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378 full-text articles. Page 1 of 16.

A Fluorescent Reporter Mouse For Inflammasome Assembly Demonstrates An Important Role For Cell-Bound And Free Asc Specks During In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, Douglas T. Golenbock 2016 University of Massachusetts Medical School

A Fluorescent Reporter Mouse For Inflammasome Assembly Demonstrates An Important Role For Cell-Bound And Free Asc Specks During In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, Douglas T. Golenbock

Katherine A. Fitzgerald

Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that ectopically express the fluorescent adaptor protein, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and characterized the formation of assembled inflammasome complexes ("specks") in primary cells and tissues. In addition to hematopoietic cells, we have found that a stromal population in the lung tissues formed specks during the early phase of influenza infection, whereas myeloid cells showed speck formation after 2 days. In a peritonitis and group B streptococcus ...


A Fluorescent Reporter Mouse For Inflammasome Assembly Demonstrates An Important Role For Cell-Bound And Free Asc Specks During In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, Douglas T. Golenbock 2016 University of Massachusetts Medical School

A Fluorescent Reporter Mouse For Inflammasome Assembly Demonstrates An Important Role For Cell-Bound And Free Asc Specks During In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, Douglas T. Golenbock

Open Access Articles

Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that ectopically express the fluorescent adaptor protein, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and characterized the formation of assembled inflammasome complexes ("specks") in primary cells and tissues. In addition to hematopoietic cells, we have found that a stromal population in the lung tissues formed specks during the early phase of influenza infection, whereas myeloid cells showed speck formation after 2 days. In a peritonitis and group B streptococcus ...


Chronic Saline Exposures Interfere With Basal And Induced Immunity In Striped Catfish (Pangasianodon Hypophthalmus, Sauvage) Exposed To Virulent Strain Of Edwardsiella Ictaluri., Mélodie Schmitz 2016 University of Namur

Chronic Saline Exposures Interfere With Basal And Induced Immunity In Striped Catfish (Pangasianodon Hypophthalmus, Sauvage) Exposed To Virulent Strain Of Edwardsiella Ictaluri., Mélodie Schmitz

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Constitutively Overexpressed Type I Interferon Transgenic Medaka Fish Down-Regulate The Antiviral Response, Shun Maekawa 2016 Institute of Biotechnology, National Cheng Kung University,Taiwan

Constitutively Overexpressed Type I Interferon Transgenic Medaka Fish Down-Regulate The Antiviral Response, Shun Maekawa

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Membrane Disruption Antimicrobial Mechanism Of Channa Striatus Lysozyme-Derived Antimicrobial Peptide, Venkatesh Kumaresan 2016 SRM University

Membrane Disruption Antimicrobial Mechanism Of Channa Striatus Lysozyme-Derived Antimicrobial Peptide, Venkatesh Kumaresan

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Functional Characterization Of Recombinant Interleukin (Il)-17a/F1 In The Japanese Pufferfish (Takifugu Rubripes), Jun-ichi Hikima Dr., Koshin Mihara, Shun Maekawa, Han-Ching Wang, Takashi Aoki, Tomoya Kono, Masahiro Sakai 2016 University of Miyazaki, Faculty of Agriculture

Functional Characterization Of Recombinant Interleukin (Il)-17a/F1 In The Japanese Pufferfish (Takifugu Rubripes), Jun-Ichi Hikima Dr., Koshin Mihara, Shun Maekawa, Han-Ching Wang, Takashi Aoki, Tomoya Kono, Masahiro Sakai

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, Rajesh Palanisamy 2016 SRM Institute of Science and Technology

Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, Rajesh Palanisamy

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Characterization Of Igm In Norwegian Cleaner Fish (Lumpfish And Wrasses), Sumaira Bilal, kai kristoffer Lie PhD, Odd Andre Karlsen Associate Professor, Ivar Hordvik Professor 2016 Universitet i Bergen, Norway

Characterization Of Igm In Norwegian Cleaner Fish (Lumpfish And Wrasses), Sumaira Bilal, Kai Kristoffer Lie Phd, Odd Andre Karlsen Associate Professor, Ivar Hordvik Professor

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


The Ifitms Inhibit Zika Virus Replication, George Savidis, Jill Perreira, Jocelyn M. Portmann, Paul Meraner, Zhiru Guo, Sharone Green, Abraham L. Brass 2016 University of Massachusetts Medical School

The Ifitms Inhibit Zika Virus Replication, George Savidis, Jill Perreira, Jocelyn M. Portmann, Paul Meraner, Zhiru Guo, Sharone Green, Abraham L. Brass

Sharone Green

Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. Moreover, IFITM3 can prevent Zika-virus-induced cell death. These results suggest that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.


Liposomal- And Cpg Oligodeoxynucleotide-Based Vaccine Formulations Offer Protection With Reduced Adverse Effects In Rainbow Trout, Kasper Rømer Villumsen, Dennis Christensen, Erling Olaf Koppang, Anders Miki Bojesen 2016 University of Copenhagen

Liposomal- And Cpg Oligodeoxynucleotide-Based Vaccine Formulations Offer Protection With Reduced Adverse Effects In Rainbow Trout, Kasper Rømer Villumsen, Dennis Christensen, Erling Olaf Koppang, Anders Miki Bojesen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Characterization And Involvement Of Toll And Imd Pathways In Ahpnd-Infected Shrimp, Mi-De Yeh 2016 National Cheng Kung University

Characterization And Involvement Of Toll And Imd Pathways In Ahpnd-Infected Shrimp, Mi-De Yeh

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


White Spot Syndrome Virus Entry Is Multiple Ways Dependent, Haipeng Liu 2016 The University of Maine

White Spot Syndrome Virus Entry Is Multiple Ways Dependent, Haipeng Liu

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Ahpnd Biomarker Profile Identified By Transcriptome Sequencing In Litopenaeus Vannamei Stomach, Tze Hann Ng 2016 National Cheng Kung University

Ahpnd Biomarker Profile Identified By Transcriptome Sequencing In Litopenaeus Vannamei Stomach, Tze Hann Ng

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


The Expression Analysis Of Per1 Gene In Fugu, Takifugu Rubripes Administered With Immunostimulants, Goshi Nishi, Jun-ichi Hikima Dr., Masahiro Sakai, Tomoya Kono 2016 University of Miyazaki, Faculty of Agriculture

The Expression Analysis Of Per1 Gene In Fugu, Takifugu Rubripes Administered With Immunostimulants, Goshi Nishi, Jun-Ichi Hikima Dr., Masahiro Sakai, Tomoya Kono

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Three Hamp Genes Of Nile Tilapia Were Differentially Activated In Spleen To Defend Against Streptococcus Iniae Infection, Hong-Yi Gong, Chia-Hui Ho, Sheng-Han Wu, Wen-Fu Lin, Yi-Hsuan Kuo, Yu-Hsuan Chang 2016 National Taiwan Ocean University

Three Hamp Genes Of Nile Tilapia Were Differentially Activated In Spleen To Defend Against Streptococcus Iniae Infection, Hong-Yi Gong, Chia-Hui Ho, Sheng-Han Wu, Wen-Fu Lin, Yi-Hsuan Kuo, Yu-Hsuan Chang

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, Hakim Samai 2016 Université Reims Champagne-Ardenne, UMR-I 02 SEBIO

Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, Hakim Samai

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Identification And Expression Analysis On Two Forms Bactericidal Permeability-Increasing Protein (Bpi)/Lipopolysaccharide-Binding Protein (Lbp) Of Triangle Mussel, Hyriopsis Cumingii, Wen Chungen 2016 The University of Maine

Identification And Expression Analysis On Two Forms Bactericidal Permeability-Increasing Protein (Bpi)/Lipopolysaccharide-Binding Protein (Lbp) Of Triangle Mussel, Hyriopsis Cumingii, Wen Chungen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Stat6 Negatively Regulates Tbk1-Triggered Ifnφ1 Activation In Zebrafish, Yong-An Zhang 2016 Institute of Hydrobiology, Chinese Academy of Sciences

Stat6 Negatively Regulates Tbk1-Triggered Ifnφ1 Activation In Zebrafish, Yong-An Zhang

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Expression Kinetics Of Interferon Stimulated Genes In Atlantic Salmon Head Kidney Cells (Ask) Nucleofected With Poly(I:C), Adriana Magalhaes Santos Andresen 19821, Tor Gjøen 2016 University of Oslo

Expression Kinetics Of Interferon Stimulated Genes In Atlantic Salmon Head Kidney Cells (Ask) Nucleofected With Poly(I:C), Adriana Magalhaes Santos Andresen 19821, Tor Gjøen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Optimization Of A Plaque Neutralization Test Capable Of Assessing The Exposure History Of Pacific Herring To Viral Hemorrhagic Septicemia Virus, Ashley MacKenzie 2016 USGS- Marrowstone Marine Field Station

Optimization Of A Plaque Neutralization Test Capable Of Assessing The Exposure History Of Pacific Herring To Viral Hemorrhagic Septicemia Virus, Ashley Mackenzie

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


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