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390 full-text articles. Page 1 of 17.

Novel Mutation Of Interferon-Γ Receptor 1 Gene Presenting As Early Life Mycobacterial Bronchial Disease, Maria J. Gutierrez, Neelu Kaira, Alexandra Horwitz, Gustavo Nino 2016 George Washington University

Novel Mutation Of Interferon-Γ Receptor 1 Gene Presenting As Early Life Mycobacterial Bronchial Disease, Maria J. Gutierrez, Neelu Kaira, Alexandra Horwitz, Gustavo Nino

Pediatrics Faculty Publications

Mendelian susceptibility to mycobacterial diseases (MSMD) are a spectrum of inherited disorders characterized by localized or disseminated infections caused by atypical mycobacteria. Interferon-γ receptor 1 (IFNGR1) deficiency was the first identified genetic disorder recognized as MSMD. Mutations in the genes encoding IFNGR1 can be recessive or dominant and cause complete or partial receptor deficiency. We present the case of a 2½-year-old boy with a history of recurrent wheezing, diagnosed with endobronchial mycobacterial infection. Immunological workup revealed a homozygous nonsense mutation in the IFNGR1 gene, a novel mutation predicted in silico to cause complete IFNGR1 deficiency. This case demonstrates that (a ...


A Test Of The Effects Of Androgens On Immunity: No Relationship Between 11-Keto Testosterone And Immune Performance In Bluegill Sunfish (Lepomis Macrochirus), John W. Loggie 2016 The University of Western Ontario

A Test Of The Effects Of Androgens On Immunity: No Relationship Between 11-Keto Testosterone And Immune Performance In Bluegill Sunfish (Lepomis Macrochirus), John W. Loggie

Electronic Thesis and Dissertation Repository

The posited immunosuppressive effects of androgens are a key component of the immunocompetence handicap hypothesis (ICHH). My thesis uses bluegill sunfish (Lepomis macrochirus) to test two predictions arising from this hypothesis: (1) natural concentrations of the androgen 11-keto testosterone (11-KT) will be negatively related with immunity, and (2) an immunochallenge will lower 11-KT concentration. I found no evidence for a relationship between natural 11-KT concentration and measures of immunity (leukocyte counts, respiratory burst, cytokine gene expression), and an immunochallenge with Vibrio vaccine did not affect 11-KT concentration. I performed a meta-analysis of immunochallenge studies to help interpret my results, and ...


Dynamic Host-Pathogen Interactions Result In Fungal Epitope Unmasking, Alex Hopke 2016 University of Maine

Dynamic Host-Pathogen Interactions Result In Fungal Epitope Unmasking, Alex Hopke

Electronic Theses and Dissertations

Molecular camouflage is used by a diverse set of pathogens to disguise their identity and avoid recognition by protective host receptors. The opportunistic fungal pathogen Candida albicans is a good example, as it masks the inflammatory component β-glucan in its cell wall to evade detection by the immune receptor Dectin-1. Interestingly, it has been seen that β-glucan becomes unmasked during infection in vivo, though the underlying mechanisms remained unclear. Exposure levels of this epitope may be important, as Dectin-1 mediates protection from some strains of C. albicans and alterations in the organization and composition of the Candida cell wall can ...


A Fluorescent Reporter Mouse For Inflammasome Assembly Demonstrates An Important Role For Cell-Bound And Free Asc Specks During In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, Douglas T. Golenbock 2016 University of Massachusetts Medical School

A Fluorescent Reporter Mouse For Inflammasome Assembly Demonstrates An Important Role For Cell-Bound And Free Asc Specks During In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, Douglas T. Golenbock

Katherine A. Fitzgerald

Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that ectopically express the fluorescent adaptor protein, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and characterized the formation of assembled inflammasome complexes ("specks") in primary cells and tissues. In addition to hematopoietic cells, we have found that a stromal population in the lung tissues formed specks during the early phase of influenza infection, whereas myeloid cells showed speck formation after 2 days. In a peritonitis and group B streptococcus ...


Long-Term Activation Of The Innate Immune System In Atherosclerosis, Anette Christ, Siroon Bekkering, Eicke Latz, Niels P. Riksen 2016 University of Massachusetts Medical School

Long-Term Activation Of The Innate Immune System In Atherosclerosis, Anette Christ, Siroon Bekkering, Eicke Latz, Niels P. Riksen

Open Access Articles

Efforts to reverse the pathologic consequences of vulnerable plaques are often stymied by the complex treatment resistant pro-inflammatory environment within the plaque. This suggests that pro-atherogenic stimuli, such as LDL cholesterol and high fat diets may impart longer lived signals on (innate) immune cells that persist even after reversing the pro-atherogenic stimuli. Recently, a series of studies challenged the traditional immunological paradigm that innate immune cells cannot display memory characteristics. Epigenetic reprogramming in these myeloid cell subsets, after exposure to certain stimuli, has been shown to alter the expression of genes upon re-exposure. This phenomenon has been termed trained innate ...


A Fluorescent Reporter Mouse For Inflammasome Assembly Demonstrates An Important Role For Cell-Bound And Free Asc Specks During In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, Douglas T. Golenbock 2016 University of Massachusetts Medical School

A Fluorescent Reporter Mouse For Inflammasome Assembly Demonstrates An Important Role For Cell-Bound And Free Asc Specks During In Vivo Infection, Te-Chen Tzeng, Stefan A. Schattgen, Brian G. Monks, Donghai Wang, Anna M. Cerny, Eicke Latz, Katherine A. Fitzgerald, Douglas T. Golenbock

Open Access Articles

Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that ectopically express the fluorescent adaptor protein, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and characterized the formation of assembled inflammasome complexes ("specks") in primary cells and tissues. In addition to hematopoietic cells, we have found that a stromal population in the lung tissues formed specks during the early phase of influenza infection, whereas myeloid cells showed speck formation after 2 days. In a peritonitis and group B streptococcus ...


Chronic Saline Exposures Interfere With Basal And Induced Immunity In Striped Catfish (Pangasianodon Hypophthalmus, Sauvage) Exposed To Virulent Strain Of Edwardsiella Ictaluri., Mélodie Schmitz 2016 University of Namur

Chronic Saline Exposures Interfere With Basal And Induced Immunity In Striped Catfish (Pangasianodon Hypophthalmus, Sauvage) Exposed To Virulent Strain Of Edwardsiella Ictaluri., Mélodie Schmitz

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Constitutively Overexpressed Type I Interferon Transgenic Medaka Fish Down-Regulate The Antiviral Response, Shun Maekawa 2016 Institute of Biotechnology, National Cheng Kung University,Taiwan

Constitutively Overexpressed Type I Interferon Transgenic Medaka Fish Down-Regulate The Antiviral Response, Shun Maekawa

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Membrane Disruption Antimicrobial Mechanism Of Channa Striatus Lysozyme-Derived Antimicrobial Peptide, Venkatesh Kumaresan 2016 SRM University

Membrane Disruption Antimicrobial Mechanism Of Channa Striatus Lysozyme-Derived Antimicrobial Peptide, Venkatesh Kumaresan

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Functional Characterization Of Recombinant Interleukin (Il)-17a/F1 In The Japanese Pufferfish (Takifugu Rubripes), Jun-ichi Hikima Dr., Koshin Mihara, Shun Maekawa, Han-Ching Wang, Takashi Aoki, Tomoya Kono, Masahiro Sakai 2016 University of Miyazaki, Faculty of Agriculture

Functional Characterization Of Recombinant Interleukin (Il)-17a/F1 In The Japanese Pufferfish (Takifugu Rubripes), Jun-Ichi Hikima Dr., Koshin Mihara, Shun Maekawa, Han-Ching Wang, Takashi Aoki, Tomoya Kono, Masahiro Sakai

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, Rajesh Palanisamy 2016 SRM Institute of Science and Technology

Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, Rajesh Palanisamy

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Characterization Of Igm In Norwegian Cleaner Fish (Lumpfish And Wrasses), Sumaira Bilal, kai kristoffer Lie PhD, Odd Andre Karlsen Associate Professor, Ivar Hordvik Professor 2016 Universitet i Bergen, Norway

Characterization Of Igm In Norwegian Cleaner Fish (Lumpfish And Wrasses), Sumaira Bilal, Kai Kristoffer Lie Phd, Odd Andre Karlsen Associate Professor, Ivar Hordvik Professor

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


The Ifitms Inhibit Zika Virus Replication, George Savidis, Jill Perreira, Jocelyn M. Portmann, Paul Meraner, Zhiru Guo, Sharone Green, Abraham L. Brass 2016 University of Massachusetts Medical School

The Ifitms Inhibit Zika Virus Replication, George Savidis, Jill Perreira, Jocelyn M. Portmann, Paul Meraner, Zhiru Guo, Sharone Green, Abraham L. Brass

Sharone Green

Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. Moreover, IFITM3 can prevent Zika-virus-induced cell death. These results suggest that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.


Liposomal- And Cpg Oligodeoxynucleotide-Based Vaccine Formulations Offer Protection With Reduced Adverse Effects In Rainbow Trout, Kasper Rømer Villumsen, Dennis Christensen, Erling Olaf Koppang, Anders Miki Bojesen 2016 University of Copenhagen

Liposomal- And Cpg Oligodeoxynucleotide-Based Vaccine Formulations Offer Protection With Reduced Adverse Effects In Rainbow Trout, Kasper Rømer Villumsen, Dennis Christensen, Erling Olaf Koppang, Anders Miki Bojesen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Characterization And Involvement Of Toll And Imd Pathways In Ahpnd-Infected Shrimp, Mi-De Yeh 2016 National Cheng Kung University

Characterization And Involvement Of Toll And Imd Pathways In Ahpnd-Infected Shrimp, Mi-De Yeh

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


White Spot Syndrome Virus Entry Is Multiple Ways Dependent, Haipeng Liu 2016 The University of Maine

White Spot Syndrome Virus Entry Is Multiple Ways Dependent, Haipeng Liu

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Ahpnd Biomarker Profile Identified By Transcriptome Sequencing In Litopenaeus Vannamei Stomach, Tze Hann Ng 2016 National Cheng Kung University

Ahpnd Biomarker Profile Identified By Transcriptome Sequencing In Litopenaeus Vannamei Stomach, Tze Hann Ng

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Stat6 Negatively Regulates Tbk1-Triggered Ifnφ1 Activation In Zebrafish, Yong-An Zhang 2016 Institute of Hydrobiology, Chinese Academy of Sciences

Stat6 Negatively Regulates Tbk1-Triggered Ifnφ1 Activation In Zebrafish, Yong-An Zhang

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, Hakim Samai 2016 Université Reims Champagne-Ardenne, UMR-I 02 SEBIO

Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, Hakim Samai

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Identification And Expression Analysis On Two Forms Bactericidal Permeability-Increasing Protein (Bpi)/Lipopolysaccharide-Binding Protein (Lbp) Of Triangle Mussel, Hyriopsis Cumingii, Wen Chungen 2016 The University of Maine

Identification And Expression Analysis On Two Forms Bactericidal Permeability-Increasing Protein (Bpi)/Lipopolysaccharide-Binding Protein (Lbp) Of Triangle Mussel, Hyriopsis Cumingii, Wen Chungen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


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