Engineering Commons^™

Coldstartcpi: Induced-Fit Theory-Guided Dti Predictive Model With Improved Generalization Performance, Qichang Zhao, Haochen Zhao, Linyuan Gao, Kai Zheng, Yajie Li, Qiao Ling, Jing Tang, Yaohang Li, Jianxin Wang

Computer Science Faculty Publications

Predicting compound-protein interactions (CPIs) plays a crucial role in drug discovery. Traditional methods, based on the key-lock theory and rigid docking, often fail with novel compounds and proteins due to their inability to account for molecular flexibility and the high sparsity of CPI data. Here, we introduce ColdstartCPI, a framework inspired by induced-fit theory, which leverages unsupervised pre-training features and a Transformer module to learn both compound and protein characteristics. ColdstartCPI treats proteins and compounds as flexible molecules during inference, aligning with biological insights. It outperforms state-of-the-art sequence-based models, particularly for unseen compounds and proteins, and shows strong generalization capability …

Csc 22100 Software Development Laboratory Homework Assignment #1, Mitch Gershonowitz

Open Educational Resources

This is the first homework assignment for an Introduction to Java Programming course, which requires the students to write Java code using industry-accepted conventions. The assignment requires the student to write a Java method that accepts a date in an internationally-recognized format and returns a String object in Julian Date Format (JDF) with format YYDDD.

Csc 22100 Software Development Laboratory Homework Assignment #3, Mitch Gershonowitz

Open Educational Resources

This is the third homework assignment for an Introduction to Java Programming course, which requires the students to write Java code using industry-accepted conventions. The assignment requires the student to write a Java classes and interfaces that demonstrate usage of passing lambda expressions to methods, as well as demonstrating polymorphism and inheritance.

Nebraska Water Center Annual Report 2025

Nebraska Water Center: Administrative Materials

Training Nebraska's future water professionals, research publications, water sciences laboratory impact and know your well curriculums and community impact

Systematic Analysis Of Fatal Collisions Between Mobile Equipment And Pedestrian Workers To Inform The Use Of Proximity Detection Devices, Damien Burlet-Vienney, François Gauthier, Chantal Gauvin

Articles dans des actes de congrès

Context.

Collisions between mobile industrial equipment and pedestrian workers (PWs) are a major occupational health and safety concern, particularly on construction sites (e.g., during earth-moving operations). The use of driver aids, such as proximity warning devices designed to alert workers and drivers of potential collisions, is a growing and constantly developing avenue of prevention (e.g., AI-enhanced cameras; RFID tags). However, structured feedback to guide the implementation of these technologies on mobile equipment remains rare (e.g., technology choice, installation and settings).

Objective/Methodology.

 In this context, a systematic analysis of all fatal accident reports related to this issue for the province of …

How Inclusive Are Degree Programs In Operations Research And Analytics In The U.S.?, Michael P. Johnson Jr., Tayo Fabusuyi, Elham Hesari, Salina Chu

Public Policy and Public Affairs Faculty Publication Series

Academic programs in colleges and universities in the United States have increasingly embraced principles of equity and inclusion to support student success and diversity within professions. Innovations in diversity, equity, and inclusion (DEI) in university programs require baseline data on students, faculty and administrators, curricula, and programmatic support. A review of data shows that underrepresented groups in the US workforce have limited visibility in operations research and analytics. A review of DEI-related research reveals some relevant insights including a gap in studies specific to operations research and analytics.

To provide evidence in support of DEI initiatives in OR/analytics, we describe …

Cost-Effective Hierarchical Cobalt Nanostructured Laser-Induced Graphene For Enhanced Uric Acid Detection, Anju Joshi, Gymama Slaughter

Center for Bioelectronics Publications

This study presents an innovative, cost-effective strategy to develop a flexible, enzyme-free biosensor for the sensitive detection of uric acid (UA). Utilizing electrochemically modified cobalt nanostructured on laser-induced graphene electrodes (CoNCs/LIG), this approach surpasses traditional noble metal-based electrocatalysts in sensitivity and affordability. The one-step electrochemical modification method is efficient and straightforward, enabling the uniform deposition of hierarchical flower-like cobalt nanostructures. These structures synergistically enhance the performance of the LIG, resulting in a broad detection range of 5 to 700 µM with a sensitivity of 6.75 µA µM^-¹ cm^-² and a low detection limit of 3.66 µM for UA. …

Nanomaterial-Enabled Enhancements In Thylakoid-Based Biofuel Cells, Amit Sarode, Gymama Slaughter

Center for Bioelectronics Publications

Thylakoid-based photosynthetic biofuel cells (TBFCs) harness the inherent light-driven electron transfer pathways of photosynthesis to enable sustainable solar-to-electrical energy conversion. While TBFCs offer a unique route toward biohybrid energy systems, their practical deployment is hindered by sluggish electron transfer kinetics, unstable redox mediators, and inefficient interfacing between biological and electrode components. This review critically examines recent advances in TBFCs, with a focus on three key surface engineering strategies: (i) incorporation of nanostructured materials to enhance electrode conductivity and surface area; (ii) application of redox mediators to facilitate charge transfer between photosynthetic proteins and electrodes; and (iii) functional exploitation of individual …

Increased Visual Response Delay Impact On Sensorimotor Control In Persons With Multiple Sclerosis, Julie C. Wagner, Frankie M. Ingram, Vincenzo Daniele Boccia, Matilde Inglese, Maura Casadio, Camilla Pierella, Andrea Canessa, Robert A. Scheidt, Scott A. Beardsley

Biomedical Engineering Faculty Research and Publications

Multiple Sclerosis negatively affects hand function in 60% of cases. Upper extremity dysfunction in persons with Multiple Sclerosis (PwMS) has previously been linked to slower, more variable movement, increased visual response delays (T_v), and neuroimaging evidence of altered brain activity; yet no one knows how these aspects relate to each other. This work combines clinical, kinematic, sensorimotor control, and neural imaging techniques to gain a more complete understanding of how upper extremity dysfunction arises in PwMS. Twenty PwMS and 20 Controls completed a reach and hold task with simultaneous electroencephalography recorded to determine if increased T_v in …

Characterization Of Cancer Cell Migration Through Brain Vascular Endothelium Model, Malak Taysser Al-Noubani

2025 Fall Honors Capstones Projects - Archive

One of the hallmarks of cancer is increased vessel growth to feed the tumor’s rapid expansion. The newly formed blood vessels are immature and often leaky due to structural and functional abnormalities. This leads to ineffective anti-cancer drug delivery and provides tumor cells with additional opportunities to metastasize. We propose to develop an in vitro vascular endothelium model and introduce aggressive triple-negative breast cancer (TNBC) cells to mimic the tumor environment, utilizing a Transwell migration assay. The impact of TNBC cells on vessel permeability will be assessed by staining for tight junction proteins, and the migratory capabilities of TNBC cells …

Ioto: Never Open A Stiff Lid Again, Gabriel Portugal

Libraries Award for Undergraduate Scholarship

Background: From baby food to pickles, food jars are a common find in American homes. Unfortunately,  the task of opening a stiff jar lid can be very difficult for consumers with lower grip strength, parkinsons,  or arthritis. While there are a variety of products on the market to help make this easier, there exist few jar  openers that can be used by these consumers. Objective: This project aimed to research and develop  (R&D) an improved hands-free jar opener that is accessible for consumers with the most advanced  cases of limited arm strength. Methods: R&D followed a Design Thinking approach with …

Indigenous Technology Futurisms: Reclaiming Mackinac Island In Virtual Reality, Madeline A. Gupta

Library Map Prize

In Indigenous Technology Futurisms: Reclaiming Mackinac Island in Virtual Reality, Madeline A. Gupta introduces a place-based digital storytelling project that uses interactive mapping as the foundation for cultural reconnection and community wellness. Centered on Mackinac Island—ancestral land of the Anishinaabe people—the project features a custom-designed map by an Anishinaabe artist, allowing users to navigate a VR website by selecting specific locations across northern Michigan. Each map point opens into a spatial video experience paired with traditional audio content, including oral histories, poetry, and songs.

The project reframes digital cartography through an Indigenous lens, challenging Western colonial mapping practices that …

Generative Adversarial Networks For Dimensionality Reduction In Evtol Aircraft Takeoff Trajectory Optimization, Samuel Sisk, Farzaam Khorasani-Gerdehkouhi, Abdulaziz Abutunis, K. Chandrashekhara, Xiaosong Du

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Electric vertical takeoff and landing (eVTOL) aircraft play a key role in urban air mobility (UAM), which aims to alleviate traffic congestion in urban areas. Despite their value, eVTOL aircraft suffer from battery energy consumption, which affects their range and endurance in real world flight tasks. Especially, the takeoff process has been identified for excessive power demands. Multidisciplinary analysis and optimization manage to discover optimal takeoff trajectories with minimum energy consumption while balancing multidisciplinary trade-offs, such as short distance takeoff and passengers' comfort. However, conventional parametrization methods (such as B-spline curves) leverage an empirically high-dimensional design space to include real …

Ai-Powered Image-Based Assessment Of Pressure Injuries Using You Only Look Once (Yolo) Version 8 Models, Mehedi Hasan Tusar, Fateme Fayyazbakhsh, Niloofar Zendehdel, Eduard Mochalin, Igor Melnychuk, Lisa Gould, Ming C. Leu

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Objective: The primary objective of this study is to enhance the detection and staging of pressure injuries using machine learning capabilities for precise image analysis. This study explores the application of the You Only Look Once version 8 (YOLOv8) deep learning model for pressure injury staging. Approach: We prepared a high-quality, publicly available dataset to evaluate different variants of YOLOv8 (YOLOv8n, YOLOv8s, YOLOv8m, YOLOv8l, and YOLOv8x) and five optimizers (Adam, AdamW, NAdam, RAdam, and stochastic gradient descent) to determine the most effective configuration. We followed a simulation-based research approach, which is an extension of the Consolidated Standards of Reporting Trials …

Multifidelity Dust Erosion Analysis Of Mars Entry Vehicles, Adam Boland, Dominic Zanti, Serhat Hosder, Andrew Hinkle

Mechanical and Aerospace Engineering Faculty Research & Creative Works

The objective of this paper is to present a multifidelity approach for estimating recession rate and kinetic energy impact rate on the surface of planetary entry vehicles operating in dusty atmospheric environments at hypersonic speeds. The multifidelity model used a co-Kriging approach that combined a low-fidelity correlation with a correction factor from high-fidelity CFD solutions. The developed multifidelity model enables efficient and accurate exploration of a design space to determine at what conditions encountering dust is most dangerous to TPS survivability. Two sample problems are used to demonstrate the effectiveness of the approach: the Mars 2020 lander and a HIAD-type …

Hands-Free Uav Control: Real-Time Eye Movement Detection Using Eog And Lstm Networks, Niloofar Zendehdel, Khosro Ghorbani Zadeh, Haodong Chen, Yun Seong Song, Ming C. Leu

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Industry 4.0 has created a growing need for effective human-robot collaboration (HRC). As robots and humans work more closely together, efficient communication becomes essential for coordinating their actions seamlessly. While speech may seem like the obvious choice for communication, noisy factory environments can render it impractical. Additionally, workers often have their hands occupied with assembly tasks, making hand-controlled interfaces less practical for controlling robots. To address these challenges, this paper presents a novel, hands-free method for robot control using electrooculography (EOG) signals–specifically, eye movements and blinks–with unmanned aerial vehicles (UAVs) used as the demonstration platform. We developed a real-time system …

Phase Change Cells And Verification Of Gallium As Thermal Calibration Reference In Space, Harri Latvakoski, T. Shane Topham, Gail Bingham, Mike Watson, Igor Podolski

Space Dynamics Laboratory Publications

• Phase change cell introduction

• Design and ground testing of on-orbit phase cells

• ISS phase cell flight experiment

Radiometric Sensor Level Calibration For Remote Sensing (Planning, Testing, And Operation), Joe Tansock

Space Dynamics Laboratory Publications

Contents

• What is Calibration and Why is it Important (example) 
• Remote Sensor Calibration Approaches
• Typical Space-based Sensor Lifecycle and Calibration Efforts at SDL
• EO Calibration Applications (example) 
• Example Calibrations at SDL
• Calibration Testing at SDL and example Calibration Equipment
• Calibration is Multi-Path
• Student Employment/Projects to Support SDL Calibration

Calibration For Small Satellite Payloads, Jason Knudsen, Christian Conkle, Alex Allgrunn, Deron Scott

Space Dynamics Laboratory Publications

SDL Presentation on Calibration for Small Satellite Payloads

Rbi Ground Calibration, Harri Latvakoski, Greg Cantwell, James Peterson, Joel Cardon

Space Dynamics Laboratory Publications

• RBI overview

• Ground calibration objectives

• Calibration configurations & chamber setup

• Calibration tests & equipment

Small Satellite Payload Calibration, Deron Scott, Cole Miller, Eli Salay, Shane Canfield, Scott Hansen, Matt Berghout, Jan Kunzler, Duane Miles

Space Dynamics Laboratory Publications

SmallSat missions have cost, time, and scale limitations. Calibration methods can be optimized to enable mission success at a low cost by providing customers the best “bang for their buck.”

Multi-Layered Security Approaches For A Modular Open Network Architecture-Based Satellite, Brandon Shirley, Quinn Young, Peter Wegner, Jacob Christensen, Jeffrey Janicik

Space Dynamics Laboratory Publications

Overview

• Introduction
• Open System Architecture (OSA) and Modular Open Network Architecture (MONA) background
• Security Challenges
• Security Principles
• Solutions

The Atmospheric Waves Experiment (Awe), Ludger Scherliess, Yucheng Zhao, Pierre-Dominique Pautet

Space Dynamics Laboratory Publications

Modern theory and modeling indicate vertically propagating Gravity Waves (GWs), waves generated primarily by severe weather disturbances, have profound effects on the variability and mean state of the Ionosphere-Thermosphere-Mesosphere (ITM) system, and can significantly impact space-based communications, navigation, and tracking.

Physics-Constrained Generative Artificial Intelligence For Rapid Takeoff Trajectory Design, Samuel Sisk, Xiaosong Du

Mechanical and Aerospace Engineering Faculty Research & Creative Works

The urban air mobility (UAM) industry is rapidly growing to alleviate regional transportation congestion. Electric vertical takeoff and landing (eVTOL) aircraft plays a critical role in this growth due to their efficiency and reduced operating cost. However, excessive energy demands by the takeoff phase impact the practicality of the aircraft. Conventional multidisciplinary analysis and optimization (MDAO) identifies a minimum energy trajectory but can be computationally intensive due to iteratively evaluating high-fidelity simulation models. In addition, complex constraints in practical MDAO pose crucial challenges to the already demanding process. Surrogate models enable efficient design optimization, but complex constraints could prohibit surrogate-based …

Versatile Injector Platform: A Modular Design For Supersonic Flow Research, Connor Bell, Davide Viganò

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Fuel–air mixing remains a critical challenge in the development of high-speed air-breathing propulsion due to the extremely short residence times in supersonic combustors. Experimental studies are essential to investigate the underlying mixing mechanisms, but they require injection systems that can deliver repeatable and controlled flow conditions. In this work, we present the design of a modular strut-type injection platform developed for the Missouri S&T Supersonic Wind Tunnel. In its initial configuration, the platform features a planar trailing-edge slit to generate a two-dimensional jet and includes interchangeable trailing-edge modules to support a wide range of geometries and flow-control strategies. Designed with …

An Iterative Shifting Disaggregation Algorithm For Multi-Source, Irregularly Sampled, And Overlapped Time Series, Colin O. Quinn, Ronald H. Brown, George F. Corliss, Richard J. Povinelli

Electrical and Computer Engineering Faculty Research and Publications

Accurate time series forecasting often requires higher temporal resolution than that provided by available data, such as when daily forecasts are needed from monthly data. Existing temporal disaggregation techniques, which typically handle only single, uniformly sampled time series, have limited applicability in real-world, multi-source scenarios. This paper introduces the Iterative Shifting Disaggregation (ISD) algorithm, designed to process and disaggregate time series derived from sensor-sourced low-frequency measurements, transforming multiple, nonuniformly sampled sensor data streams into a single, coherent high-frequency signal. ISD operates in an iterative, two-phase process: a prediction phase that uses multiple linear regression to generate high-frequency series from low-frequency …

A Century Of Sediment Metal Contamination Of Mar Menor, Europe's Largest Saltwater Lagoon, Irene Alorda-Montiel, Valentí Rodellas, Ariane Arias-Ortiz, Albert Palanques, Andrea G. Bravo, Júlia Rodriguez-Puig, Aaron Alorda-Kleinglass, Carlos Green-Ruiz, Marc Diego-Feliu, Pere Masqué, Javier Gilabert, Jordi Garcia-Orellana

OES Faculty Publications

Coastal enclosed ecosystems, such as lagoons, are vulnerable to anthropogenic impacts because they favor the accumulation of contaminants from the surrounding watersheds, particularly in their sediments. Europe's largest saltwater lagoon, the Mar Menor (SE, Iberian Peninsula), is a highly impacted ecosystem and the first in the continent to be granted personhood rights. Based on a high-resolution spatial and temporal dataset, we present the historical reconstruction of metal contamination in this ecosystem during the last century. Our results highlight that sediment metal contamination has been mainly driven by the development of the mining industry in the nearby Sierra Minera de Cartagena-La …

Ensemble Machine Learning Approaches For Bathymetry Estimation In Multi-Spectral Images, Kazi A. Islam, Omar Abdul-Hassan, Hongfang Zhang, Victoria Hill, Blake Schaeffer, Richard Zimmerman, Jiang Li

OES Faculty Publications

Traditional bathymetry measures require a large number of human hours, and many bathymetry records are obsolete or missing. Automated measures of bathymetry would reduce costs and increase accessibility for research and applications. In this paper, we optimized a recent machine learning model, named CatBoostOpt, to estimate bathymetry based on high-resolution WorldView-2 (WV-2) multi-spectral optical satellite images. CatBoostOpt was demonstrated across the Florida Big Bend coastline, where the model learned correlations between in situ sound Navigation and Ranging (Sonar) bathymetry measurements and the corresponding multi-spectral reflectance values in WV-2 images to map bathymetry. We evaluated three different feature transformations as inputs …

Tidal Flooding Contributes To Eutrophication: Constraining Nonpoint Source Inputs To An Urban Estuary Using A Data Driven Statistical Model, Alfonso Macías-Tapia, Margaret R. Mulholland, Corday R. Selden, Sophie Clayton, Peter W. Bernhardt, Thomas R. Allen

OES Faculty Publications

In coastal urban areas, tidal flooding brings water carrying nutrients and particles back from land to estuarine and coastal waters. A statistical model to predict nutrient loads during tidal flooding events can help estimate nutrient loading from previous and future flooding events and adapt nutrient reduction strategies. We measured concentrations of dissolved inorganic nitrogen and phosphorus in floodwater at seven sentinel sites during 15 tidal flooding events from January 2019 to September 2020. The study area was the Lafayette River watershed in Norfolk, VA, USA, which is prone to tidal flooding and is predicted to experience more frequent and intense …

Experimental And Simulation Of Compression After Impact (Cai) Tests For Thermoplastic Composite Materials, M. M. Shahzamanian, Sydney Houck, Li Ai, Md Mushfiqur Rahman Fahim, Sourav Banerjee, Wout De Backer, Paul Ziehl

Civil Engineering Faculty Publications

Damage caused by low velocity impacts in composite materials may go undetected, resulting in significant damage being unnoticeable. This phenomenon has been studied using experiments and simulations on a typical composite material, Toray T1225 LM-PAEK UD Tape, following impacts with varying energy levels. To the authors’ knowledge, there is a lack of information on thermoplastics and compression after impact (CAI) in the publicly available literature, and there have been insufficient results and discussions regarding CAI tests on thermoplastic composite materials at the relatively high levels of impact used, especially with the rise in the use of thermoplastic materials for the …