Pharmacy and Pharmaceutical Sciences Commons^™

Update On The Efficacy Of Aerosol Therapy Delivered To Obstructive Lung Disease Patients, Mohammed A. Amin, Hasanain Kamil Hasan, Hebatullah K. Taha, Raghda R.S. Hussein, Mohamed E.A. Abdelrahim

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The distribution of many medications to the body via the respiratory tract system is crucial. This route has emerged as one of the most crucial techniques for the delivery of locally acting medications that can be used to treat a variety of respiratory conditions, including asthma and chronic obstructive pulmonary disease (COPD). The advantages of this focused drug delivery to the lungs over systemic administration methods include an improved therapeutic effect, a faster onset of action, and fewer systemic side effects.

Many formulations as suspension and solutions, such as bronchodilators, corticosteroids, and antibiotics have been recommended in a wide area …

A Study Of Serum Levels Of Ferritin, Hepatic And Renal Functions In Beta-Thalassemia Major (Btm) Patients Treated With Deferasirox (Dfx) Tablets, Desferioxamine (Dfo) Vial, Or Combination Of Both (Dfx + Dfo) In Thalassemia Center/Karbala, Shereen M. Mekkey, Maysam Ali Ameen, Najwa Kahtan Hadi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

A category of inherited blood illnesses known as beta-thalassemias are defined by abnormalities in the synthesis of hemoglobin beta chains, which can result in a wide range of phenotypes, from severe anemia to people who show no symptoms at all. People who have thalassemia major typically experience severe anemia during the first two years of life, necessitating frequent red blood cell (RBC) transfusions.

Management of individuals with β-thalassemia is centered on appropriate, safe blood transfusions (free of transfusion-transmitted illnesses) and prevention of iron excess. Complications from iron overload are brought on by routine transfusion therapy.

This study is a retrospective …

Greenness Assessment And Development Of An Innovative Hplc Method For The Determination Of Rifaximin And Sodium Benzoate In Oral Suspension, Hani M. Hafez, Naser F. Al-Tannak, Mohamed A. Rabeh

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The pharmaceutical industry has brought advancement and opportunities. However, it has also presented challenges and complexity that must be addressed. The pharmaceutical industry aims to protect public health by providing economical, effective, safe, and appropriate treatments. The analytical method monitors medication concentrations to ensure efficacy and safety. Chemical preservations protect drugs from microbes until administration. In Refax suspensions, the concentration of rifaximin (Antibacterial, API) and sodium benzoate (chemical preservative) must be determined to ensure the suspension's effectiveness, stability, and safety with regulatory standards.

An innovative HPLC method was created to monitor the concentrations of rifaximin (Antibacterial, API) and sodium benzoate …

Assessing Pharmacy Students' Knowledge And Awareness Regarding The Rational Utilization Of Antibiotics And The Issue Of Antimicrobial Resistance In Iraq, Hasanain Kamil Hasan, Mohamed Mahmoud Abdelrahman, Ali A. R. Aldallal, Hayder Ridha Salman, Montadher Mohammad Majeed, Mohammad Jabbar Hassan, Alaa Shukry Mtasher, Ahmed Majid Ibrahim

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Introduction: The Non rational use and overall volume of antibiotic consumption in the community is one of the foremost causes of antimicrobial resistance. In developing countries like Iraq, pharmacists often dispense ‘prescription-only’ drugs, like antibiotics, to patients who do not have a prescription. The objectives of this study are to estimate the prevalence of irrational use of antibiotics bought from pharmacies and other medication outlets in some areas in Iraq, as well as to investigate the factors related with such usage.

Method: The cross-sectional face to face survey was conducted in AL Mustaqbal University, were 267 students at College of …

Development Of A Multi-Target Pharmacophore-Based Virtual Screening Agent Against Covid-19, Nashwa A. Ibrahim, Ahmed M. Gouda, Hany A. M. El-Sherief

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The worldwide outbreak of the COVID-19 pandemic compelled scientists to develop new, highly effective therapeutic approaches to fight it. Multitarget drugs have been proven to be effective in managing complex disorders. But designing multitarget drugs is a great challenge. In this study, to prevent a lack of efficacy due to viral mutation escape, a multi-target agent against the COVID-19 virus was discovered. As crucial targets, RNA-dependent RNA polymerase (RdRp), COVID-19 main protease (Mpro), and SARS-CoV-2 Nsp15 were selected. A pharmacophore model was developed using the native ligands of the chosen targets. This model was used to screen the ZINC Drug …

A Cross – Sectional Observational Study On Pharmacoeconomics Burden Of Covid -19 In Ashmoun Fever Hospital Delta Egypt, Marwa Helmi Desouki, Marwa G. Elhennawy, Samar F. Farid

Bulletin of Faculty of Pharmacy Cairo University

Background: A wide range of respiratory illnesses like common colds, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) are caused by coronaviruses.

In 2019 scientists in Wuhan, China discovered a new coronavirus (COVID-19). Unknown new coronavirus that infected people for the first time and causes losses for humans. It has caused a large number of deaths around the world and a greater number of injuries, and the countries of the world began to take measures and closures to confront the spread of this virus, and the economy was greatly affected.

Aim of Study: This study provides …

Assessing Health Needs In A Dominican Republic Community During An Interprofessional Service-Learning Trip, Gabriela Andonie, Hanna Rotundo, Ashanti Jones, Logan Dugas, Shylon Francis

Journal of Interprofessional Practice and Collaboration

Purpose: International medical missions may increase access to medicines and care, but international teams must understand local needs to implement appropriate services. In 2023, a multidisciplinary team from our institution partnered with a nonprofit organization in the barrio of Cienfuegos, Dominican Republic with the goal of strengthening local health services. The primary objective of this study was to identify health-related needs in Cienfuegos from the perspective of community members and local health care workers.

Methods: A qualitative study was conducted as part of a service-learning initiative. After obtaining informed consent, the investigators conducted individual semi-structured interviews facilitated by multi-lingual interpreters. …

Concept Analysis: Undergraduate Nursing Student Clinical Performance Anxiety, Maria Gros

Journal of Interprofessional Practice and Collaboration

Concept Analysis: Undergraduate Nursing Student Clinical Performance Anxiety

Maria Gros, MSN, RN, CEN

Department of Nursing, Nicholls State University

Correspondence to: Maria Gros, MSN, RN, CEN. Department of Nursing, Nicholls State University, 906 East 1^st Street, Thibodaux, Louisiana, 70301. Phone: 985-448-4730. Email: maria.gros@nicholls.edu

Article type: Original article written in a doctoral course in the Doctorate in Nursing Education at University of West Georgia

Word count: 3023 words

Abstract

Purpose: This paper defines and clarifies clinical performance anxiety (CPA) as it pertains to undergraduate nursing students in the clinical setting. This research also identifies how CPA can be detrimental to …

Phytochemical Assay And In – Vitro Cytotoxicity Assessment Of Cassava Peel (Manihot Esculenta) From Ethanol And Ethyl Acetate Extract Against Cervical Cancer Cells (Hela), Alice Hari Soejono, Surya Dwira, Puji Sari

Indonesian Journal of Medical Chemistry and Bioinformatics

Introduction: Cervical cancer is a type of cancer that develops in a woman’s cervix. It is a result of HPV (Human Papilloma Virus) and is one of the deadliest types of cancer. Some cervical cancer management including chemotherapy, which until recently continues to develop to cure the condition, is relatively expensive and comes with multiple different side effects.

Method: Manihot esculenta undergoes multilevel maceration with the solvent of ethanol and ethyl acetate. This leads to the formation of ethanol extract and ethyl acetate extract of Manihot esculenta that is analyzed through phytochemical assay and thin layer chromatography (TLC) to determine …

Hpv Vaccine Knowledge, Attitudes, Beliefs, And Behaviors Among Community College Students: A Scoping Review, E. Pittman, D. Barker, S. Veeramachaneni, B. Suttles, M. Nagra, A. Ford-Wade, M. Kang, H. Allen, M. Barnard

Faculty and Student Publications

Background: Human Papillomavirus is the most common sexually transmitted infection in the United States. Approximately 42.5 million individuals in the U.S. are infected with disease-associated HPV and 13 million new cases occur every year. It is estimated that 85% of sexually active adults will be infected with HPV at some point during their lifetime. Most individuals infected with HPV are asymptomatic and clear the virus without any complications. However, in some individuals, the virus persists. Prolonged HPV infection has been associated with six different types of cancer and genital warts. There are approximately 37,000 cases of HPV-associated cancers diagnosed annually …

Proteomic Characterization And Cytotoxic Potential Of Proteins From Cuscuta (Cuscuta Epithymum (L.) Crude Herbal Product Against Mcf-7 Human Breast Cancer Cell Line, Umaima Akhtar, Yamna Khurshid, Bishoy El-Aarag, Basir Syed, Ishtiaq A. Khan, Keykavous Parang, Aftab Ahmed

Pharmacy Faculty Articles and Research

Background

The burden of breast cancer, the second leading cause of death worldwide, is increasing at an alarming rate. Cuscuta, used in traditional medicine for different ailments, including cancer, is known for containing phytochemicals that exhibit anticancer activity; however, the bioactivities of proteins from this plant remain unexplored. This study aimed to screen the cytotoxic potential of proteins from the crude herbal product of Cuscuta epithymum(L.) (CE) harvested from the host plants Alhagi maurorum and Medicago sativa.

Methods

The proteins from CE were extracted using a salting-out method, followed by fractionation with a gel filtration chromatography column. Gel-free shotgun …

What Can Pharmacists Do To Reduce Drug Abuse?, Saul E. Alvarado-Rosario

College of Pharmacy Student Research

This review paper provides an overview of the current status of substance abuse, involving both illicit drugs and medically regulated medications. Although global statistics are considered, the primary focus is the substance abuse crisis within the United States. Through review of experimental and observational peer-reviewed articles, this report examines the definition of substance abuse, demographic impacts, and governmental interventions, with particular emphasizes on the role of the pharmacy profession and individual pharmacists in addressing this widespread issue.

Improving Prolonged Antibiotics Education In A Pediatric Unit, Zerena S. Silva Villamonte

Master's Projects and Capstones

Problem Children’s Hospital A's incidence report tool, iCares, demonstrates that 50% of the issues related to prolonged intravenous (IV) antibiotics are categorized as administration issues. This leads to the medication being delivered at the wrong time or rate. Having these issues increases patient length of stay, increasing hospital costs. Context The microsystems for this quality improvement project include inpatient pediatric patient care units (PCU) 300, 360, and 400. Children’s Hospital A is a 361-bed San Francisco Bay Area hospital. Interventions The Clinical Nurse Leader students implemented a presentation defining prolonged IV antibiotics, their rationale, and a video demonstrating the correct …

Knowledge And Attitude Of Lebanese Adults Towards Asthma In Beirut, Lebanon, Farah Hatem Haidar, Doaa Issa, Maha Aboul Ela, Karim Raafat

BAU Journal - Health and Wellbeing

Asthma, a serious global health problem, has been an area of interest due to its increasing prevalence, expanding treatment costs, and rising burden on patients and the community. Since asthma cannot be cured, clinical episodes can be prevented and controlled by adequate management and sufficient knowledge of the disease. Appropriate treatment may relieve asthma symptoms and improve quality of life. However, poor knowledge of asthma disease and medication use, misdiagnoses, misuse of inhalers and inadequate self-management of disease symptoms may have a greater impact on the disease process. Therefore, assessment of the population’s knowledge and attitude toward asthma is essential. …

Pour Une Diffusion Éthique Des Connaissances De La Médecine Traditionnelle: L’Intersection De La Culture Yoruba Et Des Besoins Médicaux, Isabel Sala

CISLA Senior Integrative Projects

No abstract provided.

Basic Structure Of The Pharmacophore Virtual Screening Protein 7kg7 For Candidate Therapeutic Options Covid-19, Ahmad Ridha Al Fiqri

Indonesian Journal of Medical Chemistry and Bioinformatics

Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome, namely coronaviruses (SARS-CoV-2) has been a pandemic to date and is contagious with relatively high mortality rates. Various efforts have been made to control the pandemic to finding the best solution to reduce the spread such as rapid detection based on molecular and serological, as well as efforts to find the best medicine for COVID-19 patients continue to be carried out. We analyzed and concluded that the presatovir compound is capable of being a substitute for the native protein ligand 7KG7, this is proved with a ΔG value of -13.22 kcal/mol …

School Of Pharmacy Class Of 2024 Hooding Program, Cedarville University

Doctor of Pharmacy Hooding Ceremony

No abstract provided.

Oncology Treatment Plan Updates In Epic-Beacon, Rose Dimarco, Pharmd, Bcps, Bcop, Gloria Espinosa, Mat, Pharmd, Bcop, Kelly Miskovsky, Pharmd, Bcop, Gina Hemmert, Pharmd

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Background

In Medical Oncology, the utilization of EPIC-Beacon Treatment Plans is integral for prescribing and administering cancer treatments. These treatment plans typically consist of anticancer infusion medications (chemotherapy, immunotherapy, etc.), supportive care medications, required laboratory orders, and other monitoring recommendations to ensure that patients receive safe and effective care. In 2017, TJUH transitioned from Varian’s Aria to EPIC’s electronic medical record system. Since then, there has not been a formal review of existing plans, and there are many inconsistencies between plans in different cancer types.

Problem Statement:

• Currently, there is not a formal process for review of existing treatment plans, …

Opioid Prescription Rates Before And After Alto Program And Various Factors Affecting Emergency Department Opioid Prescription Rates, Neel B. Patel, James F. Baird

Rowan-Virtua Research Day

Opioid prescription rates vary between patient population, diagnosis, location, and emergency department characteristics. High prescription rates offer an avenue for potential opioid addiction and overdoses. Alternatives to opioids (ALTO) is a new program already implemented in certain emergency departments to help change opioid prescription rates by introducing new protocols for first line treatments for pain management. With current trends still showing that South Jersey opioids prescription rates are the highest in the state of New Jersey, ALTO was introduced at Inspira Health Network located in South Jersey. This study retrospectively analyzed opioids prescription rates for abdominal pain, renal colic, migraines, …

An Integrative Review Of The Absorption Of Fda-Approved Chemical Sunscreen Filters Into The Blood, Srinidhi Banala, Samrat Gollapudi, Abhiram Gollapudi, Bhaumik Patel

Rowan-Virtua Research Day

Introduction: This integrative review examines the absorption of FDA-approved chemical sunscreen filters, specifically avobenzone and oxybenzone, into the bloodstream. The study aims to compare the levels of absorption and potential health effects of systemic exposure to these sunscreen ingredients in the United States.

Methods: The researchers conducted a literature search of 57 articles, of which 15 were used for the review. Inclusion criteria focused on studies discussing absorption levels of avobenzone and oxybenzone, as well as methods of absorption into the bloodstream. Exclusion criteria included sunscreen ingredients not approved in the United States, non-English studies, and studies on methods to …