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Full-Text Articles in Biomedical Engineering and Bioengineering

Viscoelastic Properties Of Shock Wave Exposed Brain Tissue Subjected To Unconfined Compression Experiments, Annastacia K. Mccarty, Ling Zhang, Sarah Hansen, William J. Jackson, Sarah A. Bentil Dec 2019

Viscoelastic Properties Of Shock Wave Exposed Brain Tissue Subjected To Unconfined Compression Experiments, Annastacia K. Mccarty, Ling Zhang, Sarah Hansen, William J. Jackson, Sarah A. Bentil

Mechanical Engineering Publications

Traumatic brain injuries (TBI) affect millions of people each year. While research has been dedicated to determining the mechanical properties of the uninjured brain, there has been a lack of investigation on the mechanical properties of the brain after experiencing a primary blast-induced TBI. In this paper, whole porcine brains were exposed to a shock wave to simulate blast-induced TBI. First, ten (10) brains were subjected to unconfined compression experiments immediately following shock wave exposure. In addition, 22 brains exposed to a shock wave were placed in saline solution and refrigerated between 30 minutes and 6.0 hours before undergoing ...


Influence Of Naoh Concentration On Transfer Process Of Graphene, Francisco Saldana, Chengyu Wen, George Patrick Watson Sep 2019

Influence Of Naoh Concentration On Transfer Process Of Graphene, Francisco Saldana, Chengyu Wen, George Patrick Watson

Protocols and Reports

The process of transferring a monolayer of graphene using two different concentrations of sodium hydroxide (NaOH) solution unto a silicon dioxide (SiO2) coated Si chip using electrochemistry was performed. The transfer process is crucial for the delamination of a continuous graphene monolayer film from copper foil. After examining and inspecting the integrity of the graphene monolayer, it was observed that the lower concentration to NaOH led to slower rate of hydrogen bubble generation; this condition was found to be less destructive and yielded a graphene film with fewer visible tears.


Milk Oligopeptide Inhibition Of (Α)-Tocopherol Fortified Linoleic Acid Oxidation, Haina Yuan, Jinyan Gong, Kun Tang, Jinge Huang, Gongnian Xiao, Jianmin Lv Sep 2019

Milk Oligopeptide Inhibition Of (Α)-Tocopherol Fortified Linoleic Acid Oxidation, Haina Yuan, Jinyan Gong, Kun Tang, Jinge Huang, Gongnian Xiao, Jianmin Lv

Biological and Irrigation Engineering Student Research

This study investigated the effect of milk oligopeptides and (α)-tocopherol on inhibition of linoleic acid oxidation using Fe2+-vitamin C induced linoleic acid oxidation model through analysis of malondialdehyde, peroxide value, and conjugated diene and triene in the model. The alteration of milk oligopeptides maximal absorption wavelength, fluorescent feature, and secondary structure were further investigated to elucidate the interactions between milk oligopeptide and (α)-tocopherol that altered the inhibitory effect of linoleic acid oxidation. Results showed that Pro-Tyr-Tyr-Ala-Lys (PYYAK) and Ile-Pro-Ile-Gln-Tyr (IPIQY) with (α)-tocopherol significantly inhibited the oxidation of linoleic acid and reduced the formation of malondialdehyde ...


Model Based Analysis Of The Accuracy And Precision Of Auscultatory Blood Pressure Measurements In Patients With Atrial Fibrillation, Charles F. Babbs Sep 2019

Model Based Analysis Of The Accuracy And Precision Of Auscultatory Blood Pressure Measurements In Patients With Atrial Fibrillation, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

Accurate measurement of blood pressure in the presence of atrial fibrillation remains an open problem. The present study combines the techniques of stochastic mathematical modeling with physiological models of the systemic circulation, cuff, and arm (1) to explore mechanisms underlying both the lack of accuracy and the lack of precision in cuff-based arterial pressure measurements during atrial fibrillation and (2) to develop strategies to correct for errors. Both the cardiovascular system and the measurement technique are described using mathematics, including both numerical techniques and analytical probability theory. Preliminary results with numerical models suggested that, despite variability, average systolic pressures tend ...


Sheet‐Extruded Films From Blends Of Hydroxypropylated And Native Corn Starches, And Their Characterization, Hee-Young Kim, Buddhi P. Lamsal, Jay-Lin Jane, David A. Grewell Aug 2019

Sheet‐Extruded Films From Blends Of Hydroxypropylated And Native Corn Starches, And Their Characterization, Hee-Young Kim, Buddhi P. Lamsal, Jay-Lin Jane, David A. Grewell

Food Science and Human Nutrition Publications

Sheet‐extruded films from the blends of hydroxypropylated normal corn starch (HP) and native normal corn starch (NS) at weight ratios of 100:0, 90:10, 70:30, 50:50, 30:70, and 0:100 were prepared and characterized. Glycerol and water were added as plasticizers at 11 and 27% starch weight, respectively. The highest tensile strength (TS) and longest elongation to break (EB) for dry films were observed at 70:30 HP: NS ratio, which was 25.76 MPa, and 3.97%, respectively. However, TS and EB of this 70:30 blend extruded starch film exhibited low resistance upon ...


Monitoring Silane Sol-Gel Kinetics With In-Situ Optical Turbidity Scanning And Dynamic Light Scattering, Abul Bashar Mohammad Giasuddin, David W. Britt Aug 2019

Monitoring Silane Sol-Gel Kinetics With In-Situ Optical Turbidity Scanning And Dynamic Light Scattering, Abul Bashar Mohammad Giasuddin, David W. Britt

Biological Engineering Faculty Publications

Organosilanes (e.g., R’-SiOR3) provide hydrophobic functionality in thin-film coatings, porous gels, and particles. Compared with tetraalkoxysilanes (SiOR4), organosilanes exhibit distinct reaction kinetics and assembly mechanisms arising from steric and electronic properties of the R’ group on the silicon atom. Here, the hydrolysis and condensation pathways of n-propyltrimethoxy silane (nPM) and a tri-fluorinated analog of nPM, 3,3,3-trifluoropropyl trimethoxy silane (3F), were investigated under aqueous conditions at pH 1.7, 2.0, 3.0, and 4.0. Prior to hydrolysis, 3F and nPM are insoluble in water and form a lens at the bottom (3F) or ...


Workshop On Convergence In Biological Engineering, Keith Roper Aug 2019

Workshop On Convergence In Biological Engineering, Keith Roper

Funded Research Records

No abstract provided.


Application Of Micro-Scale 3d Printing In Pharmaceutics, Andrew Kjar, Yu Huang Aug 2019

Application Of Micro-Scale 3d Printing In Pharmaceutics, Andrew Kjar, Yu Huang

Biological Engineering Faculty Publications

3D printing, as one of the most rapidly-evolving fabrication technologies, has released a cascade of innovation in the last two decades. In the pharmaceutical field, the integration of 3D printing technology has offered unique advantages, especially at the micro-scale. When printed at a micro-scale, materials and devices can provide nuanced solutions to controlled release, minimally invasive delivery, high-precision targeting, biomimetic models for drug discovery and development, and future opportunities for personalized medicine. This review aims to cover the recent advances in this area. First, the 3D printing techniques are introduced with respect to the technical parameters and features that are ...


False-Match Symmetry: Data Files And Simulation Code, Cherlyn J. Ng, Bart Farell Jul 2019

False-Match Symmetry: Data Files And Simulation Code, Cherlyn J. Ng, Bart Farell

Biomedical and Chemical Engineering

This record provides data from random-dot stereograms to use in solving the binocular correspondence problem through false-match symmetry. It also provides an implementation of the algorithm used in the article ‘Solving the stereo correspondence problem with false matches’ [Ng CJ, Farell B (2019) Solving the stereo correspondence problem with false matches. PLoSONE 14(7): e0219052. https://doi.org/10.1371/journal.pone.0219052].

The record consists of two parts, Data and Algorithm Demo. The Data component consists of pre-computed Keplerian arrays of all possible matches between filtered random-dot image pairs containing stereoscopically defined surfaces. The Algorithm Demo allows data files ...


Multimodal Quantitative Imaging Of Brain Cancer In Cultured Cells, Xin Feng, Alona Muzikansky, Alonzo H. Ross, Michael R. Hamblin, Peter R. Jermain, Anna N. Yaroslavsky Jul 2019

Multimodal Quantitative Imaging Of Brain Cancer In Cultured Cells, Xin Feng, Alona Muzikansky, Alonzo H. Ross, Michael R. Hamblin, Peter R. Jermain, Anna N. Yaroslavsky

Open Access Articles

Fluorescence emission, polarization and subcellular localization of methylene blue (MB) were studied in four cancerous and two normal human brain cell lines. Fluorescence emission and polarization images were acquired and analyzed. The co-localization of MB with mitochondria, lysosomes and nuclei of the cells was evaluated. Glioblastoma cells exhibited significantly higher MB fluorescence polarization compared to normal astrocytes. Preferential accumulation of MB in mitochondria of glioblastoma cells may explain higher fluorescence polarization values in cancer cells as compared to normal. These findings may lead to the development of a quantitative method for the detection of brain cancer in single cells.


Design, Development, And Field Testing A Visnir Integrated Multi-Sensing Soil Penetrometer, Nuwan K. Wijewardane Jul 2019

Design, Development, And Field Testing A Visnir Integrated Multi-Sensing Soil Penetrometer, Nuwan K. Wijewardane

Biological Systems Engineering--Dissertations, Theses, and Student Research

The research community in soil science and agriculture lacks a cost-effective and rapid technology for in situ, high resolution vertical soil sensing. Visible and near infra-red (VisNIR) technology has the potential to be used for such sensor development due to its ability to derive multiple soil properties rapidly using a single spectrum. Such efforts must, however, overcome a few challenges: (i) a dry ground soil spectral library that can be used to predict the target soil properties accurately, (ii) a robust design which can acquire high quality VisNIR spectra of soil, (iii) an effective method that can link field intact ...


A Novel Technique To Characterize The Surface Hydrophobicity Of Proteins Using Inverse Liquid Chromatography, Dilip Sethi, Sarah Hedberg, Daryl Williams Jul 2019

A Novel Technique To Characterize The Surface Hydrophobicity Of Proteins Using Inverse Liquid Chromatography, Dilip Sethi, Sarah Hedberg, Daryl Williams

Biological and Pharmaceutical Complex Fluids III: Protein Self-Assembly, Rheology and Interfacial Properties

This work presents a novel technique to characterize the surface hydrophobicity and other surface properties of proteins. The surface properties of industrial and therapeutic proteins are key to understanding their behavior in-situ, in the laboratory and in processes. Protein surface hydrophobicity is a marker for three dimensional structure, stability and function. Inverse Liquid Chromatography of Proteins (ILCP) with small molecule hydrophobic probes can be used to obtain direct measurements of the surface hydrophobicity of column resin-bound proteins using changes in probe retention behavior. The dimensionless hydrophobicity factor (Hf) for Lysozyme and BSA was obtained with changing pH and temperature ...


Biophysical Characterization Approaches To Aid The Selection Of Protein Formulations By Predicting Their Physical Stability During Long-Term Storage, Hristo Svilenov, Gerhard Winter Jul 2019

Biophysical Characterization Approaches To Aid The Selection Of Protein Formulations By Predicting Their Physical Stability During Long-Term Storage, Hristo Svilenov, Gerhard Winter

Biological and Pharmaceutical Complex Fluids III: Protein Self-Assembly, Rheology and Interfacial Properties

The formulation of therapeutic proteins is a critical process which aims at finding the most suitable conditions that impede protein degradation during long-term storage. One degradation path of high interest is the non-native aggregation1. The latter can be greatly suppressed by the selection of suitable solution conditions2. Over the years, various biophysical techniques have been explored as tools to quickly select the most promising formulations for long-term storage.

In this talk, we share the experience in our lab how some of these techniques can be integrated into protein formulation studies. We discuss the application of differential scanning calorimetry ...


Aggregation Challenges In The Formulation Development Of Multi-Dose Peptide Products, Jingtao Zhang, Katelyn Smith, Wei Xu, Yongchao Su, Suzanne D’Addio, Yogita Krishnamachari, Jameson Bothe, Daniel Yin, Xinpei Mao Jul 2019

Aggregation Challenges In The Formulation Development Of Multi-Dose Peptide Products, Jingtao Zhang, Katelyn Smith, Wei Xu, Yongchao Su, Suzanne D’Addio, Yogita Krishnamachari, Jameson Bothe, Daniel Yin, Xinpei Mao

Biological and Pharmaceutical Complex Fluids III: Protein Self-Assembly, Rheology and Interfacial Properties

The formulation development of parenteral peptide therapeutics frequently encounters aggregation challenges. In-depth biophysical understanding of the molecule and formulation are required to achieve formulation robustness. Further, unique considerations need to be given for peptide products that require multi-dose as the use of preservatives can promote aggregation while preservative effectiveness can also be impacted by its interaction with the peptide. This presentation will focus on the reversible and irreversible fibril aggregates in peptide formulations. Biophysical characterization of aggregation and formulation will be discussed in detail. Formation of reversible aggregates and the impact of excipients especially preservatives will be discussed. For the ...


Conference Program, Samiul Amin, Paolo Arosio, Miguel Rodrigues Jul 2019

Conference Program, Samiul Amin, Paolo Arosio, Miguel Rodrigues

Biological and Pharmaceutical Complex Fluids III: Protein Self-Assembly, Rheology and Interfacial Properties

No abstract provided.


Resolving Intravoxel White Matter Structures In The Human Brain Using Regularized Regression And Clustering, Andrea Hart, Brianna Smith, Sean Smith, Elijah Sales, Jacqueline Hernandez-Camargo, Yarlin Mayor Garcia, Felix Zhan, Lori Griswold, Brian Dunkelberger, Michael R. Schwob, Sharang Chaudhry, Justin Zhan, Laxmi Gewali, Paul Oh Jul 2019

Resolving Intravoxel White Matter Structures In The Human Brain Using Regularized Regression And Clustering, Andrea Hart, Brianna Smith, Sean Smith, Elijah Sales, Jacqueline Hernandez-Camargo, Yarlin Mayor Garcia, Felix Zhan, Lori Griswold, Brian Dunkelberger, Michael R. Schwob, Sharang Chaudhry, Justin Zhan, Laxmi Gewali, Paul Oh

Computer Science Faculty Publications

The human brain is a complex system of neural tissue that varies significantly between individuals. Although the technology that delineates these neural pathways does not currently exist, medical imaging modalities, such as diffusion magnetic resonance imaging (dMRI), can be leveraged for mathematical identification. The purpose of this work is to develop a novel method employing machine learning techniques to determine intravoxel nerve number and direction from dMRI data. The method was tested on multiple synthetic datasets and showed promising estimation accuracy and robustness for multi-nerve systems under a variety of conditions, including highly noisy data and imprecision in parameter assumptions.


Microwave Assisted Sol-Gel Synthesis Of Silica-Spider Silk Composites, Abul Bashar Mohammad Giasuddin, David W. Britt Jul 2019

Microwave Assisted Sol-Gel Synthesis Of Silica-Spider Silk Composites, Abul Bashar Mohammad Giasuddin, David W. Britt

Biological Engineering Faculty Publications

This study introduces a simple and environmentally friendly method to synthesize silica-protein nanocomposite materials using microwave energy to solubilize hydrophobic protein in an aqueous solution of pre-hydrolyzed organo- or fluoro-silane. Sol-gel functionality can be enhanced through biomacromolecule incorporation to tune mechanical properties, surface energy, and biocompatibility. Here, synthetic spider silk protein and organo- and fluoro-silane precursors were dissolved and mixed in weakly acidic aqueous solution using microwave technology. Scanning electron microscopy (SEM) and Atomic force microscopy (AFM) images revealed the formation of spherical nanoparticles with sizes ranging from 100 to 500 nm depending, in part, on silane fluoro- or organo-side ...


Fibrinogen, Factor Xiii And Fibronectin: A Biophysical And Kinetic Characterization Of Their Interactions, Frank Fabian Jun 2019

Fibrinogen, Factor Xiii And Fibronectin: A Biophysical And Kinetic Characterization Of Their Interactions, Frank Fabian

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

The development of recombinant-based liquid fibrin tissue sealants having enhanced hemostatic and wound healing properties will involve understanding as yet not well characterized interactions between fibrinogen, fibrin (Fbn) factor XIII, thrombin and fibronectin. We study these phenomena in the context of comparing plasma derived fibrinogen to recombinant fibrinogen (rFI) produced in the milk of transgenic cows. An abundance of purified γγ and γγ’ FI subspecies enables detailed study of γγ or γγ’ biomonomer and their respective Fbn biopolymer formation as having different substrate behaviors of activated plasma derived factor XIII (pFXIIIa2b2). High pressure size exclusion (HPSEC) and ...


Unravel The Cellular Biophysical Dynamics Of Spatial Constraint-Induced Membrane Blebbing And 3d Migration Using A Microfluidic Platform And Data-Driven Mathematical Modeling, Yu Huang Jun 2019

Unravel The Cellular Biophysical Dynamics Of Spatial Constraint-Induced Membrane Blebbing And 3d Migration Using A Microfluidic Platform And Data-Driven Mathematical Modeling, Yu Huang

Funded Research Records

No abstract provided.


Developing A Control System To Better Understand The Effects Of Pyruvate Decarboxylase Activity On Clostridium Thermocellum Metabolism, Nicholas Cervenka Jun 2019

Developing A Control System To Better Understand The Effects Of Pyruvate Decarboxylase Activity On Clostridium Thermocellum Metabolism, Nicholas Cervenka

ENGS 88 Honors Thesis (AB Students)

In order for cellulosic biofuels from Clostridium thermocellum to be commercially viable, the ethanol yield and titer of the microbe must be increased. To accomplish this, it has been suggested to introduce the Pyruvate Decarboxylase (PDC) enzyme into C. thermocellum. In order to demonstrate effects on ethanol production by PDC prior to genetic modification, a cell free system (CFS) has been developed. A purified enzyme system was developed with the CFS to function as a control. Using the purified enzyme system, PDC from Saccharomyces cerevisiae was demonstrated to be a good candidate for further testing in the CFS.


A Physical And Computational Reverse-Engineering Approach To Determine Dimensional Change And Its Relationship To Oxidation In Retrieved Orthopedic Implants, Josephine Kalshoven Jun 2019

A Physical And Computational Reverse-Engineering Approach To Determine Dimensional Change And Its Relationship To Oxidation In Retrieved Orthopedic Implants, Josephine Kalshoven

ENGS 88 Honors Thesis (AB Students)

Oxidation of the Ultra-High Molecular Weight Polyethylene (UHMWPE) tibial inserts of total knee arthroplasty devices is a major factor underlying multiple modes of failure for these devices, including delamination, wear, and fracture. Previous research has demonstrated that oxidation of UHMWPE is driven by a high concentration of free radicals in the polyethylene. However, even new devices created with undetectable amounts of free radicals are oxidizing in vivo. One theory is that, in the absence of residual free radicals, oxidation is facilitated by absorbed species (e.g. lipids, ROS) delivered or exacerbated by contact stress. However, no method exists to comprehensively ...


Conference Program, Erin Buckley, Christophe Moser, Brian Pogue, David Sampson Jun 2019

Conference Program, Erin Buckley, Christophe Moser, Brian Pogue, David Sampson

Advances in Optics for Biotechnology, Medicine and Surgery XVI

No abstract provided.


Spatial Frequency Domain Imaging Of Short-Wave Infrared Fluorescence For Biomedical Applications, Joseph P. Leonor Jun 2019

Spatial Frequency Domain Imaging Of Short-Wave Infrared Fluorescence For Biomedical Applications, Joseph P. Leonor

ENGS 88 Honors Thesis (AB Students)

Fluorescence imaging has become a standard in many clinical applications, such as tumor and vasculature imaging. One application that is becoming more prominent in cancer treatment is fluorescence-guided surgery (FGS). Currently, FGS allows surgeons the ability to visually navigate tumors and tissue structures intraoperatively. As a result, they can remove tumor more efficiently while maintaining critical structures within the patient, creating better outcomes and lower recovery times. However, background fluorescence and inability to localize depth create challenges when determining resection boundaries.

Different techniques, such as spatially modulating the illumination and imaging at longer light wavelengths, have been developed to accurately ...


Modulation Of Biological Responses To 2 Ns Electrical Stimuli By Field Reversal, Esin B. Sözer, P. Thomas Vernier Jun 2019

Modulation Of Biological Responses To 2 Ns Electrical Stimuli By Field Reversal, Esin B. Sözer, P. Thomas Vernier

Bioelectrics Publications

Nanosecond bipolar pulse cancellation, a recently discovered Phenomenon, is modulation of the effects of a unipolar electric pulse exposure by a second pulse of opposite polarity. This attenuation of biological response by reversal of the electric field direction has been reported with pulse durations from 60 ns to 900 ns for a wide range of endpoints, and it is not observed with conventional electroporation pulses of much longer duration (> 100 mu s) where pulses are additive regardless of polarity. The most plausible proposed mechanisms involve the field-driven migration of ions to and from the membrane interface (accelerated membrane discharge). Here ...


Generation Of Functional Human Adipose Tissue In Mice From Primed Progenitor Cells, Raziel Rojas-Rodriguez, Jorge Lujan-Hernandez, So Yun Min, Tiffany Desouza, Patrick Teebagy, Anand Desai, Heather Tessier, Robert Slamin, Leah Siegel-Reamer, Cara Berg, Angel Baez, Janice F. Lalikos, Silvia Corvera Jun 2019

Generation Of Functional Human Adipose Tissue In Mice From Primed Progenitor Cells, Raziel Rojas-Rodriguez, Jorge Lujan-Hernandez, So Yun Min, Tiffany Desouza, Patrick Teebagy, Anand Desai, Heather Tessier, Robert Slamin, Leah Siegel-Reamer, Cara Berg, Angel Baez, Janice F. Lalikos, Silvia Corvera

Senior Scholars Program

Adipose tissue (AT) is used extensively in reconstructive and regenerative therapies, but transplanted fat often undergoes cell death, leading to inflammation, calcification, and requirement for further revision surgery. Previously, we have found that mesenchymal progenitor cells within human AT can proliferate in three-dimensional culture under proangiogenic conditions. These cells (primed ADipose progenitor cells, PADS) robustly differentiate into adipocytes in vitro (ad-PADS). The goal of this study is to determine whether ad-PADS can form structured AT in vivo, with potential for use in surgical applications. Grafts formed from ad-PADS were compared to grafts formed from AT obtained by liposuction after implantation ...


Composite Biomaterial Repair Strategy To Restore Biomechanical Function And Reduce Herniation Risk In An Ex Vivo Large Animal Model Of Intervertebral Disc Herniation With Varying Injury Severity, Warren W. Hom, Melanie Tschopp, Huizi A. Lin, Philip Nasser, Damien M. Laudier, Andrew C. Hecht, Steven B. Nicoll, James C. Iatridis May 2019

Composite Biomaterial Repair Strategy To Restore Biomechanical Function And Reduce Herniation Risk In An Ex Vivo Large Animal Model Of Intervertebral Disc Herniation With Varying Injury Severity, Warren W. Hom, Melanie Tschopp, Huizi A. Lin, Philip Nasser, Damien M. Laudier, Andrew C. Hecht, Steven B. Nicoll, James C. Iatridis

Publications and Research

Back pain commonly arises from intervertebral disc (IVD) damage including annulus fibrosus (AF) defects and nucleus pulposus (NP) loss. Poor IVD healing motivates developing tissue engineering repair strategies. This study evaluated a composite injectable IVD biomaterial repair strategy using carboxymethylcellulose-methylcellulose (CMC-MC) and genipincrosslinked fibrin (FibGen) that mimic NP and AF properties, respectively. Bovine ex vivo caudal IVDs were evaluated in cyclic compression-tension, torsion, and compression-to-failure tests to determine IVD biomechanical properties, height loss, and herniation risk following experimentally-induced severe herniation injury and discectomy (4 mm biopsy defect with 20% NP removed). FibGen with and without CMC-MC had failure strength similar ...


A Simplified Crossing Fiber Model In Diffusion Weighted Imaging, Sheng Yang, Kaushik Ghosh, Ken Sakaie, Satya S. Sahoo, Sarah J. Ann Carr, Curtis Tatsuoka May 2019

A Simplified Crossing Fiber Model In Diffusion Weighted Imaging, Sheng Yang, Kaushik Ghosh, Ken Sakaie, Satya S. Sahoo, Sarah J. Ann Carr, Curtis Tatsuoka

Math Faculty Publications

Diffusion MRI (dMRI) is a vital source of imaging data for identifying anatomical connections in the living human brain that form the substrate for information transfer between brain regions. dMRI can thus play a central role toward our understanding of brain function. The quantitative modeling and analysis of dMRI data deduces the features of neural fibers at the voxel level, such as direction and density. The modeling methods that have been developed range from deterministic to probabilistic approaches. Currently, the Ball-and-Stick model serves as a widely implemented probabilistic approach in the tractography toolbox of the popular FSL software package and ...


Development Of A Foot Interface To Control Supernumerary Robotics Limbs, Emma Morris May 2019

Development Of A Foot Interface To Control Supernumerary Robotics Limbs, Emma Morris

Rose-Hulman Summer Undergraduate Research Fellowships

Supernumerary robotic limbs (SRLs) can be used to provide a person with extra arms to help with difficult tasks. For example, a task that normally requires three hands to complete could be accomplished by just one person with an SRL. One way to control an SRL and still leave both hands available is to use the foot. This paper describes two parts of developing this foot interface: characterizing the range of forces that the foot can apply, and prototyping systems for different control methods. First, a small sample of data was collected to learn how much force the foot can ...


The Effect Of Heterobifunctional Crosslinkers On Hema Hydrogel Modulus And Toughness, Elizabeth M. Boazak, Vaughn K. Greene Jr., Debra T. Auguste May 2019

The Effect Of Heterobifunctional Crosslinkers On Hema Hydrogel Modulus And Toughness, Elizabeth M. Boazak, Vaughn K. Greene Jr., Debra T. Auguste

Publications and Research

The use of hydrogels in load bearing applications is often limited by insufficient toughness. 2-Hydroxyethyl methacrylate (HEMA) based hydrogels are appealing for translational work, as they are affordable and the use of HEMA is FDA approved. Furthermore, HEMA is photopolymerizable, providing spatiotemporal control over mechanical properties. We evaluated the ability of vinyl methacrylate (VM), allyl methacrylate (AM), and 3-(Acryloyloxy)-2-hydroxypropyl methacrylate (AHPM) to tune hydrogel toughness and Young’s modulus. The crosslinkers were selected due to their heterobifunctionality (vinyl and methacrylate) and similar size and structure to EGDMA, which was shown previously to increase toughness as compared to longer ...


Using The Xenopus Developmental Eye Regrowth Stystem To Distinguish The Role Of Developmental Versus Regenerative Mechanisms, Cindy X. Kha, Dylan J. Guerin, Kelly Ai-Sun Tseng May 2019

Using The Xenopus Developmental Eye Regrowth Stystem To Distinguish The Role Of Developmental Versus Regenerative Mechanisms, Cindy X. Kha, Dylan J. Guerin, Kelly Ai-Sun Tseng

Life Sciences Faculty Publications

A longstanding challenge in regeneration biology is to understand the role of developmental mechanisms in restoring lost or damaged tissues and organs. As these body structures were built during embryogenesis, it is not surprising that a number of developmental mechanisms are also active during regeneration. However, it remains unclear whether developmental mechanisms act similarly or differently during regeneration as compared to development. Since regeneration is studied in the context of mature, differentiated tissues, it is difficult to evaluate comparative studies with developmental processes due to the latter’s highly proliferative environment. We have taken a more direct approach to study ...