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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Increased Susceptibility Of Arterial Tissue To Wire Perforation With The Application Of High Frequency Mechanical Vibrations, Mark Wylie, Garrett Mcguinness, Graham Gavin
Increased Susceptibility Of Arterial Tissue To Wire Perforation With The Application Of High Frequency Mechanical Vibrations, Mark Wylie, Garrett Mcguinness, Graham Gavin
Articles
High frequency mechanical vibrations (20–50 kHz), delivered via small diameter flexible wire waveguides represent a minimally invasive technology for the treatment of chronic total occlusions (CTOs) and in other tissue ablation applications. Tissue disruption is reported to be caused by repetitive mechanical contact and cavitation. This work focuses on the effects of vibrating wire waveguides in contact with arterial tissue. An apparatus with clinically relevant parameters was used, characterized as operating at 22.5 kHz and delivering amplitudes of vibration of 17.8 - 34.3 µm (acoustic intensity, ISATA: 1.03 - 3.83 W/cm2) via 1.0 mm diameter waveguides. …
A Linear Finite Element Acoustic Fluid-Structure Model Of Ultrasonic Angioplasty In Vivo, Mark Wylie, Garrett Mcguinness, Graham Gavin
A Linear Finite Element Acoustic Fluid-Structure Model Of Ultrasonic Angioplasty In Vivo, Mark Wylie, Garrett Mcguinness, Graham Gavin
Articles
The delivery of high-power ultrasonic energy via small diameter wire waveguides represents a new alternative therapy for the treatment of chronic totally occluded arteries (CTOs). This type of energy manifests itself as a mechanical vibration at the distal-tip of the waveguide with amplitudes of vibration up to 60 µm and at frequencies of 20- 50 kHz. Disruption of diseased tissue is reported to be a result of direct mechanical ablation, cavitation, pressure components and acoustic streaming and that ablation was only evident above the cavitation threshold. This work presents a linear finite element acoustic fluid-structure model of an ultrasonic angioplasty …
Experimental And Numerical Investigation Of Wire Waveguides For Therapeutic Ultrasound Angioplasty, Declan Noone (Thesis)
Experimental And Numerical Investigation Of Wire Waveguides For Therapeutic Ultrasound Angioplasty, Declan Noone (Thesis)
Other resources
Therapeutic ultrasound angioplasty is an emerging minimally invasive cardiovascular procedure for disrupting atherosclerotic lesions using small diameter wire waveguides. The lesions are damaged through a combination of direct ablation, pressure waves, cavitation and acoustic streaming caused by distal-tip displacements at ultrasonic frequencies. Numerical and experimental methods are used to investigate the outputs of the wire waveguides during ultrasonic activation. A commercially available generator and acoustic horn are used in combination with Nickel-Titanium (NiTi) wire waveguides in this study. A laser sensor is used to measure the frequency and amplitude output of the distal tip of the wire waveguide, and this …
An Acoustic Fluid-Structure Simulation Of A Theraputic Ultrasound Wire Waveguide Apparatus, Graham Gavin, M.S. Hashmi, Finbar Dolan, Garrett Mcguinness
An Acoustic Fluid-Structure Simulation Of A Theraputic Ultrasound Wire Waveguide Apparatus, Graham Gavin, M.S. Hashmi, Finbar Dolan, Garrett Mcguinness
Conference Papers
The use of high-power low-frequency ultrasound transmitted down small diameter wire waveguides is an emerging technology that may have potential in the treatment of complicated atherosclerotic plaques in cardiovascular surgery. This form of energy delivery results in vibrating the distal-tip of the wire waveguide disrupting material by means of direct contact ablation and also cavitation, pressure waves and acoustic streaming in the surrounding fluid. This work describes a numerical acoustic fluid-structure model of the ultrasound wire waveguide and blood surrounding the distal tip. The structural analysis of the model predicts the natural frequencies of the waveguide and shows the extent …