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Full-Text Articles in Biomedical Engineering and Bioengineering
Finite Element Analysis Of Balloon-Expandable Coronary Stent Deployment: Influence Of Angioplasty Balloon Configuration, David Martin, Fergal Boyle
Finite Element Analysis Of Balloon-Expandable Coronary Stent Deployment: Influence Of Angioplasty Balloon Configuration, David Martin, Fergal Boyle
Articles
Today, the majority of coronary stents are balloon-expandable and are deployed using a balloon-tipped catheter. To improve deliverability, the membrane of the angioplasty balloon is typically folded about the catheter in a pleated configuration. As such, the deployment of the angioplasty balloon is governed by the material properties of the balloon membrane, its folded configuration and its attachment to the catheter. Despite this observation, however, an optimum strategy for modelling the configuration of the angioplasty balloon in finite element studies of coronary stent deployment has not been identified, and idealised models of the angioplasty balloon are commonly employed in the …
Predicting Neointimal Hyperplasia In Stented Arteries Using Time-Dependant Computational Fluid Dynamics: A Review, Jonathan Murphy, Fergal Boyle
Predicting Neointimal Hyperplasia In Stented Arteries Using Time-Dependant Computational Fluid Dynamics: A Review, Jonathan Murphy, Fergal Boyle
Articles
This paper reviews the recent literature regarding the time-dependant computational fluid dynamics (CFD) analyses of blood flow through implanted coronary stents. The in vivo processes which result in arterial restenosis are identified. The definition and range of the computationally predicted variables which are believed to stimulate the restenosis processes are evaluated. The reviewed literature is subdivided into effect-based in which the effects of altering the flow model are investigated and design-based in which different geometric stent configurations are compared. Finally, conclusions are made regarding the body of work reviewed and recommendations are provided for future work in this field.
Computational Structural Modelling Of Coronary Stent Deployment: A Review, David Martin, Fergal Boyle
Computational Structural Modelling Of Coronary Stent Deployment: A Review, David Martin, Fergal Boyle
Articles
The finite element (FE) method is a powerful investigative tool in the field of biomedical engineering, particularly in the analysis of medical devices such as coronary stents whose performance is extremely difficult to evaluate in vivo. In recent years, a number of FE studies have been carried out to simulate the deployment of coronary stents, and the results of these studies have been utilised to assess and optimise the performance of these devices. The aim of this paper is to provide a thorough review of the state-of-the-art research in this area, discussing the aims, methods and conclusions drawn from a …
Comparison Of Stent Designs Using Computational Fluid Dynamics, Jonathan Murphy, Fergal Boyle
Comparison Of Stent Designs Using Computational Fluid Dynamics, Jonathan Murphy, Fergal Boyle
Conference Papers
Coronary artery disease (CAD) is one of the leading causes of death in the developed world. CAD occurs due to the build up of plaque in the coronary arteries which supply fresh blood to the constantly active heart muscle. Several methods exist to alleviate CAD such as coronary artery bypass grafting, balloon angioplasty and coronary stenting. A coronary stent is a small tubular prosthesis which can improve blood flow by acting as a scaffold to prop the diseased artery open. However, stent restenosis (re-blockage) remains a common problem with different stent designs leading to different restenosis rates. This work investigates …
Application Of Advanced Computational Modelling In The Numerical Prediction Of The Haemodynamic Impact Of Coronary Stent Implantation, Jonathan Murphy, Fergal Boyle
Application Of Advanced Computational Modelling In The Numerical Prediction Of The Haemodynamic Impact Of Coronary Stent Implantation, Jonathan Murphy, Fergal Boyle
Conference Papers
Coronary stent implantation can improve blood flow in an artery narrowed by the build up of arterial plaque. However, the haemodynamic effect of stent placement is unclear and may influence arterial restenosis (re-blockage). In this investigation the stent induced, non-Newtonian blood flow disturbances have been captured in a three dimensional computational domain. The results clearly show areas of low wall shear stress proximal and distal to the stent wires, a characteristic which is known to encourage restenosis. Furthermore, this computational method of observing the complex haemodynamics of the stent environment can be used in conjunction with medical trial data to …