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The Effect Of Visual Wulst Lesions And Trigeminal Nerve Sectioning On The Discrimination Of Magnetic Inclination In The Homing Pigeon (Columba Livia), Merissa Acerbi 2013 Bowling Green State University - Main Campus

The Effect Of Visual Wulst Lesions And Trigeminal Nerve Sectioning On The Discrimination Of Magnetic Inclination In The Homing Pigeon (Columba Livia), Merissa Acerbi

Honors Projects

The ability of homing pigeons to return to their loft from unknown places has fascinated scientists for centuries. It is well established that homing pigeons, like migratory birds, posses an innate magnetic inclination compass to determine direction by measuring the angle between the magnetic field vector and the Earth's surface. Recent work has indicated that the avian magnetic compass is light mediated and appears to mediate magnetic information to the brain. This occurs via a visual pathway with processing in the visual Wulst area of the forebrain. There is, however, also evidence from other avian species that magnetic direction ...


The Post-Combat Couple Adjustment Questionnaire: A Preliminary Validation, Valerie Maine 2013 Antioch University - New England

The Post-Combat Couple Adjustment Questionnaire: A Preliminary Validation, Valerie Maine

Dissertations & Theses

This dissertation presents the results of a psychometric study regarding the preliminary validation of The Post-Combat Couple Adjustment Questionnaire (PCCAQ). This measure was designed to assess post-combat and post-deployment adjustment for male veterans and their female partners. The measure was created using existing literature on veterans, posttraumatic stress disorder (PTSD), and couples. The PCCAQ consists of four domains of couple functioning, including: (a) redefining roles, expectations, and division of household responsibilities; (b) managing strong emotions; (c) abandoning emotional constriction and creating intimacy in relationships; and (d) creating a sense of shared meaning surrounding the deployment experience. The PCCAQ was compared ...


Clinical Features Of Patients With Dysthymia In A Large Cohort Of Han Chinese Women With Recurrent Major Depression, Wenqing Wu, Zhoubing Wang, Yan Wei, Guanghua Zhang, Shenxun Shi, Jingfang Gao, Youhui Li, Ming Tao, Kerang Zhang, Xumei Wang, Chengge Gao, Lijun Yang, Kan Li, Jianguo Shi, Gang Wang, Lanfen Liu, Jinbei Zhang, Bo Du, Guoqing Jiang, Jianhua Shen, Ying Liu, Wei Liang, Jing Sun, Jian Hu, Tiebang Liu, Xueyi Wang, Guodong Miao, Huaqing Meng, Yi Li, Guoping Huang, Gongying Li, Baowei Ha, Hong Deng, Qiyi Mei, Hui Zhong, Shugui Gao, Hong Sang, Yutang Zhang, Xiang Fang, Fengyu Yu, Donglin Yang, Tieqiao Liu, Yunchun Chen, Xiaohong Hong, Wenyuan Wu, Guibing Chen, Min Cai, Yan Song, Jiyang Pan, Jicheng Dong, Runde Pan, Wei Zhang, Zhenming Shen, Zhengrong Liu, Danhua Gu, Xiaoping Wang, Xiaojuan Liu, Qiwen Zhang, Yihan Li, Yiping Chen, Kenneth S. Kendler, Jonathan Flint, Zhen Zhang 2013 No. 4 Affiliated Hospital of Jiangsu University

Clinical Features Of Patients With Dysthymia In A Large Cohort Of Han Chinese Women With Recurrent Major Depression, Wenqing Wu, Zhoubing Wang, Yan Wei, Guanghua Zhang, Shenxun Shi, Jingfang Gao, Youhui Li, Ming Tao, Kerang Zhang, Xumei Wang, Chengge Gao, Lijun Yang, Kan Li, Jianguo Shi, Gang Wang, Lanfen Liu, Jinbei Zhang, Bo Du, Guoqing Jiang, Jianhua Shen, Ying Liu, Wei Liang, Jing Sun, Jian Hu, Tiebang Liu, Xueyi Wang, Guodong Miao, Huaqing Meng, Yi Li, Guoping Huang, Gongying Li, Baowei Ha, Hong Deng, Qiyi Mei, Hui Zhong, Shugui Gao, Hong Sang, Yutang Zhang, Xiang Fang, Fengyu Yu, Donglin Yang, Tieqiao Liu, Yunchun Chen, Xiaohong Hong, Wenyuan Wu, Guibing Chen, Min Cai, Yan Song, Jiyang Pan, Jicheng Dong, Runde Pan, Wei Zhang, Zhenming Shen, Zhengrong Liu, Danhua Gu, Xiaoping Wang, Xiaojuan Liu, Qiwen Zhang, Yihan Li, Yiping Chen, Kenneth S. Kendler, Jonathan Flint, Zhen Zhang

Psychiatry Publications

Background

Dysthymia is a form of chronic mild depression that has a complex relationship with major depressive disorder (MDD). Here we investigate the role of environmental risk factors, including stressful life events and parenting style, in patients with both MDD and dysthymia. We ask whether these risk factors act in the same way in MDD with and without dysthymia.

Results

We examined the clinical features in 5,950 Han Chinese women with MDD between 30–60 years of age across China. We confirmed earlier results by replicating prior analyses in 3,950 new MDD cases. There were no significant differences ...


Suicidal Risk Factors Of Recurrent Major Depression In Han Chinese Women, Yuzhang Zhu, Hongni Zhang, Shenxun Shi, Jingfang Gao, Youhui Li, Ming Tao, Kerang Zhang, Xumei Wang, Chengge Gao, Lijun Yang, Kan Li, Jiangguo Shi, Gang Wang, Lanfen Liu, Jinbei Zhang, Bo Du, Guoqing Jiang, Jianhua Shen, Zhen Zhang, Wei Liang, Jing Sun, Jian Hu, Tiebang Liu, Xueyi Wang, Guodong Miao, Huaqing Meng, Yi Li, Chunmei Hu, Yi Li, Guoping Huang, Gongying Li, Baowei Ha, Hong Deng, Qiyi Mei, Hui Zhong, Shugui Gao, Hong Sang, Yutang Zhang, Xiang Fang, Fengyu Yu, Donglin Yang, Tieqiao Liu, Yunchun Chen, Xiaohong Hong, Wenyuan Wu, Guibing Chen, Min Cai, Yan Song, Jiyang Pan, Jicheng Dong, Runde Pan, Wei Zhang, Zhenming Shen, Zhengrong Liu, Danhua Gu, Xiaoping Wang, Xiaojuan Liu, Qiwen Zhang, Yihan Li, Yiping Chen, Kenneth S. Kendler, Jonathan Flint, Ying Liu 2013 The First Hospital of China Medical University

Suicidal Risk Factors Of Recurrent Major Depression In Han Chinese Women, Yuzhang Zhu, Hongni Zhang, Shenxun Shi, Jingfang Gao, Youhui Li, Ming Tao, Kerang Zhang, Xumei Wang, Chengge Gao, Lijun Yang, Kan Li, Jiangguo Shi, Gang Wang, Lanfen Liu, Jinbei Zhang, Bo Du, Guoqing Jiang, Jianhua Shen, Zhen Zhang, Wei Liang, Jing Sun, Jian Hu, Tiebang Liu, Xueyi Wang, Guodong Miao, Huaqing Meng, Yi Li, Chunmei Hu, Yi Li, Guoping Huang, Gongying Li, Baowei Ha, Hong Deng, Qiyi Mei, Hui Zhong, Shugui Gao, Hong Sang, Yutang Zhang, Xiang Fang, Fengyu Yu, Donglin Yang, Tieqiao Liu, Yunchun Chen, Xiaohong Hong, Wenyuan Wu, Guibing Chen, Min Cai, Yan Song, Jiyang Pan, Jicheng Dong, Runde Pan, Wei Zhang, Zhenming Shen, Zhengrong Liu, Danhua Gu, Xiaoping Wang, Xiaojuan Liu, Qiwen Zhang, Yihan Li, Yiping Chen, Kenneth S. Kendler, Jonathan Flint, Ying Liu

Psychiatry Publications

The relationship between suicidality and major depression is complex. Socio- demography, clinical features, comorbidity, clinical symptoms, and stressful life events are important factors influencing suicide in major depression, but these are not well defined. Thus, the aim of the present study was to assess the associations between the above-mentioned factors and suicide ideation, suicide plan, and suicide attempt in 6008 Han Chinese women with recurrent major depression (MD). Patients with any suicidality had significantly more MD symptoms, a significantly greater number of stressful life events, a positive family history of MD, a greater number of episodes, a significant experience of ...


Association Testing Strategy For Data From Dense Marker Panels, Donghyung Lee, Silviu-Alin Bacanu 2013 Virginia Commonwealth University

Association Testing Strategy For Data From Dense Marker Panels, Donghyung Lee, Silviu-Alin Bacanu

Psychiatry Publications

Genome wide association studies have been usually analyzed in a univariate manner. The commonly used univariate tests have one degree of freedom and assume an additive mode of inheritance. The experiment-wise significance of these univariate statistics is obtained by adjusting for multiple testing. Next generation sequencing studies, which assay 10-20 million variants, are beginning to come online. For these studies, the strategy of additive univariate testing and multiple testing adjustment is likely to result in a loss of power due to (1) the substantial multiple testing burden and (2) the possibility of a non-additive causal mode of inheritance. To reduce ...


Improved Detection Of Common Variants Associated With Schizophrenia And Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate, Ole A. Andreassen, Wesley K. Thompson, Andrew J. Schork, Stephan Ripke, Morten Mattingsdal, John R. Kelsoe, Kenneth S. Kendler, Michael C. O'Donovan, Dan Rujescu, Thomas Werge, Pamela Sklar, J. Cooper Roddey, Chi-Hua Chen, Linda McEvoy, Rahul S. Desikan, Srdjan Djurovic, Anders M. Dale 2013 University of Oslo

Improved Detection Of Common Variants Associated With Schizophrenia And Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate, Ole A. Andreassen, Wesley K. Thompson, Andrew J. Schork, Stephan Ripke, Morten Mattingsdal, John R. Kelsoe, Kenneth S. Kendler, Michael C. O'Donovan, Dan Rujescu, Thomas Werge, Pamela Sklar, J. Cooper Roddey, Chi-Hua Chen, Linda Mcevoy, Rahul S. Desikan, Srdjan Djurovic, Anders M. Dale

Psychiatry Publications

Several lines of evidence suggest that genome-wide association studies (GWAS) have the potential to explain more of the “missing heritability” of common complex phenotypes. However, reliable methods to identify a larger proportion of single nucleotide polymorphisms (SNPs) that impact disease risk are currently lacking. Here, we use a genetic pleiotropy-informed conditional false discovery rate (FDR) method on GWAS summary statistics data to identify new loci associated with schizophrenia (SCZ) and bipolar disorders (BD), two highly heritable disorders with significant missing heritability. Epidemiological and clinical evidence suggest similar disease characteristics and overlapping genes between SCZ and BD. Here, we computed conditional ...


Association Study Of 167 Candidate Genes For Schizophrenia Selected By A Multi-Domain Evidence-Based Prioritization Algorithm And Neurodevelopmental Hypothesis, Zhongming Zhao, Bradley T. Webb, Peilin Jia, T. Bernard Bigdeli, Brion S. Maher, Edwin van den Oord, Sarah Bergen, Richard L. Amdur, Francis A. O'Neill, Dermot Walsh, Dawn L. Thiselton, Xianging Chen, Carlos N. Pato, The International Schizophrenia Consortium, Brien P. Riley, Kenneth S. Kendler, Ayman H. Fanous 2013 Virginia Commonwealth University, Vanderbilt University

Association Study Of 167 Candidate Genes For Schizophrenia Selected By A Multi-Domain Evidence-Based Prioritization Algorithm And Neurodevelopmental Hypothesis, Zhongming Zhao, Bradley T. Webb, Peilin Jia, T. Bernard Bigdeli, Brion S. Maher, Edwin Van Den Oord, Sarah Bergen, Richard L. Amdur, Francis A. O'Neill, Dermot Walsh, Dawn L. Thiselton, Xianging Chen, Carlos N. Pato, The International Schizophrenia Consortium, Brien P. Riley, Kenneth S. Kendler, Ayman H. Fanous

Psychiatry Publications

Integrating evidence from multiple domains is useful in prioritizing disease candidate genes for subsequent testing. We ranked all known human genes (n = 3819) under linkage peaks in the Irish Study of High-Density Schizophrenia Families using three different evidence domains: 1) a meta-analysis of microarray gene expression results using the Stanley Brain collection, 2) a schizophrenia protein-protein interaction network, and 3) a systematic literature search. Each gene was assigned a domain-specific p-value and ranked after evaluating the evidence within each domain. For comparison to this ranking process, a large-scale candidate gene hypothesis was also tested by including genes with Gene Ontology ...


Venlafaxine-Induced Orthostatic Hypotension In A Geriatric Patient, Vidyashree Chikkaramanjegowda, Jose de Leon 2013 University of Kentucky

Venlafaxine-Induced Orthostatic Hypotension In A Geriatric Patient, Vidyashree Chikkaramanjegowda, Jose De Leon

Psychiatry Faculty Publications

Venlafaxine is not usually associated with risk of orthostatic hypotension. A 65-year-old US Caucasian female taking 225 mg/day of venlafaxine extended-release developed symptomatic orthostatic hypotension. The systolic and diastolic blood pressure dropped by 25 and 18 mm Hg, respectively, from supine position to standing position within 3 minutes. The patient was otherwise healthy and the orthostatic hypotension resolved with venlafaxine discontinuation. This was a probable venlafaxine adverse drug reaction according to the Naranjo scale. This case contributes to the scarce literature that indicates that clinicians need to be aware that occasionally venlafaxine can induce clinically significant orthostatic hypotension, particularly ...


Are Apes’ Responses To Pointing Gestures Intentional?, Olivia Sultanescu, Kristin Andrews 2013 York University

Are Apes’ Responses To Pointing Gestures Intentional?, Olivia Sultanescu, Kristin Andrews

Animal Sentience, Intelligence, and Emotion

This paper examines the meaningfulness of pointing in great apes. We appeal to Hannah Ginsborg’s conception of primitive normativity, which provides an adequate criterion for establishing whether a response is meaningful, and we attempt to make room for a conception according to which there is no fundamental difference between the responses of human infants and those of other great apes to pointing gestures. This conception is an alternative to Tomasello’s view that pointing gestures and reactions to them reveal a fundamental difference between humans and other apes.


The Association Between Optimism And Serum Antioxidants In The Midlife In The United States Study, Julia K. Boehm, David R. Williams, Eric B. Rimm, Carol Ryff, Laura D. Kubzansky 2013 Chapman University

The Association Between Optimism And Serum Antioxidants In The Midlife In The United States Study, Julia K. Boehm, David R. Williams, Eric B. Rimm, Carol Ryff, Laura D. Kubzansky

Psychology Faculty Articles and Research

Objective Psychological and physical health are often conceptualized as the absence of disease, but less research addresses positive psychological and physical functioning. For example, optimism has been linked with reduced disease risk and biological dysfunction, but very little research has examined associations with markers of healthy biological functioning. Thus, we investigated the association between two indicators of positive health: optimism and serum antioxidants.

Methods The cross-sectional association between optimism and antioxidant concentrations was examined in 982 men and women from the Midlife in the United States study. Primary measures included self-reported optimism (assessed with the revised Life Orientation Test) and ...


Criticalthinkrx May Reduce Psychiatric Prescribing To Foster Youth: Results From An Intervention Trial, David Cohen, Jeffrey R. Lacasse, Rui Duan, Inge Senglemann 2013 Florida International University

Criticalthinkrx May Reduce Psychiatric Prescribing To Foster Youth: Results From An Intervention Trial, David Cohen, Jeffrey R. Lacasse, Rui Duan, Inge Senglemann

College of Social Work Faculty Publications

Objectives: To test the potential impact of a critical curriculum on psychiatric medications designed for child welfare workers. Method: In a quasiexperimental, longitudinal study, the monthly proportion of medicated foster children and the average number of prescriptions per medicated child at Agency 1 (669 clients) exposed to the CriticalThinkRx curriculum were compared to Agencies 2–9 (3,346 clients) in the same two-county service network. Data were collected during 6 months of preintervention, 1 month of intervention, and 9 months of postintervention. Practitioners were not informed of data collection. Results: During postintervention months 1–8, the proportion of medicated children ...


The Development Of Intimate Partner Relationships Among Men Sexually Abused As Children, Laura Beltran-Medina 2013 Antioch University - Santa Barbara

The Development Of Intimate Partner Relationships Among Men Sexually Abused As Children, Laura Beltran-Medina

Dissertations & Theses

This phenomenological study sought to understand the experience of seven men who came forward to contribute and discuss their intimate partner relationships for what relational intimacy could reveal about themselves, the meaning of intimate partnership, and their understanding of being in intimate relationships. The theoretical assumptions applied to this study are: (a) Childhood sexual abuse interferes with the ability to achieve deeper experiences of idealized love; (b) Negative effects of adult relational attachment are manifested in anxiety related to sexual intimacy, fear of emotional intimacy, and inability to fulfill dependency needs such as trust, love, and security; and (c) There ...


Dead Men, Walking: Actors, Networks, And Actualized Metaphors In Mrs. Dalloway And Raymond, Elizabeth Outka 2013 University of Richmond

Dead Men, Walking: Actors, Networks, And Actualized Metaphors In Mrs. Dalloway And Raymond, Elizabeth Outka

English Faculty Publications

This article takes up Rita Felski’s recent call to modernists to explore how Bruno Latour’s latest work on actor-network theory might be adapted for literary studies. It examines two accounts of World War I soldiers who (allegedly) return from the dead in material form: Virginia Woolf’s fictional account of Septimus Smith, who is convinced his friend Evans has come back from the dead, and Oliver Lodge’s best-selling memoir, Raymond, or Life and Death, which recounts in detail how Lodge believed his dead son sent messages to the family to assure them of his continued material existence ...


Young Adults Getting Involved: Participatory Action Research & Transition Age Youth, Jonathan Delman 2013 University of Massachusetts Medical School

Young Adults Getting Involved: Participatory Action Research & Transition Age Youth, Jonathan Delman

Systems and Psychosocial Advances Research Center Publications and Presentations

Research presented on improving supports for transition age youth and young adults who have serious mental health conditions and want to complete schooling and training to move into work lives, through actively participating in the research and dissemination process.


Implementing The Massachusetts Child Trauma Project (Mctp) To Improve Services For Children With Complex Trauma In Child Welfare: Phase I Needs And Readiness Assessment, Charmaine B. Lo, Melodie Wenz-Gross, Jessica L. Griffin 2013 University of Massachusetts Medical School

Implementing The Massachusetts Child Trauma Project (Mctp) To Improve Services For Children With Complex Trauma In Child Welfare: Phase I Needs And Readiness Assessment, Charmaine B. Lo, Melodie Wenz-Gross, Jessica L. Griffin

Systems and Psychosocial Advances Research Center Publications and Presentations

MCTP seeks to improve placement stability and outcomes for children with complex trauma in the care of the Massachusetts Department of Children and Families (DCF) by creating a sustainable capacity for providing evidence-based trauma interventions within provider agencies, and trauma-informed practices within DCF.


Gender: An Important Factor In The Implementation Of Services For Juvenile Offenders, Geno Salomone, Rebecca J. Nelson, Scarlet P. Woods, Laura S. Guy, Gina M. Vincent 2013 University of Massachusetts Medical School Worcester

Gender: An Important Factor In The Implementation Of Services For Juvenile Offenders, Geno Salomone, Rebecca J. Nelson, Scarlet P. Woods, Laura S. Guy, Gina M. Vincent

Systems and Psychosocial Advances Research Center Publications and Presentations

The Child Welfare League of America (2003) reported that between 1980 and 2000 the arrest rate for boys declined by 11% but increased for girls by 35%. A well tested case management approach being applied more commonly in juvenile justice is the Risk-Needs-Responsivity (RNR) approach, which suggests that interventions and services should be commensurate with ones level of risk and specific dynamic risk factors (criminogenic needs). The RNR model tends to be seen as "gender-neutral", based on assumption that it works equally well with both sexes. Few studies have examined whether gender differences exist in the effectiveness of RNR-type case ...


Creating A “Community Of Practice” On Transition Age Youth & Young Adults With Serious Mental Health Conditions In Northeast Massachusetts, Lisa M. Smith, Marsha Langer Ellison, Joann Starks, Amanda Costa 2013 University of Massachusetts Medical School

Creating A “Community Of Practice” On Transition Age Youth & Young Adults With Serious Mental Health Conditions In Northeast Massachusetts, Lisa M. Smith, Marsha Langer Ellison, Joann Starks, Amanda Costa

Systems and Psychosocial Advances Research Center Publications and Presentations

The Northeast Massachusetts Community of Practice for Transition Age Youth and Young Adults (MACOPTAYYA) was initiated through the involvement of a champion, a regional director of the state Departmentof Mental Health (DMH). With support from the Transitions Research and Training Center (RTC), the CoP built a partnership of committed stakeholders from various points of the system of service for Transition Age Youth and Young Adults, thus building bridges across the adult and children mental health agencies.


Patterns Of Psychotherapy Attendance In Emerging And Mature Adults, Maryann Davis, William H. Fisher, Charles W. Lidz, Bernice Gershenson 2013 University of Massachusetts Medical School

Patterns Of Psychotherapy Attendance In Emerging And Mature Adults, Maryann Davis, William H. Fisher, Charles W. Lidz, Bernice Gershenson

Systems and Psychosocial Advances Research Center Publications and Presentations

Approximately 760,000 emerging adults use outpatient psychotherapy in the U.S. each year (Olfson et al.,2002). Emerging adults are 1.6-7.9 times more likely to drop out of mental health treatment than fully mature adults (Edlund et al., 2002; Olfson et al., 2002). This Study compared temporal patterns of attendance and non attendance between emerging and mature adults


Lamotrigine Augmentation Of Serotonin Reuptake Inhibitors In Severe And Long-Term Treatment-Resistant Obsessive-Compulsive Disorder, Manuel Arrojo-Romero, María Tajes Alonso, Jose de Leon 2013 Complejo Hospitalario Universitario, Spain

Lamotrigine Augmentation Of Serotonin Reuptake Inhibitors In Severe And Long-Term Treatment-Resistant Obsessive-Compulsive Disorder, Manuel Arrojo-Romero, María Tajes Alonso, Jose De Leon

Psychiatry Faculty Publications

The treatment recommendations in obsessive-compulsive disorder (OCD) after lack of response to selective serotonin reuptake inhibitors (SSRIs) include augmentation with other drugs, particularly clomipramine, a more potent serotonin reuptake inhibitor (SRI), or antipsychotics. We present two cases of response to lamotrigine augmentation in treatment-refractory OCD; each received multiple SRI trials over a >10-year period. The first patient had eleven years of treatment with multiple combinations including clomipramine and SSRIs. She had a >50% decrease of Y-BOCS (from 29 to 14) by augmenting paroxetine (60 mg/day) with lamotrigine (100 mg/day). The second patient had 22 years of treatment with ...


Relation Between Optimism And Lipids In Midlife, Julia K. Boehm, David R. Williams, Eric B. Rimm, Carol Ryff, Laura D. Kubzansky 2013 Chapman University

Relation Between Optimism And Lipids In Midlife, Julia K. Boehm, David R. Williams, Eric B. Rimm, Carol Ryff, Laura D. Kubzansky

Psychology Faculty Articles and Research

This research examined optimism’s relationship with total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, and triglycerides. The hypothesis that optimism is associated with a healthier lipid profile was tested. Participants were 990 mostly white men and women from the Midlife in the United States study who were on average 55.1 years old. Optimism was assessed by self-report with the Life Orientation Test. A fasting blood sample was used to assess serum lipid levels. Linear and logistic regression models examined the cross-sectional association between optimism and lipids accounting for covariates such as demographic characteristics (e ...


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