Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Drug delivery (2)
- 3D modeling (1)
- ABAQUS (1)
- Actuators (1)
- Adaptive Strategies (1)
-
- Allergy (1)
- Anaphylaxis (1)
- Auto-injector (1)
- Bearing component (1)
- Bicuspid valve (1)
- Biological Inspiration (1)
- Biomechanics (1)
- Biomimicry (1)
- Cancer (1)
- Capsule pump (1)
- Center for Orthopaedic Biomechanics (1)
- Contact pressure (1)
- Cytotoxic assay (1)
- Daniel Felix Ritchie School of Engineering and Computer Science (1)
- Fault-Adaptation (1)
- Finite Element Analysis (1)
- Finite Element Modeling (1)
- High throughput (1)
- Hydrogels (1)
- Insulin pump (1)
- Internet of Things (1)
- Internet-of-things (1)
- Magneto-Fluid-Solid interaction. (1)
- Magnetorheological elastomer (MRE) (1)
- Mechanical Loading (1)
- Publication
- Publication Type
Articles 1 - 7 of 7
Full-Text Articles in Mechanical Engineering
Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb
Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb
Theses and Dissertations
Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …
Pulse Modulation In Braided Pneumatic Actuators Mimics Contractile Behavior Of Biological Muscles, Mohamad Elzein
Pulse Modulation In Braided Pneumatic Actuators Mimics Contractile Behavior Of Biological Muscles, Mohamad Elzein
Student Research Symposium
Advancements in robotics and bioengineering aim to emulate biological muscle systems through robotic actuators, blending mechanical strength with biological adaptability. A lesser-explored aspect is mimicking the pulse-like control characteristic of biological muscles, which contract in response to action potentials from motoneurons, with muscle contractile force relying heavily on the timing between these potentials. This study explores the effect of pulse lengths and the gaps between pulses on braided pneumatic actuators (BPAs), which mimic the nonlinearity and dynamic response of biological muscles. It hypothesizes that artificial muscles utilizing pulse-based control will exhibit a similar force dependency on the intervals between pulses …
Model-Based Comparison Of Biological Organism And Electro-Mechanical System Resiliency Strategies, Nicholas Ratycz
Model-Based Comparison Of Biological Organism And Electro-Mechanical System Resiliency Strategies, Nicholas Ratycz
Mechanical Engineering Undergraduate Honors Theses
Bio-inspired design has been used by many engineers to solve difficult problems or to make manufacturing processes more efficient. Biomimetics is the study of implementing the structure or function of biological substances, materials, mechanisms, and processes onto artificial ones that mimic the original. The goal of the BIASD tool is to provide bio-inspiration for engineers by studying the fault-adaptive strategies that biological systems use, rather than just their structure or function. In this thesis, the fault adaptive strategies of both a biological example and that of a real cubesat are compared using three types of model-based system diagrams to show …
Environment And Response Of 3d-Encapsulated Mesenchymal Stem Cells To Mechanical Loading, Augustus Greenwood
Environment And Response Of 3d-Encapsulated Mesenchymal Stem Cells To Mechanical Loading, Augustus Greenwood
McKelvey School of Engineering Theses & Dissertations
This thesis explores the micromechanical environment induced when cyclically compressing hydrogels via finite element modeling and experimentally on the impact of loading on mesenchymal stem cells (MSCs) when encapsulated withing 3D hydrogel matrices. Degenerative joint diseases, characterized by cartilage degradation, present significant challenges due to cartilage's limited self-repair capacity. Innovative approaches, including stem cell-based therapies and engineered biomaterials, have emerged as promising strategies for cartilage repair and regeneration. This work specifically investigates the calibration of a bioreactor, the uniformity of load response across the hydrogel constructs via finite element modeling (FEM), and the stress response of MSCs subjected to various …
Finite Element Analysis Of The Bearing Component Of Total Ankle Replacement Implants During The Stance Phase Of Gait, Timothy S. Jain
Finite Element Analysis Of The Bearing Component Of Total Ankle Replacement Implants During The Stance Phase Of Gait, Timothy S. Jain
Master's Theses
Total ankle replacement (TAR) implants are an effective option to restore the range of motion of the ankle joint for arthritic patients. An effective tool for analyzing these implants’ mechanical performance and longevity in-silico is finite element analysis (FEA). ABAQUS FEA was used to statically analyze the von Mises stress and contact pressure on the articulating surface of the bearing component in two newly installed fixed-bearing total ankle replacement implants (the Wright Medical INBONE II and the Exactech Vantage). This bearing component rotates on the talar component to induce primary ankle joint motion of plantarflexion and dorsiflexion. The stress response …
Simultaneous Evaluation Of Tibiofemoral And Patellofemoral Mechanics In Total Knee Arthroplasty: A Combined Experimental And Computational Approach, Yashar A. Behnam, Ahilan Anantha Krishnan, Hayden Wilson, Chadd W. Clary
Simultaneous Evaluation Of Tibiofemoral And Patellofemoral Mechanics In Total Knee Arthroplasty: A Combined Experimental And Computational Approach, Yashar A. Behnam, Ahilan Anantha Krishnan, Hayden Wilson, Chadd W. Clary
Center for Orthopaedic Biomechanics: Faculty Scholarship
Contemporary total knee arthroplasty (TKA) has not fully restored natural patellofemoral (P-F) mechanics across the patient population. Previous experimental simulations have been limited in their ability to create dynamic, unconstrained, muscle-driven P-F articulation while simultaneously controlling tibiofemoral (T-F) contact mechanics. The purpose of this study was to develop a novel experimental simulation and validate a corresponding finite element model to evaluate T-F and P-F mechanics. A commercially available wear simulator was retrofitted with custom fixturing to evaluate whole-knee TKA mechanics with varying patella heights during a simulated deep knee bend. A corresponding dynamic finite element model was developed to validate …
A Novel Magnetorheological Pump Concept For Insulin Delivery, Mohammad Towhidul Islam Rimon
A Novel Magnetorheological Pump Concept For Insulin Delivery, Mohammad Towhidul Islam Rimon
Electronic Theses and Dissertations
Over the past 25 years, awareness of type 1 diabetes has significantly increased, leading to a comprehensive understanding of various aspects, including its genetics, epidemiology, and disease burden. According to the Type 1 Diabetic Index, about 8.7 million people around the world live with this long-term autoimmune disease characterized by insulin deficiency and resultant hyperglycemia. However, the increased availability and utilization of artificial pancreas systems could potentially save 673,000 lives by 2040. Although, the advancement of diabetes technology offers Type 1 diabetic patients more tools to enhance glycemic management and achieve effective outcomes, many patients are still hesitant to adopt …