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Recombinant Ferritin-H Induces Immunosupression In European Sea Bass Larvae (Dicentrarchus Labrax) Rather Than Immunostmulation And Protection Against Vibrio Anguillarum, Daisy Vanrompay 2016 UGhent

Recombinant Ferritin-H Induces Immunosupression In European Sea Bass Larvae (Dicentrarchus Labrax) Rather Than Immunostmulation And Protection Against Vibrio Anguillarum, Daisy Vanrompay

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Administration Of Bacterial Heat Shock Protein 70 To Induce A Protective Innate Immune Response In European Sea Bass Larvae (Dicentrarchus Labrax) Against Vibrio Anguillarum, Daisy Vanrompay 2016 UGhent

Administration Of Bacterial Heat Shock Protein 70 To Induce A Protective Innate Immune Response In European Sea Bass Larvae (Dicentrarchus Labrax) Against Vibrio Anguillarum, Daisy Vanrompay

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Data From: A Higher Activation Threshold Of Memory Cd8+ T Cells Has A Fitness Cost That Is Modified By Tcr Affinity During Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, Samuel M. Behar 2015 University of Massachusetts Medical School

Data From: A Higher Activation Threshold Of Memory Cd8+ T Cells Has A Fitness Cost That Is Modified By Tcr Affinity During Tuberculosis, Stephen M. Carpenter, Claudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, Samuel M. Behar

MaPS Research Data

This dataset is the primary data source for a manuscript submitted for publication.


Epidemiology Of Infant Dengue Cases Illuminates Serotype-Specificity In The Interaction Between Immunity And Disease, And Changes In Transmission Dynamics, Hannah Clapham, Derek A. Cummings, Ananda Nisalak, Siripen Kalayanarooj, Butsaya Thaisomboonsuk, Chonticha Klungthong, Stefan Fernandez, Anon Srikiatkhachorn, Louis R. Macareo, Justin Lessler, Julia Reiser, In-Kyu Yoon 2015 Johns Hopkins School of Public Health

Epidemiology Of Infant Dengue Cases Illuminates Serotype-Specificity In The Interaction Between Immunity And Disease, And Changes In Transmission Dynamics, Hannah Clapham, Derek A. Cummings, Ananda Nisalak, Siripen Kalayanarooj, Butsaya Thaisomboonsuk, Chonticha Klungthong, Stefan Fernandez, Anon Srikiatkhachorn, Louis R. Macareo, Justin Lessler, Julia Reiser, In-Kyu Yoon

Open Access Articles

BACKGROUND: Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antibodies, though initially protective, decline during the first year of life to levels thought to be disease enhancing, before reaching undetectable levels. Infants have long been studied to understand the interaction between infection and disease on an individual level.
METHODS/FINDINGS: Considering infants (cases < 1 year old) as a unique group, we analyzed serotype specific dengue case data from patients admitted to a pediatric hospital in Bangkok, Thailand. We show differences in the propensity of serotypes to cause disease in individuals with dengue antibodies (infants and post-primary cases) and in individuals without dengue antibodies (primary cases). The mean age of infant cases differed among serotypes, consistent with previously observed differential waning of maternal antibody titers by serotype. We show that trends over time in epidemiology of infant cases are consistent with those observed in the whole population, and therefore with trends in the force of infection.

CONCLUSIONS/SIGNIFICANCE: Infants with dengue are informative about the interaction between antibody and the dengue serotypes, confirming that in this population DENV-2 and DENV-4 almost exclusively cause disease in the presence of dengue antibody despite infections occurring in others. We also observe differences ...


Utilizing Cmp-Sialic Acid Analogs To Unravel Neisseria Gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance And Design Novel Therapeutics, Sunita Gulati, Ian C. Schoenhofen, Dennis M. Whitfield, Andrew D. Cox, Jianjun Li, Frank St Michael, Evgeny V. Vinogradov, Jacek Stupak, Bo Zheng, Makoto Ohnishi, Magnus Unemo, Lisa A. Lewis, Rachel E. Taylor, Corinna S. Landig, Sandra Diaz, George W. Reed, Ajit Varki, Peter A. Rice, Sanjay Ram 2015 University of Massachusetts Medical School

Utilizing Cmp-Sialic Acid Analogs To Unravel Neisseria Gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance And Design Novel Therapeutics, Sunita Gulati, Ian C. Schoenhofen, Dennis M. Whitfield, Andrew D. Cox, Jianjun Li, Frank St Michael, Evgeny V. Vinogradov, Jacek Stupak, Bo Zheng, Makoto Ohnishi, Magnus Unemo, Lisa A. Lewis, Rachel E. Taylor, Corinna S. Landig, Sandra Diaz, George W. Reed, Ajit Varki, Peter A. Rice, Sanjay Ram

Open Access Articles

Neisseria gonorrhoeae deploys a novel immune evasion strategy wherein the lacto-N-neotetraose (LNnT) structure of lipooligosaccharide (LOS) is capped by the bacterial sialyltransferase, using host cytidine-5'-monophosphate (CMP)-activated forms of the nine-carbon nonulosonate (NulO) sugar N-acetyl-neuraminic acid (Neu5Ac), a sialic acid (Sia) abundant in humans. This allows evasion of complement-mediated killing by recruiting factor H (FH), an inhibitor of the alternative complement pathway, and by limiting classical pathway activation ("serum-resistance"). We utilized CMP salts of six additional natural or synthetic NulOs, Neu5Gc, Neu5Gc8Me, Neu5Ac9Ac, Neu5Ac9Az, legionaminic acid (Leg5Ac7Ac) and pseudaminic acid (Pse5Ac7Ac), to define structural requirements of Sia-mediated serum-resistance. While ...


Protein Conformation In A Vaccine Matters, Trudy G. Morrison 2015 University of Massachusetts Medical School

Protein Conformation In A Vaccine Matters, Trudy G. Morrison

Open Access Articles

Virus-like particles (VLPs) are increasingly being considered as vaccine candidates for a variety of human and animal pathogens. Our results demonstrate that the conformation of antigens in VLPs is of critical importance for optimal stimulation of protective as well as durable immune responses.


Aav-Delivered Antibody Mediates Significant Protective Effects Against Sivmac239 Challenge In The Absence Of Neutralizing Activity, Sebastian P. Fuchs, Jose M. Martinez-Navio, Michael Piatak Jr., Jeffrey D. Lifson, Guangping Gao, Ronald C. Desrosiers 2015 University of Miami

Aav-Delivered Antibody Mediates Significant Protective Effects Against Sivmac239 Challenge In The Absence Of Neutralizing Activity, Sebastian P. Fuchs, Jose M. Martinez-Navio, Michael Piatak Jr., Jeffrey D. Lifson, Guangping Gao, Ronald C. Desrosiers

Open Access Articles

Long-term delivery of potent broadly-neutralizing antibodies is a promising approach for the prevention of HIV-1 infection. We used AAV vector intramuscularly to deliver anti-SIV monoclonal antibodies (mAbs) in IgG1 form to rhesus monkeys. Persisting levels of delivered mAb as high as 270 mug/ml were achieved. However, host antibody responses to the delivered antibody were observed in 9 of the 12 monkeys and these appeared to limit the concentration of delivered antibody that could be achieved. This is reflected in the wide range of delivered mAb concentrations that were achieved: 1-270 mug/ml. Following repeated, marginal dose, intravenous challenge with ...


Lv4 Is A Capsid-Specific Antiviral Activity In Human Blood Cells That Restricts Viruses Of The Sivmac/Sivsm/Hiv-2 Lineage Prior To Integration, Massimo Pizzato, Sean Matthew McCauley, Martha R. Neagu, Thomas Pertel, Claudia Firrito, Serena Ziglio, Ann Dauphin, Madeleine Zufferey, Lionel Berthoux, Jeremy Luban 2015 University of Trento

Lv4 Is A Capsid-Specific Antiviral Activity In Human Blood Cells That Restricts Viruses Of The Sivmac/Sivsm/Hiv-2 Lineage Prior To Integration, Massimo Pizzato, Sean Matthew Mccauley, Martha R. Neagu, Thomas Pertel, Claudia Firrito, Serena Ziglio, Ann Dauphin, Madeleine Zufferey, Lionel Berthoux, Jeremy Luban

Open Access Articles

HIV-2 and SIVMAC are AIDS-causing, zoonotic lentiviruses that jumped to humans and rhesus macaques, respectively, from SIVSM-bearing sooty mangabey monkeys. Cross-species transmission events such as these sometimes necessitate virus adaptation to species-specific, host restriction factors such as TRIM5. Here, a new human restriction activity is described that blocks viruses of the SIVSM/SIVMAC/HIV-2 lineage. Human T, B, and myeloid cell lines, peripheral blood mononuclear cells and dendritic cells were 4 to > 100-fold less transducible by VSV G-pseudotyped SIVMAC, HIV-2, or SIVSM than by HIV-1. In contrast, transduction of six epithelial cell lines was equivalent to that by HIV-1. Substitution ...


The Hunt For Protective Correlates Of Immunity To Plasmodium Falciparum Malaria, Ann Moormann, V. Stewart 2015 University of Massachusetts Medical School

The Hunt For Protective Correlates Of Immunity To Plasmodium Falciparum Malaria, Ann Moormann, V. Stewart

Ann M. Moormann

Determining an immunologic correlate of protection against Plasmodium falciparum malaria has been the holy grail of natural infection studies, and sought after as an endpoint for malaria vaccine trials. An in vitro assay that provides an accurate and precise assessment of protective immunity to malaria would make smaller, short-duration studies feasible, rather than the currently powered study designs that use morbidity or mortality as outcomes. Such a biomarker would be especially desirable in situations where malaria control measures that result in decreases in clinical endpoints and putatively waning protective immunity have been implemented. In an article published in BMC Medicine ...


A Chimeric Ebv Gp350/220-Based Vlp Replicates The Virion B-Cell Attachment Mechanism And Elicits Long-Lasting Neutralizing Antibodies In Mice, Javier Gordon Ogembo, Matthew R. Muraswki, Lori McGinnes, Agapi Parcharidou, Rujapak Sutiwisesak, Timelia Tison, Juan Avendano, Deep Agnani, Robert W. Finberg, Trudy G. Morrison, Joyce D. Fingeroth 2015 University of Massachusetts Medical School

A Chimeric Ebv Gp350/220-Based Vlp Replicates The Virion B-Cell Attachment Mechanism And Elicits Long-Lasting Neutralizing Antibodies In Mice, Javier Gordon Ogembo, Matthew R. Muraswki, Lori Mcginnes, Agapi Parcharidou, Rujapak Sutiwisesak, Timelia Tison, Juan Avendano, Deep Agnani, Robert W. Finberg, Trudy G. Morrison, Joyce D. Fingeroth

Open Access Articles

Epstein-Barr virus (EBV), an oncogenic gammaherpesvirus, causes acute infectious mononucleosis (AIM) and is linked to the development of several human malignancies. There is an urgent need for a vaccine that is safe, prevents infection and/or limits disease. Unique among human herpesviruses, glycoprotein (gp)350/220, which initiates EBV attachment to susceptible host cells, is the major ligand on the EBV envelope and is highly conserved. Interaction between gp350/220 and complement receptor type 2 (CR2)/CD21 and/or (CR1)/CD35 on B-cells is required for infection. Potent antibody responses to gp350/220 occur in animal models and humans. Thus ...


Time-To-Infection By Plasmodium Falciparum Is Largely Determined By Random Factors, Mykola Pinkevych, Kiprotich Chelimo, John Vulule, James W. Kazura, Ann M. Moormann, Miles P. Davenport 2015 University of New South Wales

Time-To-Infection By Plasmodium Falciparum Is Largely Determined By Random Factors, Mykola Pinkevych, Kiprotich Chelimo, John Vulule, James W. Kazura, Ann M. Moormann, Miles P. Davenport

University of Massachusetts Medical School Faculty Publications

BACKGROUND: The identification of protective immune responses to P. falciparum infection is an important goal for the development of a vaccine for malaria. This requires the identification of susceptible and resistant individuals, so that their immune responses may be studied. Time-to-infection studies are one method for identifying putative susceptible individuals (infected early) versus resistant individuals (infected late). However, the timing of infection is dependent on random factors, such as whether the subject was bitten by an infected mosquito, as well as individual factors, such as their level of immunity. It is important to understand how much of the observed variation ...


A Human Type 5 Adenovirus-Based Trypanosoma Cruzi Therapeutic Vaccine Re-Programs Immune Response And Reverses Chronic Cardiomyopathy, Isabela Resende Pereira, Glaucia Vilar-Pereira, Virginia Marques, Andrea Alice da Silva, Braulia Caetano, Otacilio Cruz Moreira, Alexandre Vieira Machado, Oscar Bruna-Romero, Mauricio Martins Rodrigues, Ricardo T. Gazzinelli, Joseli Lannes-Vieira 2015 Instituto Oswaldo Cruz/Fiocruz

A Human Type 5 Adenovirus-Based Trypanosoma Cruzi Therapeutic Vaccine Re-Programs Immune Response And Reverses Chronic Cardiomyopathy, Isabela Resende Pereira, Glaucia Vilar-Pereira, Virginia Marques, Andrea Alice Da Silva, Braulia Caetano, Otacilio Cruz Moreira, Alexandre Vieira Machado, Oscar Bruna-Romero, Mauricio Martins Rodrigues, Ricardo T. Gazzinelli, Joseli Lannes-Vieira

Open Access Articles

Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a prototypical neglected tropical disease. Specific immunity promotes acute phase survival. Nevertheless, one-third of CD patients develop chronic chagasic cardiomyopathy (CCC) associated with parasite persistence and immunological unbalance. Currently, the therapeutic management of patients only mitigates CCC symptoms. Therefore, a vaccine arises as an alternative to stimulate protective immunity and thereby prevent, delay progression and even reverse CCC. We examined this hypothesis by vaccinating mice with replication-defective human Type 5 recombinant adenoviruses (rAd) carrying sequences of amastigote surface protein-2 (rAdASP2) and trans-sialidase (rAdTS) T. cruzi antigens. For prophylactic vaccination, naive ...


Characterization Of Envelope-Specific Antibody Response Elicited By Hiv-1 Vaccines: A Dissertation, Yuxin Chen 2015 University of Massachusetts Medical School Worcester

Characterization Of Envelope-Specific Antibody Response Elicited By Hiv-1 Vaccines: A Dissertation, Yuxin Chen

GSBS Dissertations and Theses

Despite 30 years of intensive research,an effective human immunodeficiency virus (HIV) vaccine still remains elusive. The desirable immune response capable of providing protection against HIV acquisition is still not clear. The accumulating evidence learned from a recent vaccine efficacy correlate study not only confirmed the importance of antibody responses, but also highlighted potential protective functions of antibodies with a broad repertoire of HIV-1 epitope specificities and a wide range of different antiviral mechanisms. This necessitates a deep understanding of the complexity and diversity of antibody responses elicited by HIV-1 vaccines. My dissertation characterizes antibody response profiles of HIV-1 Env ...


The Genetics Of Hepatitis C Virus Underlie Its Ability To Escape Humoral Immunity, Jay K. Kolls, Gyongyi Szabo 2015 University of Pittsburgh

The Genetics Of Hepatitis C Virus Underlie Its Ability To Escape Humoral Immunity, Jay K. Kolls, Gyongyi Szabo

University of Massachusetts Medical School Faculty Publications

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, and efforts to develop therapeutic vaccine strategies have been limited by immune escape due to HCV variants that are resistant to current vaccines or HCV variants that rapidly acquire new resistance-conferring mutations. Recently, the crystal structure of the viral envelope protein E2 region was resolved as well as how E2 docks to the host CD81 protein; therefore, antibodies that block this interaction should prevent viral entry into host cells. In this issue of the JCI, Bailey and colleagues show that immune escape of HCV can occur by naturally ...


Characterization Of Innate Immune Pathways In Dna Vaccine-Induced, Antigen-Specific Immune Responses: A Dissertation, John J. Suschak III 2014 University of Massachusetts Medical School Worcester

Characterization Of Innate Immune Pathways In Dna Vaccine-Induced, Antigen-Specific Immune Responses: A Dissertation, John J. Suschak Iii

GSBS Dissertations and Theses

A major advantage of DNA vaccination is the ability to induce both humoral and cellular immune responses. DNA vaccines are currently used in veterinary medicine, but their tendency to display low immunogenicity in humans has hindered their usage, despite excellent tolerability and safety profiles. Various approaches have been used to improve the immunogenicity of DNA vaccines. Recent human study data re-established the value of DNA vaccines, especially in priming high-level antigen-specific antibody responses. Data suggests that innate immune responses to the DNA vaccine plasmid itself contribute to the immunogenicity of DNA vaccines, however the underlying mechanisms responsible remain unclear. In ...


Managing Devil Facial Tumour Disease In Tasmanian Devils (Sarcophilus Harrisii): An Investigation Of Heat Shock Proteins As Potential Vaccine Adjuvants, Monika Payerhin 2014 SIT Study Abroad

Managing Devil Facial Tumour Disease In Tasmanian Devils (Sarcophilus Harrisii): An Investigation Of Heat Shock Proteins As Potential Vaccine Adjuvants, Monika Payerhin

Independent Study Project (ISP) Collection

The world’s largest carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii), is facing extinction from a deadly, highly communicable cancer that has already decimated over 85% of devil populations in the wild: devil facial tumour disease (DFTD). DFTD cells effectively evade recognition by the immune system, and every devil that contracts the disease dies from it. Many attempts have been made at developing a vaccine that could help save this now-threatened species. Heat shock proteins have been linked to enhanced immune recognition of pathogens, making them potential candidates for acting as adjuvants to such a vaccine against DFTD. In this ...


Allele-Specific Induction Of Il-1beta Expression By C/Ebpbeta And Pu.1 Contributes To Increased Tuberculosis Susceptibility, Guoliang Zhang, Boping Zhou, Shaoyuan Li, Jun Yue, Hui Yang, Yuxin Wen, Senlin Zhan, Wenfei Wang, Mingfeng Liao, Mingxia Zhang, Gucheng Zeng, Carl G. Feng, Christopher M. Sassetti, Xinchun Chen 2014 Guangdong Medical College

Allele-Specific Induction Of Il-1beta Expression By C/Ebpbeta And Pu.1 Contributes To Increased Tuberculosis Susceptibility, Guoliang Zhang, Boping Zhou, Shaoyuan Li, Jun Yue, Hui Yang, Yuxin Wen, Senlin Zhan, Wenfei Wang, Mingfeng Liao, Mingxia Zhang, Gucheng Zeng, Carl G. Feng, Christopher M. Sassetti, Xinchun Chen

Open Access Articles

Mycobacterium tuberculosis infection is associated with a spectrum of clinical outcomes, from long-term latent infection to different manifestations of progressive disease. Pro-inflammatory pathways, such as those controlled by IL-1beta, have the contrasting potential both to prevent disease by restricting bacterial replication, and to promote disease by inflicting tissue damage. Thus, the ultimate contribution of individual inflammatory pathways to the outcome of M. tuberculosis infection remains ambiguous. In this study, we identified a naturally-occurring polymorphism in the human IL1B promoter region, which alters the association of the C/EBPbeta and PU.1 transcription factors and controls Mtb-induced IL-1beta production. The high-IL-1beta ...


Regulation Of Tissue-Dependent Differences In Cd8+ T Cell Apoptosis During Viral Infection, Varun N. Kapoor, HyunMu Shin, Ok Hyun Cho, Leslie J. Berg, Joonsoo Kang, Raymond M. Welsh 2014 University of Massachusetts Medical School

Regulation Of Tissue-Dependent Differences In Cd8+ T Cell Apoptosis During Viral Infection, Varun N. Kapoor, Hyunmu Shin, Ok Hyun Cho, Leslie J. Berg, Joonsoo Kang, Raymond M. Welsh

GSBS Student Publications

Virus-specific CD8+ T cells in the lymphoid organs contract at the resolution of virus infections by apoptosis or by dissemination into peripheral tissues, and those residing in nonlymphoid organs, including the peritoneal cavity and fat pads, are more resistant to apoptosis than those in the spleen and lymph nodes. This stability of memory T cells in the nonlymphoid tissues may enhance protection to secondary challenges. Here, we show that lymphocytic choriomeningitis virus (LCMV)-specific CD8+ T cells in nonlymphoid tissues were enriched for memory precursors (expressing high levels of interleukin-7 receptor and low levels of killer cell lectin-like receptor G1 ...


Evaluation Of Naturally Acquired Igg Antibodies To A Chimeric And Non-Chimeric Recombinant Species Of Plasmodium Vivax Reticulocyte Binding Protein-1: Lack Of Association With Hla-Drb1*/Dqb1* In Malaria Exposed Individuals From The Brazilian Amazon, Amanda Ribeiro Ferreira, Balwan Singh, Monica Cabrera-Mora, Alana Cristina Magri De Souza, Maria Teresa Queiroz Marques, Luis Cristovao Sobrino Porto, Fatima Santos, Dalma Maria Banic, J. Mauricio Calvo-Calle, Joseli Oliveira-Ferreira, Alberto Moreno, Josue Da Costa Lima-Junior 2014 Oswaldo Cruz Institute

Evaluation Of Naturally Acquired Igg Antibodies To A Chimeric And Non-Chimeric Recombinant Species Of Plasmodium Vivax Reticulocyte Binding Protein-1: Lack Of Association With Hla-Drb1*/Dqb1* In Malaria Exposed Individuals From The Brazilian Amazon, Amanda Ribeiro Ferreira, Balwan Singh, Monica Cabrera-Mora, Alana Cristina Magri De Souza, Maria Teresa Queiroz Marques, Luis Cristovao Sobrino Porto, Fatima Santos, Dalma Maria Banic, J. Mauricio Calvo-Calle, Joseli Oliveira-Ferreira, Alberto Moreno, Josue Da Costa Lima-Junior

Open Access Articles

The development of modular constructs that include antigenic regions targeted by protective immune responses is an attractive approach for subunit vaccine development. However, a main concern of using these vaccine platforms is how to preserve the antigenic identity of conformational B cell epitopes. In the present study we evaluated naturally acquired antibody responses to a chimeric protein engineered to contain a previously defined immunodominant domain of the Plasmodium vivax reticulocyte binding protein-1 located between amino acid positions K435-I777. The construct also includes three regions of the cognate protein (F571-D587, I1745-S1786 and L2235-E2263) predicted to contain MHC class II promiscuous T ...


The Hunt For Protective Correlates Of Immunity To Plasmodium Falciparum Malaria, Ann M. Moormann, V. Ann Stewart 2014 University of Massachusetts Medical School

The Hunt For Protective Correlates Of Immunity To Plasmodium Falciparum Malaria, Ann M. Moormann, V. Ann Stewart

Open Access Articles

Determining an immunologic correlate of protection against Plasmodium falciparum malaria has been the holy grail of natural infection studies, and sought after as an endpoint for malaria vaccine trials. An in vitro assay that provides an accurate and precise assessment of protective immunity to malaria would make smaller, short-duration studies feasible, rather than the currently powered study designs that use morbidity or mortality as outcomes. Such a biomarker would be especially desirable in situations where malaria control measures that result in decreases in clinical endpoints and putatively waning protective immunity have been implemented. In an article published in BMC Medicine ...


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