Biology and Biomimetic Materials Commons^™

Insect Antennae As Bioinspirational Superstrong Fiber-Based Microfluidics, Griffin J. Donley

All Theses

Nature is frequently turned to for inspiration for the creation of new materials. Insect antennae are hollow, blood-filled fibers with complex shape, and are cantilevered at the head. The antenna is muscle-free, but the insect can controllably flex, twist, and maneuver it laterally. To explain this behavior, a comparative study of structural and tensile properties of the antennae of Periplaneta americana (American cockroach), Manduca sexta (Carolina hawkmoth), and Vanessa cardui (painted lady butterfly) was performed. These antennae demonstrate a range of distinguishable tensile properties, responding either as brittle fibers (Manduca sexta) or strain-adaptive fibers that stiffen when stretched (Vanessa cardui ...

Life Cycle Analysis And Implications Of 3d Printed Bio-Based Homes, A Preliminary Study, Claire Liedtka

Honors College

The purpose of this study is to evaluate the life cycle, embodied energy, and sustainability potential for large scale additive manufacturing of 3D printed homes. Additive manufacturing is the process of selectively depositing materials using a 3D printing process, which optimizes material usage and reduces waste. I performed a preliminary Cradle to Cradle Life Cycle Analysis for constructing 3D printed homes using a bio-based material, poly-lactic acid (PLA) filled with wood flour. For purposes of this study, I consider the Life Cycle Analysis to be the environmental assessment of each stage of a product’s life cycle, from material sourcing ...

Limits Of Detection Of Mycotoxins By Laminar Flow Strips: A Review, Xinyi Zhao, Hugh J. Byrne, Christine M. O’Connor, James Curtin, Furong Tian

Articles

Mycotoxins are secondary metabolic products of fungi. They are poisonous, carcinogenic, and mutagenic in nature and pose a serious health threat to both humans and animals, causing severe illnesses and even death. Rapid, simple and low-cost methods of detection of mycotoxins are of immense importance and in great demand in the food and beverage industry, as well as in agriculture and environmental monitoring, and, for this purpose, lateral flow immunochromatographic strips (ICSTs) have been widely used in food safety and environmental monitoring. The literature to date describing the development of ICSTs for the detection of different types of mycotoxins using ...

The Tin Man Needs A Heart: A Proposed Framework For The Regulation Of Bioprinted Organs, Linda Foit

Fordham Law Review

Each day, seventeen people die in the United States while waiting for an organ transplant. At least part of this need could be met by bioprinting, a technology that allows the on-demand production of custom-sized organs from a patient’s own cells. The field of bioprinting is progressing rapidly: the first bioprinted organs have already entered the clinic. Yet, developers of bioprinted organs face significant uncertainty as to how their potentially lifesaving products will be regulated—and by which government agency. Such regulatory uncertainty has the potential to decrease investment and stifle innovation in this promising technological field. This Note ...

Euplectella Aspergillum’S Natural Lattice Structure For Structural Design & Stability Landscape Of Thin Cylindrical Shells With Dimple Imperfections, Zoe Y. Sloane

Masters Theses

The first portion of this thesis assesses the structural application of a bracing design inspired by the deep-sea sponge, Euplectella Aspergillum. Many studies have investigated the natural strength found in the unique skeletal structure of this species. The braced design inspired by the sponge features square frames with two sets of cross-braces that are offset from the corners of each frame, creating a pattern of open and closed cells. This study reports the results of multiple Finite Element Analysis (FEA) computations that compare the described bracing pattern to a more common bracing design used in structural design. The designs are ...

3d Bioprinted Structures From Cells Of Non-Epithelial Mesodermal And Endodermal Lineage Using A Custom Accessible 3d Bioprinting Platform, Xavier-Lewis Palmer, Annette Berkin, Patrick C. Sachs, Robert D. Bruno

College of Engineering & Technology (Batten) Posters

Prior work within our lab has demonstrated the ability to print both murine and human mammary organoids and tumoroids in vitro that can also be reliably transplanted into a murine host for translational studies. Peripherally, this bioprinting system has also been used for 3D printing neurons, stem cells, cancer cells, and a primary cell line rich with fibroblasts, but each of these efforts were with cells of ectodermal lineage. Thus, the system's capacity for use on cells of other origins had been untested. To address this, we have now developed protocols for cells of endodermal and non-epithelial mesodermal/mesenchymal ...

Effects Of Bonding Pressure And Lamina Thickness On Mechanical Properties Of Clt Composed Of Southern Yellow Pine, Cody S. Bates

Theses and Dissertations

This study produced cross-laminated timber panels at a range of four lamina thickness (5/8, 1, 1 1/8, and 1 1/4 inch) and three bonding pressures (50, 125, 200 psi), producing a total of 12 panels for mechanical testing. The goal of this study is to observe how the thickness and pressure trends affect the mechanical properties of CLT. Tests include flatwise bending, flatwise shear, internal-bond, and delamination. Results showed that bending MOE decreases as the panel thickness increases while bonding pressure had no significance. Bending MOR was less significant for the thickness and more significant for pressure ...

Effect Of Mechanical Systems In Combating The Schistosomiasis Snails, Sherine Ahmed El Baradei

Archived Theses and Dissertations

No abstract provided.

Structural Dynamics And Encapsulation Properties Of Polyelectrolyte Complex Micelles, Sachit Shah

Electronic Theses and Dissertations, 2020-

Charged therapeutics such as nucleic acids and proteins can treat a vast range of human diseases that are traditionally undruggable. Their broadness in treating disease is due to their ability to influence cellular function. However, their high charge density and physiological barriers such as enzymatic degradation, hinder the deliverability of these molecules to the sites of disease. Polyelectrolyte complex (PEC) micelles are core-corona nanostructures that can encapsulate charged molecules and offer a platform for delivery. PECs form the core, when two oppositely charged polyelectrolytes are mixed in an aqueous solution, and the micelle corona is a neutral hydrophilic polymer that ...

Using Peptide Design To Engineer Polyelectrolyte Complex Biomaterials, Sara Tabandeh

Electronic Theses and Dissertations, 2020-

The self-assembly of oppositely charged polymers provides a versatile platform to design materials for diverse applications in biology and medicine. Electrostatically-driven phase separation of oppositely charged polymers in aqueous solution gives rise to the formation of a polymer-rich phase called a polyelectrolyte complex (PEC). PECs can be in the form of liquid droplets (complex coacervates) or amorphous solid precipitates. Unlike synthetic polymers, peptides are good candidates for developing tailor-made formulations and structure-property relationships due to their biocompatibility, precise control over sequences, and ability to program hydrogen bonding interactions. However, little is known about the effect of combining additional molecular interactions ...

Synergistic Anticancer Response Of Curcumin And Piperine Loaded Lignin-G-P (Nipam-Co-Dmaema) Gold Nanogels Against Glioblastoma Multiforme, Xinyi Zhao, Bilal Javad, Daxing Cui, James Curtin, Furong Tian

Articles

Glioblastoma multiforme (GBM) is the most aggressive and commonly diag- 11 nosed brain cancer and presents a strong resistance to routine chemotherapeutic drugs. 12 The present study involves the synthesis of Lignin-g- p (NIPAM-co-DMAEMA) gold 13 nanogel, loaded with curcumin and piperine to treat GBM. The application has three 14 functions: (1) overcome the limitations of biodistribution, (2) enhance the toxicity of an- 15 ticancer drugs against GBM, (3) identify the uptake pathway. Atom transfer radical 16 polymerization was used to synthesize the Lignin-g-PNIPAM network, crosslinked with 17 the gold nanoparticles (GNPs) to self-assemble into nanogels. The size distribution and ...

Improving Healthspan Through Patient-Derived Artificial Organs From Induced Pluripotent Stem Cells And Two-Photon Polymerization, Connor Espenshade

Protocols and Reports

Senescence, from the shortening of telomeres, accumulation of mutations, epigenetic hypomethylation, and other causes, begins an eventual cycle of decline in every patient. Stem cells disappear as a function of age, which in turn impairs cellular replication. Moreover, when fully differentiated cells are induced back into induced pluripotent stem cells (iPSCs), they not only revert to a state of pre-differentiation, but also to a younger cellular age. Their aging clocks turn back: their telomeres become longer and DNA methylation reverts back to an earlier age. It should therefore be possible to use iPSCs to replace the missing stem cells from ...

Molecular Dynamics Simulations Of Self-Assemblies In Nature And Nanotechnology, Phu Khanh Tang

Dissertations, Theses, and Capstone Projects

Nature usually divides complex systems into smaller building blocks specializing in a few tasks since one entity cannot achieve everything. Therefore, self-assembly is a robust tool exploited by Nature to build hierarchical systems that accomplish unique functions. The cell membrane distinguishes itself as an example of Nature’s self-assembly, defining and protecting the cell. By mimicking Nature’s designs using synthetically designed self-assemblies, researchers with advanced nanotechnological comprehension can manipulate these synthetic self-assemblies to improve many aspects of modern medicine and materials science. Understanding the competing underlying molecular interactions in self-assembly is always of interest to the academic scientific community ...

Tools And Strategies For The Patterning Of Bioactive Molecules And Macromolecules, Daniel J. Valles

Dissertations, Theses, and Capstone Projects

Hypersurface Photolithography (HP) is a printing method for fabricating structures and patterns composed of soft materials bound to solid surfaces and with ~1 micrometer resolution in the x, y, and z dimensions. This platform leverages benign, low intensity light to perform photochemical surface reactions with spatial and temporal control of irradiation, and, as a result, is particularly useful for patterning delicate organic and biological material. In particular, surface- initiated controlled radical polymerizations can be leveraged to create arbitrary polymer and block- copolymer brush patterns. Chapter 1 will review the advances in instrumentation architectures from our group that have made these ...

Experimental Investigation Of The Performance Of A Hybrid Self-Healing System In Porous Asphalt Under Fatigue Loadings, Shi Xu, Liu Xueyan, Amir Tabakovic, Erik Schlangen

Articles

Self-healing asphalt, which is designed to achieve autonomic damage repair in asphalt pavement, offers a great life-extension prospect and therefore not only reduces pavement maintenance costs but also saves energy and reduces CO2 emissions. The combined asphalt self-healing system, incorporating both encapsulated rejuvenator and induction heating, can heal cracks with melted binder and aged binder rejuvenation, and the synergistic effect of the two technologies shows significant advantages in healing efficiency over the single self-healing method. This study explores the fatigue life extension prospect of the combined healing system in porous asphalt. To this aim, porous asphalt (PA) test specimens with ...

Effects Of Uv Exposure On The Thermo-Mechanical Properties Of Cactus Based Biopolymers, Madison Glozer, Megan Bolling, Addison Wolfson

Materials Engineering

The viability of renewable biopolymers as sustainable alternatives to synthetic plastics is promising, however ultra-violet (UV) radiation can lead to premature degradation and reduction in the material’s performance. Biopolymers comprised of nopal cactus juice, animal protein, natural wax, and glycerin in differing percentages were studied to obtain thermo-mechanical data in relation to UV exposure. To quantify degradation, dynamic mechanical analysis, thermogravimetric analysis, differential scanning calorimetry, infrared spectroscopy, goniometry and gravimetric measurements were performed. Each formulation experienced mass loss as a result of UV exposure, which could be attributed to water evaporation. The thermogravimetric analysis indicated a reduction in the ...

Use Of Biomimicry Design Approach In Constructing Sustainable Resilient Structures (Case Study: Port Of Beirut), Farouk Bader, Marwan Halabi, Hiba Mohsen, Maged Youssef

BAU Journal - Creative Sustainable Development

Resiliency is not the same as sustainability, nor its substitute, but definitely the two concepts complement each other’s. Sustainability is the avoidance of depletion of natural resources to maintain ecological balance whereas resiliency is to recover, adapt and keep going in the face of setbacks. While designing with green approach is important but what will happen to leed points if the building becomes uninhabitable due to disasters, that’s where resiliency comes into play. The 2019 statistics showed that natural disasters accounted for 133 billion dollars losses and manmade ones accounted for other 7 billion in addition to 11 ...

Exploration Of The Sludge Biodiesel Pathway, Zachary Christman

Theses, Dissertations, and Student Research in Agronomy and Horticulture

Wastewater sludge is an overlooked source of fat, oil, and grease (FOG) that could be converted into biodiesel. The United States produces about 8 million tons of sludge per year. The disposal cost for this amount of sludge is about 2 billion dollars. The widespread availability and low cost of sludge compared to other biodiesel raw materials make it an economical choice for a renewable fuel. Using sludge as a raw material can produce 25 to 30 mg per gram of fatty acid methyl ester (FAME); the main component of biodiesel. Sludge biodiesel has the potential of transforming a portion ...

Susceptibility Of Riverine Fishes To Anthropogenically-Linked Trauma: Strikes From Hydropower Turbine Blades, Ryan K. Saylor

Doctoral Dissertations

Hydropower accounts for nearly 40% of renewable electricity generation in the US; however, dams significantly impact the surrounding aquatic ecosystems. One of the most visible impacts of hydropower―beyond the dam itself―is the direct negative impacts (injury or death) to fish populations that must pass through hydropower turbines to access desired downstream habitat. During passage, fishes face many potential stressors that can cause severe injuries and often leads to high rates of mortality. In this dissertation, I have focused on quantifying how fishes respond to impacts from turbine blades that may occur during turbine passage. Laboratory research into blade ...

Biofabricated Constructs Of Carbon-Based Nanoparticles With Mesenchymal Stem Cells For Orthopedic Repair, Steven D. Newby

Doctoral Dissertations

Breakthroughs in tissue engineering are moving at a rapid rate especially in the regenerative bone biofabrication. Technology growth in the field of additive manufacturing (AM) such 3D bioprinting which provides the ability to create biocompatible 3D construct on which a cell source could be seeded is an encouraging substitute to autologous grafts.

This present research aims to biofabricate a construct for bone tissue engineering using AM technology. The biocompatible material was chosen corresponding to bones extracellular matrix (ECM) composition, which demonstrates an inorganic and organic development phase: Poly (lactic-glycolic acid) was chosen as the polymeric matrix of the compound, due ...