Mechanical Engineering Commons^™

Optimization Of An Automated Algorithm For Analysis Of Spontaneous Rhythmic Bladder Contractions During Urodynamics Testing, Isabelle Pummill, Rui Li, Zachary Cullingsworth, Adam Klausner, John Speich

Summer REU Program

No abstract provided.

Modeling Of Patient-Specific Periaortic Mechanics And Pulmonary Artery Hemodynamics Based On Phase-Contrast Magnetic Resonance Imaging Sequences., Johane H. Bracamonte

Theses and Dissertations

Inverse modeling in cardiovascular medicine is a collection of methodologies that can provide non-invasive patient-specific estimations of clinical risk factors using medical imaging as inputs. Its incorporation into clinical practice has the potential to improve diagnosis and treatment planning with low associated risks and costs.

Herein, three different phase contrast magnetic resonance imaging (MRI) modalities were implemented as input data, displacement encoding with stimulated echoes (DENSE MRI) applied, and time-resolved velocity encoding phase-contrast MRI, in 1D and 3D, applied to pulmonary artery (PA) hemodynamics.

A model to account for the effect of periaortic interactions due to static and dynamic structures …

Improving Quantification Of Mitral Regurgitation Through Computational Fluid Dynamics And Ex Vivo Testing, Alexandra Flowers

Electronic Theses and Dissertations

Mitral regurgitation (MR) is a prominent cardiac disease affecting more than two million people in the United States alone. In order for patients to receive proper therapy, regurgitant volume must first be quantified. As there are an array of methods to do so, the proximal isovelocity surface area (PISA) method continues to be the most accurate and clinically used method. However, there are some difficulties obtaining the necessary measurements need for this when performing transthoracic echocardiography. This study aims to evaluate and present techniques that may be used to more accurately quantify regurgitation through ex vivo testing and computational fluid …

Structural And Hemodynamic Analysis Of Transcatheter Aortic Valves, Dong Qiu

Electronic Theses and Dissertations

The transcatheter aortic valve replacement (TAVR) procedure has become a well-established procedure for high, intermediate-risk, and low-risk patients. However, there is limited clinical data on the TAV's long-term durability, unlike SAV devices. Computational simulations can be an alternative way to evaluate the TAV devices. This dissertation aims to conduct structural and hemodynamic analyses on the TAV devices under different conditions using computational simulation approaches.

Initially, the impact of the bicuspid aortic valve on the TAV devices was evaluated. The result indicated that the CoreValve-like supra-annular self-expandable device was likely to have increased stress and strain on the leaflet when it …

Prolonged Exposure To Microgravity Increases Susceptibility To Traumatic Brain Injury, Ryan Baskerville

UNF Graduate Theses and Dissertations

With the prospect of semi-permanent and permanent habitable fixtures on the moon and Mars, the complications associated with long-term exposure to microgravity should be investigated exhaustively. Spaceflight Associated Neuro-Ocular Syndrome (SANS), a group of neurological and ocular effects resulting from prolonged exposure to microgravity, is characterized by significant fluid shifts into the cranium, namely cerebrospinal fluid and blood, and an upward shift of the brain relative to the skull. This syndrome, along with its immediate effects on visual acuity, cognitive ability, and motor function are recognized by NASA, but its effects on susceptibility to traumatic brain injury have yet to …

An Introduction To The Comparison Of Seismocardiography And Phonocardiography, Anna C. Voyatzoglou

Honors Undergraduate Theses

The intent of this thesis is to lay groundwork for examining the relationship between seismocardiography (SCG) and phonocardiography (PCG). Both are methods of measuring and describing heart mechanical function. SCG is described as chest vibrations while the heart beats, and PCG is described as acoustic chest surface signal believed to represent the heart valves opening or closing. SCG and PCG have both been used separately in clinical and research settings, but there is currently no clear comparison between the two. Therefore, there has been no way at the present to understand how one signal might inform the other. This study …

Numerical Design Of Steerable Guidewires, Onkar Prakash Salunkhe

Dissertations, Master's Theses and Master's Reports

Biomedical devices are an integral part of the medical industry nowadays. With the increase in cases of heart disease, catheterization procedures are becoming more frequent. Small-scale actuators are needed for the guidance of small-scale catheters and guidewires to remote targets in the human body. Numerical modelling is needed to guide the experiments in developing such steerable devices and to optimize their design. Here, we designed small-scale steerable guidewires by first developing bending actuators and then assembling them with guidewires. The actuators use materials with strain response to electric potential in a very low voltage range that is not harmful to …

Modeling Human Control Behavior In Command-Following Tasks, Sajad Koushkbaghi

Theses and Dissertations--Mechanical Engineering

Humans interact with a variety of complex dynamic systems on a daily basis. However, they are often the lesser understood component of human-in-the-loop (HITL) systems. In this dissertation, we present the results of two HITL experiments to investigate the control strategies that humans use when performing command-following tasks. The first experiment is designed to investigate the control strategies that humans use to interact with nonlinear dynamic systems. Two groups of human subjects interact with a dynamic system and perform a command-following task. One group interacts with a linear time-invariant (LTI) dynamic system and the other group interacts with a Wiener …

Antagonistic Co-Contraction Can Minimize Muscular Effort In Systems With Uncertainty, Anne D. Koelewijn, Antonie J. Van Den Bogert

Mechanical Engineering Faculty Publications

Muscular co-contraction of antagonistic muscle pairs is often observed in human movement, but it is considered inefficient and it can currently not be predicted in
simulations where muscular effort or metabolic energy are minimized. Here, we investigated the relationship between minimizing effort and muscular co-contraction
in systems with random uncertainty to see if muscular co-contraction can minimize effort in such system. We also investigated the effect of time delay in the muscle, by varying the time delay in the neural control as well as the activation time constant.We solved optimal control problems for a one-degree-of-freedom pendulum actuated by two identical …

Contact Simulation For Evaluating Patient Specific Surgical Guide Stability, Vincent Nierste

Electronic Theses and Dissertations

This study proposes a novel computational method to quantify guide stability for Patient Specific Instrumentation (PSI) guides. A finite element contact model was used to analyze the final position of PSI guides on a femur across a range of loading parameters representing forces applied by a surgeon during operative use. Separate segmentation methods were used for the guide and bone geometry to represent differences between segmentation and actual patient geometry. The region of loading parameters over which the guide exhibited a consistent final position was measured and reported as Guide Stability Score. The model was verified using cadaver specimens for …

In-Flow Dynamics Of An Area-Difference-Energy Spring-Particle Red Blood Cell Model On Non-Uniform Grids, Brendan Walsh, Fergal Boyle

Articles

In this paper the area-difference-energy spring-particle (ADE-SP) red blood cell (RBC) structural model developed by Chen and Boyle is coupled with a lattice Boltzmann flux solver to simulate RBC dynamics. The novel ADE-SP model accounts for bending resistance due to the membrane area difference of RBCs while the lattice Boltzmann flux solver offers reduced computational runtimes through GPU parallelisation and enabling the employment of non-uniform meshes. This coupled model is used to simulate RBC dynamics and predictions are compared with existing experimental measurements. The simulations successfully predict tumbling, tank-treading, swinging and intermittent behaviour of an RBC in shear flow, and …

Controlled Voltage Of Hot Snare Polypectomy Device In Electrosurgical Device, Saidi Olayinka Olalere

Electronic Theses and Dissertations

The study is used to understand the working procedure of the Olympus PSD-30 Electrosurgical Unit which a high-frequency alternating current is to measure the voltage and power output from the unit when used for a surgical operation to determine the extent of tissue damage. The output power and voltage were as examined with the stopwatch, then with an Arduino time based for 1, 2, and 3 seconds to understand the different modes of the cut and coagulation feedback with an RCC circuit used to mimic the human body. This shows a pattern in which the feedback power increases, and voltage …

A Note From The Co-Editors, Jada C. Johnson

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

An introduction to the fifth issue of the third volume of Ideas Magazine, concerning the thoughts, experience, and work of Dr. Marcelo J.S. de Lemos.

Numerical Study Of Laryngeal Control Of Phonation Using Realistic Finite Element Models Of A Canine Larynx, Biao Geng

Electronic Theses and Dissertations

While many may take it for granted, the human voice is an incredible feat. An average person can produce a great variety of voices and change voice characteristics agilely even without formal training. Last several decades of research has established that the production of voice is largely a mechanical process: i.e., the sustained vibration of the vocal folds driven by the glottal air flow. Since one only has a single pair of vocal folds, the versatility comes with the ability to change the mechanical status of the vocal folds, including vocal fold length and thickness, tension, and level of adduction, …

A Survey Of Stainless Steel In Medical And Surgical Application, Noah Slack, Clint Balch

ME 4133/6133 Mechanical Metallurgy

Stainless steels can be separated into four families based on the microstructure of the material: Austenitic, Ferritic, Martensitic, and Duplex. Each family provides a specific set of advantages and disadvantages, and material selection should be based on the specific application the material will be used for. For this study, the processing, microstructure, and performance of the four families of stainless steels will be compared in the context of medical device applications. The most important factors in medical device materials are biocompatibility, surface properties, mechanical properties and life span/corrosion resistance. This study will focus on medical devices that will be permanently …

Force-Feedback Design For Robotics: Bio-Based Design And Simulation, Husnain Khan, Zhou Zhang

Publications and Research

The great challenge for the Virtual Assembly Platform is how to make the users have the in-person feeling with the augmented tools. Hands are the most important organs that are used to provide touch feeling. In a real assembly scenario, the force from the components and tools will be feedback to the brain via the hands. Unfortunately, the virtual assembly failed to mimic the in-person scenarios since it will not provide such kind of feedback. As a result, the users’ real identities are lost. Then, the users’ slower-progressing wrong habits will prevent them from success in the future. Therefore, it …

Respiratory Compensated Robot For Liver Cancer Treatment: Design, Fabrication, And Benchtop Characterization, Mishek Jair Musa

Graduate Theses and Dissertations

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in the world. Radiofrequency ablation (RFA) is an effective method for treating tumors less than 5 cm. However, manually placing the RFA needle at the site of the tumor is challenging due to the complicated respiratory induced motion of the liver. This paper presents the design, fabrication, and benchtop characterization of a patient mounted, respiratory compensated robotic needle insertion platform to perform percutaneous needle interventions. The robotic platform consists of a 4-DoF dual-stage cartesian platform used to control the pose of a 1-DoF needle insertion module. The active …

Medial And Lateral Tibiofemoral Contact Forces For Individuals With High Body Mass Index In Gait And Cycling Training, Reymil Fernandez

Master's Theses

The prevalence of knee osteoarthritis, a degenerative joint disease characterized by the degradation of articular cartilage, is correlated with the rise in obesity. The rising rates of obesity in children and adults highlight the need for identifying a sustainable physical activity that promotes fitness while mitigating initiation and progression of osteoarthritis. The objective of this study was to determine an effective rehabilitation and lifelong fitness sustainment exercise regimen that minimize risk of osteoarthritis in individuals with high body mass index (BMI). The aim was to examine knee medial and lateral contact forces in gait and cycling training. Gait at self-selected …

Triangular Cosserat Point Element Method For Reducing Soft Tissue Artifact: Validation And Application To Gait, Jake Edward Deschamps, Stephen Klisch

Master's Theses

Human motion capture technology is a powerful tool for advancing the understanding of human motion biomechanics (Andriacchi and Alexander, 2000). This is most readily accomplished by applying retroreflective markers to a participant’s skin and tracking the position of the markers during motion. Skin and adipose tissue move independently of the underlying bone during motion creating error known as soft tissue artifact (STA), the primary source of error in human motion capture (Leardini et al., 2005).

(Solav et al., 2014) proposed and (Solav et al., 2015) expanded the triangular Cosserat point element (TCPE) method to reduce the effect of STA on …

Using Dynamic In Vivo Kinematics For Subject-Specific Calibration Of Knee Ligament Parameters, Stephen Nelson

Boise State University Theses and Dissertations

In vivo clinical studies are the optimal way to investigate the biomechanical outcomes of new prosthetic devices. This particular style of testing can be difficult and, in certain cases, unethical to perform. The testing of unproven devices, surgical techniques, and materials put patients at risk from unanticipated outcomes in how these devices respond to the in vivo environment and patient-specific loading conditions. Biomechanical computational models were developed to provide validation to new devices prior to clinical testing. Computational models for use in optimizing knee prosthetics frequently include ligament representations, but these representations have inherent uncertainty due to wide intersubject variation …

Significance Of The Vehicle Front Design And Gait Postures On Traumatic Brain Injuries Sustained By Different Pedestrian Populations During Car-To-Pedestrian Collisions (Cpcs) - A Computational Approach, Thava Kalishwara Kumar Gunasekaran

Electronic Thesis and Dissertation Repository

With the increasing prevalence of traumatic brain injuries (TBIs) in road traffic accidents (RTAs), it was identified that the shape of the vehicle's front end and pedestrian postures prior to impact significantly influence pedestrian head injuries. However, the effect of vehicle front shape parameters and gait postures on TBIs sustained in car-to-pedestrian collisions (CPCs) has yet to be quantified. This study used a computational approach to analyze the effect of vehicle shape parameters and pedestrian gait postures on pedestrian TBI risks across a diverse pedestrian population with varying body sizes. Our findings indicate that vehicle shape parameter such as BLEH …

Collision Tracking And Brain Mapping, Carl Russell Iii

The Journal of Purdue Undergraduate Research

No abstract provided.

Creating Reel Designs: Reflecting On Arthrogryposis Multiplex Congenita In The Community, Iris Layadi

Purdue Journal of Service-Learning and International Engagement

Because of its extreme rarity, the genetic disease arthrogryposis multiplex congenita (AMC) and the needs of individuals with the diagnosis are often overlooked. AMC refers to the development of nonprogressive contractures in disparate areas of the body and is characterized by decreased flexibility in joints, muscle atrophy, and developmental delays. Colton Darst, a seven-year-old boy from Indianapolis, Indiana, was born with the disorder, and since then, he has undergone numerous surgical interventions and continues to receive orthopedic therapy to reduce his physical limitations. His parents, Michael and Amber Darst, have hopes for him to regain his limbic motion and are …

Visuomotor Adaptation During Asymmetric Walking, Charles Napoli

Masters Theses

Necessary for effective ambulation, head stability affords optimal conditions for the perception of visual information during dynamic tasks. This maintenance of head-in-space equilibrium is achieved, in part, by the attenuation of the high frequency impact shock resulting from ground contact. While a great deal of experimentation has been done on the matter during steady state locomotion, little is known about how head stability or dynamic visual acuity is maintained during asymmetric walking.

In this study, fifteen participants were instructed to walk on a split-belt treadmill for ten minutes while verbally reporting the orientation of a randomized Landolt-C optotype that was …

Numerical Study Of Fully Coupled Fluid-Structure Interaction Of Stented Ureter By Varying The Stent Side-Holes, Erick Martinez, Ben Xu, Jianzhi Li, Yingchen Yang

Mechanical Engineering Faculty Publications and Presentations

Ureteral stents are a measure used for many medical issues involving urology, such as kidney stones or kidney transplants. The purpose of applying stents is to help relieve the urine flow while the ureter is either blocked or trying to close itself, which creates blockages. These ureteral stents, while necessary, cause pain and discomfort to patients due to them being a solid that moves around inside the patients’ body. The ureter normally moves urine to the bladder through peristaltic forces. Due to the ureter being a hyperelastic material, these peristaltic forces cause the ureter to deform easily, making it necessary …

Building A Biomechanical Model Of A Rat Forelimb, Joshua Nathaniel Eric Mak

Dissertations and Theses

This paper presents a biomechanical model of the rat forelimb to test theories of determining viscoelastic muscle parameters. Several biomechanical models of rat hindlimbs have been developed and have explored the effects of multi-muscle control during locomotion. The forelimb model uses two ball-and-socket joints to model clavicle and scapula movement. A third ball-and-socket joint is used at the shoulder and two hinge joints are used at the elbow and wrist. Scapula motion is further constrained by muscle and spring elements. Each forelimb has 11 degrees of freedom, and 23 Hill-type muscles. The model has been created in Animatlab, which includes …

Use Of Pressure-Measuring Insoles To Characterize Gait Parameters In Simulated Reduced-Gravity Conditions, Christian Ison, Connor Neilsen, Jessica Deberardinis, Mohamed B. Trabia, Janet S. Dufek

Mechanical Engineering Faculty Research

Prior researchers have observed the effect of simulated reduced-gravity exercise. However, the extent to which lower-body positive-pressure treadmill (LBPPT) walking alters kinematic gait characteristics is not well understood. The purpose of the study was to investigate the effect of LBPPT walking on selected gait parameters in simulated reduced-gravity conditions. Twenty-nine college-aged volunteers participated in this cross-sectional study. Participants wore pressure-measuring insoles (Medilogic GmBH, Schönefeld, Germany) and completed three 3.5-min walking trials on the LBPPT (AlterG, Inc., Fremont, CA, USA) at 100% (normal gravity) as well as reduced-gravity conditions of 40% and 20% body weight (BW). The resulting insole data were …

Build Your Own Body Mod: Empowerment Through Prototyping And Design, Anaiss Arreola, Katherine R. Ganim

Journal of Science Education for Students with Disabilities

When you don’t have a hand, what could you have instead? This article introduces the impact of inviting youth with disabilities to learn tools and technology to design their own solutions and advocate for their own future. This approach to programming is rooted in a mindset of designing WITH, not FOR. Not only are design outcomes improved when users are incorporated into the process, but this approach has been shown to improve confidence in creating one’s own solutions. These programs include hands-on “design-your-own-body-mod” workshops, as well as a budding inclusive design consultancy led by youth with disabilities. Through this programming, …

Development Of A Shoulder Implant Testing System To Evaluate Implant Fixation, Allen Sun

Undergraduate Student Research Internships Conference

This poster outlines the initial methodology and testing related to the development of an optical measurement system used to quantify shoulder implant micromotion in the laboratory.

Development Of A Novel Haptic Feedback System For Gait Training Applications, Mohsen Alizadeh Noghani

Electronic Theses and Dissertations

Until recently, study and correction of motor or gait functions required costly sensors and measurement setups (e.g., optical motion capture systems) which were only available in laboratories or clinical environments. However, due to (1) the growing availability and affordability of inertial measurement units (IMUs) with high accuracy, and (2) progress in wireless, high bandwidth, and energy-efficient networking technologies such as Bluetooth Low Energy (BLE), it is now possible to measure and provide feedback in real-time for biomechanical parameters outside of those specialized settings. To enable gait training without an expert who can provide verbal feedback, augmented feedback, which is divided …