Biomechanical Engineering Commons^™

Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence

Theses and Dissertations

Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …

Evaluation Of Regional Extrathoracic Deposition Of Low- And High-Momentum Aerosol Using Anatomically-Correct In Vitro Airway Models, Sana Hosseini

Theses and Dissertations

The popularity of pulmonary aerosol delivery is increasing due to numerous advantages including non-invasiveness, fast onset of action, avoidance of the first-pass metabolism, and relatively good patient compliance. However, aerosol delivery to the site of action within the extrathoracic regions is challenging to quantify from a regulatory perspective due to the combined effects of the device and formulation characteristics, complex morphology of the airways resulting in extreme anatomical variabilities, and user dependent administration methods. Besides the therapeutic aerosol delivery, electronic nicotine delivery systems (ENDS) are a user-driven aerosol technology used to deliver nicotine as one of the electronic liquid (e-liquid) …

Cycloidal-Drive Joint Design For Wearable Exoskeletons, Abhi J. Rawal

Theses

This thesis's scope was to construct a highly back drivable and compact joint design that can be used for wearable exoskeletons specifically designed to assist with rehabilitation. A compact cycloidal gear transmission was designed to satisfy the compactness requirement while ensuring the minimum torque is required for backdriving the mechanism. The joint was designed based on the compact cycloidal drive specifications, and the backdrivability test was performed to measure the minimum torque required (1.20 Nm) to backdrive. The joint design incorporates various important features such as rotation lock feature to prevent hyperextension, a housing design that offers the benefit of …

Microparticle Propulsion For In Vivo Navigation, Louis Rogowski

Mechanical Engineering Research Theses and Dissertations

Microscale propulsion impacts a diverse array of fields, with simplistic microrobots allowing for novel innovations in microscale surgery and drug delivery. Propulsion at the microscale is constrained by physics, with time-reversal and geometric symmetries limiting available propulsion mechanisms. However, certain fluid environments and surface coatings allow for the propulsion of microparticles through externally applied magnetic fields. Presented here is a detailed analysis of microparticles propelling using spontaneous symmetry breaking, flagella surface coatings, and multi-modal actuation mechanisms. Spontaneous symmetry breaking in nonlinearly viscoelastic fluids is presented for the first time in literature, with two equal and opposite propulsion states existing along …

Constitutive Modeling Of Force-Controlled Fatigue Testing In Human Meniscus Tissue, Bradley Scott Henderson

Boise State University Theses and Dissertations

The meniscus is a wedge-shaped fibrocartilaginous tissue located between the femur and tibia that helps stabilize the knee and protect the underlying cartilage. There are 2.5 million reported knee injuries each year, making it the most injured joint in the human body. Nearly twenty percent of these injuries are due to a torn meniscus, leading to over half a million meniscus surgeries performed in the United States annually. Therefore, it is critical to understand the failure modes of meniscus tissue to prevent these debilitating injuries. A failure mode that accounts for one-third of all meniscus injuries is repeated exposure to …

In Vitro Method To Quantify And Visualize Volumetric Wear In Meniscus Subjected To Joint Loading Using A 3d Optical Scanner, Kate J. Benfield

Boise State University Theses and Dissertations

The menisci are fibrocartilaginous soft tissues that act to absorb and distribute load across the surface of the knee joint. As a result of mechanical wear and large repetitive loading, meniscus tissue can begin to breakdown, or degenerate. Meniscus degeneration increases the risk of tearing, weakened tissue integrity, and the progression of osteoarthritis. Therefore, it is imperative to understand the wear behavior of whole human meniscus to identify conditions that may significantly increase the risk of degeneration.

The objective of this study is to develop and validate an in vitro methodology for characterizing volumetric wear behavior in whole human meniscus …

Understanding The Effects Of Long-Duration Spaceflight On Fracture Risk In The Human Femur Using Finite Element Analysis, Keyanna Brielle Henderson

Master's Theses

Long-duration spaceflight has been shown to have significant, lasting effects on the bone strength of astronauts and to contribute to age-related complications later in life. The microgravity environment of space causes a decrease in daily mechanical loading, which signals a state of disuse to bone cells. This affects the bone remodeling process, which is responsible for maintaining bone mass, causing an increase in damage and a decrease in density. This leads to bone fragility and decreases overall strength, posing a risk for fracture. However, there is little information pertaining to the timeline of bone loss and subsequent fracture risk.

This …

Final Design Review Report: The Underdogs, Parker Johnson, Jack Montgomery, Katherine Thomas

Mechanical Engineering

Aspen is a three-legged dog with mobility issues from Berkeley, California. She was hit by a car and her rear left leg was amputated at the hip. Robin Swanson, Aspen's owner, and her friend, Audrey Beil, are the sponsors for this project. Jack Montgomery, Katherine Thomas, and Parker Johnson, “The Underdogs”, are tasked with helping Aspen regain some of her mobility and the ability to go on walks. Research was done into the problem by talking with the sponsors and looking into existing products, designs, and patents. This document, the Final Design Review Report, outlines the background information, problem specification, …

Deep-Sea Water Collector, Chandler Jones, Jenny Verheul, Michael Di Giorgio

Mechanical Engineering

Properties such as nutrients, DNA, pH levels, and primary productivity are difficult to measure onboard an Underwater Remotely Operated Vehicle (UROV) as mobile submarine sensors are highly expensive and conventional water capture devices are too large to be equipped. However, these properties provide an integral view into our oceans, the species that inhabit them, and our influence on the environment. Collected samples of seawater taken back to labs allow researchers to see a clearer picture of ecosystems’ inhabitants and lifecycle with the analysis of Environmental DNA (eDNA) among many other properties. The scope of this project is to design a …

In The Pursuit Of Assistance: A Team's Desire To Not Let A Congenital Amputation Get In A Young Boy's Way, Carl Russell Iii, Gavin Loucks, Kirsten Wozniak

Purdue Journal of Service-Learning and International Engagement

EPICS is a service-learning design program run through Purdue University. It strives to teach students design skills through providing for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Biomedical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. William Sevick is an elementary school student with a congenital arm amputation. William and his family have been working with the BME team for the past three years designing assistive devices with the purpose of improving his actions in daily life such as eating, playing games, and riding his bike.

Efficient Trajectory Optimization For Curved Running Using A 3d Musculoskeletal Model With Implicit Dynamics, Marlies Nitschke, Eva Dorschky, Dieter Heinrich, Heiko Schlarb, Bjoern M. Eskofier, Anne D. Koelewijn, Antonie J. Van Den Bogert

Mechanical Engineering Faculty Publications

Trajectory optimization with musculoskeletal models can be used to reconstruct measured movements and to predict changes in movements in response to environmental changes. It enables an exhaustive analysis of joint angles, joint moments, ground reaction forces, and muscle forces, among others. However, its application is still limited to simplified problems in two dimensional space or straight motions. The simulation of movements with directional changes, e.g. curved running, requires detailed three dimensional models which lead to a high-dimensional solution space. We
extended a full-body three dimensional musculoskeletal model to be specialized for running with directional changes. Model dynamics were implemented implicitly …

Surface Modification Of Biomaterials To Reduce Polyethylene Wear In Metal-Polymer Contact / Tan Mean Yee, Tan Mean Yee

Student Works (2020-2029)

This research focus on studying different surface modification (Texturing and DLC coating) on the metal part of TKR (Total knee replacement) in improving UHMWPE (Ultra-high molecular weight polyethylene) wear. TKR was widely being used to relieve knee pain due to osteoarthritis and further restore knee function of patients. Generally, TKR consists of metal femoral component, metal tibial component, and UHMWPE tibial insert. TKR will fail due to various factors over time, however, this study will be focusing on failure cause by loosening. Loosening failure of TKR was mainly caused by wear debris generated during articulation motion, where UHMWPE wear was …

An Affordable And Portable Palpable System For Sensing Breast Tissue Abnormalities, Cody J. Clarke

Montview Journal of Research & Scholarship

Due to the high cost of equipment and lack of trained personnel, manual palpation is a preferred alternative breast examination technique over mammography. The process involves a thorough search pattern using trained fingers and applying adequate pressure, with the objective of identifying solid masses from the surrounding breast tissue. However, palpation requires skills that must be obtained through adequate training in order to ensure proper diagnosis. Consequently, palpation performance and reporting techniques have been inconsistent. Automating the palpation technique would optimize the performance of self-breast examination, optimize clinical breast examinations (CBE), and enable the visualization of breast abnormalities as well …

Quantifying Changes In Muscle Force In The Presence Of Fatigue, Emily Bywater

The Journal of Purdue Undergraduate Research

No abstract provided.

Biomechanical Investigation Of Individual With Over-Pronation And Over-Supination Foot During Walking, Ghani Nur Saibah

Student Works (2020-2029)

Over-pronation and over-supination foot conditions are foot deformity that can lead to unstable ankle and subtalar joint during walking. They are define as condition where the foot roll in and out excessively from its neutral line and can lead to misalignment of the foot and leg in human in which can create abnormal gait cycle. Therefore, the purposes of this study are to analyze the foot-ankle joint biomechanical behavior including the range of motion, joint moment, joint power and GRF in a complete gait cycle for all subjects in this study and to compare the foot-ankle biomechanical behavior between normal …

Elevate Dental, Connor Merrick, Everett Johnson, Jonah Holbrook

Mechanical Engineering

During a dental procedure, patients are often required to have a bite block placed in their mouths to keep them open for the duration of their procedure. These can be very uncomfortable for patients due to lack of properly-fitting sizes. This project presents an alternative fully adjustable bite block that is affordable, comfortable, and easy to use for dental personnel.The bite block is a two piece side loading design that uses interlocking teeth to supply a range of five sizes.

Adaptive Exercise Equipment, Jake Ryan Walejko, Spencer Goodman, Kalina Burns, Journey Martinson

Mechanical Engineering

This document outlines the senior design project carried out by a team of mechanical engineering students at California Polytechnic State University, San Luis Obispo. The task is to design adapted exercise equipment for the non-profit organization, Achievement House. The objective of this Final Design Review is to document the final design, manufacturing plan, design verification plan, and project management plan. In addition, this document includes previously presented information on the project background, objectives, and concept design. The background and objective sections document various forms of customer research and include the project goals developed by the athletes and fitness instructors of …

Control And Locomotion Of Inertially And Magnetically Actuated Multi-Scale Robotic Systems, Ehab Al Khatib

Mechanical Engineering Research Theses and Dissertations

In this research, two actuation systems were introduced, inertial and magnetic actuation. In the inertial actuation, the robot used the transfer of momentum to navigate, and this momentum could be generated by spinning masses and wheels. Recent studies in our System Laboratory proved that a wide range of inertially actuated locomotion systems could be generated. This can be achieved by using a family tree approach, starting from a very simple system, and progressively evolving it to more complex ones. The motion diversity of these robots inspired us to extend their locomotion from a macro scale to millimeter and micro scales. …

Effects Of Hard-To-Soft Segment Ratios On The Synthesis And Physico-Mechanical Properties Of Polyurethane Films, Aaron C. Wilson

Mechanical Engineering Theses

Blood-contacting cardiovascular stents often induce a secondary clotting event due to unrestricted enzymatic activities. The use of hemocompatible polyurethane coatings on these implantable devices is one of the most promising methods to reduce device rejection. In this study, four commercial polyurethane films of various thicknesses and compositions were evaluated for their anticoagulation properties. Results suggested that these films exhibited excellent thermal and physico-mechanical properties while capable of increasing contact time with blood plasma by over a thousand-fold as compared to a control surface. Due to the unknown structure and composition of these commercial films, polyurethane samples were synthesized from toluene …

Design Of A 3d Printed Bioreactor For Bone Cancer Research, Brooklyn K. Vanderwolde, Katelyn Hillson

The Journal of Undergraduate Research

Bone cancer is an aggressive disease and has peak occurrence during physiological stimulation of growth and aging. Astronauts who undergo long-term space missions also acquire an increased risk of bone tissue degeneration and cancer. Few in-vitro models currently exist capable of reproducing the complex microenvironment of bone tissue to support multicellular activity in a three-dimensional structure. This limits the ability to understand disease progression and develop suitable treatment strategies. Therefore, developing a bone tissue model and an associated bioreactor is critical to understand the risks associated with cancer progression and improve treatment and preventions related to those risks. The goal …