Biomedical Engineering and Bioengineering Commons^™

List Of 121 Papers Citing One Or More Skin Lesion Image Datasets, Neda Alipour

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An Investigation Of The Effect Of Cyclic Loading Of Bone On Osteocyte Processes Spanning Micro-Cracks As A Driver Of Targeted Remodelling Of Bone, Morgana Pires Afonso Shirsath

Doctoral

Bone remodelling is essential to maintain and improve the quality of bones. This occurs with the action of specialised cells - osteoclasts and osteoblasts - which replace the old bone tissue with new in regions where damage has occurred. Osteocytes are responsible for signalling the presence of damage and trigger the bone remodelling response. According to the Scissors Model, the presence of micro-cracks causes rupture of the osteocyte processes by fatigue because of the repeated stretching resulting from the relative movement of micro-crack faces, when bone is subjected to cyclic loads.

Extraction, Quantification, Characterization, And Application In Food Packaging Of Chitin And Chitosan From Mushrooms: A Review, Bullyamini Alimi, Shivani Pathania, Jude Wilson, Brendan Duffy, Jesus Maria Frias

Articles

The application of chitin in food systems is limited by its insolubility in some common solvents and poor degradability. Hence, it is deacetylated to obtain chitosan, an industrially important derivative with excellent biological properties. Fungal-sourced chitosan is gaining prominence and industrial attraction because of its superior functional and biological properties, and vegan appeal. Further, the absence of such compounds as tropomyosin, myosin light chain, and arginine kinase, which are known to trigger allergic reactions, gives it an edge over marine-sourced chitosan in food and pharmaceutical applications. Mushrooms are macro-fungi with a significant content of chitin, with many authors reporting the …

High-Sensitivity Vector Bend Sensor Based On A Fiber Directional Coupler Inscribed By A Femtosecond Laser, Ke Tian, Mingyuan Zhang, Chuanzhein Zhao, Huibin Li, Shilong Li, Yuxuan Jiang, Gerald Farrell, Pengfei Wang

Articles

In this Letter, we demonstrate a high-sensitivity vector bend sensor based on a fiber directional coupler. The fiber directional coupler is composed of two parallel waveguides inscribed within a no-core fiber (NCF) by a femtosecond laser. Since the two written waveguides have closely matched refractive indices and geometries, the transmission spectrum of the fiber directional coupler possesses periodic resonant dips. Such a fiber directional coupler exhibits a good bending-dependent spectral shift response due to its asymmetric structure. Experimental results show that bending sensitivities of -97.11 nm/m-1 and 58.22 nm/m-1 are achieved for the 0° and 180° orientations in the curvature …

A Label-Free Fiber Ring Laser Biosensor For Ultrahigh Sensitivity Detection Of Salmonella Typhimurium, Shi Qiu, Bin Liu, Yuankui Leng, Edward Fox, Xian Zhou, Binbin Yan, Xinzhu Sang, Long Long, Xingdao He, Jinhui Yuan, Gerald Farrell, Qiang Wu

Articles

The rapid detection of low concentrations of Salmonella Typhimurium (S. Typhimurium) is an essential preventive measure for food safety and prevention of foodborne illness. The study presented in this paper addresses this critical issue by proposing a single mode-tapered seven core-single mode (STSS) fiber ring laser (FRL) biosensor for S. Typhimurium detection. The experimental results show that the specific detection time of S. Typhimurium is less than 20 min and the wavelength shift can achieve -0.906 nm for an S. Typhimurium solution (10 cells/mL). Furthermore, at a lower concentration of 1 cell/mL applied to the biosensor, a result of -0.183 …

Advances In 3d Culture Systems For Therapeutic Discovery And Development In Brain Cancer, Janith Wanigasekara, Patrick J. Cullen, Paula Bourke, Brijesh Tiwari, James F. Curtin

Articles

This review focuses on recent advances in 3D culture systems that promise more accurate therapeutic models of the glioblastoma multiforme (GBM) tumor microenvironment (TME), such as the unique anatomical, cellular, and molecular features evident in human GBM. The key components of a GBM TME are outlined, including microbiomes, vasculature, extracellular matrix (ECM), infiltrating parenchymal and peripheral immune cells and molecules, and chemical gradients. 3D culture systems are evaluated against 2D culture systems and in vivo animal models. The main 3D culture techniques available are compared, with an emphasis on identifying key gaps in knowledge for the development of suitable platforms …

Morton-Ordered Gpu Lattice Boltzmann Cfd Simulations With Application To Blood Flow, Gerald Gallagher, Fergal J. Boyle

Conference Papers

Computational fluid dynamics (CFD) is routinely used for numerically predicting cardiovascular-system medical device fluid flows. Most CFD simulations ignore the suspended cellular phases of blood due to computational constraints, which negatively affects simulation accuracy. A graphics processing unit (GPU) lattice Boltzmann-immersed boundary (LB-IB) CFD software package capable of accurately modelling blood flow is in development by the authors, focusing on the behaviour of plasma and stomatocyte, discocyte and echinocyte red blood cells during flow. Optimised memory ordering and layout schemes yield significant efficiency improvements for LB GPU simulations. In this work, comparisons of row-major-ordered Structure of Arrays (SoA) and Collected …

Analysis Of Rule-Based And Shallow Statistical Models For Covid-19 Cough Detection For A Preliminary Diagnosis, Arshia Arif, Eisa Alanazi, Ayesha Zeb, Waqar Shahid Qureshi

Conference papers

Coronavirus pandemic that has spread all over the world, is one of its kind in the recent past, that has mobilized researchers in areas such as (not limited to) pre-screening solutions, contact tracing, vaccine developments, and crowd estimation. Pre-screening using symptoms identification, cough classification, and contact tracing mobile applications gained significant popularity during the initial outbreak of the pandemic. Audio recordings of coughing individuals are one of the sources that can help in the pre-screening of COVID-19 patients. This research focuses on quantitative analysis of covid cough classification using audio recordings of coughing individuals. For analysis, we used three different …

In-Flow Dynamics Of An Area-Difference-Energy Spring-Particle Red Blood Cell Model On Non-Uniform Grids, Brendan Walsh, Fergal Boyle

Articles

In this paper the area-difference-energy spring-particle (ADE-SP) red blood cell (RBC) structural model developed by Chen and Boyle is coupled with a lattice Boltzmann flux solver to simulate RBC dynamics. The novel ADE-SP model accounts for bending resistance due to the membrane area difference of RBCs while the lattice Boltzmann flux solver offers reduced computational runtimes through GPU parallelisation and enabling the employment of non-uniform meshes. This coupled model is used to simulate RBC dynamics and predictions are compared with existing experimental measurements. The simulations successfully predict tumbling, tank-treading, swinging and intermittent behaviour of an RBC in shear flow, and …

A Step Closer To Elastogenesis On Demand; Inducing Mature Elastic Fibre Deposition In A Natural Biomaterial Scaffold, Francisco R. Almeida-González, Arlyng González-Vázquez, Suzanne M. Mithieux, Fergal J. O'Brien, Anthony S. Weiss, Claire Brougham

Articles

Elastic fibres play a key role in bodily functions where fatigue resistance and elastic recovery are necessary while regulating phenotype, proliferation and migration in cells. While in vivo elastic fibres are created at a late foetal stage, a major obstacle in the development of engineered tissue is that human vascular smooth muscle cells (hVSMCs), one of the principal elastogenic cells, are unable to spontaneously promote elastogenesis in vitro. Therefore, the overall aim of this study was to activate elastogenesis in vitro by hVSMCs seeded in fibrin, collagen, glycosaminoglycan (FCG) scaffolds, following the addition of recombinant human tropoelastin. This combination …

A Linear Predictive Coding Filtering Method For Time-Resolved Morphology Of Eeg Activity, Jin Xu, Mark Davis, Ruairí De Fréin

Conference papers

This paper introduces a new time-resolved spectral analysis method based on the Linear Prediction Coding (LPC) method that is particularly suited to the study of the dynamics of EEG (Electroencephalography) activity. The spectral dynamics of EEG signals can be challenging to analyse as they contain multiple frequency components and are often corrupted by noise. The LPC Filtering (LPCF) method described here processes the LPC poles to generate a series of reduced-order filter transform functions which can accurately estimate the dominant frequencies. The LPCF method is a parameterized time-frequency method that is suitable for identifying the dominant frequencies of multiple-component signals …

Red Blood Cell Dynamics On Non-Uniform Grids Using A Lattice Boltzmann Flux Solver And A Spring-Particle Red Blood Cell Model, Brendan Walsh

Doctoral

The Computational Haemodynamics Research Group (CHRG) in Technological University Dublin is developing a computational fluid dynamics (CFD) software package aimed specifically at physiologically-realistic modelling of blood flow. A physiologically-realistic model of blood flow involves calculating the deformation of individual red blood cells (RBCs) and the contribution of this deformation to the overall blood flow. The CHRG has developed an enhanced spring-particle RBC structural model that is capable of modelling the full stomatocyte-discocyteechinocyte (SDE) transformation. This RBC model, incorporated into a fluid dynamics solver, will provide a physiologically-realistic blood flow model. In this work the overall plasma flow is modelled using …

A Robust Lpc Filtering Method For Time-Resolved Morphology Of Eeg Activity Analysis, Jin Xu, Mark Davis, Ruairí De Fréin

Conference Papers

This paper introduces a new time-resolved spectral analysis method based on Linear Prediction Coding (LPC) method that is particularly suited to the study of the dynamics of EEG (Electroencephalogram) activity. The spectral dynamic of EEG signals can be challenging to analyse as they contain multiple frequency components and are often heavily corrupted by noise. Furthermore, the temporal and spectral resolution that can be achieved is limited by the Heisenberg-Gabor uncertainty principle [1]. The method described here is based on a z-plane analysis of the poles of the LPC which allows us to identify and estimate the frequency of the dominant …

Finite Element Simulation Of Head Impacts In Mixed Martial Arts, Stephen Tiernan, Aidan Meagher, David O'Sullivan Dr, Eoin O'Kelly Dr

Articles

This study determined brain stress and strain in an unhelmeted sport and correlated this with concussive injuries. Thirteen MMA athletes were fitted with the MiG2.0 Stanford instrumented mouthguard. The mouthguard records linear acceleration and angular velocity in 6 degrees of freedom. Angular acceleration was calculated by differentiation. All events were video recorded, time stamped and reported impacts confirmed. 298 impacts above 10g were recorded during sparring sessions and 153 impacts in competitive events. The competitive events resulted in five concussions which were diagnosed by a medical doctor. The impact with the highest angular acceleration from each sparring session and competitive …

Concussion And The Severity Of Head Impacts In Mixed Martial Arts, Stephen Tiernan, Aidan Meagher, David O'Sullivan, Eoin O'Keefe, Eoin O'Kelly, Eugene Wallace, Colin Doherty, Mathew Campbell, Yuzhe Liu, August Domel

Articles

Background: Concern about the consequences of head impacts in US football motivated researchers to investigate and develop instrumentation to measure the severity of these impacts. However, the severity of head impacts in unhelmeted sports is largely unknown as miniaturised sensor technology has only recently made it possible to measure these impacts in vivo.

Aim: The objective of this study was to measure the linear and angular head accelerations in impacts in mixed martial arts (MMA), and correlate these with concussive injuries.

Methods: Thirteen MMA fighters were fitted with the Stanford instrumented mouthguard (MiG2.0). The mouthguard records linear acceleration and angular …

Comparison Of Hybridizing Options For Solar Heat, Biomass And Heat Storage For Electricity Generation In Spain, Cm Iftekhar Hussain, Brian Norton, Aidan Duffy

Articles

Diurnal and seasonal variations of direct solar energy circumscribe locations suitable for sole use of concentrated solar power for electricity generation, whereas to generate electricity at night and during winter months, biomass systems can be used that incur fuel expenditures and may encounter fuel supply discontinuities. Combining solar heat, biomass conversion and heat storage in a hybrid electricity generation plant may overcome the limitations of sole use of any one of these energy sources in specific geographic and/or economic conditions. In this work standalone biomass, hybrid concentrated solar power-biomass and hybrid concentrated solar power-biomass-thermal energy storage power generation systems are …

Spectral Dependence Of Transmission Losses In High-Index Polymer Coated No-Core Fibers, Xiaokang Lian, Gerald Farrell, Qiang Wu, Wei Han, Changyu Shen, Youqiao Ma, Yuliya Semenova

Articles

A high-index polymer coated no-core fiber (PC-NCF) is effectively a depressed core fiber, where the light is guided by the anti-resonant, inhibited coupling and total internal reflection effects and the dispersion diagram shows periodic resonant and anti-resonant bands. In this paper, the transmission spectra of the straight and bent PC-NCFs (length > 5 cm) are measured and analyzed from a modal dispersion perspective. For the purpose of the study, the PC-NCFs are contained within a fiber hetero-structure using two single-mode fiber (SMF) pigtails forming a SMF-PC-NCF-SMF structure. The anti-resonance spectral characteristics are suppressed by the multimode interference in the PC-NCF with …

Is It Time To Give Athletes A Voice In The Dissemination Strategies Of Concussion-Related Information? Exploratory Examination Of 2444 Adolescent Athletes, Mark Beakey, Brian Keenan, Stephen Tiernan, Kieran Collins

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Objective: The objective of the research was to screen male and female adolescent athletes on their concussion educational histories and preferred future methods of education in terms of educational messenger, modality, and concussion-related areas of interest.

Design: Cross-sectional survey.

Setting: Examination setting within the classroom.

Participants: Adolescent male (n = 1854) and female (n = 590) athletes aged 12 to 18 years.

Main outcome measures: To explore the concussion educational histories and preferred future methods of education in Irish male and female adolescent athletes.

Results: 19.7% (n = 482) of the sample received education in the past 12 months. Male …

The Effect Of Impact Location On Brain Strain, Stephen Tiernan, Gary Byrne Mr

Articles

Objective: To determine the effect of impact direction on strains within the brain.

Research design: Laboratory drop tests of hybrid III head-form and finite element simulation of impacts.

Methods and procedures: A head-form instrumented with accelerometers and gyroscopes was dropped from 10 different heights in four orientations: front, rear, left and right hand side. Twelve impacts with constant impact energy were chosen to simulate, to determine the effect of impact location. A finite element head model was used to simulate these impacts, using 6 degrees of freedom. Following this a further set of simulations were performed, where the same acceleration …

Nanostructured Materials For Food Applications: Spectroscopy, Microscopy And Physical Properties, Shubham Sharma, Swana Jaiswal, Brendan Duffy, Amit Jaiswal

Articles

Nanotechnology deals with the matter of atomic or molecular scale. Other factors that define the character of a nanoparticle are its physical and chemical properties, such as surface area, surface charge, hydrophobicity of the surface, the thermal stability of the nanoparticle, and its antimicrobial activity. A nanoparticle is usually characterized by using microscopic and spectroscopic techniques. Microscopic techniques are used to characterize the size, shape, and location of the nanoparticle by producing an image of the individual nanoparticle. Several techniques, such as scanning electron microscopy (SEM), transmission electron microscopy/high resolution transmission electron microscopy (TEM/HRTEM), atomic force microscopy (AFM) and scanning …

Design And Development Of Artificial Spinal Ligaments For Paediatric Synthetic Spine, Nor Amalina Muhayudin, Khairul Salleh Basaruddin, Fiona Mcevoy, Anthony Tansey

Articles

A synthetic spine is a model fabricated from artificial materials consisting of the vertebrae, intervertebral discs and ligaments for spinal testing. The synthetic spine overcomes many difficulties associated with biological specimens such as handling, biohazard concerns, high costs, and limited availability of specimens, quality and large inter-specimen variability. This paper presents the design and development of spinal ligaments to mimic the stiffness of the paediatric ligaments for use in the synthetic spine. Spinal ligaments are uniaxial structures in the spine that carry tensile loads along the direction of the fibres. Early in the research, silicone materials were used to cover …

Identification Of Unique Features And Exploration Of Leap Motion Controller For Detecting Hand Hygiene Stages, Rashmi Bakshi, Jane Courtney, Damon Berry, Graham Gavin

Conference Papers

Hospital acquired infections (HAIs) are contracted by the patients during the hospital stay. Antibiotic resistant microbes are the major cause and spread due to the contaminated medical equipment, crowded hospitals, frequent transfer of patients from one unit to another and poor hand hygiene. [1] In high income countries, approximately 30% of patients in intensive care units are affected by at least one HAI. [2] Hand hygiene is identified as a measure to prevent cross-transmission and to reduce the rate of HAI. [3] Technology is now used as a means of assessing hand hygiene compliance. Current approaches involve the use of …

Nanostructured Apatite-Mullite Glass-Ceramics For Enhanced Primary Human Osteoblast Cell Response, Gordon Cooke, Conor Dunne, Sarah Keane, Daithi De Faoite, Seamas Donnelly, Kenneth Stanton

Articles

This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca₁₀(PO₄)₆F₂) and bioinert mullite (Si₂Al₆O₁₃) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched …

Measurement Of The Frequency Response Of Clinical Gas Analysers, Kabita Shakya, Catherine Deegan, Fran Hegarty, Charles Markham

The ITB Journal

A technique for the time and frequency response measurement of clinical CO2 analysers has been established. The time and frequency response of several analyser systems has been determined. This paper presents the case for the routine measurement of the dynamic performance of such systems in the context of their application in high-frequency ventilation schemes. The importance of these measurements has been demonstrated in the comparison of older and newer systems in the sense that older systems demonstrate significant deterioration in peiformance. In the context of the use of capnographs in life-support systems, it is essential to measure and monitor the …

Review Of Assistive Devices For Electric Powered Wheelchairs Navigation, K. Arshak, D. Buckley, K. Kaneswaran

The ITB Journal

The decreasing costs of microprocessor systems and increasing range of “Smart Sensors” have led to a boom in Assistive Device Technology. The annual rate of expenditure for mobility related devices has reached $1 billion dollars in the United States alone. The industries current focus is to develop a wider range of Independent Mobility Controllers to allow, even the most severely disabled person, the ability to control an Electric Powered Wheelchair (EPW). Advances in Autonomous Robot Design have led to corresponding improvements in EPW technology. This paper outlines user interfaces and input device technologies used at present to navigate an EPW.

Oxygen Transport In Carotid And Stented Coronary Arteries, Eoin A. Murphy

Doctoral

Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation can have significant effects on the oxygen transport into the arterial wall. Helical flow has been theorised to improve the local haemodynamics and the oxygen transport within stented arteries. In this study an advanced oxygen transport model was developed to assess different stent designs. This advanced oxygen transport model incorporates both the free and bound oxygen contained in blood and includes a shear-dependent dispersion coefficient for red blood cells. In two test cases …

Freeze-Drying As A Novel Biofabrication Method For Achieving A Controlled Microarchitecture Within Large, Complex Natural Biomaterial Scaffolds, Claire Brougham, Tanya J. Levingstone, Nian Shen, Gerard M. Cooney, Thomas C. Flanagan, Stefan Jockenhoevel, Fergal J. O’Brien

Articles

The biofabrication of large scaffolds from natural biomaterials into complex 3D shapes with controllable microarchitecture remains a major challenge. Freeze-drying (or lyophilization) is a technique used to create bioactive scaffolds with a porous architecture and is typically only used to generate scaffolds in planar 3D geometries. Here we report the development of a new biofabrication process to form a collagen-based scaffold into a large, complex geometry which has a large height to width ratio, and a controlled porous microarchitecture. This biofabrication process was validated through the successful development of a heart valve shaped scaffold, fabricated from a collagen-glycosaminoglycan co-polymer. Notably, …

An Enhanced Spring-Particle Model For Red Blood Cell Structural Mechanics: Application To The Stomatocyte–Discocyte– Echinocyte Transformation, Mingzhu Chen, Fergal Boyle

Articles

Red blood cells (RBCs) are the most abundant cellular element suspended in blood. Together with the usual biconcave-shaped RBCs, i.e., discocytes, unusual-shaped RBCs are also observed under physiological and experimental conditions, e.g., stomatocytes and echinocytes. Stomatocytes and echinocytes are formed from discocytes and in addition can revert back to being discocytes; this shape change is known as the stomatocyte–discocyte–echinocyte (SDE) transformation. To-date, limited research has been conducted on the numerical prediction of the full SDE transformation. Spring- particle RBC (SP-RBC) models are commonly used to numerically predict RBC mechanics and rheology. However, these models are incapable of predicting the full …

Enhanced Corrosion Protection And Biocompatibility Of A Plga-Silane Coating On Az31 Mg Alloy For Orthopaedic Applications, Sankalp Agarwal, Muhammad Morshed, Marie-Noelle Labour, David Hoey, Brendan Duffy, James Curtin, Swarna Jaiswal

Articles

This paper reports a multi-step procedure to fabricate a novel corrosion resistant and biocompatible PLGA-silane coating on the magnesium (Mg) alloy AZ31. The first step involves alkaline passivation followed by dip coating in a methyltriethoxysilane (MTES) and tetraethoxysilane (TEOS) mixture to produce a cross-linked siloxane coating. The second step is to impart an amine functionalization to the silane modified surface by using 3-aminopropyl-triethoxy silane (APTES) for promoting adhesion of the acid terminated poly-(lactic-co-glycolic) acid (PLGA) as a final coating step. Static contact angle measurements, Fourier transform infrared spectroscopy and scanning electron microscopy analysis confirmed the successful assembly of coatings on …

A Method To Calculate Adherence To Inhaled Therapy That Reflects The Changes In Clinical Features Of Asthma, Imran Sulaiman, Jansen Seheult, Elaine Machale, Fiona Boland, Susan M. O’Dwyer, Viliam Rapcan, Shona D’Arcy, Breda Cushen, Matshediso Mokoka, Isabelle Killane, Sheila A. Ryder, Richard B. Reilly, Richard W. Costello

Articles

Electronic monitors are considered the gold standard for objectively quantifying adherence to inhaled therapy (1). Most studies using electronic recording devices have reported adherence as the mean adherence, or the mean daily dose, over the study period (2–4). However, this method does not reflect variations in the way that patients use their treatments. For example, the mean adherence is the same whether an individual took the medication according to the prescribed schedule or took all the doses in the first half of a dosing period, leaving none in the second half. Inhaler technique must …