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Contextual And Behavioral Control Of Antipsychotic Sensitization Induced By Haloperidol And Olanzapine, Chen Zhang, Ming Li 2012 University of Nebraska - Lincoln

Contextual And Behavioral Control Of Antipsychotic Sensitization Induced By Haloperidol And Olanzapine, Chen Zhang, Ming Li

Faculty Publications, Department of Psychology

Repeated administration of haloperidol (HAL) and olanzapine (OLZ) causes a progressively enhanced disruption of the conditioned avoidance response (CAR) and a progressively enhanced inhibition of phencyclidine (PCP)-induced hyperlocomotion in rats (termed antipsychotic sensitization). Both actions are thought to reflect intrinsic antipsychotic activity. The present study examined the extent to which antipsychotic- induced sensitization in one model (e.g. CAR) can be transferred or maintained in another (e.g. PCP hyperlocomotion) as a means of investigating the contextual and behavioral controls of antipsychotic sensitization. Well-trained male Sprague-Dawley rats were first repeatedly tested in the CAR or the PCP (3.2 ...


Gender, Gender Roles, And Anxiety: Perceived Confirmability Of Self Report, Behavioral Avoidance, And Physiological Reactivity, Milena Stoyanova, Debra Anne Hope 2012 University of Nebraska - Lincoln

Gender, Gender Roles, And Anxiety: Perceived Confirmability Of Self Report, Behavioral Avoidance, And Physiological Reactivity, Milena Stoyanova, Debra Anne Hope

Faculty Publications, Department of Psychology

Despite the well-documented gender effect in anxiety, less is known about contributing factors to women’s greater risk for anxiety and fears. The present study examined the relationship between gender, gender role orientation (i.e., expressivity/instrumentality) and fear of harmless insects (tarantula), using a multimodal approach of self-report measures, a Behavioral Approach Test (BAT), and physiological reactivity. Participants (144 college students; 67 women, 77 men) completed a questionnaire packet and then were instructed to approach a tarantula. We were unable to replicate Pierce and Kirkpatrick’s (1992) findings that men underreport anxiety. Consistent with the literature, women in the ...


Anthropological Data Regarding The Adaptiveness Of Hebephilia, Raymond B. Hames, Ray Blanchard 2012 University of Nebraska - Lincoln

Anthropological Data Regarding The Adaptiveness Of Hebephilia, Raymond B. Hames, Ray Blanchard

Anthropology Faculty Publications

Hebephilia is the sexual attraction to early pubertal children in Tanner Stages 2 and 3, generally ages 11 through 14.

The second author of this letter (R.B.), a member of the Paraphilias Subworkgroup of the Work Group on Sexual and Gender Identity Disorders for DSM-5, proposed a diagnostic entity for DSM-5 that resembles the ICD-10 model, but with a different name: Pedohebephilic Disorder. In the original proposal (Blanchard, 2010a), this disorder would have three subtypes: pedophilic, hebephilic, and pedohebephilic. In the current version of the proposal, which is still under consideration, the name has been changed to Pedophilic Disorder ...


Confirmatory Factor Analysis Of The Preschool Behavioral And Emotional Rating Scale (Prebers) With Preschool Children With Disabilities, Cynthia J. Cress, Lori Synhorst, Michael Epstein, Elizabeth Allen 2012 University of Nebraska - Lincoln

Confirmatory Factor Analysis Of The Preschool Behavioral And Emotional Rating Scale (Prebers) With Preschool Children With Disabilities, Cynthia J. Cress, Lori Synhorst, Michael Epstein, Elizabeth Allen

Faculty Publications, Department of Psychology

The Preschool Behavioral and Emotional Rating Scale (PreBERS) is a standardized, norm-referenced instrument that assesses emotional and behavioral strengths of preschool children. This study investigated whether the PreBERS four-factor structure (i.e., emotional regulation, school readiness, social confidence, and family involvement) could be replicated with an early childhood special education (ECSE) sample of children. Teachers who participated in the study rated a total of 1,103 preschool children with disabilities. Confirmatory factor analysis determined the extent to which the ECSE data fit the original four-factor PreBERS structure identified with the national normative sample. Results indicated that the four-factor structure demonstrated ...


Clozapine, But Not Olanzapine, Disrupts Conditioned Avoidance Response In Rats By Antagonizing 5-Ht2a/2c Receptors, Ming Li, Tao Sun, Alexa Mead 2012 University of Nebraska - Lincoln

Clozapine, But Not Olanzapine, Disrupts Conditioned Avoidance Response In Rats By Antagonizing 5-Ht2a/2c Receptors, Ming Li, Tao Sun, Alexa Mead

Faculty Publications, Department of Psychology

The present study was designed to assess the role of 5-HT2A/2C receptors in the acute and repeated effect of clozapine and olanzapine in a rat conditioned avoidance response model, a validated model of antipsychotic activity. Male Sprague–Dawley rats that were previously treated with either phencyclidine (0.5–2.0 mg/kg, sc), amphetamine (1.25–5.0 mg/kg, sc), or saline and tested in a prepulse inhibition of acoustic startle study were used. They were first trained to acquire avoidance response to a white noise (CS1) and a pure tone (CS2) that differed in their ability ...


Post-Traumatic Stress Disorder: A Look Into The Cause, Gender Differences, And Treatment, Barbara Wallen 2012 University of Nevada, Las Vegas

Post-Traumatic Stress Disorder: A Look Into The Cause, Gender Differences, And Treatment, Barbara Wallen

McNair Poster Presentations

Posttraumatic stress disorder, better known as PTSD came to light during the Vietnam Era. Throughout history, this stress disorder has been called various things in the 150 years since it was first recognized. However, each new word had several characteristics in common, such as re-experiencing, numbing and physiological arousal.

The process of Darwinian “natural selection” corroborated the evolution of people with highly developed stress responses. Those pre-historic people with the most useful “fight or flight” reflexes became our ancestors. An example of this is that during the 19th Century, PTSD was called “Railway Spine” and was associated with what ...


Is Asenapine More Effective Than Other Interventions In The Treatment Of Adult Patients With Bipolar I Disorder?, Mary H. Tsakiris 2012 Philadelphia College of Osteopathic Medicine

Is Asenapine More Effective Than Other Interventions In The Treatment Of Adult Patients With Bipolar I Disorder?, Mary H. Tsakiris

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Asenapine is more effective than other interventions in the treatment of adult patients with bipolar I disorder.

STUDY DESIGN: Review of three English language primary randomized controlled trial studies published from 2009-2010.

DATA SOURCES: Three randomized controlled trials studying the effectiveness of Asenapine in the treatment of mania in adult patients with bipolar I disorder in comparison to other interventions.

OUTCOME MEASURED: Outcomes measured were reduction in severity of manic symptoms and tolerability of the medication. The severity of manic symptoms was measured using the Young ...


Is Rivastigmine Effective In The Treatment Of Alzheimer’S Disease?, Beena Patel 2012 Philadelphia College of Osteopathic Medicine

Is Rivastigmine Effective In The Treatment Of Alzheimer’S Disease?, Beena Patel

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not rivastigmine is effective for the treatment of Alzheimer’s Disease.

STUDY DESIGN: Review of two trials in the English language published in 2007 and 2010, and an open-label, singlearm, multi-center study from 2008.

DATA SOURCES: Randomized, double-blind, placebo-controlled trials comparing rivastigmine to a visually-matched capsule (placebo) was found using PubMed and Cochrane databases.

OUTCOMES MEASURED: Overall global performance using the Alzheimer’s Disease Assessment Scale (ADAS-cog), ability to perform activities of daily living, cognitive function using the mini mental status exam (MMSE), and neuropsychiatric symptoms using ...


Reducing The Stigma Of Mental Illness Among Medical Students, Victoria Lawn, Matthew Jaffa, Catherine Babbitt-Cook, Burton Mark, Jane Dumsha, Marcus G. Bell, Denah M. Appelt 2012 Philadelphia College of Osteopathic Medicine

Reducing The Stigma Of Mental Illness Among Medical Students, Victoria Lawn, Matthew Jaffa, Catherine Babbitt-Cook, Burton Mark, Jane Dumsha, Marcus G. Bell, Denah M. Appelt

Scholarly Posters

Abstract: The American Osteopathic Association House of Delegates Resolution 205 recommends “increased awareness of depression amongst U.S. Medical students” due to the increasing body of research describing the rise of depression, burn-out and suicide ideation among medical students. There is consequently a need to understand mental health issues as a component of professional development. Hypothesis: A student-led symposium addressing mental and emotional health topics relevant to medical students would reduce the stigma associated with mental illness. Materials and Methods: A 2-hour student-run “Patient Perspective” was held during the second neuroscience block at an osteopathic medical school in the northeastern ...


Umass Worcester Prevention Research Center Annual Report 2012, UMass Worcester Prevention Research Center 2012 University of Massachusetts Medical School

Umass Worcester Prevention Research Center Annual Report 2012, Umass Worcester Prevention Research Center

UMass Worcester Prevention Research Center Publications and Presentations

Second annual report of the UMass Worcester Prevention Research Center.


Nicotine Sensitization And Brain-Derived Neurotrophic Factor Content In Adolescent Rats Neonatally Treated With Quinpirole., Addie Roberts 2011 East Tennessee State University

Nicotine Sensitization And Brain-Derived Neurotrophic Factor Content In Adolescent Rats Neonatally Treated With Quinpirole., Addie Roberts

Undergraduate Honors Theses

Neonatal treatment of quinpirole in rats increases dopamine D2-like receptor sensitivity over the animal’s lifetime, a phenomenon referred to as D2 priming. Male and female Sprague-Dawley rats were given quinpirole (1mg/kg, i.p.) or saline on postnatal days (P)1-21. After habituation to a locomotor arena on P29-31, beginning P33, animals were administered nicotine (0.3 mg/kg, 0.5 mg/kg, or 0.7 mg/kg, i.p.) or saline and placed into a locomotor arena for behavioral testing every second day for a total of 9 treatments. The results showed that adolescents neonatally treated with quinpirole ...


Brain-Derived Neurotrophic Factor Levels In D2 Receptor Primed Adolescent Rats Given Twice Daily Nicotine Administrations., Josie Minnigh 2011 East Tennessee State University

Brain-Derived Neurotrophic Factor Levels In D2 Receptor Primed Adolescent Rats Given Twice Daily Nicotine Administrations., Josie Minnigh

Undergraduate Honors Theses

Nicotine use is very prevalent in the schizophrenic population, which is a 2.5 fold greater than the general population. In the present study, the drug quinpirole (dopamine D2/D3 agonist) or saline was given neonatally to 25 Sprague-Dawley male and female rats. Rats were randomly assigned to condition. Beginning postnatal day 33 animals were given twice daily administrations of nicotine (0.5 mg/kg free base). After the first of the daily injections they were placed in a locomotor arena every other day for behavioral testing. One day after behavioral testing, the dorsal striatum and nucleus accumbens were removed ...


Cannabis Use And Bipolar Disorder: Bipolar Disorder Case Identification And Cannabis Use Risk Assessment: A Dissertation, Patrick J. McCabe 2011 University of Massachusetts Medical School

Cannabis Use And Bipolar Disorder: Bipolar Disorder Case Identification And Cannabis Use Risk Assessment: A Dissertation, Patrick J. Mccabe

GSBS Dissertations and Theses

Bipolar disorders (BD) are characterized by symptoms of grandiosity, decreased need for sleep, pressure to keep talking, flight of ideas, distractibility, increased goal-directed activities, psychomotor agitation, and excessive involvement in pleasurable activities. Those with a bipolar disorder have a high degree of psychiatric comorbidity including substance use disorders, and they also experience increased mortality. Despite the widespread recognition of BD as an important psychiatric condition, available population-based estimates for BD prevalence differs across data sources.

Cannabis is one of the most widely-used illicit substances. Evidence supports it as a risk factor for psychotic symptoms and disorders. Because populations with psychotic ...


Personality Traits Prospectively Predict Verbal Fluency In A Lifespan Sample, Angelina R. Sutin PhD, Antonio Terracciano PhD, Melissa H. Kitner-Triolo, Manuela Uda, David Schlessinger, Alan B. Zonderman 2011 The Florida State University

Personality Traits Prospectively Predict Verbal Fluency In A Lifespan Sample, Angelina R. Sutin Phd, Antonio Terracciano Phd, Melissa H. Kitner-Triolo, Manuela Uda, David Schlessinger, Alan B. Zonderman

Behavioral Sciences and Social Medicine Faculty Publications

In a community-dwelling sample (N = 4,790; age range 14-94), we examined whether personality traits prospectively predicted performance on a verbal fluency task. Open, extraverted, and emotionally stable participants had better verbal fluency. At the facet level, dispositionally happy and self-disciplined participants retrieved more words; those prone to anxiety and depression and those who were deliberative retrieved fewer words. Education moderated the association between conscientiousness and fluency such that participants with lower education performed better on the fluency task if they were also conscientious. Age was not a moderator at the domain level, indicating that the personality-fluency associations were consistent ...


Rater Wealth Predicts Perceptions Of Outgroup Competence, Wayne Chan, Robert R. McCrae, Darrin L. Rogers, Amy A. Weimer, David M. Greenberg, Antonio Terracciano PhD 2011 The Florida State University

Rater Wealth Predicts Perceptions Of Outgroup Competence, Wayne Chan, Robert R. Mccrae, Darrin L. Rogers, Amy A. Weimer, David M. Greenberg, Antonio Terracciano Phd

Department of Geriatrics Faculty Publications

National income has a pervasive influence on the perception of ingroup stereotypes, with high status and wealthy targets perceived as more competent. In two studies we investigated the degree to which economic wealth of raters related to perceptions of outgroup competence. Raters' economic wealth predicted trait ratings when 1) raters in 48 other cultures rated Americans' competence and 2) Mexican Americans rated Anglo Americans' competence. Rater wealth also predicted ratings of interpersonal warmth on the culture level. In conclusion, raters' economic wealth, either nationally or individually, is significantly associated with perception of outgroup members, supporting the notion that ingroup conditions ...


Examining The Effect Of Medical Risk, Parental Stress, And Self-Efficacy On Parent Behaviors And The Home Environment Of Premature Children, Kathryn Woods 2011 University of Nebraska - Lincoln

Examining The Effect Of Medical Risk, Parental Stress, And Self-Efficacy On Parent Behaviors And The Home Environment Of Premature Children, Kathryn Woods

Open Access Theses and Dissertations from the College of Education and Human Sciences

The purpose of this study was to examine the relationship between medical risk and parenting stress and the extent to which parental self-efficacy moderates the relationship between medical risk, parenting stress, specific parenting behaviors (i.e., parental responsivity, acceptance of child, parental involvement) and the home environment (i.e., organization of environment, learning materials, variety in experience, and IT-HOME total score) of premature children. Participants included 72 parent-child dyads with premature children between the ages of 7 and 35 months corrected age. Measures included parent reports of medical risk, stress, self-efficacy, and the IT-HOME. Results show that medical risk was ...


Do Exercise Motives Predict Obligatory Exercise?, Mary Pritchard, Jessica L. Beaver 2011 Boise State University

Do Exercise Motives Predict Obligatory Exercise?, Mary Pritchard, Jessica L. Beaver

Psychology Faculty Publications and Presentations

Few studies have examined whether factors predicting obligatory exercise differ by gender. 303 participants completed the Obligatory Exercise Questionnaire and the Reason for Exercise Inventory. All variables correlated significantly. However, the correlation between exercising for fitness and obligatory exercise was significantly stronger in women than men. In women, obligatory exercise was predicted by exercising to improve body tone, fitness, and to enhance mood; in men, obligatory exercise was predicted by exercising to improve body tone, enjoyment, and perceived attractiveness. Implications for treatment are discussed.


Development Of A Cohesion Inventory For Children's Sport Teams, Luc J. Martin 2011 Western University

Development Of A Cohesion Inventory For Children's Sport Teams, Luc J. Martin

University of Western Ontario - Electronic Thesis and Dissertation Repository

The general purpose of this dissertation was to develop an inventory designed to measure cohesion in children’s (ages 9-12) sport teams. To this end, three studies were conducted. In Study 1, children became active agents in the process of test construction. More specifically, children (N = 167) participated in focus groups and completed open-ended questionnaires in order to provide information on their perceptions of cohesion as well as motives for participating, continuing, and ceasing involvement on sport teams. Study 2 involved the use of the information obtained from Study 1 to develop potential items for the questionnaire. In addition, the ...


Relational Discrimination By Pigeons In A Go/No-Go Procedure With Compound Stimuli: A Methodological Note, Heloisa Cursi Campos, Paula Debert, Romariz da Silva Barros, William J. McIlvane 2011 University of Massachusetts Medical School

Relational Discrimination By Pigeons In A Go/No-Go Procedure With Compound Stimuli: A Methodological Note, Heloisa Cursi Campos, Paula Debert, Romariz Da Silva Barros, William J. Mcilvane

Shriver Center Publications and Presentations

A go/no-go procedure with compound stimuli typically establishes emergent behavior that parallels in structure and typical outcome that of conventional tests for symmetric, transitive, and equivalence relations in normally capable adults. The present study employed a go/no-go compound stimulus procedure with pigeons. During training, pecks to two-component compounds A1B1, A2B2, B1C1, and B2C2 were followed by food. Pecks to compounds A1B2, A2B1, B1C2, and B2C1 re-started the 30-s stimulus presentation interval. The absence of pecking to those compounds for 30 s ended the trial. Subsequent tests presented these components in new spatial arrangements and/or in recombinative compounds ...


Overcoming Barriers To Perinatal Depression Treatment, Nancy Byatt, Kathleen Biebel, Liz Friedman, Jeroan J. Allison, Douglas M. Ziedonis 2011 University of Massachusetts Medical School

Overcoming Barriers To Perinatal Depression Treatment, Nancy Byatt, Kathleen Biebel, Liz Friedman, Jeroan J. Allison, Douglas M. Ziedonis

Community Engagement and Research Symposium

Background

Untreated perinatal depression is common and has deleterious effects on mother, fetus/child and family

  • Despite effective evidence-based treatment for perinatal depression, most women do not get treatment
  • Obstetricians have not traditionally identified and/or responded to the mental health needs of perinatal women
  • Caring and committed providers are frustrated and confused5 and mothers do not feel seen, heard or understood by their providers
  • Implementing supports for perinatal women within the traditional medical model poses many challenges to mental health and obstetric providers

MotherWoman is a community-based grassroots organization dedicated to preventing and treating perinatal depression through an innovative ...


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