Mechanical Engineering Commons^™

Development And Validation Of A 3-D Model To Predict Knee Joint Loading During Dynamic Movement, Scott G. Mclean, Anne Su, Antonie J. Van Den Bogert

Mechanical Engineering Faculty Publications

The purpose of this study was to develop a subject-specific 3-D model of the lower
extremity to predict neuromuscular control effects on 3-D knee joint loading during movements that can potentially cause injury to the anterior cruciate ligament (ACL) in the knee. The simulation consisted of a forward dynamic 3-D musculoskeletal model of the lower extremity, scaled to represent a specific subject. Inputs of the model were the initial position and velocity of the skeletal elements, and the muscle stimulation patterns. Outputs of the model were movement and ground reaction forces, as well as resultant 3-D forces and moments acting …

Exotendons For Assistance Of Human Locomotion, Antonie J. Van Den Bogert

Mechanical Engineering Faculty Publications

Background: Powered robotic exoskeletons for assistance of human locomotion are currently
under development for military and medical applications. The energy requirements for such devices are excessive, and this has become a major obstacle for practical applications. Legged locomotion in many animals, however, is very energy efficient. We propose that poly-articular elastic mechanisms are a major contributor to the economy of locomotion in such specialized animals. Consequently, it should be possible to design unpowered assistive devices that make effective use of similar mechanisms.

Methods: A passive assistive technology is presented, based on long elastic cords attached to an
exoskeleton and guided …

A Growth Mixture Theory For Cartilage With Application To Growth-Related Experiments On Cartilage Explants, Stephen M. Klisch, Silvia S. Chen, Robert L. Sah, Anne Hoger

Mechanical Engineering

In this paper, we present a growth mixture model for cartilage. The main features of this model are illustrated in a simple equilibrium boundary-value problem that is chosen to illustrate how a mechanical theory of cartilage growth may be applied to growth-related experiments on cartilage explants. The cartilage growth mixture model describes the independent growth of the proteoglycan and collagen constituents due to volumetric mass deposition, which leads to the remodeling of the composition and the mechanical properties of the solid matrix. The model developed here also describes how the material constants of the collagen constituent depend on a scalar …

Entrainment Of Electrical Activation By Spatio-Temporal Distributed Pacing During Ventricular Fibrillation, Yiping Gu

University of Kentucky Master's Theses

Spatio-temporal variation in action intervals during ventricular fibrillation (VF) suggestthat the excitable gap may also be distributed spatio-temporally. The observation leadus to hypothesize that distributed pacing can be used to modify and entrain electricalactivation during VF. We tested this hypothesis using simulated VF and animal studies.

We simulated VF in a 400 by 400 cell matrix. Simulation results showed that activationpattern could be entrained using spatially distributed stimulation. Up to a certain limit,increasing stimulus strength and density led to improved entrainment. Best entrainmentwas obtained by pacing at a cycle length similar to the intrinsic cycle length.

In order to verify …