Immunology of Infectious Disease Commons™
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Recent Articles in Immunology of Infectious Disease
Cellular Adaptation Of Macrophages To Anthrax Lethal Toxin-Induced Pyroptosis Via Epigenetic Mechanisms, Chae Young Han 
Western University
Cellular Adaptation Of Macrophages To Anthrax Lethal Toxin-Induced Pyroptosis Via Epigenetic Mechanisms, Chae Young Han
University of Western Ontario - Electronic Thesis and Dissertation Repository
Cellular adaptation to microbial stresses has been demonstrated in several cell types. Macrophages (MФ) are sentinel immune cells fending off invading microbes. Anthrax lethal toxin (LeTx) is a key virulence factor released by Bacillus anthracis that causes rapid cell death, pyroptosis. A small number of RAW246.7 macrophages (~4%) exposed to a non-lethal dose of LeTx become resistant to LeTx-induced pyroptosis for ~ 4 weeks, termed “toxin-induced resistance (TIR)”. Here, I showed that high levels of DNA methyl transferase1 (DNMT1) expression were maintained although global genomic methylation levels were not high in TIR. TIR cells treated with the DNMT inhibitor 5-azacitidine ...
Lung Immunopathology Following Influenza And Pneumococcus Infection: Mechanisms Of Disease And Therapeutic Approaches, Daniela Damjanovic 
McMaster University
Lung Immunopathology Following Influenza And Pneumococcus Infection: Mechanisms Of Disease And Therapeutic Approaches, Daniela Damjanovic
Open Access Dissertations and Theses
Influenza is a highly contagious respiratory disease. Yearly epidemics and pandemics account for high morbidity and mortality worldwide. Lung immunopathology is a major factor causing death following influenza. In addition, secondary bacterial superinfections that occur after influenza further complicate the lung immunopathology and contribute to higher morbidity and mortality. The research presented in this thesis addressed important, understudied questions in the complicated field of tissue immunopathogenesis and host defense to influenza and pneumococcal infections. Firstly, in a model of acute respiratory influenza infection, we found that the classically proinflammatory cytokine TNF plays a dual and biphasic role at different times ...
Inhibition Of Burkholderia Multivorans Adhesion To Lung Epithelial Cells By Bivalent Lactosides, Ciara Wight, Rosaria Leyden, Paul V. Murphy, Máire Callaghan, Trinidad Velasco-Torrijos, Siobhan McClean 
Dublin Institute of Technology
Inhibition Of Burkholderia Multivorans Adhesion To Lung Epithelial Cells By Bivalent Lactosides, Ciara Wight, Rosaria Leyden, Paul V. Murphy, Máire Callaghan, Trinidad Velasco-Torrijos, Siobhan Mcclean
Articles
Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in cystic fibrosis patients which is inherently resistant to antimicrobial agents. The mechanisms of attachment and pathogenesis of Bcc, a group of 17 species, are poorly understood. The most commonly identified Bcc species in newly colonised patients, Burkholderia multivorans, continues to be acquired from the environment. Development of therapies which can prevent or reduce the risk of colonization on exposure to Bcc in the environment would be a better alternative to antimicrobial agents. Previously, it has been shown that Bcc strains bound to many glycolipid receptors on lung epithelia. Using a real-time ...
Popular Institutions
Popular Authors
Danielle Fontenot
Texas Medical Center Library
Jaymie Estrella
Texas Medical Center Library
Matthew Cohen
University of Pennsylvania
Lingshuang Sun
University of Kentucky
Thandi Onami
University of Tennessee, Knoxville
Federico Beasley
Western University
Máire Callaghan
Dublin Institute of Technology
Ciara Wight
Dublin Institute of Technology
Siobhan McClean
Dublin Institute of Technology
Ashutosh Wadhwa
University of Tennessee, Knoxville
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Popular Articles
Interactions Between Complement And Cellular Mediated Mechanisms Of Monoclonal Antibody Therapy
Next Generation Monoclonal Antibodies And Their Mechanisms Of Action Against B-Cell Lymphomas
Regulation Of Immune Responses By Apoptotic Cells
The Role Of Mucosal Epithelial Cells In Hiv-1 Infection, Danielle Fontenot
T Regulatory Cells And The Germinal Center
Regulation Of Memory Cd8 T Cell Differentiation
Role Of Vitamin-D3 And Retinoic Acid In A Human Thp-1 Macrophage Model Of Mycobacterium Tuberculosis Infection, Jaymie Estrella
Analysis And Interpretation Of Factors Leading To Increased Aids Prevalence In Sub-Saharan Africa
Complement Factor H Regulation In The Central Nervous System
Mechanisms Of Antibody-Mediated Protection For A Protein-Based Smallpox Vaccine, Matthew Cohen
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