Engineering Commons^™

Three-Dimensional Plasma Cell Survival Microniche In Multiple Myeloma, Katrina A. Harmon

Theses and Dissertations

Multiple myeloma (MM) is an incurable malignancy characterized by the uncontrolled proliferation of long-lived plasma cells (PCs) in the bone marrow (BM), which constitute at least 10% of BM cellularity. Normally, long-lived plasma cells make up less than 1% of BM cells. Plasma cells become neoplastic when a clonal PC population produces a monoclonal immunoglobulin protein. A diagnosis of monoclonal gammopathy of undetermined significance (MGUS) is made when there is an increase in monoclonal PCs within the BM, but less than 10%, and the patient does not present with end-organ damage, which is associated with active MM. Though not considered …

Plasma Surface Functionalization Of Afp Manufactured Composites For Improved Adhesive Bond Performance, Ibrahim Sarikaya

Theses and Dissertations

High-performance composite structures not only require a reliable fabrication process when creating primary structures, but also a high fidelity and repeatable bonding process for the assembled components. During the assembly process, surface contaminants are a major concern as they have the potential to compromise the bond quality resulting in poor bond strength, low failure load, and undesirable failure modes of the adhesively bonded structures. This is further complicated by composite materials inherently possessing low surface energy and thus exhibiting low adhesive property. Therefore, detecting and removing contaminants on the pre-bond composite surface is an active research topic in pursuit of …

Electrode Development And Electrocatalysts Design For Polymer Electrolyte Membrane Fuel Cells, Xiong Peng

Theses and Dissertations

Because of environmental issues and national conflicts caused by overuse of fossil fuels, there is a need to seek renewable ways to utilize energy. In the transportation sector, hydrogen-based polymer electrolyte membrane fuel cells, including proton exchange membrane fuel cells (PEMFCs) and anion exchange membrane fuel cells (AEMFCs), have been considered as a promising alternative to conventional combustion engines. However, the widespread commercialization of both PEMFCs and AEMFCs has been hindered by several factors, including cost and performance. In this thesis, a series of topics including electrode fabrication, electrocatalyst development for both PEMFCs and AEMFCs, as well as the water …

Path Loss Models For Two Small Airport Indoor Environments At 31 Ghz, Alexander L. Grant

Theses and Dissertations

Path loss modeling plays a fundamental role in the design of fixed and mobile communication systems for a range of applications. Another term for path loss is channel attenuation, or reduction in signal power from transmitter to receiver. Work here was in support of a NASA project for advanced air traffic management (ATM) applications, specifically for improving the efficiency of airports. Measurements in the millimeter wave (mmWave) band were conducted at 31 GHz in indoor settings at a small municipal airport, the Jim Hamilton–L.B. Owens Airport, in Columbia, SC. Some measurements were also taken at 5 GHz for comparison. A …

Low Frequency Injection As A Method Of Low-Level Dc Microgrid Communication, Matthew Davidson

Theses and Dissertations

In the last ten years, DC microgrid approaches have gained more popularity for the interconnection of distributed energy resources (DERs) and prosumers. The devices (generation, storage, and load) connected to the network may contain operational parameters that have the ability to be adjusted in real-time as to optimize the operation of the microgrid. In this thesis, a simple unidirectional global communication scheme is defined, implemented, and tested. The proposed approach relies on low frequency sinusoidal components that are injected into the DC microgrid power lines. Using the proposed communication approach, multiple parameters can be transmitted to the devices connected to …

Surface Science And Engineering Of Nano-Structured Cathodes For Intermediate Temperature Solid Oxide Fuel Cells, Yeting Wen

Theses and Dissertations

The bulk-to-surface Sr-segregation can seriously compromise the stability of oxygen electrocatalysis in Sr-doped perovskite oxides such as La1-xSrxCoO3-δ and La1-xSrxCo1- yFeyO3-δ and limit their practical applications as cathode materials in solid oxide fuel cells. Although such chemical instability has been actively studied in recent years, fundamental understanding of Sr-segregation process vs temperature and time, particularly under real-world conditions, as well as the suppression method, are still needed. This PhD dissertation aims to acquire fundamental knowledge of Sr-segregation process under practical conditions in solid oxide fuel cells and develop suppression method to ensure the long-term stability through surface modifications.

To gain …

Acoustoelastic Metamaterial With Simultaneous Noise Filtering And Energy Harvesting Capability From Ambient Vibrations, Fariha Mir

Theses and Dissertations

Harvesting unused and untapped energy from ambient vibration noise and acoustic sound waves is an emerging field of research in the recent years. Utilization of the energy with a wide band of the frequency spectrum from the vibrational sources alone stands as one of the most promising ways to power small electronic devices, smartphones, local structural health monitoring (SHM) sensors and home and workshop appliances. Various sources of ambient vibration and acoustic noise can be found around us in our everyday life. These sources are abundant in almost all the engineering industries and manufacturing facilities for example in aerospace, mechanical …

Landslide Detection Using Remote Sensing Methods A Review Of Current Techniques, Sumanth Varma Byrraju

Theses and Dissertations

Landslides are among the most dangerous natural disasters, as they generally follow other major disasters thereby causing significant damage to already weakened systems. In the U.S. alone they cause an excess of 1 billion in damages and an average 25-50 deaths annually(USGC). Remote sensing techniques for landslide monitoring and prediction has gained popularity in recent years since it enables hazard mitigation. Synthetic Aperture Radar (SAR) interferometry is among the remote sensing techniques used. DInSAR is an advanced interferometric technique which uses radar sensors to estimate the phase of a given area from which the landslide activity can be predicted. The …

The Use Of Multi-Targeting Natural Products For The Treatment Of Cancer, Wesley Taylor

Theses and Dissertations

The paradigm shift in cancer treatments from traditional chemotherapeutics to targeted therapies has rapidly improved prognoses for patients for whom cancer was once a death sentence. This is especially true in the case of targeted immune therapies which activate the body’s own natural defense system to fight cancer. Despite these advances, however, cancer remains the second leading cause of death in the United States. The promise of targeted therapeutics has faced significant hurdles in providing effective cancer treatments, namely the limited percentage of susceptible cancers for each treatment, high cost burden, high toxicities, and significant risk of treatment induced resistance. …

Friction Stir Additive Manufacturing(Fsam) Of 2050 Al-Cu-Li Alloy, Ilana Lu

Theses and Dissertations

As a solid state process, friction stir welding (FSW) is an advantageous joining method for higher strength aluminum alloys such as 2050 Al-Cu-Li which are not readily fusion welded. This study explores the potential of friction stir lap welding (FSLW) as an additive manufacturing process for this aluminum-lithium alloy. To accomplish this, lap weld joints were performed so that each additional layer would penetrate the preceding weld pass which creates a large, stacked build. Excess material is machined away leaving only weld. Cast AA2050 is explored in this study as a more cost-efficient feedstock for this process as compared to …

Bridgr: An Ios Application For Organizing And Discussing Long-Distance Carpooling, Harrison Engoren, Erik Zorn

Senior Theses

Bridgr is an iOS application that facilitates long distance carpooling. This application allows drivers to post destinations on an interactable map so that they can be linked with students that need a ride to a location within close proximity of the posted destination. The riders and driver are linked in a common chat board where they can discuss ride details among themselves. The goal of Bridgr is to allow drivers to utilize extra space in their car in turn for fellowship and/or gas money.

Process Design: Maleic Anhydride Unit, Valerie Kay, Jacqueline Phillips, Olivia Smithson

Senior Theses

Gamecock Chemical Company has proposed the construction of a maleic anhydride plant at its Houston refinery. The plant is to produce 40,000 metric tons per year of maleic anhydride from a mixture of excess butanes. This design team has been asked to produce a conceptual design, simulation, and profitability analysis for the proposed plant. The simulation software Aspen Plus by AspenTech was the primary software used to design the plant, and the CAPCOST program in Microsoft suite’s Excel was utilized for the economic review of the process.

Maleic anhydride is produced by the thermal oxidation of n-butane at an elevated …

A Strategic Audit Of Microsoft Azure, Lee Fitchett

Honors Program: Senior Projects (Public)

This paper looks at Microsoft Azure's current strategies and proposes possible options for the future. It looks at several competitors and explores how Azure will affect and react to Microsoft’s vision.

Radio Frequency Interference Cancellation,Appraisal, Detection, And Correction, Michael J. Lambert

Theses and Dissertations

Radio Astronomy, the study of distant objects in the radio spectrum, is set at defiance against all other users of the electromagnetic spectrum. Where traditional use would fill the electromagnetic spectrum with as much transmission and information as possible, Radio Astronomy would rather no man-made signals existed. Since that is not possible, they grumble and have to deal with unwanted transmissions impinging upon their instruments. I have demonstrated that subspace projection can remove these unwanted signals from Radio Astronomical data in post processing. I demonstrate it both on simulated data and on data taken from the Very Large Array radio …

Molecular Methods For The Identification And Quantification Of Cyanobacteria In Surface Water Sources, Treyton Michael Moore

Theses and Dissertations

Geosmin is a strong musty-flavored organic compound that is responsible for many taste-and-odor events in surface drinking water sources like lakes and reservoirs. The taste threshold of geosmin for humans is lower than 10 ng/L. Traditional treatment methods will not remove geosmin to this level. Additional water treatment methods must be implemented to successfully remove the geosmin and its associated flavor and odor from drinking water. Furthermore, geosmin is produced by cyanobacteria somewhat sporadically, so it is difficult to predict when taste-and-odor events are going to occur. The difficulty involved with predicting geosmin events has led most water treatment facilities …

Model Testing Of Soil Bacteria Population Dynamics, Adam Harlan Heninger

Theses and Dissertations

This is one of the first time series studies of bacteria in soils supporting actively growing corn crops. Mathematically modeling bacteria population dynamics has the potential as a tool to more precisely assess the economic optimal nitrogen fertilizer rate for farmers. As a first step in this modeling effort, we examine the possibility that the bacteria population growth might be described by a dynamic model developed in the food sciences describing bacteria growth in food meant for human consumption. We make the assumption that air temperature above the soil can be used as an approximation for soil temperature. Also, because …

An Evaluation Of Two Controller Implementations For An Inverted Pendulum On Cart System, Shaima Abdul Wahab Ali Al Habsi

Electrical Engineering Theses

Various embedded systems are available for control system design and implementation in either lab experiments of postgraduate and undergraduate courses in the area of dynamics and control, or in experimental academic research. The focus of this Master thesis project is set to study, compare and evaluate the performance of two options of controller implementations ranging from a low-cost microcontroller based embedded system to a relatively high-end, high-cost controller prototyping system. In the work reported here, the Arduino® DUE board, which is an Atmel ARM Cortex CPU based, and the dSPACE_® DS1104 prototyping system are used. Another objective of the …

Metamaterial-Based Sensor Design Using Split Ring Resonator And Hilbert Fractal For Biomedical Application, Nadin M. N. Alrayes

Electrical Engineering Theses

In this research, a simple and efficient approach is presented to design a metamaterial-based sensitive sensor for biomedical applications. The metamaterial based sensor is designed to differentiate between different types of cancer cell lines based on their electrical properties. The sensor is designed by incorporating a single circular split ring resonator (SRR) and a Hilbert fractal curve. The SRR is used considering its capacitive and inductive resonance properties, thereby making the SRR a favorable candidate for sensing applications. Moreover, the Hilbert fractal curve was used as a defected ground structure to increase sensor sensitivity and selectivity. The Hilbert fractal ground …

Using Theoretical And Experimental Particle Packing For Aggregate Gradation Optimization To Reduce Cement Content In Pavement Concrete Mixtures, Miras Mamirov

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

The main objective of this study was to evaluate the effect of aggregate particle packing optimization and cement reduction on Nebraska slip-form pavement concrete performance. A literature review was conducted to examine different aggregate optimization tools, quality control tests, and historical data of Nebraska Department of Transportation (NDOT) mixtures. It was found that the Modified Toufar Model has good potential in optimizing particle packing and predicting packing degrees. The combined void content test was found to be useful to experimentally justify optimized aggregate gradations. Two specific pavement concrete workability tests, i.e., the Box Test and the VKelly Test, were used …

Simulation Of Antimicrobial Resistance Gene Fate In Narrow Grass Hedges, Marzieh Khedmati

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Vegetative Filter Strips (VFS) are used for controlling the volume of runoff and decreasing the contaminants in runoff before entering the water bodies. Many studies investigated the role of VFS in sediment and nutrient removal, but little is known about their efficiency in the removal of emerging contaminants such as antimicrobial resistance genes (ARGs). VFSMOD was used to simulate the efficiency of VFS in this regard. The objectives of this study were to calibrate the VFSMOD with some experimental data and asses the efficiency of the model in simulating the filter behavior in removing ARGs. The tests were conducted in …

Proportion And Evaluation Of Ultra-High Performance Concrete Using Local Materials, Flavia Ribeiro Furtado De Mendonca

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Ultra-high performance concrete (UHPC) is a new class of concrete that has superior workability, as well as mechanical and durability properties that far exceed those of conventional concrete. To achieve these properties, a very dense internal structure and the very low water-to-binder ratio (w/b) generally are necessary. While particle packing models are typically used to design UHPC, due to the complexity of the composition interaction and characteristics of UHPC, these models might not necessarily provide the best design, which leads to the need of experimental study to justify UHPC performance. The evaluation of the impact of various design parameters on …

The Professional Constructor, Full Issue, Volume 44, Number 01

The Professional Constructor

No abstract provided.

Fabrication And Characterization Of Thin Films For Heterojunction Solar Cells And Radiation Detectors, Towhid A. Chowdhury

Theses and Dissertations

The dissertation study has undertaken research in two areas: (1) development of Cu2ZnSnS4 (CZTS) thin film photo-absorber using low-cost fabrication technique for roll- to-roll commercial production for photovoltaic application, and (2) development of enriched lithium-doped amorphous selenium alloy film, a new solid-state detector material for neutron detection.

In this study CZTS thin film was developed by employing low-cost, high- throughput spray pyrolysis technique, followed by sulfurization under a 5% H2S flow at 550°C. Characterization of deposited films revealed better structural, compositional, and optical properties for sulfurized film compared to as-deposited film. The ‘sulfurized’ CZTS films deposited at 380°C substrate temperature …

Biophysical Analyses Of Left Ventricular Remodeling Secondary To Myocardial Infarction And Left Ventricular Pressure Overload, William Manuel Torres

Theses and Dissertations

Left ventricular (LV) remodeling is nominally an adaptive process that restores biomechanical function following myocardial injury and/or sustained alterations in loading conditions. This remodeling can materialize as changes in myocardial geometry, composition, and mechanical properties. When these changes fail to restore LV biomechanical function, remodeling is termed maladaptive. It is generally accepted that maladaptive LV remodeling underlies the progression to heart failure in various forms of heart disease. The central hypothesis of this study is that we can leverage echocardiographic imaging techniques to non-invasively quantify changes in biomechanical function and mechanical properties in a serial manner throughout the progression towards …

A Partially Automated Process For The Generation Of Believable Human Behaviors, Bridgette Parsons

Theses and Dissertations

Modeling believable human behavior for use in simulations is a difficult task. It re- quires a great deal of time, and frequently requires coordination between members of different disciplines. In our research, we propose a method of partially automating the process, reducing the time it takes to create the model, and more easily allowing domain experts that are not programmers to adjust the models as necessary. Using Agent-Based modeling, we present MAGIC (Models Automatically Generated from Information Collected), an algorithm designed to automatically find points in the model’s decision process that require interaction with other agents or with the sim- …

Modeling Complex Oxides: Thermochemical Behavior Of Nepheline-Forming Na-Al-Si-B-K-Li-Ca-Mg-Fe-O And Hollandite-Forming Ba-Cs-Ti-Cr-Al-Fe- Ga-O Systems, Stephen A. Utlak

Theses and Dissertations

High concentrations of Na2O and Al2O3 in the liquid high-level radioactive waste (HLW) stored at the Hanford Site can cause nepheline (NaAlSiO4) to precipitate in a vitrified monolithic waste form upon cooling. Nepheline phase formation removes glass- former SiO2 and -modifier Al2O3 from the immobilization matrix in greater proportion to alkalis, which can reduce glass durability and consequently increase the leach rate of radionuclides into the surrounding environment.

Current uncertainty in defining the HLW glass composition region prone to precipitating nepheline necessitates targeting a conservative waste loading, which raises operational costs by extending the liquid radioactive waste disposal mission and …

Development Of Scalable And Tunable Super- Hydrophilic And - Hydrophobic Coatings On The Cu Substrate For Phase Change Heat Transfer Applications, Raikan Saad Dawas

Theses and Dissertations

The aim of this study is to enhance and sustain the thin liquid film evaporation (TLFE) as well as dropwise condensation (DWC) on scalable copper substrates. The current dissertation consists of two sections. The objective of the first section is to enhance the dry cooling technology which is widely used in industrial applications such as in the air side of power plants, AC unit, or electronic cooling. However, the thermal dissipation performance is limited with low heat transfer coefficients (HTCs) due to the low thermal conductivity and density of the air. Inspired by the phase change heat transfer during the …

An Anatomical Basis Of The Differential Cholinergic Modulation Of Valence-Specific Pyramidal Neurons In The Basolateral Amygdala, Nguyen Vu

Theses and Dissertations

Emotion is a crucial component of the decision-making process. The amygdala, known as the “orchestrator” of the emotion circuit, associates emotional valence with incoming sensory stimuli and thus contributes to decision- making. Within the basolateral nucleus of the amygdala (BLA), spatially segregated and genetically distinct pyramidal neurons (PNs) have been identified based on their correspondence to distinct behavioral stimuli. These PNs project to several brain regions mediating different aspects of the emotional spectrum.

For example, BLA PNs projecting to prelimbic (PL) and infralimbic (IL) cortex are involved in fear acquisition and fear extinction, respectively. However, the mechanism by which these …

Continuous Tow Path Generation For Constant And Variable Stiffness Composite Laminates On Single And Double Curved Surfaces, Caleb R. Pupo

Theses and Dissertations

A novel approach for the generation of steered tow paths on curved shell surfaces is presented. The approach is used to translate optimal theoretical analysis expressed from ply to ply as fiber angle distributions for steered laminates into discrete tow paths on planar, single and double curved surfaces. By adapting the multi mesh approach earlier developed by van Tooren and Elham [1–3] to the new tow path generation code. Two meshes are utilized, a coarse mesh which is generated during the optimization and contains the optimal fiber angle distributions, and a denser mesh obtained from tessellating the surface to better …

Beneficial Effects Of Resveratrol Against Colitis And Colorectal Cancer Mediated By The Host Microbiome, Epigenome, And Immune Response, Haider Rasheed Daham Alrafas

Theses and Dissertations

Resveratrol, a natural polyphenol compound found in red wine, the skins of grapes, and other plant products, has been used as a traditional medicine for thousands of years throughout human history, but current research has revealed this natural component is capable of modulating a variety of immunological, microbial, and epigenetic mechanisms to improve overall health and well-being of hosts that consume it. Colitis, an inflammatory bowel disease characterized by chronic inflammation in the colon and rectum, which has been associated with colon cancer. This cancer incidence is rising in younger adults in the US. Thus, newer approaches to prevent colitis …