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Articles 1 - 30 of 598

Full-Text Articles in Biomedical Engineering and Bioengineering

Multiple Path Particle Dosimetry For Prediction Of Mouse Lung Deposition Of Nanoaerosol Particles, Mohammed Ali Sep 2019

Multiple Path Particle Dosimetry For Prediction Of Mouse Lung Deposition Of Nanoaerosol Particles, Mohammed Ali

Mohammed Ali

Nanoaerosolized particle (dia.<200 >nm) antibiotic inhalation therapy was tested to treat pneumonic tularemia in mice caused by Francisella novicida infection. Very limited experimental techniques are available to properly estimate inhaled doses and distribution of the drug inside the mouse lungs. To overcome this problem, computational simulation of particle deposition based on the Multiple Path Particle Dosimetry (MPPD) model was employed to simulate in vivo experimental conditions which included nasal breathing with whole body exposure to the antibiotic in the form of nano-aerosolized medicine. The deposition results were compared with several in vivo experimental data reported in literature; and satisfactory agreements ...


Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali Sep 2019

Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali

Mohammed Ali

The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva Handihaler, Advair Diskus, and Pulmicort Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available DPIs by means of ...


Sheet‐Extruded Films From Blends Of Hydroxypropylated And Native Corn Starches, And Their Characterization, Hee-Young Kim, Buddhi P. Lamsal, Jay-Lin Jane, David A. Grewell Aug 2019

Sheet‐Extruded Films From Blends Of Hydroxypropylated And Native Corn Starches, And Their Characterization, Hee-Young Kim, Buddhi P. Lamsal, Jay-Lin Jane, David A. Grewell

Jay-Lin Jane

Sheet‐extruded films from the blends of hydroxypropylated normal corn starch (HP) and native normal corn starch (NS) at weight ratios of 100:0, 90:10, 70:30, 50:50, 30:70, and 0:100 were prepared and characterized. Glycerol and water were added as plasticizers at 11 and 27% starch weight, respectively. The highest tensile strength (TS) and longest elongation to break (EB) for dry films were observed at 70:30 HP: NS ratio, which was 25.76 MPa, and 3.97%, respectively. However, TS and EB of this 70:30 blend extruded starch film exhibited low resistance upon ...


Viscoelastic Properties Of Shock Wave Exposed Brain Tissue Subjected To Unconfined Compression Experiments, Annastacia K. Mccarty, Ling Zhang, Sarah Hansen, William J. Jackson, Sarah A. Bentil Aug 2019

Viscoelastic Properties Of Shock Wave Exposed Brain Tissue Subjected To Unconfined Compression Experiments, Annastacia K. Mccarty, Ling Zhang, Sarah Hansen, William J. Jackson, Sarah A. Bentil

Sarah A. Bentil

Traumatic brain injuries (TBI) affect millions of people each year. While research has been dedicated to determining the mechanical properties of the uninjured brain, there has been a lack of investigation on the mechanical properties of the brain after experiencing a primary blast-induced TBI. In this paper, whole porcine brains were exposed to a shock wave to simulate blast-induced TBI. First, ten (10) brains were subjected to unconfined compression experiments immediately following shock wave exposure. In addition, 22 brains exposed to a shock wave were placed in saline solution and refrigerated between 30 minutes and 6.0 hours before undergoing ...


A Systems Biology Approach Toward Understanding Seed Composition In Soybean, Ling Li, Manhoi Hur, Joon-Yong Lee, Wenxu Zhou, Zhihong Song, Nick Ransom, Cumhur Yusuf Demirkale, Daniel S. Nettleton, Mark E. Westgate, Zebulun Wayne Arendsee, Vidya Vaancheeswaran Iyer, Jacqueline V. Shanks, Basil Nikolau, Eve Wurtele Jun 2019

A Systems Biology Approach Toward Understanding Seed Composition In Soybean, Ling Li, Manhoi Hur, Joon-Yong Lee, Wenxu Zhou, Zhihong Song, Nick Ransom, Cumhur Yusuf Demirkale, Daniel S. Nettleton, Mark E. Westgate, Zebulun Wayne Arendsee, Vidya Vaancheeswaran Iyer, Jacqueline V. Shanks, Basil Nikolau, Eve Wurtele

Dan Nettleton

Background

The molecular, biochemical, and genetic mechanisms that regulate the complex metabolic network of soybean seed development determine the ultimate balance of protein, lipid, and carbohydrate stored in the mature seed. Many of the genes and metabolites that participate in seed metabolism are unknown or poorly defined; even more remains to be understood about the regulation of their metabolic networks. A global omics analysis can provide insights into the regulation of seed metabolism, even without a priori assumptions about the structure of these networks.

Results

With the future goal of predictive biology in mind, we have combined metabolomics, transcriptomics, and ...


Accounting For Host Cell Protein Behavior In Anion-Exchange Chromatography, Ryan K. Swanson, Ruo Xu, Daniel S. Nettleton, Charles Glatz Jun 2019

Accounting For Host Cell Protein Behavior In Anion-Exchange Chromatography, Ryan K. Swanson, Ruo Xu, Daniel S. Nettleton, Charles Glatz

Dan Nettleton

Host cell proteins (HCP) are a problematic set of impurities in downstream processing (DSP) as they behave most similarly to the target protein during separation. Approaching DSP with the knowledge of HCP separation behavior would be beneficial for the production of high purity recombinant biologics. Therefore, this work was aimed at characterizing the separation behavior of complex mixtures of HCP during a commonly used method: anion-exchange chromatography (AEX). An additional goal was to evaluate the performance of a statistical methodology, based on the characterization data, as a tool for predicting protein separation behavior. Aqueous two-phase partitioning followed by two-dimensional electrophoresis ...


Challenges Of Erau’S First Suborbital Flight Aboard Blue Origin’S New Shepard M7 For The Cell Research Experiment In Microgravity (Crexim), Pedro Llanos, Kristina Andrijauskaite, Vijay V. Duraisamy, Francisco F. Pastrana, Erik Seedhouse, Sathya Gangadharan, Leonid Bunegin, Mariel Rico Jun 2019

Challenges Of Erau’S First Suborbital Flight Aboard Blue Origin’S New Shepard M7 For The Cell Research Experiment In Microgravity (Crexim), Pedro Llanos, Kristina Andrijauskaite, Vijay V. Duraisamy, Francisco F. Pastrana, Erik Seedhouse, Sathya Gangadharan, Leonid Bunegin, Mariel Rico

Pedro J. Llanos (www.AstronauticsLlanos.com)

Cell Research Experiment In Microgravity (CRExIM) was launched aboard Blue Origin’s New Shepard suborbital vehicle on Tuesday, December 12, 2017, from the West Texas Launch Site in Van Horn, Texas. One of the aims of this science experiment was to assess the effects of microgravity on murine T-cells during suborbital flight. These cells were placed in a NanoLab with a data logger that sensed the acceleration, temperature, and relative humidity during preflight, flight, and postflight operations. Some discrepancies in sensor measurement were noticed, and these errors were attributed partly to the difference in sampling rates and partly to the ...


Biomedical Engineering - An Art Or A Science?, Sowmya Anjur Apr 2019

Biomedical Engineering - An Art Or A Science?, Sowmya Anjur

Sowmya Anjur

Students discussed recent advances in technology and classified them as belonging to science or engineering. Students were introduced to the human heart and its mechanics, after which they brainstormed in groups to build their own life-sized heart models, choosing from the materials provided and demonstrated their working models to each other. Students were encouraged to create "diseases" in their heart models and explain how they would correlate this to "real'life" experiences. Students were also introduced to my newest project, arduino heart rate monitors and asked to suggest creative projects that they could work on in the near future.


Simulations Of Hydrogel-Coated Neural Microelectrodes To Assess Biocompatibility Improvement Using Strain As A Metric For Micromotion, Sarah A. Bentil, Rebecca B. Dupaix Feb 2019

Simulations Of Hydrogel-Coated Neural Microelectrodes To Assess Biocompatibility Improvement Using Strain As A Metric For Micromotion, Sarah A. Bentil, Rebecca B. Dupaix

Sarah A. Bentil

This study investigates the benefit of coating silicon-substrate microelectrode arrays with hydrogel material for improved biocompatibility. Varying coating thicknesses and hydrogel material descriptions were considered to determine the impact on reducing strain in the surrounding brain tissue caused by relative micromotion of the electrode. Finite element simulations were used to explore biocompatibility by focusing on the longitudinal micromotion of an implanted single electrode shank. The finite element model for the brain and electrode, both with and without the hydrogel coating, remained constant. Three constitutive models were considered to describe the brain and/or hydrogel material: linear elastic, hyperviscoelastic, and fractional ...


The Subject Librarian Newsletter, Engineering And Computer Science, Fall 2017, Buenaventura "Ven" Basco Oct 2018

The Subject Librarian Newsletter, Engineering And Computer Science, Fall 2017, Buenaventura "Ven" Basco

Buenaventura "Ven" Basco

No abstract provided.


Sbaigs18.Pdf, Sarfaraz Niaz Ali Baig Aug 2018

Sbaigs18.Pdf, Sarfaraz Niaz Ali Baig

Sarfaraz Baig

No abstract provided.


A Metabolic Energy Expenditure Model With A Continuous First Derivative And Its Application To Predictive Simulations Of Gait, Anne D. Koelewijn, Eva Dorschky, Antonie J. Van Den Bogert Jul 2018

A Metabolic Energy Expenditure Model With A Continuous First Derivative And Its Application To Predictive Simulations Of Gait, Anne D. Koelewijn, Eva Dorschky, Antonie J. Van Den Bogert

Antonie J. van den Bogert

Whether humans minimize metabolic energy in gait is unknown. Gradient-based optimization could be used to predict gait without using walking data, but requires a twice di#11;erentiable metabolic energy model. Therefore, the metabolic energy model of Umberger et al. (2003) was adapted to be twice di#11;fferentiable. Predictive simulations of a reaching task and gait were solved using this continuous model and by minimizing e#11;ffort. The reaching task simulation showed that energy minimization predicts unrealistic movements when compared to e#11;ffort minimization. The predictive gait simulations showed that objectives other than metabolic energy are also ...


An Analytical Model For Rotator Cuff Repairs, A. Aurora, Jorge E. Gatica, Antonie J. Van Den Bogert, J. A. Mccarron, Kathleen A. Derwin May 2018

An Analytical Model For Rotator Cuff Repairs, A. Aurora, Jorge E. Gatica, Antonie J. Van Den Bogert, J. A. Mccarron, Kathleen A. Derwin

Jorge E. Gatica

Background

Currently, natural and synthetic scaffolds are being explored as augmentation devices for rotator cuff repair. When used in this manner, these devices are believed to offer some degree of load sharing; however, no studies have quantified this effect. Furthermore, the manner in which loads on an augmented rotator cuff repair are distributed among the various components of the repair is not known, nor is the relative biomechanical importance of each component. The objectives of this study are to (1) develop quasi-static analytical models of simplified rotator cuff repairs, (2) validate the models, and (3) predict the degree of load ...


Cip2a Immunosensor Comprised Of Vertically-Aligned Carbon Nanotube Interdigitated Electrodes Towards Point-Of-Care Oral Cancer Screening, Shaowei Ding, Suprem R. Das, Benjamin J. Brownlee, Kshama Parate, Taylor Davis, Loreen Stromberg, Edward K.L. Chan, Joseph Katz, Brian D. Iverson, Jonathan C. Claussen Apr 2018

Cip2a Immunosensor Comprised Of Vertically-Aligned Carbon Nanotube Interdigitated Electrodes Towards Point-Of-Care Oral Cancer Screening, Shaowei Ding, Suprem R. Das, Benjamin J. Brownlee, Kshama Parate, Taylor Davis, Loreen Stromberg, Edward K.L. Chan, Joseph Katz, Brian D. Iverson, Jonathan C. Claussen

Jonathan C. Claussen

Vertically aligned carbon nanotube array (VANTA) coatings have recently garnered much attention due in part to their unique material properties including light absorption, chemical inertness, and electrical conductivity. Herein we report the first use of VANTAs grown via chemical vapor deposition in a 2D interdigitated electrode (IDE) footprint with a high height-to-width aspect ratio (3:1 or 75:25 µm). The VANTA-IDE is functionalized with an antibody (Ab) specific to the human cancerous inhibitor PP2A (CIP2A)—a salivary oncoprotein that is associated with a variety of malignancies such as oral, breast, and multiple myeloma cancers. The resultant immunosensor is capable ...


Recent Approaches In Designing Bioadhesive Materials Inspired By Mussel Adhesive Protein, Pegah Kord Forooshani, Bruce P. Lee Mar 2018

Recent Approaches In Designing Bioadhesive Materials Inspired By Mussel Adhesive Protein, Pegah Kord Forooshani, Bruce P. Lee

Bruce Lee

Marine mussels secret protein-based adhesives, which enable them to anchor to various surfaces in a saline, intertidal zone. Mussel foot proteins (Mfps) contain a large abundance of a unique, catecholic amino acid, Dopa, in their protein sequences. Catechol offers robust and durable adhe-sion to various substrate surfaces and contributes to the curing of the adhesive plaques. In this article, we review the unique features and the key functionalities of Mfps, catechol chemistry, and strategies for preparing catechol-functionalized poly- mers. Specifically, we reviewed recent findings on the contributions of various features of Mfps on interfacial binding, which include coacervate formation, surface ...


Fibrin Gel As An Injectable Biodegradable Scaffold And Cell Carrier For Tissue Engineering, Yuting Li, Hao Meng, Yuan Liu, Bruce P. Lee Mar 2018

Fibrin Gel As An Injectable Biodegradable Scaffold And Cell Carrier For Tissue Engineering, Yuting Li, Hao Meng, Yuan Liu, Bruce P. Lee

Bruce Lee

Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. Fibrin gel exhibits excellent biocompatibility, promotes cell attachment, and can degrade in a controllable manner. Additionally, fibrin gel mimics the natural ...


Effect Of Exercise Dosages On Adiposity Indices In Overweight Girls, Stephanie Kellam, Norma Olvera, Patrick Leung, Jian Liu, Dennis Smith Mar 2018

Effect Of Exercise Dosages On Adiposity Indices In Overweight Girls, Stephanie Kellam, Norma Olvera, Patrick Leung, Jian Liu, Dennis Smith

Jian Liu

Objective. The primary purpose of this study was to determine the impact of two exercise dosages on reducing adiposity in minority girls. Materials and methods. Sixty-two overweight Hispanic and African-American girls participated in one of two intense summer interventions in Houston, TX: Intervention A (exposure to about 40 hours physical activities) or Intervention B (exposure to 60 hours of physical activities). Adiposity indices (percent body fat, waist circumference, body mass index) were taken pre- and post-intervention.

Results.

Intervention B had a significantly greater decrease in adiposity indicators (p= 0.006) when compared to Intervention A. Waist circumference displayed the most ...


Evaluating The Quick Fix: Weight Loss Drugs And Cellular Respiration, Pamela L. Freeman, Jennifer A. Maki, Kara R. Thoemke, Monica H. Lamm, Clark R. Coffman Jan 2018

Evaluating The Quick Fix: Weight Loss Drugs And Cellular Respiration, Pamela L. Freeman, Jennifer A. Maki, Kara R. Thoemke, Monica H. Lamm, Clark R. Coffman

Monica H. Lamm

One key to student success in introductory and cell biology courses is a foundational knowledge of cellular respiration. This is a content area in which students often harbor misconceptions that make cellular respiration particularly challenging to teach. Conventional approaches presenting cellular respiration as a complex series of isolated steps creates a situation where students tend to memorize the steps but fail to appreciate the bigger picture of how cells transform and utilize energy. Instructors frequently struggle to find ways to motivate students and encourage deeper learning. The learning goals of this cellular respiration lesson are to understand energy transfer in ...


Multidisciplinary Game-Based Approach For Generating Student Enthusiasm For Addressing Critical Infrastructure Challenges, John F. Gardner Nov 2017

Multidisciplinary Game-Based Approach For Generating Student Enthusiasm For Addressing Critical Infrastructure Challenges, John F. Gardner

John Gardner

Building upon experiences from past course offering,1 several universities across the United States (U.S) have incorporated a critical infrastructure educational game platform as a unifying platform to integrate different disciplines to a common goal. The critical infrastructure backbones of the world provide the delivery mechanisms for energy and other utilities that provide the lifestyle we have come to expect in our society. As these critical infrastructure systems have evolved, the complexity of their integration has generated numerous challenges as a side effect of increased automation that are more pronounced as the infrastructure ages. Although still a modern technological ...


Analysis Of Gait Characteristics In Mentally Handicapped Individuals, Prakriti Parijat, Jian Liu, Thurmon E. Lockhart, Courtney Haynes Nov 2017

Analysis Of Gait Characteristics In Mentally Handicapped Individuals, Prakriti Parijat, Jian Liu, Thurmon E. Lockhart, Courtney Haynes

Jian Liu

Physical and motor dysfunctions in mentally handicapped individuals predispose them to a higher risk of slip and fall accidents. It is estimated that over 60 million people are currently suffering with some level of developmentally related cognitive impairment (American Disability Act ADA, 2000). Mental retardation occurs in 2.5-3% of the general population. About 6-7.5 million mentally retarded individuals live in the United States alone (ADA, 2000). Slip induced fall accidents are a primary source of injury in people with mental retardation (MR). Often, the incidence of falls among this population is compounded by other disabilities such as autism ...


Emg And Kinematic Responses To Unexpected Slips After Slip Training In Virtual Reality, Prakriti Parijat, Thurmon E. Lockhart, Jian Liu Oct 2017

Emg And Kinematic Responses To Unexpected Slips After Slip Training In Virtual Reality, Prakriti Parijat, Thurmon E. Lockhart, Jian Liu

Jian Liu

The objective of the study was to design a virtual reality (VR) training to induce perturbation in older adults similar to a slip and examine the effect of the training on kinematic and muscular responses in older adults. Twenty-four older adults were involved in a laboratory study and randomly assigned to two groups (VR training and control). Both groups went through three sessions including baseline slip, training, and transfer of training on slippery surface. The training group experienced 12 simulated slips using a visual perturbation induced by tilting a VR scene while walking on the treadmill and the control group ...


A Review Focujsed On The Psychological Effectiveness Of Tai Chi On Different Populations, Long Zhang, Thomas Lowder, Jian Liu Sep 2017

A Review Focujsed On The Psychological Effectiveness Of Tai Chi On Different Populations, Long Zhang, Thomas Lowder, Jian Liu

Jian Liu

No abstract provided.


Utilizing Functional Near-Infrared Spectroscopy For Prediction Of Cognitive Workload In Noisy Work Environments, Ryan Gabbard, Mary E. Fendley, Irfaan A. Dar, Rik Warren, Nasser H. Kashou Aug 2017

Utilizing Functional Near-Infrared Spectroscopy For Prediction Of Cognitive Workload In Noisy Work Environments, Ryan Gabbard, Mary E. Fendley, Irfaan A. Dar, Rik Warren, Nasser H. Kashou

Nasser Kashou

Occupational noise frequently occurs in the work environment in military intelligence, surveillance, and reconnaissance operations. This impacts cognitive performance by acting as a stressor, potentially interfering with the analysts’ decision-making process. We investigated the effects of different noise stimuli on analysts’ performance and workload in anomaly detection by simulating a noisy work environment. We utilized functional near-infrared spectroscopy (fNIRS) to quantify oxy-hemoglobin (HbO) and deoxy-hemoglobin concentration changes in the prefrontal cortex (PFC), as well as behavioral measures, which include eye tracking, reaction time, and accuracy rate. We hypothesized that noisy environments would have a negative effect on the participant in ...


Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman Aug 2017

Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman

Lisa Hoffman

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease that affects 1 in 3500 boys. The disease is characterized by progressive muscle degeneration that results from mutations in or loss of the cytoskeletal protein, dystrophin, from the glycoprotein membrane complex, thus increasing the susceptibility of contractile muscle to injury. To date, disease progression is typically assessed using invasive techniques such as muscle biopsies, and while there are recent reports of the use of magnetic resonance, ultrasound and optical imaging technologies to address the issue of disease progression and monitoring therapeutic intervention in dystrophic mice, our study aims to validate ...


A Systems Biology Approach Toward Understanding Seed Composition In Soybean, Ling Li, Manhoi Hur, Joon-Yong Lee, Wenxu Zhou, Zhihong Song, Nick Ransom, Cumhur Yusuf Demirkale, Daniel S. Nettleton, Mark E. Westgate, Zebulun Wayne Arendsee, Vidya Vaancheeswaran Iyer, Jacqueline V. Shanks, Basil Nikolau, Eve Wurtele Aug 2017

A Systems Biology Approach Toward Understanding Seed Composition In Soybean, Ling Li, Manhoi Hur, Joon-Yong Lee, Wenxu Zhou, Zhihong Song, Nick Ransom, Cumhur Yusuf Demirkale, Daniel S. Nettleton, Mark E. Westgate, Zebulun Wayne Arendsee, Vidya Vaancheeswaran Iyer, Jacqueline V. Shanks, Basil Nikolau, Eve Wurtele

Ling Li

Background

The molecular, biochemical, and genetic mechanisms that regulate the complex metabolic network of soybean seed development determine the ultimate balance of protein, lipid, and carbohydrate stored in the mature seed. Many of the genes and metabolites that participate in seed metabolism are unknown or poorly defined; even more remains to be understood about the regulation of their metabolic networks. A global omics analysis can provide insights into the regulation of seed metabolism, even without a priori assumptions about the structure of these networks.

Results

With the future goal of predictive biology in mind, we have combined metabolomics, transcriptomics, and ...


Direct Numerical Simulation Of Turbulent Katabatic Slope Flows With An Immersed-Boundary Method, Clancy Umphrey, Ray Deleon, Inanc Senocak Jun 2017

Direct Numerical Simulation Of Turbulent Katabatic Slope Flows With An Immersed-Boundary Method, Clancy Umphrey, Ray Deleon, Inanc Senocak

Inanc Senocak

We investigate a Cartesian-mesh immersed-boundary formulation within an incompressible flow solver to simulate laminar and turbulent katabatic slope flows. As a proof-of-concept study, we consider four different immersed-boundary reconstruction schemes for imposing a Neumann-type boundary condition on the buoyancy field. Prandtl’s laminar solution is used to demonstrate the second-order accuracy of the numerical solutions globally. Direct numerical simulation of a turbulent katabatic flow is then performed to investigate the applicability of the proposed schemes in the turbulent regime by analyzing both first- and second-order statistics of turbulence. First-order statistics show that turbulent katabatic flow simulations are noticeably sensitive to ...


Dynamic Rating Of Overhead Transmission Lines Over Complex Terrain Using A Large-Eddy Simulation Paradigm, Tyler Phillips, Ray Deleon, Inanc Senocak Jun 2017

Dynamic Rating Of Overhead Transmission Lines Over Complex Terrain Using A Large-Eddy Simulation Paradigm, Tyler Phillips, Ray Deleon, Inanc Senocak

Inanc Senocak

Dynamic Line Rating (DLR) enables rating of power line conductors using real-time weather conditions. Conductors are typically operated based on a conservative static rating that assumes worst case weather conditions to avoid line sagging to unsafe levels. Static ratings can cause unnecessary congestion on transmission lines. To address this potential issue, a simulation-based dynamic line rating approach is applied to an area with moderately complex terrain. A micro-scale wind solver — accelerated on multiple graphics processing units (GPUs) — is deployed to compute wind speed and direction in the vicinity of powerlines. The wind solver adopts the large-eddy simulation technique and the ...


Near-Infrared Optical Imaging For Monitoring The Regeneration Of Osteogenic Tissue-Engineered Constructs., Elizabeth A. Cowles, Joy L. Kovar, Evan T. Curtis, Huihui Xu, Shadi F. Othman Jun 2017

Near-Infrared Optical Imaging For Monitoring The Regeneration Of Osteogenic Tissue-Engineered Constructs., Elizabeth A. Cowles, Joy L. Kovar, Evan T. Curtis, Huihui Xu, Shadi F. Othman

Huihui Xu

Millions of cases of bone injury or loss due to trauma, osteoporosis, and cancer occur in the United States each year. Because bone is limited in its ability to regenerate, alternative therapy approaches are needed. Bone tissue engineering has the potential to correct musculoskeletal disorders through the development of cell-based substitutes for osteogenic tissue replacement. Multiple medical imaging techniques such as magnetic resonance microscopy (MRM) were investigated recently; these techniques are able to provide useful information on the anatomical and structural changes of developing bone. However, there is a need for noninvasive approaches to evaluate biochemical constituents and consequent compositional ...


Rapid Cell Extraction In Aqueous Two-Phase Microdroplet Systems, Kalpana Vijayakumar, Shelly Gulati, Andrew J. De Mello, Joshua B. Edel Jun 2017

Rapid Cell Extraction In Aqueous Two-Phase Microdroplet Systems, Kalpana Vijayakumar, Shelly Gulati, Andrew J. De Mello, Joshua B. Edel

Shelly Gulati

Distinguishing specific cells is an essential technique in cell research and clinical diagnostics. We report a novel method to passively isolate and extract cells in a microfluidic device. We utilise a droplet-based microfluidic system to generate an aqueous two phase system in which aqueous droplets consist of two phases in the form of a double emulsion. Specifically, we generate PEG droplets that completely encapsulate DEX droplets within a microfluidic channel. Target cells can be introduced directly into the droplets and driven to partition to the more favourable phase, whilst still being contained within the aqueous droplet. Human T lymphoma cells ...


Epitaxially Grown Collagen Fibrils Reveal Diversity In Contact Guidance Behavior Among Cancer Cells, Juan Wang, Joseph W. Petefish, Andrew C. Hillier, Ian C. Schneider May 2017

Epitaxially Grown Collagen Fibrils Reveal Diversity In Contact Guidance Behavior Among Cancer Cells, Juan Wang, Joseph W. Petefish, Andrew C. Hillier, Ian C. Schneider

Andrew C. Hillier

Invasion of cancer cells into the surrounding tissue is an important step during cancer progression and is driven by cell migration. Cell migration can be random, but often it is directed by various cues such as aligned fibers composed of extracellular matrix (ECM), a process called contact guidance. During contact guidance, aligned fibers bias migration along the long axis of the fibers. These aligned fibers of ECM are commonly composed of type I collagen, an abundant structural protein around tumors. In this paper, we epitaxially grew several different patterns of organized type I collagen on mica and compared the morphology ...