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Permission To Publish Agreement, Concepts In Animal Parasitology, University of Nebraska-Lincoln 2018 University of Nebraska - Lincoln

Permission To Publish Agreement, Concepts In Animal Parasitology, University Of Nebraska-Lincoln

Concepts in Animal Parasitology Textbook

Blank Permission to Publish agreement form for authors of the Concepts in Animal Parasitology textbook/open educational resource.


Investigation Of Bradyzoite Differentiation Initiation In Toxoplasma Gondii, Harim I. Won, Paul H. Davis Ph.D. 2018 University of Nebraska at Omaha

Investigation Of Bradyzoite Differentiation Initiation In Toxoplasma Gondii, Harim I. Won, Paul H. Davis Ph.D.

Theses/Capstones/Creative Projects

Like other eukaryotic organisms, Toxoplasma gondii promoters feature both constitutive and life-stage regulated cis-elements. Using a transcriptomic microarray approach, a cluster of transcripts upregulated early during bradyzoite differentiation was identified. Computational analysis of the promoter regions of these “up-early” transcripts identified a shared upstream consensus motif, a putative transcription factor binding site. Using a dual luciferase assay adapted for recombinational cloning and reporter gene quantification by qPCR, we demonstrate developmental stage-specific expression of the luciferase reporter gene inserted downstream of the transcription factor binding site. The shared consensus motif was found to be an autonomous cis-element by conversion ...


The Small Rna Complement Of Adult Schistosoma Haematobium., Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Ross S Hall, Aaron R Jex, Bonnie L Webster, David Rollinson, Paul J Brindley, Robin B Gasser 2018 George Washington University

The Small Rna Complement Of Adult Schistosoma Haematobium., Andreas J Stroehlein, Neil D Young, Pasi K Korhonen, Ross S Hall, Aaron R Jex, Bonnie L Webster, David Rollinson, Paul J Brindley, Robin B Gasser

Microbiology, Immunology, and Tropical Medicine Faculty Publications

BACKGROUND: Blood flukes of the genus Schistosoma cause schistosomiasis-a neglected tropical disease (NTD) that affects more than 200 million people worldwide. Studies of schistosome genomes have improved our understanding of the molecular biology of flatworms, but most of them have focused largely on protein-coding genes. Small non-coding RNAs (sncRNAs) have been explored in selected schistosome species and are suggested to play essential roles in the post-transcriptional regulation of genes, and in modulating flatworm-host interactions. However, genome-wide small RNA data are currently lacking for key schistosomes including Schistosoma haematobium-the causative agent of urogenital schistosomiasis of humans.

METHODOLOGY: MicroRNAs (miRNAs) and other ...


Analysis Of Antimicrobial Peptide Efficacy Against Chytridiomycosis From Skin Secretions Of Columbia Spotted Frogs (Lithobates Luteiventris), Emma Esposito 2018 Carroll College

Analysis Of Antimicrobial Peptide Efficacy Against Chytridiomycosis From Skin Secretions Of Columbia Spotted Frogs (Lithobates Luteiventris), Emma Esposito

Carroll College Student Undergraduate Research Festival

Amphibian populations have been declining in size in recent years. A major contributing factor to this decline is the fungal disease chytridiomycosis. Chytridiomycosis occurs when the zoospores of the fungus Batrachochytrium dendrobatidis (Bd) imbed into amphibian skin and disrupt the homeostatic functions the skin provides, leading to death in most amphibians. Amphibian skin can produce antimicrobial peptides (AMPs) that inhibit Bd infection. The goal of this experiment was to determine whether or not the amount and type of AMPs a frog produces affect its ability to defend against chytridiomycosis. Columbia spotted frogs were chosen as a model organism because they ...


Recovering Parasites From Mummies And Coprolites: An Epidemiological Approach, Morgana Camacho, Adauto Araújo, Johnica J. Morrow, Jane E. Buikstra, Karl Reinhard 2018 Escola Nacional de Saúde Pública Sergio Arouca/Fundação Oswaldo Cruz

Recovering Parasites From Mummies And Coprolites: An Epidemiological Approach, Morgana Camacho, Adauto Araújo, Johnica J. Morrow, Jane E. Buikstra, Karl Reinhard

Karl Reinhard Papers/Publications

In the field of archaeological parasitology, researchers have long documented the distribution of parasites in archaeological time and space through the analysis of coprolites and human remains. This area of research defined the origin and migration of parasites through presence/absence studies. By the end of the 20th century, the field of pathoecology had emerged as researchers developed an interest in the ancient ecology of parasite transmission. Supporting studies were conducted to establish the relationships between parasites and humans, including cultural, subsistence, and ecological reconstructions. Parasite prevalence data were collected to infer the impact of parasitism on human health. In ...


Creative Commons Attribution-Noncommercial 4.0 International Public License (Cc By-Nc 4.0), Creative Commons 2018 University of Nebraska - Lincoln

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Concepts in Animal Parasitology Textbook

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Information For Authors [Slides]: Concepts In Animal Parasitology, Sue Ann Gardner, Scott Lyell Gardner 2018 University of Nebraska - Lincoln

Information For Authors [Slides]: Concepts In Animal Parasitology, Sue Ann Gardner, Scott Lyell Gardner

Concepts in Animal Parasitology Textbook

Broadcast via Zoom live online, the following are the slides from an information session held for authors and reviewers of the Concepts in Animal Parasitology (working title: Animal Parasitology Concepts) textbook. The work will be written collaboratively and published in 2019 as an open educational resource under a CC BY-NC 4.0 International license.


Instructions For Authors, Concepts In Animal Parasitology: Zea Books Manuscript Preparation Guidelines, Festschriften & Edited Books, Paul Royster, Sue Ann Gardner, Scott Lyell Gardner 2018 University of Nebraska - Lincoln

Instructions For Authors, Concepts In Animal Parasitology: Zea Books Manuscript Preparation Guidelines, Festschriften & Edited Books, Paul Royster, Sue Ann Gardner, Scott Lyell Gardner

Concepts in Animal Parasitology Textbook

Zea Books manuscript preparation guidelines for authors of the Concept in Animal Parasitology free, online textbook.


References Style Guide, Concepts In Animal Parasitology, Sue Ann Gardner, Scott Lyell Gardner 2018 University of Nebraska - Lincoln

References Style Guide, Concepts In Animal Parasitology, Sue Ann Gardner, Scott Lyell Gardner

Concepts in Animal Parasitology Textbook

References style guide for authors of the Concepts in Animal Parasitology free, online textbook.


Instructions For Authors, Concepts In Animal Parasitology, Sue Ann Gardner, Scott Lyell Gardner 2018 University of Nebraska - Lincoln

Instructions For Authors, Concepts In Animal Parasitology, Sue Ann Gardner, Scott Lyell Gardner

Concepts in Animal Parasitology Textbook

Instructions for authors for the Concepts in Animal Parasitology free, online textbook.


Template For Authors For Part Two (Endoparasites) And Part Three (Ectoparasites), Concepts In Animal Parasitology, Sue Ann Gardner, Scott Lyell Gardner 2018 University of Nebraska - Lincoln

Template For Authors For Part Two (Endoparasites) And Part Three (Ectoparasites), Concepts In Animal Parasitology, Sue Ann Gardner, Scott Lyell Gardner

Concepts in Animal Parasitology Textbook

Support material for authors of the open educational resource, Concepts in Animal Parasitology, Part 2 (Endoparasites) and Part 3 (Ectoparasites).


Analysis Of Antimicrobial Peptide Efficacy Against Chytridiomycosis From Skin Secretions Of Columbia Spotted Frogs (Lithobates Luteiventris), Emma Esposito 2018 Carroll College, Helena, MT

Analysis Of Antimicrobial Peptide Efficacy Against Chytridiomycosis From Skin Secretions Of Columbia Spotted Frogs (Lithobates Luteiventris), Emma Esposito

Life and Environmental Sciences Undergraduate Theses

Amphibian populations have been declining in size in recent years. A major contributing factor to this decline is the fungal disease chytridiomycosis. Chytridiomycosis occurs when the zoospores of the fungus Batrachochytrium dendrobatidis (Bd) imbed into amphibian skin and disrupt the homeostatic functions the skin provides, leading to death in most amphibians. Amphibian skin can produce antimicrobial peptides (AMPs) that inhibit Bd infection. The goal of this experiment was to determine whether or not the amount and type of AMPs a frog produces affect its ability to defend against chytridiomycosis. Columbia spotted frogs were chosen as a model organism because they ...


Sequence Analysis Of The Potato Aphid Macrosiphum Euphorbiae Transcriptome Identified Two New Viruses, Marcella A. Texeira, Noa Sela, Hagop S. Atamian, Ergude Bao, Rita Chaudhury, Jacob MacWilliams, Jiangman He, Sophie Mantelin, Thomas Girke, Isgouhi Kaloshian 2018 University of California, Riverside

Sequence Analysis Of The Potato Aphid Macrosiphum Euphorbiae Transcriptome Identified Two New Viruses, Marcella A. Texeira, Noa Sela, Hagop S. Atamian, Ergude Bao, Rita Chaudhury, Jacob Macwilliams, Jiangman He, Sophie Mantelin, Thomas Girke, Isgouhi Kaloshian

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The potato aphid, Macrosiphum euphorbiae, is an important agricultural pest that causes economic losses to potato and tomato production. To establish the transcriptome for this aphid, RNA-Seq libraries constructed from aphids maintained on tomato plants were used in Illumina sequencing generating 52.6 million 75±105 bp paired-end reads. The reads were assembled using Velvet/Oases software with SEED preprocessing resulting in 22,137 contigs with an N50 value of 2,003bp. After removal of contigs from tomato host origin, 20,254 contigs were annotated using BLASTx searches against the non-redundant protein database from the National Center for Biotechnology Information ...


Down-Regulation Of Microrna-203-3p Initiates Type 2 Pathology During Schistosome Infection Via Elevation Of Interleukin-33, Xing He, Jun Xie, Yange Wang, Xiaobin Fan, Qin Su, Yue Sun, Nanhang Lei, Dongmei Zhang, Guangping Gao, Weiqing Pan 2018 Second Military Medical University

Down-Regulation Of Microrna-203-3p Initiates Type 2 Pathology During Schistosome Infection Via Elevation Of Interleukin-33, Xing He, Jun Xie, Yange Wang, Xiaobin Fan, Qin Su, Yue Sun, Nanhang Lei, Dongmei Zhang, Guangping Gao, Weiqing Pan

Open Access Articles

The type 2 immune response is the central mechanism of disease progression in schistosomiasis, but the signals that induce it after infection remain elusive. Aberrant microRNA (miRNA) expression is a hallmark of human diseases including schistosomiasis, and targeting the deregulated miRNA can mitigate disease outcomes. Here, we demonstrate that efficient and sustained elevation of miR-203-3p in liver tissues, using the highly hepatotropic recombinant adeno-associated virus serotype 8 (rAAV8), protects mice against lethal schistosome infection by alleviating hepatic fibrosis. We show that miR-203-3p targets interleukin-33 (IL-33), an inducer of type 2 immunity, in hepatic stellate cells to regulate the expansion and ...


New Vaccine Formulations Containing A Modified Version Of The Amastigote 2 Antigen And The Non-Virulent Trypanosoma Cruzi Cl-14 Strain Are Highly Antigenic And Protective Against Leishmania Infantum Challenge, Ana Paula M. M. Almeida, Leopoldo F.M. Machado, Daniel Doro, Frederico C. Nascimento, Leonardo Damasceno, Ricardo T. Gazzinelli, Ana Paula Fernandes, Caroline Junqueira 2018 Federal University of Minas Gerais

New Vaccine Formulations Containing A Modified Version Of The Amastigote 2 Antigen And The Non-Virulent Trypanosoma Cruzi Cl-14 Strain Are Highly Antigenic And Protective Against Leishmania Infantum Challenge, Ana Paula M. M. Almeida, Leopoldo F.M. Machado, Daniel Doro, Frederico C. Nascimento, Leonardo Damasceno, Ricardo T. Gazzinelli, Ana Paula Fernandes, Caroline Junqueira

Open Access Articles

Visceral leishmaniasis (VL) is a major public health issue reported as the second illness in mortality among all tropical diseases. Clinical trials have shown that protection against VL is associated with robust T cell responses, especially those producing IFN-gamma. The Leishmania amastigote 2 (A2) protein has been repeatedly described as immunogenic and protective against VL in different animal models; it is recognized by human T cells, and it is also commercially available in a vaccine formulation containing saponin against canine VL. Moving toward a more appropriate formulation for human vaccination, here, we tested a new optimized version of the recombinant ...


Taxonomy Based On Science Is Necessary For Global Conservation [Formal Comment], Scott A. Thomson, Richard L. Pyle, Scott Monks, Neal L. Evenhuis, Ronald H. Pine, Luis A. Ruedas, Jorge A. Salazar-Bravo, Robert M. Timm, Douglas Yanega, 163 other co-authors 2018 Museu de Zoologia da Universidade de São Paulo

Taxonomy Based On Science Is Necessary For Global Conservation [Formal Comment], Scott A. Thomson, Richard L. Pyle, Scott Monks, Neal L. Evenhuis, Ronald H. Pine, Luis A. Ruedas, Jorge A. Salazar-Bravo, Robert M. Timm, Douglas Yanega, 163 Other Co-Authors

Faculty Publications from the Harold W. Manter Laboratory of Parasitology

Taxonomy is a scientific discipline that has provided the universal naming and classification system of biodiversity for centuries and continues effectively to accommodate new knowledge. A recent publication by Garnett and Christidis expressed concerns regarding the difficulty that taxonomic changes represent for conservation efforts and proposed the establishment of a system to govern taxonomic changes. Their proposal to “restrict the freedom of taxonomic action” through governing subcommittees that would “review taxonomic papers for compliance” and their assertion that “the scientific community's failure to govern taxonomy threatens the effectiveness of global efforts to halt biodiversity loss, damages the credibility of ...


Towards A Mechanism Of Action Of An Antischistosomal Drug: Measuring Granulocytic Activity, Samantha Sack 2018 University of Nebraska at Omaha

Towards A Mechanism Of Action Of An Antischistosomal Drug: Measuring Granulocytic Activity, Samantha Sack

Student Research and Creative Activity Fair

Schistosomiasis is a neglected tropical disease caused by a family of schistosome parasites which leads to vital organ damage. Praziquantel (PZ) is the only available treatment, but it is effective only against the adult worm. Partner labs have tested an antischistosomal drug which has been shown to have a higher efficacy against both juvenile and mature parasites in mice and monkeys compared to PZ. This effectiveness does not transfer to in vitro experiments; it kills the parasite outside of its host only at extremely high concentrations. This indicates that its efficacy is host-dependent, but the mechanism by which it functions ...


Tetratrichomonas And Trichomonas Spp.-Associated Disease In Free-Ranging Common Eiders (Somateria Mollissima) From Wellfleet Bay, Ma And Description Of Its1 Region Genotypes, Caroline M. Grunenwald, Inga Sidor, Randal Mickley, Chris Dwyer, Richard W. Gerhold Jr. 2018 University of Tennessee, Knoxville

Tetratrichomonas And Trichomonas Spp.-Associated Disease In Free-Ranging Common Eiders (Somateria Mollissima) From Wellfleet Bay, Ma And Description Of Its1 Region Genotypes, Caroline M. Grunenwald, Inga Sidor, Randal Mickley, Chris Dwyer, Richard W. Gerhold Jr.

Faculty Publications and Other Works -- Biomedical and Diagnostic Sciences

During an outbreak of Wellfleet Bay virus (WFBV) in common eiders (Somateria mollissima) from the Cape Cod region of Massachusetts, several birds were diagnosed with trichomonosis consisting of multiple trichomonad species. Six birds were examined, with trichomonads found in ceca in four birds and associated typhlitis in three of these four birds. PCR and DNA sequencing utilizing trichomonad-specific primers targeting the ITS1 region of the ribosomal DNA (rDNA) revealed the presence of Tetratrichomonas gallinarum in the gastrointestinal tracts of five birds and Trichomonas spp. in the livers of two birds, one of which had a dual Te. gallinarum-Trichomonas gallinae infection ...


Drug Repurposing For Schistosomiasis: Combinations Of Drugs Or Biomolecules., Maria João Gouveia, Paul J Brindley, Fátima Gärtner, José M Correia da Costa, Nuno Vale 2018 George Washington University

Drug Repurposing For Schistosomiasis: Combinations Of Drugs Or Biomolecules., Maria João Gouveia, Paul J Brindley, Fátima Gärtner, José M Correia Da Costa, Nuno Vale

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently relies on a single drug, praziquantel, and despite its efficacy against the all schistosome species that parasitize humans, it displays some problematic drawbacks and alone is ineffective in counteracting adverse pathologies associated with infection. Moreover, due to the development of the potential emergence of PZQ-resistant strains, the search for additional or alternative antischistosomal drugs have become a public health priority. The current drug discovery for schistosomiasis has been slow and uninspiring. By contrast, repurposing of existing approved drugs may offer a safe, rapid and cost-effective alternative. Combined treatment with ...


A Comparative Analysis Of Preservation Techniques For The Optimal Molecular Detection Of Hookworm Dna In A Human Fecal Specimen, Marina Papaiakovou, Nils Pilotte, Ben Baumer, Jessica Grant, Kristjana Asbjornsdottir, Fabian Schaer, Yan Hu, Raffi V. Aroian, Judd Walson, Steven A. Williams 2018 Smith College

A Comparative Analysis Of Preservation Techniques For The Optimal Molecular Detection Of Hookworm Dna In A Human Fecal Specimen, Marina Papaiakovou, Nils Pilotte, Ben Baumer, Jessica Grant, Kristjana Asbjornsdottir, Fabian Schaer, Yan Hu, Raffi V. Aroian, Judd Walson, Steven A. Williams

Open Access Articles

BACKGROUND: Proper collection and storage of fecal samples is necessary to guarantee the subsequent reliability of DNA-based soil-transmitted helminth diagnostic procedures. Previous research has examined various methods to preserve fecal samples for subsequent microscopic analysis or for subsequent determination of overall DNA yields obtained following DNA extraction. However, only limited research has focused on the preservation of soil-transmitted helminth DNA in stool samples stored at ambient temperature or maintained in a cold chain for extended periods of time.

METHODOLOGY: Quantitative real-time PCR was used in this study as a measure of the effectiveness of seven commercially available products to preserve ...


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