Immunoprophylaxis and Therapy Commons^™

Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung, Todd Bartkowiak

UT GSBS Dissertations and Theses (Open Access)

The binding of immune inhibitory receptor Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a subset of patients with advanced melanoma, yet current response rates are low for reasons that remain unclear. Hypothesizing that the PD-1/PD-L1 pathway regulates T cell surveillance within the tumor microenvironment, we employed intravital microscopy to investigate the in vivo impact of PD-L1 blocking antibody upon tumor-associated immune cell migration. However, current analytical methods of ...

Immunological Mechanisms Of Extracorporeal Photopheresis In Cutaneous T Cell Lymphoma And Graft Versus Host Disease, Lisa Shiue

UT GSBS Dissertations and Theses (Open Access)

IMMUNOLOGICAL MECHANISMS OF EXTRACORPOREAL PHOTOPHERESIS IN CUTANEOUS T CELL LYMPHOMA AND GRAFT VERSUS HOST DISEASE

Publication No.___________

Lisa Harn-Ging Shiue, B.S.

Supervisory Professor: Madeleine Duvic, M.D.

Extracorporeal photopheresis (ECP) is an effective, low-risk immunomodulating therapy for leukemic cutaneous T cell lymphoma (L-CTCL) and graft versus host disease (GVHD), but whether the mechanism(s) of action in these two diseases is (are) identical or different is unclear. To determine the effects of ECP in vivo, we studied regulatory T cells (T-regs), cytotoxic T lymphocytes (CTLs), and dendritic cells (DCs) by immunofluorescence flow cytometry in 18 L-CTCL and 11 ...

Determination Of The Active Components Of Elderberry Extracts On Immune Function And Tumor Cell Growth, Sahar Rizvi

Master's Theses

Present cancer treatments cause the cessation of the body’s own natural defenses, resulting in the susceptibility of patients to other illnesses, namely infection, during therapy. Contemporary research must focus on developing treatments to preserve or even augment the body’s natural defenses by pursuing naturally-derived elements devoid of such adverse effects. Seeking more natural treatments, Sambucus Nigra (elderberry) proves to be an important source of known immune stimulators including anthocyanins, catechins, and tannins, as wells as several known antioxidants and tumor suppressive agents in the form of flavonoids and proanthocyanidins.

Our primary goal was to separate the distinctive components ...