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Immunoprophylaxis and Therapy Commons

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Recombinant Ferritin-H Induces Immunosupression In European Sea Bass Larvae (Dicentrarchus Labrax) Rather Than Immunostmulation And Protection Against Vibrio Anguillarum, Daisy Vanrompay 2016 UGhent

Recombinant Ferritin-H Induces Immunosupression In European Sea Bass Larvae (Dicentrarchus Labrax) Rather Than Immunostmulation And Protection Against Vibrio Anguillarum, Daisy Vanrompay

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Administrated Grouper (Epinephelus Coioides) Recombinant Interleukin-6 As A Fish Immunestimulatant Via Various Administrated Routes, John Han You Lin, Wan-Ching Kuo, Ching-Chou Lin, Han-Tso Lin 2016 Department of Biotechnology and Bioindustry sciences, National Cheng Kung University

Administrated Grouper (Epinephelus Coioides) Recombinant Interleukin-6 As A Fish Immunestimulatant Via Various Administrated Routes, John Han You Lin, Wan-Ching Kuo, Ching-Chou Lin, Han-Tso Lin

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Combined Effects Of Dietary Mannan Oligosaccharides And Pediococcus Acidilactici And Their Combination In Low Fish Meal And Fish Oil Diets For European Sea Bass, Dicentrarchus Labrax, Juveniles, FERNANDO RIVERO-RAMÍREZ, Silvia Torrecillas, Maria José Caballero, Alex Makol, Marisol Izquierdo, Daniel Montero 2016 ULPGC (University of Las Palmas de Gran Canaria)

Combined Effects Of Dietary Mannan Oligosaccharides And Pediococcus Acidilactici And Their Combination In Low Fish Meal And Fish Oil Diets For European Sea Bass, Dicentrarchus Labrax, Juveniles, Fernando Rivero-Ramírez, Silvia Torrecillas, Maria José Caballero, Alex Makol, Marisol Izquierdo, Daniel Montero

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Liposomal- And Cpg Oligodeoxynucleotide-Based Vaccine Formulations Offer Protection With Reduced Adverse Effects In Rainbow Trout, Kasper Rømer Villumsen, Dennis Christensen, Erling Olaf Koppang, Anders Miki Bojesen 2016 University of Copenhagen

Liposomal- And Cpg Oligodeoxynucleotide-Based Vaccine Formulations Offer Protection With Reduced Adverse Effects In Rainbow Trout, Kasper Rømer Villumsen, Dennis Christensen, Erling Olaf Koppang, Anders Miki Bojesen

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Administration Of Bacterial Heat Shock Protein 70 To Induce A Protective Innate Immune Response In European Sea Bass Larvae (Dicentrarchus Labrax) Against Vibrio Anguillarum, Daisy Vanrompay 2016 UGhent

Administration Of Bacterial Heat Shock Protein 70 To Induce A Protective Innate Immune Response In European Sea Bass Larvae (Dicentrarchus Labrax) Against Vibrio Anguillarum, Daisy Vanrompay

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


A Cgas-Independent Sting/Irf7 Pathway Mediates The Immunogenicity Of Dna Vaccines, John Suschak, Shixia Wang, Katherine Fitzgerald, Shan Lu 2016 University of Massachusetts Medical School

A Cgas-Independent Sting/Irf7 Pathway Mediates The Immunogenicity Of Dna Vaccines, John Suschak, Shixia Wang, Katherine Fitzgerald, Shan Lu

Katherine A. Fitzgerald

It has been known since the discovery of DNA vaccines > 20 y ago that DNA vaccines can function as adjuvants. Our recent study reported the involvement of Aim2 as the sensor of DNA vaccines in eliciting Ag-specific Ab responses. Our findings indicated the presence of previously unrecognized innate immune response pathways in addition to the TLR9 pathway, which is mainly activated by the CpG motifs of DNA vaccines. Our data further demonstrated the requirement of type I IFN in DNA vaccine-induced immune responses via the Aim2 pathway, but the exact downstream molecular mechanism was not characterized. In the present study ...


A Balance Between Inhibitor Binding And Substrate Processing Confers Influenza Drug Resistance, Li Jiang, Ping Liu, Claudia Bank, Nicholas Renzette, Kristina Prachanronarong, L. Yilmaz, Daniel Caffrey, Konstantin Zeldovich, Celia Schiffer, Timothy Kowalik, Jeffrey Jensen, Robert Finberg, Jennifer Wang, Daniel Bolon 2016 University of Massachusetts Medical School

A Balance Between Inhibitor Binding And Substrate Processing Confers Influenza Drug Resistance, Li Jiang, Ping Liu, Claudia Bank, Nicholas Renzette, Kristina Prachanronarong, L. Yilmaz, Daniel Caffrey, Konstantin Zeldovich, Celia Schiffer, Timothy Kowalik, Jeffrey Jensen, Robert Finberg, Jennifer Wang, Daniel Bolon

Celia A. Schiffer

The therapeutic benefits of the neuraminidase (NA) inhibitor oseltamivir are dampened by the emergence of drug resistance mutations in influenza A virus (IAV). To investigate the mechanistic features that underlie resistance, we developed an approach to quantify the effects of all possible single-nucleotide substitutions introduced into important regions of NA. We determined the experimental fitness effects of 450 nucleotide mutations encoding positions both surrounding the active site and at more distant sites in an N1 strain of IAV in the presence and absence of oseltamivir. NA mutations previously known to confer oseltamivir resistance in N1 strains, including H275Y and N295S ...


A Higher Activation Threshold Of Memory Cd8+ T Cells Has A Fitness Cost That Is Modified By Tcr Affinity During Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, Samuel M. Behar 2016 University of Massachusetts Medical School

A Higher Activation Threshold Of Memory Cd8+ T Cells Has A Fitness Cost That Is Modified By Tcr Affinity During Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, Samuel M. Behar

Microbiology and Physiological Systems Publications and Presentations

T cell vaccines against Mycobacterium tuberculosis (Mtb) and other pathogens are based on the principle that memory T cells rapidly generate effector responses upon challenge, leading to pathogen clearance. Despite eliciting a robust memory CD8+ T cell response to the immunodominant Mtb antigen TB10.4 (EsxH), we find the increased frequency of TB10.4-specific CD8+ T cells conferred by vaccination to be short-lived after Mtb challenge. To compare memory and naïve CD8+ T cell function during their response to Mtb, we track their expansions using TB10.4-specific retrogenic CD8+ T cells. We find that the primary (naïve) response outnumbers the ...


Data From: A Higher Activation Threshold Of Memory Cd8+ T Cells Has A Fitness Cost That Is Modified By Tcr Affinity During Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, Samuel M. Behar 2015 University of Massachusetts Medical School

Data From: A Higher Activation Threshold Of Memory Cd8+ T Cells Has A Fitness Cost That Is Modified By Tcr Affinity During Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, Samuel M. Behar

MaPS Research Data

Manuscript abstract: T cell vaccines against Mycobacterium tuberculosis (Mtb) and other pathogens are based on the principle that memory T cells rapidly generate effector responses upon challenge, leading to pathogen clearance. Despite eliciting a robust memory CD8+ T cell response to the immunodominant Mtb antigen TB10.4 (EsxH), we find the increased frequency of TB10.4-specific CD8+ T cells conferred by vaccination to be short-lived after Mtb challenge. To compare memory and naïve CD8+ T cell function during their response to Mtb, we track their expansions using TB10.4-specific retrogenic CD8+ T cells. We find that the primary (naïve) response ...


Epidemiology Of Infant Dengue Cases Illuminates Serotype-Specificity In The Interaction Between Immunity And Disease, And Changes In Transmission Dynamics, Hannah Clapham, Derek A. Cummings, Ananda Nisalak, Siripen Kalayanarooj, Butsaya Thaisomboonsuk, Chonticha Klungthong, Stefan Fernandez, Anon Srikiatkhachorn, Louis R. Macareo, Justin Lessler, Julia Reiser, In-Kyu Yoon 2015 Johns Hopkins School of Public Health

Epidemiology Of Infant Dengue Cases Illuminates Serotype-Specificity In The Interaction Between Immunity And Disease, And Changes In Transmission Dynamics, Hannah Clapham, Derek A. Cummings, Ananda Nisalak, Siripen Kalayanarooj, Butsaya Thaisomboonsuk, Chonticha Klungthong, Stefan Fernandez, Anon Srikiatkhachorn, Louis R. Macareo, Justin Lessler, Julia Reiser, In-Kyu Yoon

Open Access Articles

BACKGROUND: Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antibodies, though initially protective, decline during the first year of life to levels thought to be disease enhancing, before reaching undetectable levels. Infants have long been studied to understand the interaction between infection and disease on an individual level.
METHODS/FINDINGS: Considering infants (cases < 1 year old) as a unique group, we analyzed serotype specific dengue case data from patients admitted to a pediatric hospital in Bangkok, Thailand. We show differences in the propensity of serotypes to cause disease in individuals with dengue antibodies (infants and post-primary cases) and in individuals without dengue antibodies (primary cases). The mean age of infant cases differed among serotypes, consistent with previously observed differential waning of maternal antibody titers by serotype. We show that trends over time in epidemiology of infant cases are consistent with those observed in the whole population, and therefore with trends in the force of infection.

CONCLUSIONS/SIGNIFICANCE: Infants with dengue are informative about the interaction between antibody and the dengue serotypes, confirming that in this population DENV-2 and DENV-4 almost exclusively cause disease in the presence of dengue antibody despite infections occurring in others. We also observe differences ...


Utilizing Cmp-Sialic Acid Analogs To Unravel Neisseria Gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance And Design Novel Therapeutics, Sunita Gulati, Ian C. Schoenhofen, Dennis M. Whitfield, Andrew D. Cox, Jianjun Li, Frank St Michael, Evgeny V. Vinogradov, Jacek Stupak, Bo Zheng, Makoto Ohnishi, Magnus Unemo, Lisa A. Lewis, Rachel E. Taylor, Corinna S. Landig, Sandra Diaz, George W. Reed, Ajit Varki, Peter A. Rice, Sanjay Ram 2015 University of Massachusetts Medical School

Utilizing Cmp-Sialic Acid Analogs To Unravel Neisseria Gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance And Design Novel Therapeutics, Sunita Gulati, Ian C. Schoenhofen, Dennis M. Whitfield, Andrew D. Cox, Jianjun Li, Frank St Michael, Evgeny V. Vinogradov, Jacek Stupak, Bo Zheng, Makoto Ohnishi, Magnus Unemo, Lisa A. Lewis, Rachel E. Taylor, Corinna S. Landig, Sandra Diaz, George W. Reed, Ajit Varki, Peter A. Rice, Sanjay Ram

Open Access Articles

Neisseria gonorrhoeae deploys a novel immune evasion strategy wherein the lacto-N-neotetraose (LNnT) structure of lipooligosaccharide (LOS) is capped by the bacterial sialyltransferase, using host cytidine-5'-monophosphate (CMP)-activated forms of the nine-carbon nonulosonate (NulO) sugar N-acetyl-neuraminic acid (Neu5Ac), a sialic acid (Sia) abundant in humans. This allows evasion of complement-mediated killing by recruiting factor H (FH), an inhibitor of the alternative complement pathway, and by limiting classical pathway activation ("serum-resistance"). We utilized CMP salts of six additional natural or synthetic NulOs, Neu5Gc, Neu5Gc8Me, Neu5Ac9Ac, Neu5Ac9Az, legionaminic acid (Leg5Ac7Ac) and pseudaminic acid (Pse5Ac7Ac), to define structural requirements of Sia-mediated serum-resistance. While ...


Cotton Rat Immune Responses To Virus-Like Particles Containing The Pre-Fusion Form Of Respiratory Syncytial Virus Fusion Protein, Lori McGinnes Cullen, Jorge C. G. Blanco, Trudy G. Morrison 2015 University of Massachusetts Medical School

Cotton Rat Immune Responses To Virus-Like Particles Containing The Pre-Fusion Form Of Respiratory Syncytial Virus Fusion Protein, Lori Mcginnes Cullen, Jorge C. G. Blanco, Trudy G. Morrison

Open Access Articles

BACKGROUND: Virus-like particles (VLPs) based on Newcastle disease virus (NDV) core proteins, M and NP, and containing two chimera proteins, F/F and H/G, composed of the respiratory syncytial virus (RSV) fusion protein (F) and glycoprotein (G) ectodomains fused to the transmembrane and cytoplasmic domains of the NDV F and HN proteins, respectively, stimulate durable, protective anti-RSV neutralizing antibodies in mice. Furthermore, immunization of mice with a VLP containing a F/F chimera protein with modifications previously reported to stabilize the pre-fusion form of the RSV F protein resulted in significantly improved neutralizing antibody titers over VLPs containing the ...


Protein Conformation In A Vaccine Matters, Trudy G. Morrison 2015 University of Massachusetts Medical School

Protein Conformation In A Vaccine Matters, Trudy G. Morrison

Open Access Articles

Virus-like particles (VLPs) are increasingly being considered as vaccine candidates for a variety of human and animal pathogens. Our results demonstrate that the conformation of antigens in VLPs is of critical importance for optimal stimulation of protective as well as durable immune responses.


Aav-Delivered Antibody Mediates Significant Protective Effects Against Sivmac239 Challenge In The Absence Of Neutralizing Activity, Sebastian P. Fuchs, Jose M. Martinez-Navio, Michael Piatak Jr., Jeffrey D. Lifson, Guangping Gao, Ronald C. Desrosiers 2015 University of Miami

Aav-Delivered Antibody Mediates Significant Protective Effects Against Sivmac239 Challenge In The Absence Of Neutralizing Activity, Sebastian P. Fuchs, Jose M. Martinez-Navio, Michael Piatak Jr., Jeffrey D. Lifson, Guangping Gao, Ronald C. Desrosiers

Open Access Articles

Long-term delivery of potent broadly-neutralizing antibodies is a promising approach for the prevention of HIV-1 infection. We used AAV vector intramuscularly to deliver anti-SIV monoclonal antibodies (mAbs) in IgG1 form to rhesus monkeys. Persisting levels of delivered mAb as high as 270 mug/ml were achieved. However, host antibody responses to the delivered antibody were observed in 9 of the 12 monkeys and these appeared to limit the concentration of delivered antibody that could be achieved. This is reflected in the wide range of delivered mAb concentrations that were achieved: 1-270 mug/ml. Following repeated, marginal dose, intravenous challenge with ...


Lv4 Is A Capsid-Specific Antiviral Activity In Human Blood Cells That Restricts Viruses Of The Sivmac/Sivsm/Hiv-2 Lineage Prior To Integration, Massimo Pizzato, Sean Matthew McCauley, Martha R. Neagu, Thomas Pertel, Claudia Firrito, Serena Ziglio, Ann Dauphin, Madeleine Zufferey, Lionel Berthoux, Jeremy Luban 2015 University of Trento

Lv4 Is A Capsid-Specific Antiviral Activity In Human Blood Cells That Restricts Viruses Of The Sivmac/Sivsm/Hiv-2 Lineage Prior To Integration, Massimo Pizzato, Sean Matthew Mccauley, Martha R. Neagu, Thomas Pertel, Claudia Firrito, Serena Ziglio, Ann Dauphin, Madeleine Zufferey, Lionel Berthoux, Jeremy Luban

Open Access Articles

HIV-2 and SIVMAC are AIDS-causing, zoonotic lentiviruses that jumped to humans and rhesus macaques, respectively, from SIVSM-bearing sooty mangabey monkeys. Cross-species transmission events such as these sometimes necessitate virus adaptation to species-specific, host restriction factors such as TRIM5. Here, a new human restriction activity is described that blocks viruses of the SIVSM/SIVMAC/HIV-2 lineage. Human T, B, and myeloid cell lines, peripheral blood mononuclear cells and dendritic cells were 4 to > 100-fold less transducible by VSV G-pseudotyped SIVMAC, HIV-2, or SIVSM than by HIV-1. In contrast, transduction of six epithelial cell lines was equivalent to that by HIV-1. Substitution ...


Murine Immune Responses To Virus-Like Particle-Associated Pre- And Postfusion Forms Of The Respiratory Syncytial Virus F Protein, Lori McGinnes Cullen, Madelyn R. Schmidt, Sarah A. Kenward, Robert T. Woodland, Trudy G. Morrison 2015 University of Massachusetts Medical School

Murine Immune Responses To Virus-Like Particle-Associated Pre- And Postfusion Forms Of The Respiratory Syncytial Virus F Protein, Lori Mcginnes Cullen, Madelyn R. Schmidt, Sarah A. Kenward, Robert T. Woodland, Trudy G. Morrison

Open Access Articles

Virus-like particles (VLPs) built on the Newcastle disease virus (NDV) core proteins, NP and M, and containing two chimeric proteins, F/F and H/G, composed of respiratory syncytial virus (RSV) fusion protein (F) and glycoprotein (G) ectodomains fused to the transmembrane and cytoplasmic domains of the NDV F and HN proteins, respectively, stimulate durable, protective RSV neutralizing antibodies in mice. Here, we report the properties of VLPs constructed to contain mutant RSV F protein ectodomains stabilized in prefusion (pre-F/F) or postfusion (post-F/F) configurations. The structures of the chimeric proteins assembled into VLPs were verified immunologically by their ...


Identification Of Aim2 As A Sensor For Dna Vaccines, John Suschak, Shixia Wang, Katherine Fitzgerald, Shan Lu 2015 University of Massachusetts Medical School

Identification Of Aim2 As A Sensor For Dna Vaccines, John Suschak, Shixia Wang, Katherine Fitzgerald, Shan Lu

Katherine A. Fitzgerald

Recent human study data have re-established the value of DNA vaccines, especially in priming high-level Ag-specific Ab responses, but also raised questions about the mechanisms responsible for such effects. Whereas previous reports have shown involvement of downstream signaling molecules in the innate immune system, the current study investigated the role of absent in melanoma 2 (Aim2) as a sensor for DNA vaccines. The Aim2 inflammasome directs maturation of the proinflammatory cytokines IL-1beta and IL-18 and an inflammatory form of cell death called pyroptosis. Both the humoral and cellular Ag-specific adaptive responses were significantly reduced in Aim2-deficient mice in an IL-1beta ...


A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection At The Level Of Cell Entry, Terence Bukong, Karen Kodys, Gyongyi Szabo 2015 University of Massachusetts Medical School

A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection At The Level Of Cell Entry, Terence Bukong, Karen Kodys, Gyongyi Szabo

Gyongyi Szabo

Hepatitis C virus infection of hepatocytes is a multistep process involving the interaction between viral and host cell molecules. Recently, we identified ezrin-moesin-radixin proteins and spleen tyrosine kinase (SYK) as important host therapeutic targets for HCV treatment development. Previously, an ezrin hinge region peptide (Hep1) has been shown to exert anti-HCV properties in vivo, though its mechanism of action remains limited. In search of potential novel inhibitors of HCV infection and their functional mechanism we analyzed the anti-HCV properties of different human derived radixin peptides. Sixteen different radixin peptides were derived, synthesized and tested. Real-time quantitative PCR, cell toxicity assay ...


The Genetics Of Hepatitis C Virus Underlie Its Ability To Escape Humoral Immunity, Jay Kolls, Gyongyi Szabo 2015 University of Pittsburgh

The Genetics Of Hepatitis C Virus Underlie Its Ability To Escape Humoral Immunity, Jay Kolls, Gyongyi Szabo

Gyongyi Szabo

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, and efforts to develop therapeutic vaccine strategies have been limited by immune escape due to HCV variants that are resistant to current vaccines or HCV variants that rapidly acquire new resistance-conferring mutations. Recently, the crystal structure of the viral envelope protein E2 region was resolved as well as how E2 docks to the host CD81 protein; therefore, antibodies that block this interaction should prevent viral entry into host cells. In this issue of the JCI, Bailey and colleagues show that immune escape of HCV can occur by naturally ...


Tempering Allorecognition To Induce Transplant Tolerance With Chemically Modified Apoptotic Donor Cells, Derrick McCarthy, Jane Bryant, J Galvin, Stephen Miller, Xunrong Luo 2015 Northwestern University

Tempering Allorecognition To Induce Transplant Tolerance With Chemically Modified Apoptotic Donor Cells, Derrick Mccarthy, Jane Bryant, J Galvin, Stephen Miller, Xunrong Luo

Jane Bryant

The development of organ transplantation as a therapy for end-stage organ failure is among the most significant achievements of 20th century medicine, but chronic rejection remains a barrier to achieving long-term success. Current therapeutic regimens consist of immunosuppressive drugs that are efficient at delaying rejection but are associated with significant risks such as opportunistic infections, toxicity, and malignancy. Thus, the induction of specific immune tolerance to transplant antigens is the coveted aim of researchers. The use of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (ECDI)-treated, autoantigen-coupled syngeneic leukocytes has been developed as a specific immunotherapy in preclinical models of autoimmunity and is currently ...


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