14 Institutions 56 Full-Text Articles 98 Authors 5,262 Downloads
Recent Articles in Immunity
Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter The University of Maine
Evolutionary And Molecular Analysis Of Conserved Vertebrate Immunity To Fungi, Erin Carter
The innate immune system is highly conserved amongst all multicellular organisms. Yet a constant battle exists between host cells and pathogens due to the rapid evolution of immune system components. Functional genomics and in silico methods can be employed to elucidate the evolutionary patterns of vertebrate immunity to pathogenic fungi such as Candida albicans, an opportunistic fungal pathogen that can cause lethal candidiasis in the immunocompromised. Mammals such as humans and mice possess conserved C-type lectin receptors that recognize the C. albicans cell wall. However, these receptors have not been identified in fish. Here I describe how we identified potential ...
Isolation And Characterization Of Active Elderberry Fractions That Inhibit Melanoma Growth In Vitro And In Vivo, Alexandra M. Okihiro Indiana University – Purdue University Fort Wayne
Isolation And Characterization Of Active Elderberry Fractions That Inhibit Melanoma Growth In Vitro And In Vivo, Alexandra M. Okihiro
The incidence rates of melanoma continue to rise annually despite recent progression in cancer treatments. Cancer is the most prevalent amongst elderly individuals, where immunosenescence has compromised some immune function, and therefore decreased certain tumor detection abilities. Current tumor removal strategies include radiation, chemotherapy and surgical excision: treatments that aim to lower cancer cells, but may also affect normal cells in the process. In the case of chemotherapy, which targets and kills rapidly dividing cells, many immune cells are lowered as a side effect, leaving many patients immune-suppressed and more susceptible to infection. There is a need for naturopathic treatments ...
Characterization Of Differentiation And Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma, Richard C. Wu Texas Medical Center Library
Characterization Of Differentiation And Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma, Richard C. Wu
UT GSBS Dissertations and Theses (Open Access)
CD8+ cytotoxic T lymphocytes (CTL) frequently infiltrate tumors, yet most melanoma patients fail to undergo tumor regression. We studied the differentiation of the CD8+ tumor-infiltrating lymphocytes (TIL) from 44 metastatic melanoma patients using known T-cell differentiation markers. We also compared CD8+ TIL against the T cells from matched melanoma patients’ peripheral blood. We discovered a novel subset of CD8+ TIL co-expressing early-differentiation markers, CD27, CD28, and a late/senescent CTL differentiation marker, CD57. This CD8+CD57+ TIL expressed a cytolytic enzyme, granzyme B (GB), yet did not express another cytolytic pore-forming molecule, perforin (Perf). In contrast, the CD8+CD57+ T ...
Cellular Adaptation Of Macrophages To Anthrax Lethal Toxin-Induced Pyroptosis Via Epigenetic Mechanisms, Chae Young Han Western University
Cellular Adaptation Of Macrophages To Anthrax Lethal Toxin-Induced Pyroptosis Via Epigenetic Mechanisms, Chae Young Han
University of Western Ontario - Electronic Thesis and Dissertation Repository
Cellular adaptation to microbial stresses has been demonstrated in several cell types. Macrophages (MФ) are sentinel immune cells fending off invading microbes. Anthrax lethal toxin (LeTx) is a key virulence factor released by Bacillus anthracis that causes rapid cell death, pyroptosis. A small number of RAW246.7 macrophages (~4%) exposed to a non-lethal dose of LeTx become resistant to LeTx-induced pyroptosis for ~ 4 weeks, termed “toxin-induced resistance (TIR)”. Here, I showed that high levels of DNA methyl transferase1 (DNMT1) expression were maintained although global genomic methylation levels were not high in TIR. TIR cells treated with the DNMT inhibitor 5-azacitidine ...
Is Your Immunity Compromised By Being Nice To Your Bacteria? Insights From A Social Amoeba, William E. Callison Washington University in St. Louis
Is Your Immunity Compromised By Being Nice To Your Bacteria? Insights From A Social Amoeba, William E. Callison
Undergraduate Research Symposium
Eukaryotes are dependent on beneficial microbes, but can be killed by harmful ones. How have they evolved responses that protect themselves from harmful bacteria while coddling the beneficial ones? An ideal system for investigating this relationship is the eukaryote social amoeba Dictyostelium discoideum because some clones carry commensal bacteria through the social state to use as future seed corn, while others do not. Most of its life, D. discoideum amoeba consume bacteria and divide by binary fission. Under starvation, amoebae aggregate into a multicellular body which crawls to light, then forms a fruiting body of 20% dead stalk cells and ...
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Investigating The Mechanism Of Nur77-Induced Apoptosis In T Cells, Heather Fogarty
Stat3 Controls The Neutrophil Migratory Response To Cxcr2 And Its Ligand Mip-2 (Cxcl2), Hoainam Nguyen-Jackson
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