Determination Of Ketoprofen Based On Its Quenching Effect In The Fluorescence Of Quantum Dots,
2020
Taiwan Food and Drug Administration
Determination Of Ketoprofen Based On Its Quenching Effect In The Fluorescence Of Quantum Dots, L. Molina-García, J.L.M. Santos, A. Ruiz-Medina, E.J. Llorent-Martínez
Journal of Food and Drug Analysis
Ketoprofen is a potent nonsteroidal anti-inflammatory drug used for the treatment of inflammatory diseases and musculoskeletal injuries. Taking into account the increasing consumption of this drug, it is important to develop a rapid, easy, and reliable analytical strategy for its quality control. In this work, we present a novel method for ketoprofen determination, based on its quenching effect produced in the fluorescence of CdTe quantum dots modified by mercaptopropionic acid. Under optimized conditions, the method was linear in the range of 7.5-100 μg/mL, with a detection limit of 2.3 μg/mL and relative standard deviations lower than 2%. It was applied …
Determination Of Fluorides In Pharmaceutical Products For Oral Hygiene,
2020
Taiwan Food and Drug Administration
Determination Of Fluorides In Pharmaceutical Products For Oral Hygiene, J. Švarc-Gajić, Z. Stojanović, I. Vasiljević, I. Kecojević
Journal of Food and Drug Analysis
Fluorides are common ingredients in pharmaceutical products for oral hygiene due to their recognized effect in the prevention of tooth decay. In dental products, fluorides can be added in several different forms, such as sodium fluoride, sodium monofluorophosphate, tin fluoride, or in the form of different amines. This work describes potentiometric determination of fluorides in the samples of toothpastes and mouthwash. The method was optimized for the particular analytical purpose; namely, for the analysis of toothpastes and mouthwash by applying different sample preparation protocols depending on the fluoride source. Good recovery (93-103%) confirmed the correctness of the sample preparation procedures. …
Direct Quantitative Analysis Of Benzodiazepines, Metabolites, And Analogs In Diluted Human Urine By Rapid Resolution Liquid Chromatography-Tandem Mass Spectrometry,
2020
Taiwan Food and Drug Administration
Direct Quantitative Analysis Of Benzodiazepines, Metabolites, And Analogs In Diluted Human Urine By Rapid Resolution Liquid Chromatography-Tandem Mass Spectrometry, R.-Y. Hsu, S.-A. Chan, S.-L. Lin, T.-Y. Lin, W.-L. Chu, M.-R. Fuh
Journal of Food and Drug Analysis
Rapid resolution liquid chromatography (RRLC) coupled with triple quadrupole mass spectrometry (QqQ-MS) was developed for direct quantitative analysis of benzodiazepines (BDZs) and their metabolites, as well as BDZ analogs (zopiclone, zolpidem, and zaleplon) in diluted human urine. A perfluorophenyl column packed with sub-2-mm particles and a C8 precolumn were applied to accomplish RRLC analysis with symmetric peak shapes. Urine samples were diluted 10-fold with Milli-Q water prior to autoinjection for direct quantification of 34 target analytes with negligible matrix effect. Gradient elution and dynamic multiple reaction monitoring were used for simultaneous quantitation of 34 BDZs, metabolites, and BDZ analogs. Good …
Simultaneous Quantification Of Antibiotic Dyes In Aquatic Products And Feeds By Liquid Chromatography-Tandem Mass Spectrometry,
2020
Taiwan Food and Drug Administration
Simultaneous Quantification Of Antibiotic Dyes In Aquatic Products And Feeds By Liquid Chromatography-Tandem Mass Spectrometry, R.-C. Chen, K.-J. Wei, T.-M. Wang, Y.-M. Yu, J.-Y. Li, S.-H. Lee, W.-H. Wang, T.-J. Ren, C.-W. Tsai
Journal of Food and Drug Analysis
A confirmatory and quantitative method based on liquid chromatography- tandem mass spectrometry (LC/MS/MS) has been developed for the determination of low-level residues of three antibiotic dyes and two metabolites in fish muscle and feed. The target compounds include methylene blue (MB), crystal violet (CV), leucocrystal violet (LCV), malachite green (MG), and leucomalachite green (LMG). The procedures involve solvent extraction by 50% McIlvaine's buffer with acetonitrile, followed by solid phase extraction (SPE) with an MCX cartridge. High performance liquid chromatography (HPLC) and positive electrospray ionization (ESI) MS with multiple reaction monitoring of two transition reactions was applied for each compound. The …
Harm Reduction History, Response, And Current Trends In Asia,
2020
Taiwan Food and Drug Administration
Harm Reduction History, Response, And Current Trends In Asia, N. Thomson
Journal of Food and Drug Analysis
Human immunodeficiency virus (HIV) epidemics in Asia have been initially driven through injection drug use and the use of shared needles and syringes. Molecular epidemiological work has shown that where there is heroin trafficking and use, there is also HIV. Given the often strict enforcement of national antinarcotic laws, harm reduction responses to HIV infections driven by injection drug use have been historically slow. As it became clear that preventing HIV meant embracing harm reduction, many countries in the region have adopted harm reduction as part of their national acquired immunodeficiency syndrome (AIDS) strategy and increasingly as part of their …
Genetics And Pharmacogenetics Of Substance Use Disorders,
2020
Taiwan Food and Drug Administration
Genetics And Pharmacogenetics Of Substance Use Disorders, P.-L. Tao, L.-S. Chen, C.-K. Chen, Y.-L. Liu
Journal of Food and Drug Analysis
The "Genetics and pharmacogenetics of substance use disorder" session was chaired by Dr Pao-Luh Tao and had three speakers. The speakers and topics were as follows. Dr Li-Shiun Chen discussed "Genomics and personalized medicine for smoking cessation treatments". Dr Chih-Ken Chen presented a talk on the "Genetics of methamphetamine abuse and methamphetamine psychosis". Dr Yu-Li Liu described a "Pharmacogenomics study in a Taiwan methadone maintenance cohort". Copyright © 2013, Food and Drug Administration, Taiwan.
Current Status Of Drug Use And Hiv/Aids Prevention In Drug Users In China,
2020
Taiwan Food and Drug Administration
Current Status Of Drug Use And Hiv/Aids Prevention In Drug Users In China, J. Li, X. Li
Journal of Food and Drug Analysis
The objective of this paper is to review the current status of drug use and HIV/AIDS prevention for drug users in China and to provide scientific evidence for HIV/AIDS prevention and control in drug users. This paper reviews literature and articles related to drug abuse in China, and reviews the results of prevention efforts and successful cases regarding human immunodeficiency virus (HIV)/AIDS prevention in drug users. Lessons learned are discussed for the future improvement of work and the sustainable development of treatment programs. The number of drug users in China is increasing. Even though the number of opioid-type drug users …
Prevention, Family, And Community,
2020
Taiwan Food and Drug Administration
Prevention, Family, And Community, S.-L. Yang, L.A. Rohrbach, D. Daley
Journal of Food and Drug Analysis
The "Prevention, family, and community" session was chaired by Dr Joseph Jror-Serk Cheng, who is an expert in community psychiatry and mental health policy and is Superintendent of the Bali Psychiatric Center in Taipei. Dr Shu-Lung Yang, Dean of Student Affairs and Professor/Director of the Crime Research Center, National Chung Cheng University in Chiayi, Taiwan, served as the discussant. The two presenters were Dr Louise Ann Rohrbach, who presented on "Prevention of alcohol and other drug abuse: Science, practice, critical issues, and future direction," and Dr Dennis Daley, who spoke on "Family and social aspects of drug abuse: Implications for …
Current Status Of Substance Abuse And Hiv Infection In Japan,
2020
Taiwan Food and Drug Administration
Current Status Of Substance Abuse And Hiv Infection In Japan, K. Wada, M. Funada, T. Matsumoto, T. Shimane
Journal of Food and Drug Analysis
Japan has experienced an epidemic of methamphetamine (MAP) abuse three times: the first epidemic was from 1951 to 1957, the second epidemic was from 1970 to 1994, and the third epidemic started in 1995 and continues today. Fortunately, HIV infection is not as serious a problem in Japan as it is in other countries. The major route of HIV infection in Japan has been through male homosexual transmission. In cumulative numbers, homosexual transmission accounted for 63% of the 11,146 HIV-positive patients and 40% of 5158 AIDS patients as of December 30, 2011. Intravenous drug use accounted for 0.3% and 0.4% …
Systematic Review Research On Needle/Syringe Programs And Opiate Substitution Programs In Low- And Middle-Income Countries,
2020
Taiwan Food and Drug Administration
Systematic Review Research On Needle/Syringe Programs And Opiate Substitution Programs In Low- And Middle-Income Countries, D.C.D. Jarlais
Journal of Food and Drug Analysis
People who inject drugs (PWID) are at an elevated risk of infection by human immunodeficiency virus (HIV) or hepatitis C virus (HCV). In many high-income countries, needle and syringe exchange programs (NSPs) have been associated with reductions in bloodborne infections. However, there is not a good understanding of the effectiveness of NSP in low- and middle-income countries and transitional-economy countries. A systematic literature review, based on the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) guidelines, was utilized to collect primary study data on the coverage of NSP programs and the changes in HIV and HCV infection over …
Treatment Of Methamphetamine Abuse: An Antibody-Based Immunotherapy Approach,
2020
Taiwan Food and Drug Administration
Treatment Of Methamphetamine Abuse: An Antibody-Based Immunotherapy Approach, Y.-H. Chen, K.-L. Wu, H.-M. Tsai, C.-H. Chen
Journal of Food and Drug Analysis
Methamphetamine is a highly addictive psychostimulant with tens of millions of abusers around the world. There is no effective or approved medication for treating an addiction to it. Monoclonal antibodies with a high affinity for methamphetamine have the potential to sequester the drug in the vascular compartment and reduce entry into the brain, thereby acting as peripheral pharmacokinetic antagonists without inducing adverse effects on neurons. However, to maintain the antibodies at an effective level, repeated administration is required, which would be expensive and problematic for patient compliance. In this study, we intended to investigate whether using a recombinant adeno-associated virusmediated …
Current Status Of Substance Abuse And Hiv In Taiwan,
2020
Taiwan Food and Drug Administration
Current Status Of Substance Abuse And Hiv In Taiwan, W.-J. Yu, W.-I. Tsay, J.-H. Li
Journal of Food and Drug Analysis
Methamphetamine abuse, which surged in the early 1990s, remains a major social and health issue in recent years in Taiwan. The danger of the spread of HIV among heroin injecting drug users (IDUs) gradually increased because of needle/syringe sharing in the early 2000s. The percentage of IDUs among all addiction treatment admissions increased from 34.7% in 2000 to 63.9% in 2004, and the percentage of IDUs sharing needles increased from 4.0% in 2000 to 15% in 2004. Alerted by the escalating IDU-associated HIV situation, the Department of Health launched the national pilot harm reduction program (PHRP) in four of 25 …
Ketamine Use Among Regular Tobacco And Alcohol Users As Revealed By Respondent-Driven Sampling In Taipei: Prevalence, Expectancy, And Users' Risky Decision Making,
2020
Taiwan Food and Drug Administration
Ketamine Use Among Regular Tobacco And Alcohol Users As Revealed By Respondent-Driven Sampling In Taipei: Prevalence, Expectancy, And Users' Risky Decision Making, W.J. Chen, T.-T. Ting, C.-M. Chang, Y.-C. Liu, C.-Y. Chen
Journal of Food and Drug Analysis
The popularity of ketamine for recreational use among young people began to increase, particularly in Asia, in 2000. To gain more knowledge about the use of ketamine among high-risk individuals, a respondent-driven sampling (RDS) was implemented among regular alcohol and tobacco users in the Taipei metropolitan area from 2007 to 2010. The sampling was initiated in three different settings (i.e., 2 in the community and 1 in a clinic) to recruit seed individuals. Each participant was asked to refer one to five friends known to be regular tobacco smokers and alcohol drinkers to participate in the present study. Incentives were …
A Comprehensive Approach To Addiction Medicine As An Appropriate Response To The Hiv Epidemic Among Drug Users,
2020
Taiwan Food and Drug Administration
A Comprehensive Approach To Addiction Medicine As An Appropriate Response To The Hiv Epidemic Among Drug Users, G. Gerra, L. Somaini
Journal of Food and Drug Analysis
The services for drug-dependence treatment and care, particularly in low-income countries, should not be fragmented and uncoordinated. A basic package of interventions should be provided in the same place and managed by the same team, with a one-stopshop approach. The services for substance use disorders should be appealing, accessible, voluntary-based, and science-based. They should also, like efforts to fight other diseases, be included in the community and the public health systems; that is, those who are affected by drug use and those who serve them should not face discrimination. The firstline assistance and the second-line essential elements of the comprehensive …
Brain Abnormalities In Hiv And Stimulant Users: Interventions And Prevention,
2020
Taiwan Food and Drug Administration
Brain Abnormalities In Hiv And Stimulant Users: Interventions And Prevention, L. Chang, S. Shoptaw, J. Normand
Journal of Food and Drug Analysis
The session, "HIV and other Infectious Diseases," was chaired by Dr. Jacques Normand, Director of the AIDS Research Program of the US National Institute on Drug Abuse. The two presenters (and their presentation topics) were: Dr. Linda Chang ("Neural Correlates of Cognitive Deficits and Training Effects on Brain Function in HIV-infected Individuals") and Dr. Steven Shoptaw ("HIV Prevention in Substance Users"). Copyright © 2013, Food and Drug Administration, Taiwan.
Potential Therapeutic Strategy To Treat Substance Abuse Related Disorders,
2020
Taiwan Food and Drug Administration
Potential Therapeutic Strategy To Treat Substance Abuse Related Disorders, S.L. Chang
Journal of Food and Drug Analysis
The "Potential therapeutic strategy to treat substance-abuse-related disorders" session was chaired by Dr. Sulie L. Chang, director of NeuroImmune Phamacology at Seton Hall University. The four presenters were: Dr Wenzhe Ho (Miniway to stop HIV/HCV), Dr Ru-Band Lu (Low dose of memantine in the treatment of opioid dependence in human), Dr Ping Zhang (Treatment of alcohol-related disorders: Learning from stem/progenitor cells), and Dr Yun-Hsiang Chen (Treatment of methamphetamine abuse: An antibody-based immunotherapy approach). Copyright © 2013, Food and Drug Administration, Taiwan.
Genomics And Personalized Medicine: Chrna5- Chrna3-Chrnb4 And Smoking Cessation Treatment,
2020
Taiwan Food and Drug Administration
Genomics And Personalized Medicine: Chrna5- Chrna3-Chrnb4 And Smoking Cessation Treatment, L.-S. Chen, L.J. Bierut
Journal of Food and Drug Analysis
Cigarette smoking is highly addictive, and modern genetic research has identified robust genetic influences on nicotine dependence. An important step in translating these genetic findings is to identify the genetic factors affecting smoking cessation in order to enhance current smoking cessation treatments. We review the significance of variants in the nicotinic receptor gene cluster (CHRNA5eCHRNA3eCHRNB4) in the prediction of smoking quantity, smoking cessation, and response to cessation medication in multiple studies of smoking cessation. Three common haplotypes (low-risk, intermediate-risk, and high-risk) in the CHRNA5eCHRNA3eCHRNB4 region are defined by rs16969968 and rs680244. The genetic variants in the CHRNA5eCHRNA3eCHRNB4 region that predict …
Collaborative Work Between The West And Asia,
2020
Taiwan Food and Drug Administration
Collaborative Work Between The West And Asia, Y.-I. Hser, G. Bart, L. Li, L.M. Giang
Journal of Food and Drug Analysis
The "Collaborative work between the West and Asia" session was chaired by Dr Yih-Ing Hser and had three speakers. The speakers (and their topics) were: Dr Gavin Bart (Collaborative addiction research in the United States and Asia), Dr Li Li (Implementing intervention research projects in Asia), and Dr Le Minh Giang (Building research infrastructure for international collaborative studies on substance use disorder and HIV: The case of Hanoi Medical University/Vietnam). Copyright © 2013, Food and Drug Administration, Taiwan.
Substance Use Disorders And Hiv In Vietnam Since Doi Moi (Renovation): An Overview,
2020
Taiwan Food and Drug Administration
Substance Use Disorders And Hiv In Vietnam Since Doi Moi (Renovation): An Overview, L.M. Giang, L.B. Ngoc, V.H. Hoang, K. Mulvey, R.A. Rawson
Journal of Food and Drug Analysis
Drawing frompublished and gray literature, this manuscript focuses on the following topics: (1) changing patterns of substance use and abuse in Vietnamsince the early 1990s; (2) the roles of substance use in the human immunodeficiency virus (HIV) epidemic; (3) the responses of theVietnamese government and other entities (both domestic and international) to substance use disorders (SUDs) and HIV; and (4) the current research capacity in Vietnam and ways in which furthering research in Vietnam could enrich our knowledge of the linkages between SUDsandHIVand of effectivemeasures to reduce theirpublichealth consequences.Agrowing number of studies during the past 2 decades show dynamic and …
Introduction To The Special Issue: Promoting Global Healthetreatment And Prevention Of Substance Abuse And Hiv In Asia,
2020
Taiwan Food and Drug Administration
Introduction To The Special Issue: Promoting Global Healthetreatment And Prevention Of Substance Abuse And Hiv In Asia, Y.-I. Hser, W.-I. Tsay, Y. Wang, B. Tai
Journal of Food and Drug Analysis
[No abstract available]
