Biomedical Engineering and Bioengineering Commons^™

Instantaneous Generation Of Subject-Specific Finite Element Models Of The Hip Capsule, Ahilan Anantha-Krishnan, Casey A. Myers, Clare K. Fitzpatrick, Chadd W. Clary

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Subject-specific hip capsule models could offer insights into impingement and dislocation risk when coupled with computer-aided surgery, but model calibration is time-consuming using traditional techniques. This study developed a framework for instantaneously generating subject-specific finite element (FE) capsule representations from regression models trained with a probabilistic approach. A validated FE model of the implanted hip capsule was evaluated probabilistically to generate a training dataset relating capsule geometry and material properties to hip laxity. Multivariate regression models were trained using 90% of trials to predict capsule properties based on hip laxity and attachment site information. The regression models were validated using …

A Review Of Solar Hybrid Photovoltaic-Thermal (Pv-T) Collectors And Systems, Todd Otanicar

Mechanical and Biomedical Engineering Faculty Publications and Presentations

In this paper, we provide a comprehensive overview of the state-of-the-art in hybrid PV-T collectors and the wider systems within which they can be implemented, and assess the worldwide energy and carbon mitigation potential of these systems. We cover both experimental and computational studies, identify opportunities for performance enhancement, pathways for collector innovation, and implications of their wider deployment at the solar-generation system level. First, we classify and review the main types of PV-T collectors, including air-based, liquid-based, dual air–water, heat-pipe, building integrated and concentrated PV-T collectors. This is followed by a presentation of performance enhancement opportunities and pathways for …

Engineering Cell–Ecm–Material Interactions For Musculoskeletal Regeneration, Calvin L. Jones, Brian T. Penney, Sophia K. Theodossiou

Mechanical and Biomedical Engineering Faculty Publications and Presentations

The extracellular microenvironment regulates many of the mechanical and biochemical cues that direct musculoskeletal development and are involved in musculoskeletal disease. The extracellular matrix (ECM) is a main component of this microenvironment. Tissue engineered approaches towards regenerating muscle, cartilage, tendon, and bone target the ECM because it supplies critical signals for regenerating musculoskeletal tissues. Engineered ECM–material scaffolds that mimic key mechanical and biochemical components of the ECM are of particular interest in musculoskeletal tissue engineering. Such materials are biocompatible, can be fabricated to have desirable mechanical and biochemical properties, and can be further chemically or genetically modified to support cell …

Finite Element Modeling Of Meniscal Tears Using Continuum Damage Mechanics And Digital Image Correlation, Derek Q. Nesbitt, Dylan E. Burruel, Bradley S. Henderson, Trevor J. Lujan

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Meniscal tears are a common, painful, and debilitating knee injury with limited treatment options. Computational models that predict meniscal tears may help advance injury prevention and repair, but first these models must be validated using experimental data. Here we simulated meniscal tears with finite element analysis using continuum damage mechanics (CDM) in a transversely isotropic hyperelastic material. Finite element models were built to recreate the coupon geometry and loading conditions of forty uniaxial tensile experiments of human meniscus that were pulled to failure either parallel or perpendicular to the preferred fiber orientation. Two damage criteria were evaluated for all experiments: …

Board 341: Mobile Learning In Stem: A Case Study In An Undergraduate Engineering Course, Krishna Pakala, Maeve Bakic, Diana Bairaktarova, Devshikha Bose

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Student-centered educational system is needed for better educational outcomes. Technology enabled pedagogy has helped immensely during the pandemic times when rapid transition to remote learning was essential. This poster reports findings on year one of a two-year research study to utilize mobile technologies and a technology-enhanced curriculum to improve student engagement and learning in STEM undergraduate courses. This poster describes a quasi-experimental mixed methods study on implementing mobile devices (iPad and Pencil) and a technology-enhanced curriculum in an undergraduate thermal-fluids engineering course, a foundational engineering class.

The technology-enabled curriculum was fully integrated in the thermal-fluids course to deliver content and …

Architectural Control Of Mesenchymal Stem Cell Phenotype Through Nuclear Actin, Janet Rubin, Andre J. Van Wijnen, Gunes Uzer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

There is growing appreciation that architectural components of the nucleus regulate gene accessibility by altering chromatin organization. While nuclear membrane connector proteins link the mechanosensitive actin cytoskeleton to the nucleoskeleton, actin’s contribution to the inner architecture of the nucleus remains enigmatic. Control of actin transport into the nucleus, plus the presence of proteins that control actin structure (the actin tool-box) within the nucleus, suggests that nuclear actin may support biomechanical regulation of gene expression. Cellular actin structure is mechanoresponsive: actin cables generated through forces experienced at the plasma membrane transmit force into the nucleus. We posit that dynamic actin remodeling …

Musculoskeletal Adaptation Of Young And Older Adults In Response To Challenging Surface Conditions, Amy E. Holcomb, Nicholas L. Hunt, Amanda K. Ivy, Aidan G. Cormier, Tyler N. Brown, Clare K. Fitzpatrick

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Over 36 million adults over 65 years of age experience accidental falls each year. The underlying neuromechanics (whole-body function) and driving forces behind accidental falls, as well as the effects of aging on the ability of the musculoskeletal system to adapt, are poorly understood. We evaluated differences in kinematics (lower extremity joint angles and range of motion), kinetics (ground reaction force), and electromyography (muscle co-contraction), due to changes in surface conditions during gait in 14 older adults with a history of falling and 14 young adults. We investigated the impact of challenging surfaces on musculoskeletal adaptation and compared the mechanisms …

Energy Consumption Analysis Using Measured Data From A Net-Zero Energy Commercial Building In A Cold And Dry Climate, Sukjoon Oh, John F. Gardner

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Zero-energy buildings have a critical role in reducing global energy use and greenhouse gas emissions. However, few studies have analyzed net-zero energy commercial buildings using measured energy use such as whole-building level and end-use level data. This paper presents an energy consumption analysis for the first net-zero energy commercial building in Idaho, U.S., in a cold and dry climate using measured end-use data from this building as well as measured whole-building energy use. Monthly bill data analysis, end-use data analysis, and Energy Use Intensity (EUI) analysis were conducted. The combined analysis of this study shows that the HVAC system was …

Processing Time, Temperature, And Initial Chemical Composition Prediction From Materials Microstructure By Deep Network For Multiple Inputs And Fused Data, Amir Abbas Kazemzadeh Farizhandi, Mahmood Mamivand

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Prediction of the chemical composition and processing history from microstructure morphology can help in material inverse design. In this work, we propose a fused-data deep learning framework that can predict the processing history of a microstructure. We used the Fe-Cr-Co alloys as a model material. The developed framework is able to predict the heat treatment time, temperature, and initial chemical compositions by reading the morphology of Fe distribution and its concentration. The results show that the trained deep neural network has the highest accuracy for chemistry and then time and temperature. We identified two scenarios for inaccurate predictions; 1) There …

Large Scale Energy Signature Analysis: Tools For Utility Managers And Planners, Sukjoon Oh, John F. Gardner

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Building energy signature analysis is a well-established tool for understanding the temperature sensitivity of building energy consumption and measuring energy savings. This tool has been used to measure energy savings of residential, commercial, and even industrial buildings. The public availability of electricity loads (i.e., hourly electricity demand (MW)) from entire Balancing Authorities (BAs) provide an interesting opportunity to apply this approach to a large aggregate load. In this paper, we explore that opportunity for BAs and show that the correlations for large geographical areas are surprisingly coherent when the change-point linear regression analysis is used with the daily interval data …

Effects Of Weight-Bearing On Tibiofemoral, Patellofemoral, And Patellar Tendon Kinematics In Older Adults, Vasiliki Kefala, Azhar A. Ali, Landon D. Hamilton, Erin M. Mannen, Kevin B. Shelburne

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Quantification of natural knee kinematics is essential for the assessment of joint function in the diagnosis of pathologies. Combined measurements of tibiofemoral and patellofemoral joint kinematics are necessary because knee pathologies, such as progression of osteoarthritis and patellar instability, are a frequent concern in both articulations. Combined measurement of tibiofemoral and patellofemoral kinematics also enables calculation of important quantities, specifically patellar tendon angle, which partly determines the loading vector at the tibiofemoral joint and patellar tendon moment arm. The goals of this research were to measure the differences in tibiofemoral and patellofemoral kinematics, patellar tendon angle (PTA), and patellar tendon …

Deep Learning Approach For Chemistry And Processing History Prediction From Materials Microstructure, Amir Abbas Kazemzadeh Farizhandi, Omar Betancourt, Mahmood Mamivand

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Finding the chemical composition and processing history from a microstructure morphology for heterogeneous materials is desired in many applications. While the simulation methods based on physical concepts such as the phase-field method can predict the spatio-temporal evolution of the materials’ microstructure, they are not efficient techniques for predicting processing and chemistry if a specific morphology is desired. In this study, we propose a framework based on a deep learning approach that enables us to predict the chemistry and processing history just by reading the morphological distribution of one element. As a case study, we used a dataset from spinodal decomposition …

Opportunities From Disruption: How Lifelong Learning Helped Create More Connected Classrooms, Krishna Pakala, Sreyoshi Bhaduri

Mechanical and Biomedical Engineering Faculty Publications and Presentations

The coronavirus pandemic has led to instructors worldwide seeking ways to engage students better through virtual platforms. As the world interacts online, more than ever before, this paper reflects on an educator’s experience with the virtual teaching and learning spaces pre and during the ongoing pandemic. Autoethnography is a research methodology that analyzes a phenomenon through the use of self-narratives, which would otherwise remain private or buried. This paper uses an autoethnographic approach to describe first-hand. the experiences and learnings of an educator at a Western US Public University. This paper describes how first as an international student, a first …

Auto-Ethnographic Reflections: Lessons From Leading A Stem Initiative For Girls In School While We Ourselves Were In School, Kayli Heather Battel, Kritin Mandala, Sreyoshi Bhaduri, Natalie Anna Foster, Lilianny Virguez, Lissa Erickson, Krishna Pakala

Mechanical and Biomedical Engineering Faculty Publications and Presentations

In this paper, we use an auto-ethnographic approach to describe first-hand the reflections and learnings from leading an organization to help school children, especially girls, familiarize themselves with STEM and Cyber Security. The primary authors and ethnographers are founders of STEM initiatives for young learners. The primary author is a recent high school graduate who has taken up an engineering field, and two other contributing authors are high-schoolers currently leading these initiatives. With help from the three engineering educators on our authorship team, we use our individual self-narratives to develop a set of recommendations for other young engineering educators across …

Postural Control Differences Between Patients With Posterior Tibial Tendon Dysfunction And Healthy People During Gait, Junsig Wang, L. Daniel Latt, Robert D. Martin, Erin M. Mannen

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Background: Patients with posterior tibial tendon dysfunction (PTTD) may exhibit postural instability during walking likely due to a loss of medial longitudinal arch, abnormal foot alignment, and pain. While many studies have investigated gait alterations in PTTD, there is no understanding of dynamic postural control mechanisms in this population during gait, which will help guide rehabilitation and gait training programs for patients with PTTD. The purpose of the study was to assess dynamic postural control mechanisms in patients with stage II PTTD as compared to age and gender matched healthy controls. Methods: Eleven patients with stage II PTTD (4 males …

Work-In-Progress: Mobile Assisted Gains Through Innovative Curriculum For Students In The Thermal-Fluids Science Course, Maeve Bakic, Krishna Pakala, Diana Bairaktarova, Devshikha Bose

Mechanical and Biomedical Engineering Faculty Publications and Presentations

A learner-centered higher education ecosystem is essential to effective educational outcomes and societal advancement. Mobile devices such as smartphones, tablets, and tablet computers enable learning anytime and from any location, blurring the boundaries between formal and informal learning. When paired with effective pedagogy, mobile technologies can positively impact the teaching and learning experience for students in high-demand science, technology, engineering and mathematics (STEM) disciplines, increasing the flexibility and ease with which they are able to pursue their education while developing their professional identities as engineers. Student retention remains a problem in STEM programs. In engineering, many students do not even …

Measuring Engineering Students’ Engagement In Sustainability Design Concepts, Karen Perez, Donald Plumlee

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Within industries, governments, and accreditation organizations, there has been a push to incorporate sustainability concepts into engineering education. Universities like Boise State University (BSU) are starting to place greater emphasis on the inclusion of sustainability concepts in different engineering program curricula. As part of a project funded by the National Science Foundation (NSF), the BSU mechanical engineering program is integrating sustainability concepts specifically by using active learning modules (ALMs) suitable for each level of student education, progressing from freshman to senior. ALMs have shown to be more effective in improving motivation in the classroom compared to traditional learning. To measure …

Engineering Instruction, Inclusion, And Comics: Reflections From A Student Illustrator And An Instructor, Addison Totman, Sreyoshi Bhaduri, Krishna Pakala, Cherie D. Edwards, Michelle Soledad

Mechanical and Biomedical Engineering Faculty Publications and Presentations

This paper presents the opportunity gap for comics in engineering education, through reflections from a team redesigning a mechanical engineering syllabi using illustrations. To increase a sense of belonging among diverse students, the authors of this paper propose a graphic narrative focused on the curriculum of the mechanical engineering department at a large public university in Western United States. We hope that this paper addresses the underutilized and largely missed opportunity to add engagement, better conceptual understanding, and improve inclusion in engineering classrooms through incorporating visual illustrations.

Nuclear Envelope Mechanobiology: Linking The Nuclear Structure And Function, Matthew Goelzer, Julianna Goelzer, Matthew L. Ferguson, Corey P. Neu, Gunes Uzer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

The nucleus, central to cellular activity, relies on both direct mechanical input as well as its molecular transducers to sense external stimuli and respond by regulating intra-nuclear chromatin organization that determines cell function and fate. In mesenchymal stem cells of musculoskeletal tissues, changes in nuclear structures are emerging as a key modulator of their differentiation and proliferation programs. In this review we will first introduce the structural elements of the nucleoskeleton and discuss the current literature on how nuclear structure and signaling are altered in relation to environmental and tissue level mechanical cues. We will focus on state-of-the-art techniques to …

Integration Of Neural Architecture Within A Finite Element Framework For Improved Neuromusculoskeletal Modeling, Victoria L. Volk, Landon D. Hamilton, Donald R. Hume, Kevin B. Shelburne, Clare K. Fitzpatrick

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Neuromusculoskeletal (NMS) models can aid in studying the impacts of the nervous and musculoskeletal systems on one another. These computational models facilitate studies investigating mechanisms and treatment of musculoskeletal and neurodegenerative conditions. In this study, we present a predictive NMS model that uses an embedded neural architecture within a finite element (FE) framework to simulate muscle activation. A previously developed neuromuscular model of a motor neuron was embedded into a simple FE musculoskeletal model. Input stimulation profiles from literature were simulated in the FE NMS model to verify effective integration of the software platforms. Motor unit recruitment and rate coding …

Three-Dimensional Phase Field Modeling Of Fracture In Shape Memory Ceramics, Ehsan Moshkelgosha, Mahmood Mamivand

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Despite the vast applications of transformable ceramics, such as zirconia-based ceramics, in different areas from biomedical to aerospace, the fundamental knowledge about their mechanical degradation procedure is limited. The interaction of the phase transformation and crack growth is crucial as the essential underlying mechanism in fracture of these transformable ceramics, also known as shape memory ceramics. This study develops a three-dimensional (3D) multiphysics model that couples the variational formulation of brittle crack growth to the Ginzburg-Landau equations of martensitic transformation. We parameterized the model for the 3D single crystal zirconia, which experienced stress- and thermal-induced tetragonal to monoclinic transformation. The …

Effect Of Temperature On Abrasion Erosion In Particle Based Concentrating Solar Powerplants, Nipun Goel, Tessa Mei-Lin Fong, John P. Shingledecker, Andrew Russell, Michael W. Keller, Siamack A. Shirazi, Todd Otanicar

Mechanical and Biomedical Engineering Faculty Publications and Presentations

The use of solid particles as a heat transfer medium is being explored for concentrated solar power plants (CSP) to increase their efficiency by achieving operating temperature >700 °C. During operation, these hot particles are expected to move along the various components within the collector system, resulting in material degradation from a combination of high-temperature oxidation and erosion. In the present study, the performance of candidate materials was evaluated through a series of abrasion erosion experiments at room temperature as well as at 800 °C. Wear in metallic and refractory type materials was investigated using CarboBead® HSP 40/70 particles inside …

Evaluating Stem Course Re-Design Strategies In Light Of Covid-19, Ulises Juan Trujillo Garcia, Krishna Pakala, Samantha Schauer, Diana Bairaktarova, Bhaskar Chittoori

Mechanical and Biomedical Engineering Faculty Publications and Presentations

The COVID-19 pandemic brought on unprecedented challenges to the teaching and learning communities that required faculty to make purposeful changes in their teaching approaches. Many faculty members had to shift rapidly from in-person to online mode of instruction. This study documents perceptions of STEM faculty who made the change to online teaching. It reports on what strategies faculty used to transition to remote/online teaching and how this change impacted student learning. The study results indicated that almost two-thirds of the faculty changed how they evaluated their students. Results also showed that the sudden change to remote learning negatively impacted student …

Centralized And Decentralized Optimal Control Of Variable Speed Heat Pumps, Ryan S. Montrose, John F. Gardner, Aykut C. Satici

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Utility service providers are often challenged with the synchronization of thermostatically controlled loads. Load synchronization, as a result of naturally occurring and demand-response events, has the potential to damage power distribution equipment. Because thermostatically controlled loads constitute most of the power consumed by the grid at any given time, the proper control of such devices can lead to significant energy savings and improved grid stability. The contribution of this paper is the development of an optimal control algorithm for commonly used variable speed heat pumps. By means of selective peer-to-peer communication, our control architecture allows for the regulation of home …

Lamin A/C Is Dispensable To Mechanical Repression Of Adipogenesis, Matthew Goelzer, Gunes Uzer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Mesenchymal stem cells (MSCs) maintain the musculoskeletal system by differentiating into multiple lineages, including osteoblasts and adipocytes. Mechanical signals, including strain and low-intensity vibration (LIV), are important regulators of MSC differentiation via control exerted through the cell structure. Lamin A/C is a protein vital to the nuclear architecture that supports chromatin organization and differentiation and contributes to the mechanical integrity of the nucleus. We investigated whether lamin A/C and mechanoresponsiveness are functionally coupled during adipogenesis in MSCs. siRNA depletion of lamin A/C increased the nuclear area, height, and volume and decreased the circularity and stiffness. Lamin A/C depletion significantly decreased …

Kinematic And Kinetic Changes After Total Hip Arthroplasty During Sit-To-Stand Transfers: Systematic Review, Junsig Wang, Safeer F. Siddicky, Michael P. Dohm, C. Lowry Barnes, Erin M. Mannen

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Background: Total hip arthroplasty (THA) is a common and effective surgical procedure that allows patients with hip osteoarthritis to restore functional ability and relieve pain. Sit-to-stand transfers are common demanding tasks during activities of daily living and are performed more than 50 times per day. The purpose of this systematic review is to obtain a comprehensive understanding of biomechanical changes during sit-to-stand transfers after THA.

Methods: Relevant articles were selected through MEDLINE, Scopus, Embase, and Web of Science. Articles were included if they met the following inclusion criteria: 1) participants underwent total hip arthroplasty without restriction on the arthroplasty design, …

Data-Driven Design Of Energy-Shaping Controllers For Swing-Up Control Of Underactuated Robots, Wankun Sirichotiyakul, Aykut C. Satici

Mechanical and Biomedical Engineering Faculty Publications and Presentations

We propose a novel data-driven procedure to train a neural network for the swing-up control of underactuated robotic systems. Our approach is inspired by several recent developments ranging from nonlinear control theory to machine learning. We embed a neural network indirectly into the equations of motion of the robotic manipulator as its control input. Using familiar results from passivity-based and energy-shaping control literature, this control function is determined by the appropriate gradients of a neural network, acting as an energy-like (Lyapunov) function. We encode the task of swinging-up robotic systems through the use of transverse coordinates and goal sets; which …

Low-Intensity Vibration Restores Nuclear Yap Levels And Acute Yap Nuclear Shuttling In Mesenchymal Stem Cells Subjected To Simulated Microgravity, Matthew Thompson, Kali Woods, Joshua Newberg, Julia Thom Oxford, Gunes Uzer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Reducing the musculoskeletal deterioration that astronauts experience in microgravity requires countermeasures that can improve the effectiveness of otherwise rigorous and time-expensive exercise regimens in space. The ability of low-intensity vibrations (LIV) to activate force-responsive signaling pathways in cells suggests LIV as a potential countermeasure to improve cell responsiveness to subsequent mechanical challenge. Mechanoresponse of mesenchymal stem cells (MSC), which maintain bone-making osteoblasts, is in part controlled by the “mechanotransducer” protein YAP (Yes-associated protein), which is shuttled into the nucleus in response to cyto-mechanical forces. Here, using YAP nuclear shuttling as a measurement outcome, we tested the effect of 72 h …

Annual Simulation Of Photovoltaic Retrofits Within Existing Parabolic Trough Concentrating Solar Powerplants, Nipun Goel, Hannah O'Hern, Matthew Orosz, Todd Otanicar

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Solar power for electricity production comes from either photovoltaics or concentrating solar power plants. The former has seen rapid growth and expansion due to the rapid fall in global prices, while the latter has seen moderate growth due to ability to cheaply store thermal energy for later use. Hybridization, or combining photovoltaics with concentrating solar power represents a potential way for lowering cost while enabling long term storage. Over 5 GW of capacity exist worldwide using parabolic trough style technology for concentrating solar power which presents a unique option for optimization in the form of a photovoltaic retrofit. While it …

Emerging Gene-Editing Modalities For Osteoarthritis, Alekya S. Tanikella, Makenna J. Hardy, Stephanie M. Frahs, Aidan G. Cormier, Kalin D. Gibbons, Clare K. Fitzpatrick, Julia Thom Oxford

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Osteoarthritis (OA) is a pathological degenerative condition of the joints that is widely prevalent worldwide, resulting in significant pain, disability, and impaired quality of life. The diverse etiology and pathogenesis of OA can explain the paucity of viable preventive and disease-modifying strategies to counter it. Advances in genome-editing techniques may improve disease-modifying solutions by addressing inherited predisposing risk factors and the activity of inflammatory modulators. Recent progress on technologies such as CRISPR/Cas9 and cell-based genome-editing therapies targeting the genetic and epigenetic alternations in OA offer promising avenues for early diagnosis and the development of personalized therapies. The purpose of this …