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Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
Oxygen Transport In Carotid And Stented Coronary Arteries, Eoin A. Murphy
Oxygen Transport In Carotid And Stented Coronary Arteries, Eoin A. Murphy
Doctoral
Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation can have significant effects on the oxygen transport into the arterial wall. Helical flow has been theorised to improve the local haemodynamics and the oxygen transport within stented arteries. In this study an advanced oxygen transport model was developed to assess different stent designs. This advanced oxygen transport model incorporates both the free and bound oxygen contained in blood and includes a shear-dependent dispersion coefficient for red blood cells. In two test cases …
Oxygen Mass Transport In Stented Coronary Arteries, Eoin Murphy, Adrian S. Dunne, David Martin, Fergal Boyle
Oxygen Mass Transport In Stented Coronary Arteries, Eoin Murphy, Adrian S. Dunne, David Martin, Fergal Boyle
Articles
Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation has significant effects on the oxygen transport into the arterial wall. Elucidating these effects is critical to optimizing future stent designs. In this study the most advanced oxygen transport model developed to date was assessed in two test cases and used to compare three coronary stent designs. Additionally, the predicted results from four simplified blood oxygen transport models are compared in the two test cases. The advanced model showed good agreement with experimental …
Sequential Structural And Fluid Dynamics Analysis Of Balloon-Expandable Coronary Stents., David Martin
Sequential Structural And Fluid Dynamics Analysis Of Balloon-Expandable Coronary Stents., David Martin
Doctoral
As in-stent restenosis following coronary stent deployment has been strongly linked with stent-induced arterial injury and altered vessel hemodynamics, the sequential numerical analysis of the mechanical and hemodynamic impact of stent deployment within a coronary artery is likely to provide an excellent indication of coronary stent performance. Despite this observation, very few numerical studies have considered both the mechanical and hemodynamic impact of stent deployment. In light of this observation, the aim of this research is to develop a robust numerical methodology for investigating the performance of balloon-expandable coronary stents in terms of their mechanical and hemodynamic impact within a …
Reducing In-Stent Restenosis Through Novel Stent Flow Field Augmentation, Eoin Murphy, Fergal Boyle
Reducing In-Stent Restenosis Through Novel Stent Flow Field Augmentation, Eoin Murphy, Fergal Boyle
Articles
In-stent restenosis (ISR), manifested as a re-narrowing of the arterial lumen post-implantation of a stent, is a detrimental limitation of stent technology. Understanding and consequently devising ways of reducing the frequency of ISR has been a continuing goal of research into improved stent designs. The biological processes that can lead to ISR have been found to be partially flow dependent with the local hemodynamics at the arterial wall of crucial importance. This paper investigates these biological processes and their instigating factors. Furthermore, the history and theory behind three stent technologies which endeavour to reduce ISR rates through stent flow field …