Combinatorial Approaches For Effective Design, Synthesis, And Optimization Of Enzyme-Based Conjugates,
2022
West Virginia University
Combinatorial Approaches For Effective Design, Synthesis, And Optimization Of Enzyme-Based Conjugates, Jordan Scott Chapman
Graduate Theses, Dissertations, and Problem Reports (ETD)
The specificity and efficiency with which enzymes catalyze selective chemical reactions far exceeds the performance of traditional heterogeneous catalysts that are predominant in industrial applications such as conversion of commodity chemicals to value-added products, fuel cells, and petroleum refinement. Moreover, biocatalysts exhibit exceptionally high product turnover at ambient conditions with little health and environmental burden. These advantageous qualities have led to the prolific use of enzyme catalysis in pharmaceutical, detergents, and food preservation industries wherein their use has greatly reduced waste generation, Unfortunately, the full slate of benefits that enzymes can impart to a broader range of chemical processes is …
Histological Comparison Of Shark Dermis Across Various Ecomorphologies,
2022
University of North Florida
Histological Comparison Of Shark Dermis Across Various Ecomorphologies, Olivia Schuitema
UNF Graduate Theses and Dissertations
The integument plays essential roles in the structural support, protection, and hydrodynamic capability among fishes. Most shark skin research has been done on the external epidermal layer containing the dermal denticles, while the larger dermis layer has been mostly ignored. The dermis layer in sharks is composed of two layers, the upper stratum laxum and the lower stratum compactum, holding supportive collagen and elastin fibers. There may be morphological and compositional differences in the dermis layers across various species of sharks, although the extent of such is unknown. These potential differences may be represented by various dermal thicknesses and different …
Influence Of Saturation Nonequilibrium And Variable Operation Conditions On The Electromechanical Performance Of Ionic Polymer Metal Composite Actuator Architectures,
2022
West Virginia University
Influence Of Saturation Nonequilibrium And Variable Operation Conditions On The Electromechanical Performance Of Ionic Polymer Metal Composite Actuator Architectures, Allison Maria Arnold
Graduate Theses, Dissertations, and Problem Reports (ETD)
Electroactive polymers (EAPs) continue to gain attention for their potential to offer unique and versatile solutions in the soft robotic and flexible electronic industries. Ionic Polymer-Metal Composites (IPMCs) are a class of ionic-type EAPs which can be configured as capacitor actuators with very low voltage requirements (≤ 5 V AC or DC). Their compact, portable, and lightweight properties, coupled with a biomimetic bending actuation response make them ideal for human-machine integrated technologies such as medical implants, active skins, and artificial muscles. The Nafion-based IPMC can be described as a layered composite capacitor containing an ionic polymer core, sandwiched between chemically …
Effects Of Bonding Pressure And Lamina Thickness On Mechanical Properties Of Clt Composed Of Southern Yellow Pine,
2021
Mississippi State University
Effects Of Bonding Pressure And Lamina Thickness On Mechanical Properties Of Clt Composed Of Southern Yellow Pine, Cody S. Bates
Theses and Dissertations
This study produced cross-laminated timber panels at a range of four lamina thickness (5/8, 1, 1 1/8, and 1 1/4 inch) and three bonding pressures (50, 125, 200 psi), producing a total of 12 panels for mechanical testing. The goal of this study is to observe how the thickness and pressure trends affect the mechanical properties of CLT. Tests include flatwise bending, flatwise shear, internal-bond, and delamination. Results showed that bending MOE decreases as the panel thickness increases while bonding pressure had no significance. Bending MOR was less significant for the thickness and more significant for pressure compared to the …
Effect Of Mechanical Systems In Combating The Schistosomiasis Snails,
2021
The American University in Cairo AUC
Effect Of Mechanical Systems In Combating The Schistosomiasis Snails, Sherine Ahmed El Baradei
Archived Theses and Dissertations
No abstract provided.
Structural Dynamics And Encapsulation Properties Of Polyelectrolyte Complex Micelles,
2021
University of Central Florida
Structural Dynamics And Encapsulation Properties Of Polyelectrolyte Complex Micelles, Sachit Shah
Electronic Theses and Dissertations, 2020-2023
Charged therapeutics such as nucleic acids and proteins can treat a vast range of human diseases that are traditionally undruggable. Their broadness in treating disease is due to their ability to influence cellular function. However, their high charge density and physiological barriers such as enzymatic degradation, hinder the deliverability of these molecules to the sites of disease. Polyelectrolyte complex (PEC) micelles are core-corona nanostructures that can encapsulate charged molecules and offer a platform for delivery. PECs form the core, when two oppositely charged polyelectrolytes are mixed in an aqueous solution, and the micelle corona is a neutral hydrophilic polymer that …
Using Peptide Design To Engineer Polyelectrolyte Complex Biomaterials,
2021
University of Central Florida
Using Peptide Design To Engineer Polyelectrolyte Complex Biomaterials, Sara Tabandeh
Electronic Theses and Dissertations, 2020-2023
The self-assembly of oppositely charged polymers provides a versatile platform to design materials for diverse applications in biology and medicine. Electrostatically-driven phase separation of oppositely charged polymers in aqueous solution gives rise to the formation of a polymer-rich phase called a polyelectrolyte complex (PEC). PECs can be in the form of liquid droplets (complex coacervates) or amorphous solid precipitates. Unlike synthetic polymers, peptides are good candidates for developing tailor-made formulations and structure-property relationships due to their biocompatibility, precise control over sequences, and ability to program hydrogen bonding interactions. However, little is known about the effect of combining additional molecular interactions …
Synergistic Anticancer Response Of Curcumin And Piperine Loaded Lignin-G-P (Nipam-Co-Dmaema) Gold Nanogels Against Glioblastoma Multiforme,
2021
Technological University Dublin
Synergistic Anticancer Response Of Curcumin And Piperine Loaded Lignin-G-P (Nipam-Co-Dmaema) Gold Nanogels Against Glioblastoma Multiforme, Xinyi Zhao, Bilal Javad, Daxing Cui, James Curtin, Furong Tian
Articles
Glioblastoma multiforme (GBM) is the most aggressive and commonly diag- 11 nosed brain cancer and presents a strong resistance to routine chemotherapeutic drugs. 12 The present study involves the synthesis of Lignin-g- p (NIPAM-co-DMAEMA) gold 13 nanogel, loaded with curcumin and piperine to treat GBM. The application has three 14 functions: (1) overcome the limitations of biodistribution, (2) enhance the toxicity of an- 15 ticancer drugs against GBM, (3) identify the uptake pathway. Atom transfer radical 16 polymerization was used to synthesize the Lignin-g-PNIPAM network, crosslinked with 17 the gold nanoparticles (GNPs) to self-assemble into nanogels. The size distribution and …
Tools And Strategies For The Patterning Of Bioactive Molecules And Macromolecules,
2021
CUNY Graduate Center
Tools And Strategies For The Patterning Of Bioactive Molecules And Macromolecules, Daniel J. Valles
Dissertations, Theses, and Capstone Projects
Hypersurface Photolithography (HP) is a printing method for fabricating structures and patterns composed of soft materials bound to solid surfaces and with ~1 micrometer resolution in the x, y, and z dimensions. This platform leverages benign, low intensity light to perform photochemical surface reactions with spatial and temporal control of irradiation, and, as a result, is particularly useful for patterning delicate organic and biological material. In particular, surface- initiated controlled radical polymerizations can be leveraged to create arbitrary polymer and block- copolymer brush patterns. Chapter 1 will review the advances in instrumentation architectures from our group that have made these …
Molecular Dynamics Simulations Of Self-Assemblies In Nature And Nanotechnology,
2021
CUNY Graduate Center
Molecular Dynamics Simulations Of Self-Assemblies In Nature And Nanotechnology, Phu Khanh Tang
Dissertations, Theses, and Capstone Projects
Nature usually divides complex systems into smaller building blocks specializing in a few tasks since one entity cannot achieve everything. Therefore, self-assembly is a robust tool exploited by Nature to build hierarchical systems that accomplish unique functions. The cell membrane distinguishes itself as an example of Nature’s self-assembly, defining and protecting the cell. By mimicking Nature’s designs using synthetically designed self-assemblies, researchers with advanced nanotechnological comprehension can manipulate these synthetic self-assemblies to improve many aspects of modern medicine and materials science. Understanding the competing underlying molecular interactions in self-assembly is always of interest to the academic scientific community and industry. …
Experimental Investigation Of The Performance Of A Hybrid Self-Healing System In Porous Asphalt Under Fatigue Loadings,
2021
Delft University of Technology
Experimental Investigation Of The Performance Of A Hybrid Self-Healing System In Porous Asphalt Under Fatigue Loadings, Shi Xu, Liu Xueyan, Amir Tabakovic, Erik Schlangen
Articles
Self-healing asphalt, which is designed to achieve autonomic damage repair in asphalt pavement, offers a great life-extension prospect and therefore not only reduces pavement maintenance costs but also saves energy and reduces CO2 emissions. The combined asphalt self-healing system, incorporating both encapsulated rejuvenator and induction heating, can heal cracks with melted binder and aged binder rejuvenation, and the synergistic effect of the two technologies shows significant advantages in healing efficiency over the single self-healing method. This study explores the fatigue life extension prospect of the combined healing system in porous asphalt. To this aim, porous asphalt (PA) test specimens with …
Effects Of Uv Exposure On The Thermo-Mechanical Properties Of Cactus Based Biopolymers,
2021
California Polytechnic State University, San Luis Obispo
Effects Of Uv Exposure On The Thermo-Mechanical Properties Of Cactus Based Biopolymers, Madison Glozer, Megan Bolling, Addison Wolfson
Materials Engineering
The viability of renewable biopolymers as sustainable alternatives to synthetic plastics is promising, however ultra-violet (UV) radiation can lead to premature degradation and reduction in the material’s performance. Biopolymers comprised of nopal cactus juice, animal protein, natural wax, and glycerin in differing percentages were studied to obtain thermo-mechanical data in relation to UV exposure. To quantify degradation, dynamic mechanical analysis, thermogravimetric analysis, differential scanning calorimetry, infrared spectroscopy, goniometry and gravimetric measurements were performed. Each formulation experienced mass loss as a result of UV exposure, which could be attributed to water evaporation. The thermogravimetric analysis indicated a reduction in the second …
Use Of Biomimicry Design Approach In Constructing Sustainable Resilient Structures (Case Study: Port Of Beirut),
2021
Master's Student, Faculty of Architecture - Design & Built Environment, Beirut Arab University, Lebanon
Use Of Biomimicry Design Approach In Constructing Sustainable Resilient Structures (Case Study: Port Of Beirut), Farouk Bader, Marwan Halabi, Hiba Mohsen, Maged Youssef
BAU Journal - Creative Sustainable Development
Resiliency is not the same as sustainability, nor its substitute, but definitely the two concepts complement each other’s. Sustainability is the avoidance of depletion of natural resources to maintain ecological balance whereas resiliency is to recover, adapt and keep going in the face of setbacks. While designing with green approach is important but what will happen to leed points if the building becomes uninhabitable due to disasters, that’s where resiliency comes into play. The 2019 statistics showed that natural disasters accounted for 133 billion dollars losses and manmade ones accounted for other 7 billion in addition to 11,755 people worldwide …
Ph-Responsive Oxygen/Glucose Delivery System To Increase Cell Survival Under Ischemia,
2021
Washington University in St. Louis
Ph-Responsive Oxygen/Glucose Delivery System To Increase Cell Survival Under Ischemia, Yubin Ying
McKelvey School of Engineering Graduate Student Theses & Dissertations
Ischemic diseases, including myocardial infarction, stroke and limb ischemia, are life-threatening vascular diseases with high mortality. Under ischemic condition, less blood supply causes insufficient oxygen and nutrients transported to the affected tissues, which leads to cell death. To support cell survival under ischemia, oxygen and nutrients (especially glucose) are needed for aerobic respiration to generate energy. Therefore, directly supplying oxygen and glucose to the ischemic tissues is a promising therapy for ischemic diseases. In this work, we aim to design biomaterials to deliver oxygen and glucose to enhance cell survival under ischemia. In the first project, we fabricated oxygen releasing …
Exploration Of The Sludge Biodiesel Pathway,
2021
University of Nebraska-Lincoln
Exploration Of The Sludge Biodiesel Pathway, Zachary Christman
Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research
Wastewater sludge is an overlooked source of fat, oil, and grease (FOG) that could be converted into biodiesel. The United States produces about 8 million tons of sludge per year. The disposal cost for this amount of sludge is about 2 billion US dollars. The widespread availability and low cost of sludge compared to other biodiesel raw materials make it an economical choice for a renewable fuel. Using sludge as a raw material can produce 25 to 30 mg per gram of fatty acid methyl ester (FAME); the main component of biodiesel. Sludge biodiesel has the potential of transforming a …
Surface Engineering Of Cerium Oxide Nanocyrstal Dispersions: Colloidal Properties, Ageing Effects, & Electroanalysis,
2021
University of Central Florida
Surface Engineering Of Cerium Oxide Nanocyrstal Dispersions: Colloidal Properties, Ageing Effects, & Electroanalysis, Craig Neal
Electronic Theses and Dissertations, 2020-2023
Colloidal materials are highly diverse and present complex physicochemical properties which define their utilities in applications spanning diverse industries. In particular, nano-scale colloids have received tremendous attention due to their unique, specific activities as compared to larger-sized preparations. Within the biomedical sciences, nano-colloids are routinely used as inert carriers of therapeutics and/or diagnostic agents. Beyond this, researchers have developed functional colloids which demonstrate bio-active or diagnostic properties themselves: often related to an optimized, or tuned, surface character. Among these, nanoscale cerium oxide (nanoceria) has shown great promise as a bi-functional, therapeutic material: producing pro- or anti- oxidative chemical response in …
Design And Control Of A Peristaltic Pump To Simulate Left Atrial Pressure In A Conductive Silicone Model,
2021
University of Arkansas, Fayetteville
Design And Control Of A Peristaltic Pump To Simulate Left Atrial Pressure In A Conductive Silicone Model, Jeremy Collins
Mechanical Engineering Undergraduate Honors Theses
According to the CDC, atrial fibrillation is responsible for more than 454,000 hospitalizations and approximately 158,000 deaths per year. A common treatment for atrial fibrillation is catheter ablation, a process in which a long flexible tube is guided through the femoral artery and to the source of arrhythmia in the heart, where it measures the electrical potential at various locations and converts problematic heart tissue to scar tissue via ablation. This paper details the design and control of a low-cost ($400) peristaltic pump system using repetitive control to replicate blood pressure in the left atrium in a conductive silicone model …
Peptoid-Functionalized Gold Nanoparticles For Zika Virus Envelope Protein Detection,
2021
University of Arkansas, Fayetteville
Peptoid-Functionalized Gold Nanoparticles For Zika Virus Envelope Protein Detection, Meagan Olsen
Chemical Engineering Undergraduate Honors Theses
Detection and identification of viral pathogens is essential in providing effective and rapid medical treatment. Well-established detection methods can be expensive, slow, and sometimes unable to provide the needed sensitivity and specificity. The Zika virus is one clinically relevant pathogen that cannot be easily identified due to cross-reactivity with other viruses from the same family. Electrochemical sensors enhanced with peptoid-functionalized gold nanoparticles (AuNPs) are an alternative to traditional techniques that offers rapid, accurate, label-free pathogen detection for point-of-care diagnostics. To this end, a peptoid capable of binding to the Zika virus envelope protein was developed and its binding affinity for …
Characterization Of Protein Aggregation Using A Solid-State Nanopore Device,
2021
University of Arkansas, Fayetteville
Characterization Of Protein Aggregation Using A Solid-State Nanopore Device, Mitu Chandra Acharjee
Graduate Theses and Dissertations
Protein aggregation has been linked to many chronic and devastating neurodegenerative human diseases and is also strongly associated with aging. In the case of neurodegenerative diseases, α, β tubulins and tau proteins dissociate in a neuron cell and aggregate both intra and extra-cellularly. Tau and tubulin aggregations were found as one of the major causes of many neurodegenerative diseases, such as Parkinson’s, Picks, Alzheimer’s, Huntington, and Prion. Finding the state and mechanism of protein aggregation is significant. In this work, tau and tubulin aggregations were detected in ionic solutions using the solid-state nanopore technique. Besides tau and tubulin, aggregations of …
Finite Element Analysis Of Impact Resistant Composites Inspired By Peacock Mantis Shrimp,
2021
University of Southern Maine
Finite Element Analysis Of Impact Resistant Composites Inspired By Peacock Mantis Shrimp, Nandati Shrestha
Thinking Matters Symposium
The fist-like club of the peacock mantis shrimp, a 5-inch marine crustacean, can strike its prey with speed faster than a .22-caliber bullet with an impact force more than 1,000 times its own weight. Although these creatures punch so fast that it even boils the water, they don’t take any damage. This incredible insusceptibility is due to the arrangement of mineralized fiber layers in which each fibrous layer is laid at a slightly rotated angle to form a helicoidal structure that acts as a shock absorber for the club. The goal is to perform a finite element analysis to investigate …
