairment and dementia (VCID) is the second most common form of dementia behind Alzheimer's disease (AD). It is estimated that 40% of AD patients also have some form of VCID. One promising therapeutic for AD is anti-Aβ immunotherapy, which uses antibodies against Aβ to clear it from the brain. While successful in clearing Aβ and improving cognition in mice, anti-Aβ immunotherapy failed to reach primary cognitive outcomes in several different clinical trials. We hypothesized that one potential reason the anti-Aβ immunotherapy clinical trials were unsuccessful was due to this high percentage of VCID …

Evolutionary Continuity Of Personhood, Anne Benvenuti

Animal Sentience

Rowlands applies the two organizing ideas of the Lockean concept of personhood — mental life and unity — to animals as potential persons. Especially valuable in this context is his descriptive phenomenology of pre-reflective self-awareness as a fundamental form of mental life that necessarily entails unity. Rowland describes certain fundamentals of mental experience that exist across species boundaries, challenging assumptions of early modern philosophers regarding the definition of human personhood and affirming the principle of evolutionary continuity. This opens the door to a broader and deeper set of questions, related to whether we should continue to attempt to apply to …

Darwin’S Empirical Evidence, Maxine Sheets-Johnstone

Animal Sentience

Darwin’s extensive writings may seem antiquated to current thinkers with their predilections for cognitive science, neuroscience, and analytic branches of philosophy. He showed that morphologies are not simply taxonomic distinctions that allow classification into species. They describe living animals, hence morphologies-in-motion: animate forms of life engaged in synergies of meaningful movement, all of which are testimony to animal sentience.

Animal Personhood Is An Evolutionary Issue, James E. King

Animal Sentience

The Rowlands target article makes a case, based on John Locke’s metaphysical argument, that personhood can be applied to many species beyond a few nonhuman primates. The problem with this argument is that personhood has an open-ended list of defining attributes and can, at best only be partially applied to nonhuman species. Therefore, a dichotomous distinction cannot be made between qualifying and non-qualifying species. Instead, between-species comparisons must be based on observational and experimental procedures to demonstrate the extent to which human mental attributes are shared with other species. This would allow a more informed view about the appropriateness of …

How Could Consciousness Emerge From Adaptive Functioning?, Max Velmans

Animal Sentience

The sudden appearance of consciousness that Reber posits in creatures with flexible cell walls and motility rather than non-flexible cells walls and no motility involves an evolutionary discontinuity. This kind of “miracle” is required by all “discontinuity” theories of consciousness. To avoid miraculous emergence, one may need to consider continuity theories, which accept that different forms of consciousness and material functioning co-evolve but assume the existence of consciousness to be primal in the way that matter and energy are assumed to be primal in physics.

“Cellular Basis Of Consciousness”: Not Just Radical But Wrong, Brian Key

Animal Sentience

Reber (2016) attempts to resuscitate an obscure and outdated hypothesis referred to as the “cellular basis of consciousness” that was originally formulated by the author nearly twenty years ago. This hypothesis proposes that any organism with flexible cell walls, a sensitivity to its surrounds, and the capacity for locomotion will possess the biological foundations of mind and consciousness. Reber seeks to reduce consciousness to a fundamental property inherent to individual cells rather than to centralised nervous systems. This commentary shows how this hypothesis is based on supposition, false premises and a misunderstanding of evolutionary theory. The cellular basis of consciousness …

The Person And The Self As Social Accomplishment, Leslie Irvine

Animal Sentience

Rowlands (2016) presents a compelling argument for extending personhood to nonhuman animals. Sociological conceptions of the person also do not require that animals meet the elusive standard of self-awareness. Sociological ideas on selfhood support the claims about pre-reflective awareness and extend the requisite experiences to animals.

The Evolutionary History Of Consciousness, Eirik Søvik, Clint Perry

Animal Sentience

Klein & Barron argue that insects are capable of subjective experience, i.e., sentience. Whereas we mostly agree with the conclusion of their arguments, we think there is an even more important message to be learned from their work. The line of reasoning opened by Klein & Barron proves instructive for how neuroscientists can and should explore the biological phenomenon of consciousness.