Engineering Commons^™

Impedance Analysis Of Tissues In Nspef Treatment For Cancer Therapy, Edwin Ayobami Oshin

Biomedical Engineering Theses & Dissertations

Nanosecond pulsed electric field (nsPEF) for cancer therapy is characterized by applications of high voltage pulses with low pulsed energy to induce non-thermal effects on tissues such as tumor ablation. It nonthermally treats tissues via electroporation. Electroporation is the increase in permeabilization of a cell membrane due to the application of high pulsed electric field. The objective of this study was to investigate the effect of nsPEF on tissue by monitoring the tissue’s impedance in real-time. Potato slices (both untreated and electroporated), and tumors extracted from female BALBc mice were studied. 100ns, 1-10kV pulses were applied to the tissues using …

The Impacts Of Surface Gravity Waves On Buoyant Plume Dilution, Bruce William Husselbee

Civil & Environmental Engineering Theses & Dissertations

A common practice in coastal areas is to collect, treat and discharge fluids including treated wastewater, stormwater or power plant effluent to areas of lesser impact. The discharge of these fluids, conveyed through pipelines into coastal areas, continues to be an important human health and environmental concern. The fluid discharged from these pipelines is often buoyant which allows for dilution and dispersion into these ambient waters.

Initial dilution, defined as the maximum concentration of a discharged fluid at the maximum rise in height within a buoyant plume, is critical in the consideration of the environmental impacts of a discharge into …

Nonlinearity Index Aircraft Spin Motion Analysis With Dynamic Inversion Spin Recovery Controller Design, Jeffry Walker

Mechanical & Aerospace Engineering Theses & Dissertations

The aim of this thesis research is to extend the previous work of Tapolcai utilizing nonlinearity index theory to quantitatively analyze nonlinearities in an aircraft model and to augment these undesirable nonlinear characteristics with feedback control. In his work Tapolcai utilized a simplified rotational three degree of freedom model to analyze spin conditions of the F-18 High Angle-of-Attack Research Vehicle model. Through the application of nonlinearity index theory, regions of severe nonlinearity were uncovered exhibiting chaotic non-periodic behavior, periodic limit cycling, and instability. If these conditions were encountered during flight, the aircraft would exhibit undesirable response characteristics thereby requiring augmented …

Cfd Simulations Of A Propeller-Wing Interaction, Asim Oktay Akdeniz

Mechanical & Aerospace Engineering Theses & Dissertations

In this study, 3-D turbulent flows around a propeller driven aircraft model placed in a subsonic wind tunnel were computationally simulated for qualitative investigation of near field wakes. The geometry of the model was created using commercial mesh generation software, GRIDGEN, and then simulations were performed using a commercial finite volume Reynolds-Averaged Navier-Stokes (RANS) solver FLUENT.

Initial runs were performed to validate the boundary conditions and setup of the problem where a hybrid mesh consisting of multi-blocks was in use. Sliding mesh concept used in the computations. Laminar flow simulation have been utilized and tested besides Spalart-Allmaras and k-ω SST …

Exploring The Effects Of Biases In Mark-Recapture Fish Abundance Estimation With Software Simulations, Christian Yap

Student Scholars Day Posters

Two-sample mark-recapture sampling is a common method used to estimate fish abundance. The idea is to capture and mark fish in an initial sample. The fish are then released to mix randomly with the whole population. A second sample is obtained, and the number of marked and unmarked fish is recorded. The Chapman estimator uses the number of fish marked in the first sample, the total number of fish captured in the second sample, and the number of recaptured fish to estimate abundance. The assumptions are: 1) the population is closed, meaning no immigration/emigration, and births/deaths occur, 2) all fish …

Optimal Sizing Design And Operation Of Electrical And Thermal Energy Storage Systems In Smart Buildings, Ali Baniasadi, Daryoush Habibi, Waleed Al-Saedi, Mohammad A. S. Masoum, Choton K. Das, Navid Mousavi

Research outputs 2014 to 2021

Photovoltaic (PV) systems in residential buildings require energy storage to enhance their productivity; however, in present technology, battery storage systems (BSSs) are not the most cost-effective solutions. Comparatively, thermal storage systems (TSSs) can provide opportunities to enhance PV self-consumption while reducing life cycle costs. This paper proposes a new framework for optimal sizing design and real-time operation of energy storage systems in a residential building equipped with a PV system, heat pump (HP), thermal and electrical energy storage systems. For simultaneous optimal sizing of BSS and TSS, a particle swarm optimization (PSO) algorithm is applied to minimize daily electricity and …

College Of Engineering News, Georgia Southern University

College of Engineering & Computing: News & Publications (2010-2023)

• College Support for Students

The State Of Technologies And Research For Energy Recovery From Municipal Wastewater Sludge And Biosolids, Zhongzhe Liu, Brooke K. Mayer, Kaushik Venkiteshwaran, Saba Seyedi, Arun S.K. Raju, Daniel Zitomer, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Wastewater resource recovery facilities produce wastewater solids that offer potential for energy recovery. This opinion article provides a perspective on state-of-the-art technologies to recover energy from sludge (unstabilized wastewater residual solids) and biosolids (stabilized wastewater solids meeting criteria for application on land). The production of biodiesel fuel is an emerging technology for energy recovery from sludge, whereas advancements in pretreatment technologies have improved energy recovery from anaerobic digestion of sludge. Incineration is an established technology to recover energy from sludge or biosolids. Gasification, and to a greater extent, pyrolysis are emerging technologies well-suited for energy recovery from biosolids. While gasification …

Inelastic Behavior And Seismic Design Of Multistory Chevron-Braced Frames With Yielding Beams, Charles W. Roeder, Andrew D. Sen, Hayato Asada, Sara M. Ibarra, Dawn E. Lehman, Jeffrey W. Berman, Keh-Chyuan Tsai, Ching-Yi Tsai, An-Chien Wu, Kung-Juin Wang, Ruyue Liu

Civil and Environmental Engineering Faculty Research and Publications

Chevron or inverted V-braced frames offer numerous architectural and structural advantages, but the current special concentrically braced frame (SCBF) seismic-design requirements in the American Institute of Steel Construction (AISC) Seismic Provisions for Structural Steel Buildings lead to deep, heavy chevron beams; as a result, few chevron SCBFs are built today. Recent research on single-story chevron SCBFs demonstrated that beam yielding can be advantageous at higher demand levels, and design for large, inelastic unbalanced brace-force demands may still result in acceptable seismic performance. However, this prior research did not consider the response of multistory frames. In particular, questions remain as to …

A Test Bed For Evaluating The Performance Of Iot Networks, Hope Harvey

Senior Honors Theses

The use of smaller, personal IoT networks has increased over the past several years. These devices demand a lot of resources but only have limited access. To establish and sustain a flexible network connection, 6LoWPAN with RPL protocol is commonly used. While RPL provides a low-cost solution for connection, it lacks load balancing mechanisms. Improvements in OF load balancing can be implemented to strengthen network stability. This paper proposes a test bed configuration to show the toll of frequent parent switching on 6LoWPAN. Contiki’s RPL 6LoWPAN software runs on STM32 Nucleo microcontrollers with expansion boards for this test bed. The …

The Effect Of Including Pressure Within Cracks On Failure Times Of Cylinders Subjected To Internal Air Blast Loading, Molly M. Bailey

Mechanical Engineering ETDs

The importance of internal crack pressure on the extent of crack propagation is studied using both numerical and experimental results. Experimental data were obtained from shock tube testing of internally pressurized quasi-brittle hollow cylinders loaded to failure. Half of the samples were tested with an inserted membrane that transferred the shocked fluid load but prevented the fluid from entering the developing cracks. In the other cases, the membrane was removed allowing the fluid to enter the crack and assist development of fracture. A novel approach to modeling this complex structural response involving dynamic failure and fluid structure interaction is presented, …

Assessment Of Nanoparticle Accumulation With Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Hunter Miller

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Nanoparticle (NP)-based therapeutics promise to improve medicine in multiple areas by increasing target engagement. To date, most research has focused on cancer, aiming to increase uptake using the enhanced permeability and retention (EPR) effect. Despite pre-clinical success in proof-of-concept studies, understanding of the fundamental interactions between NP and biological systems that govern outcomes remains incomplete. To realize the potential of NPs for cancer therapeutics, and to expand their application into other diseases, the roles physicochemical properties play in NP uptake must be better understood. Some investigations have been performed into the effects of size and surface charge on uptake into …

Monitoring Hydrologic Controls On Biogeochemical Process Variability In Green Infrastructure Soils, Laine Pulvermacher

Master's Theses (2009 -)

The premise of this research was to monitor biogeochemical responses to soil moisture and soil temperature within green stormwater infrastructure soils. Adopting best management practices like green infrastructure in urban areas has the potential to remove incoming nutrients from stormwater runoff through biogeochemical processes, like plant and microbial metabolism. Biogeochemical activity has been suggested to be highly variable, so this research proposed to monitor that variability by tracking the stoichiometry of soil respiration. Additionally, an advection-diffusion-reaction model was used to disaggregate physical and biogeochemical controls on the observed soil respiration. The field data was collected to investigate the biogeochemical processes, …

Design, Assessment, And Comparison Of Antagonistic, Cable-Driven, Variable Stiffness Actuators, Ryan P. Moore

Master's Theses (2009 -)

This thesis presents the designs and test results for two antagonistic, cable-driven, variable stiffness actuator designs. Each of these variable stiffness actuators is compact, has a large range of controllable stiffness, and limits the inertia at the robotic link it is controlling. Each design consists of a cable running through a set of three pulleys. Tension on the cable displaces a linear spring, which moves along a path designed to achieve quadratic spring behavior. One design uses a variable radius path to achieve the nonlinear elastic behavior while the other uses a fixed radius (lever) path.A quasi-static model of …

Multiscale Analysis Of Soil-Strap Interactions In Mechanically Stabilized Earth Retaining Walls, Max Willingham

Master's Theses (2009 -)

A numerical pullout test was built using the discrete element method (DEM) to model and capture the pullout response of steel reinforcements and soil in mechanically stabilized earth (MSE) walls. Through numerical modeling, microscale phenomena showing aggregate behavior in response to the reinforcement can be used to gain insight into the macroscale structure. The general setup of the simulation is a steel specimen encased in a rectangular apparatus filled with particles. A normal pressure is applied to the top layer of particles while the strap is slowly removed from the box until it reaches a prescribed displacement.The simulation was …

Energy Storage Systems For Traction And Renewable Energy Applications, Hamad Abdullah Aldawsari

Master's Theses (2009 -)

Energy storage systems are the set of technologies used to store various forms of energy, and by necessity, can be discharged. Energy storage technologies have a wide range of characteristics and specifications. Like any other technology, each type of energy storage has its pros and cons. Depending on the application, it is crucial to perform a tradeoff study between the various energy storage options to choose the optimal solution based on the key performance objectives and various aspects of those technologies. The purpose of this thesis is to present a thorough literature review of the various energy storage options highlighting …

Monitoring The Performance Of Green Infrastructure: Pervious Pavement And Bioretention, Elizabeth Marie Regier

Master's Theses (2009 -)

Milwaukee, like many other aging cities, struggles with combined sewer overflows, basement backups, and urban stream syndrome. It is increasingly looking to green stormwater infrastructure as a way to alleviate stormwater concerns by treating, retaining, and slowly releasing stormwater near the locations where it falls. However, green stormwater infrastructure varies in its performance, and few studies have been performed in Southeast Wisconsin. Therefore, two bioswales and a pervious pavement installation were monitored for water quantity, total nitrogen, total phosphorus, and total suspended solids. The bioswales were also monitored for dissolved phosphorus. The north bioswale reduced total phosphorus concentrations by a …

Heavy Civil Estimating Module For Cm 314, Everett A. Roberts

Construction Management

In the past, through engagement with students that have gone through the Heavy Civil class, it has been found that student understanding of typical heavy civil operations is subpar. Through an updated course module that focuses on estimating the four major operations, Earthwork, Underground, Asphalt, and Concrete, students will gain a deeper understanding of the heavy civil field of construction. The module consists of four assignments that pertain to the previously mentioned operations. Each contain a lecture detailing typical crew compositions and cycle times, reference material and resources the student can use when completing the assignments. This new module will …

Indirect Structural Connectivity As A Biomarker For Stroke Motor Recovery, Miguel Renato Sotelo Munoz

Dissertations (1934 -)

In this dissertation project, we demonstrated that diffusion magnetic resonance imaging and measures of indirect structural brain connectivity are sensitive to changes in fiber integrity and connectivity to remote regions in the brain after stroke. Our results revealed new insights into the effects local lesions have on global connectivity—in particular, the cerebellum—and how these changes in connectivity and integrity relate to motor impairment. We tested this methodology on two stroke groups—subacute and chronic—and were able to show that indirect connectivity is sensitive to differences in connectivity during stroke recovery. Our work can inform clinical methods for rehabilitating motor function in …

Fate And Transport Of Antibiotics And Antibiotic Resistance Genes In Runoff And Soil As Affected By The Timing Of Swine Manure Slurry Application, Renys Enrique Barrios, Himanshu Khuntia, Shannon L. Bartelt-Hunt, John E. Gilley, Amy M. Schmidt Schmidt, Daniel D. Snow, Xu Li

Department of Civil and Environmental Engineering: Faculty Publications

Land application of swine manure slurry is a common practice to supplement nutrients to soil for crop production. This practice can introduce antibiotic residues and antibiotic resistance genes (ARGs) into the environment. Field testing is critical in identifying manure management practices effective in minimizing the environmental impacts of manure-borne antibiotic and ARGs. The objective of this study was to determine how the timing of swine manure application relative to rainfall events impacts the fate and transport of antibiotics and ARGs in surface runoff and manure-amended soil. Swine manure slurry was either broadcast or injected on test plots in the field. …

Cellulose Based Separator For High-Performance Lithium-Ion Batteries, Akshit Vaidya

Masters Theses

During the past two decades, lithium-ion batteries (LIBs) have gained great success in the field of portable devices, and currently, are penetrating to the market of vehicles. Compared to the fast development of LIBs, little efforts have been dedicated to the separator, which is one of the most important components of LIBs. Primarily, the lithium-ion battery separator has two functions, one is to prevent direct contact between the positive and negative electrodes, and the other is to provide a path for effective ionic transportation. Currently, the separator market of LIBs is dominated by polyolefin materials such as polypropylene, polyethylene, and …

Oxidized Phospholipid Regulation Of Chronic Inflammation In Endothelial Cells, Cameron Scott Brutsche

Masters Theses

Atherosclerosis, the primary cause of Coronary Heart Disease (CHD), has become one of the top causes of death in the world. As low-density lipoprotein (LDL) particles become trapped and oxidized inside arterial walls, the primary oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphatidylcholine (PAPC) induce the binding of monocytes which can potentially lead to fatty plaque build ups. A fragment of one of these oxidation products, OxPAPC, has previously been studied and can act as standard for testing new phospholipids and how they affect protein expression levels. The central hypothesis of this study was that three newly studied classes of oxidized fatty …

Developing A Skin Phantom For The Testing Of Biowearables, Tawni Henderson, Ju Young Lee, Matthew Placide, Kiran Sutaria

Interdisciplinary Design Senior Theses

There is a demonstrated need in the biowearables industry for a benchtop model that can accurately emulate the perspiration mechanism and corresponding impedance vs. frequency spectra of skin. This model, or skin phantom, could increase the efficiency and accuracy of early-stage testing of biowearables, as well as minimize animal, human, and cadaver testing.

The objective of this project is to develop a skin phantom that can emulate the perspiration mechanism and impedance spectrum behavior of human skin for the testing of biowearables in the 2,000 - 20,000 Hz range. We also endeavored to create computer-simulated models to aid in the …

Enhanced Carrier Transport By Transition Metal Doping In Ws2 Field Effect Transistors, Maomao Liu, Sichen Wei, Simran Shahi, Hemendra Nath Jaiswal, Paolo Paletti, Sara Fathipour, Maja Remskar, Jun Jiao, Wansik Hwang, Fei Yao, Huamin Li

Physics Faculty Publications and Presentations

High contact resistance is one of the primary concerns for electronic device applications of two-dimensional (2D) layered semiconductors. Here, we explore the enhanced carrier transport through metal–semiconductor interfaces in WS₂ field effect transistors (FETs) by introducing a typical transition metal, Cu, with two different doping strategies: (i) a “generalized” Cu doping by using randomly distributed Cu atoms along the channel and (ii) a “localized” Cu doping by adapting an ultrathin Cu layer at the metal–semiconductor interface. Compared to the pristine WS₂ FETs, both the generalized Cu atomic dopant and localized Cu contact decoration can provide a Schottky-to-Ohmic contact …

2020 (Spring) Ensi Informer Magazine, Morehead State University. Engineering Sciences Department

ENSI Informer Magazine Archive

The ENSI Informer Magazine published in the spring of 2020.

The Use Of Natural Anthraquinone Emodin As A Primary And Complementary Therapeutic In The Treatment Of Colorectal Cancer, Alexander-Jacques Theodore Sougiannis

Theses and Dissertations

5 Fluorouracil (5FU) chemotherapy is widely used in the treatment of colorectal cancer (CRC), and has been the first-choice chemotherapy drug for CRC for many years. However, nearly 10% of patients receiving chemotherapy die during the first 30 days of treatment. Further, it is estimated that 70% of surviving patients will develop non-specific toxicities as a result of chemotherapy treatment. We characterize these toxicities in an animal model of chemotherapy treatment and show that perturbations in the gut microbiome might be exacerbate the prolonged effects of chemotherapy. A compound that could attenuate the multiple non-selective toxicities associated with chemotherapy could …

The Evolution Of The Southeastern North American Margin From Integrated Analyses Of Potential Field Data: Continent-Continent Collision And Rifting, Patrick D. Duff

Theses and Dissertations

The southeastern North American margin (SENAM) is one of the world’s oldest intact passive margins, containing the ancient southern Appalachian Mountains, the South Georgia Rift (SGR), and the Central Atlantic Magmatic Province (CAMP).

Potential field data is used in combination with seismic imaging, borehole data, and surface geology to better constrain the lithospheric configuration created by Appalachian orogenesis and Atlantic rifting. In combination with filtering techniques, maps and 2D potential field forward models, and Euler inverse modeling are used to illuminate the pre-Cretaceous basement including basement faults, shear zones, and granites in the hinterland of the southern Appalachians, and rift …

Influence Of Coordination Environment On Catalyst Structure And Function For Co2 Hydrogenation And Ethane Partial Oxidation, Juan D. Jimenez

Theses and Dissertations

In this work, we set out to establish strong structure/activity relationships for various catalytic compositions and reactions. Through in situ spectroscopic approaches, specifically DRIFTS, Raman XPS, and XAFS, we were able to discern the reactive species in CO₂ hydrogenation over highly active cobalt nanostructures, the relevant ensemble size and composition of single site catalysts for CO₂ hydrogenation, and active vibrational modes of mixed oxide catalysts for ethane partial oxidation (EPO).

First, we illustrate how tailoring surface orientations of Co₃O₄ catalysts on the nanoscale results in control over catalytic performance via the preferential formation of active …

Multi-Scale Modeling For Transport Study Inside Porous Layers Of Polymer Electrolyte Membrane Fuel Cell Using Direct Numerical Simulation, Pongsarun Satjaritanun

Theses and Dissertations

The direct modeling-based Lattice Boltzmann Agglomeration Method (LBAM) is used to explore the electrochemical kinetics and multi-scalar/multi-physics transport inside the detailed structure of the porous and catalyst layers inside polymer electrolyte membrane fuel cells (PEMFCs). The complete structure of the samples is obtained by both micro- and nano- X-ray computed tomography (CT). LBAM is able to predict the electrochemical kinetics in the nanoscale catalyst layer and investigate the electrochemical variables during cell operation. This work shows success in integrating the lattice elements into an agglomerate structure in the catalyst layer (CL). The predictions using LBAM were compared and validated with …

Using Human Granulosa Cells To Select The Most Competent Embryos For Uterine Transfer In In Vitro Fertilization Cycles, Richard John Kordus

Theses and Dissertations

Infertility is a worldwide epidemic often treated with in vitro fertilization. The success of in vitro fertilization is directly dependent upon the quality of oocytes produced during the controlled stimulation of the patient’s ovaries. There is a need for improved methods to allow embryologists to select the most viable embryos with the highest probability of leading to live births since in vitro fertilization success is far from optimal.

Oocyte and subsequent embryo quality are intimately influenced by the granulosa cells which surround the oocyte during follicular maturation. The oocytes require proper signaling and energy production form the surrounding granulosa cells …