Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Bioimaging and Biomedical Optics (6)
- Mechanical Engineering (3)
- Medicine and Health Sciences (3)
- Nanoscience and Nanotechnology (3)
- Medical Sciences (2)
-
- Physical Sciences and Mathematics (2)
- Agricultural and Resource Economics (1)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biological Engineering (1)
- Biology (1)
- Chemistry (1)
- Demography, Population, and Ecology (1)
- Ecology and Evolutionary Biology (1)
- Education (1)
- Food Science (1)
- Industrial Engineering (1)
- Life Sciences (1)
- Manufacturing (1)
- Medical Biotechnology (1)
- Medical Microbiology (1)
- Medical Molecular Biology (1)
- Medical Specialties (1)
- Microbiology (1)
- Molecular Biology (1)
- Oncology (1)
- Operations Research, Systems Engineering and Industrial Engineering (1)
- Physics (1)
- Keyword
-
- Optodes (2)
- AIDS (1)
- Antimicrobial activity (1)
- Antioxidant activity (1)
- Aspen Plus model (1)
-
- Atomic force microscopes (1)
- Atomic force microscopy (1)
- Autoantibody (1)
- Autoimmunity (1)
- Automotive (1)
- Bayesian statistics (1)
- Biomass thermochemical gasification (1)
- Biosensor (1)
- Calibration (1)
- Cancer (1)
- Chemical sensors (1)
- Collagen (1)
- Collision. (1)
- Combined heat and power generation (1)
- Cytokine (1)
- Economics (1)
- Essential oil (1)
- Event reconstruction (1)
- Failure (1)
- Femur - fibula - flap - tibia - fracture (1)
- Fiber optic (1)
- Fluorescence lifetime (1)
- Food Microbiology (1)
- Friction (1)
- Gaussian Plume models (1)
- Publication
- File Type
Articles 1 - 15 of 15
Full-Text Articles in Biomedical Engineering and Bioengineering
Optochemical Nanosensors For Intracellular Chemical Measurement, Raoul Kopelman, Michael T. Miller, Murphy Brasuel, Heather Clark, Marion Hoyer, Martin Philbert
Optochemical Nanosensors For Intracellular Chemical Measurement, Raoul Kopelman, Michael T. Miller, Murphy Brasuel, Heather Clark, Marion Hoyer, Martin Philbert
Heather Clark
The development of a submicron optical fiber "supertip" has provided advantages over previously produced submicron tips, such as facilitating insertion of these sensors into cells while minimizing damage to the cell membrane. Fiber optic ion correlation-based nanosensors for sodium, potassium and chloride employing these "supertips" have been applied to the monitoring of ion concentrations in single mouse oocytes. These sensors have also been used to monitor the effect of an ion channel-blocking agent. In order to address the challenge associated with single-cell simultaneous measurement of multiple analytes, the use of submicron optical fiber multiprobes has been explored.
Novel Optical Biosensors Using A Gold Colloid Monolayer Substrate, Heather Clark, Greg Merritt, Raoul Kopelman
Novel Optical Biosensors Using A Gold Colloid Monolayer Substrate, Heather Clark, Greg Merritt, Raoul Kopelman
Heather Clark
A novel optical biosensor matrix has been developed to exploit the native fluorescence of certain proteins. This matrix uses a gold colloid monolayer attached to an end of a fiber as a substrate for protein attachment. The effect of the gold monolayer size has been investigated through the techniques of fluorescence, scanning electron microscopy, and transmission electron microscopy. It has been shown that the size ofthe gold colloid does produce a marked difference in the fluorescence intesity measured. It is surmised through the use of microscopy techniques that the intensity changes seen in the fluorescence emission are not a result …
Second-Harmonic Imaging Microscopy Of Living Cells, Paul J. Campagnola, Heather Clark, William A. Mohler, Aaron Lewis (Prof.), Leslie M. Loew
Second-Harmonic Imaging Microscopy Of Living Cells, Paul J. Campagnola, Heather Clark, William A. Mohler, Aaron Lewis (Prof.), Leslie M. Loew
Heather Clark
Second harmonic generation (SHG) has been developed in our laboratories as a high-resolution nonlinear optical imaging microscopy for cellular membranes and intact tissues. SHG shares many of the advantageous features for microscopy of another more established nonlinear optical technique: two-photon excited fluorescence (TPEF). Both are capable of optical sectioning to produce threedimensional images of thick specimens and both result in less photodamage to living tissue than confocal microscopy. SHG is complementary to TPEF in that it uses a different contrast mechanism and is most easily detected in the transmitted light optical path. It can be used to image membrane probes …
A Comparative Study Of Optical Fluorescent Nanosensors ("Pebbles") And Fiber Optic Microsensors For Oxygen Sensing, Z. Chen-Esterlit, S. F. Peteu, Heather Clark, W. Mcdonald, R. Kopelman
A Comparative Study Of Optical Fluorescent Nanosensors ("Pebbles") And Fiber Optic Microsensors For Oxygen Sensing, Z. Chen-Esterlit, S. F. Peteu, Heather Clark, W. Mcdonald, R. Kopelman
Heather Clark
In this paper we report the use of phase sensitive fluorometry to obtain preliminary results from opto-chemical fluorescent oxygen nanosensors. PEBBLE (Probe Encapsulated By Biologically Localized Embedding) sensors were fabricated by immobilizing tris(4,7-diphenyl—1, 10-phenanthroline)Ru(II) chloride and tris(1,10-phenanthroline)Ru(II) chloride within a polyacrylamide matrix. PEBBLEs have diameters of 20-200 nm and exhibit excellent performance for dissolved oxygen detection. Their performance is compared with micrometer-sized (10-20 μm) optical fiber sensors and free dye in solution. Oxygen sensing ability of PEBBLEs was tested in the presence of other quenchers and compared with free dyes in solution. While PEBBLEs have been developed for minimally invasive …
Sub-Wavelength Plasmonic Readout For Direct Linear Analysis Of Optically Tagged Dna, Jonathan Varsanik, William Teynor, John Leblanc, Heather Clark, Jeffrey Krogmeier, Tian Yang, Jonathan Bernstein
Sub-Wavelength Plasmonic Readout For Direct Linear Analysis Of Optically Tagged Dna, Jonathan Varsanik, William Teynor, John Leblanc, Heather Clark, Jeffrey Krogmeier, Tian Yang, Jonathan Bernstein
Heather Clark
This work describes the development and fabrication of a novel nanofluidic flow-through sensing chip that utilizes a plasmonic resonator to excite fluorescent tags with sub-wavelength resolution. We cover the design of the microfluidic chip and simulation of the plasmonic resonator using Finite Difference Time Domain (FDTD) software. The fabrication methods are presented, with testing procedures and preliminary results. This research is aimed at improving the resolution limits of the Direct Linear Analysis (DLA) technique developed by US Genomics. In DLA, intercalating dyes which tag a specific 8 base-pair sequence are inserted in a DNA sample. This sample is pumped though …
Biomechanical Investigation Of A Novel Ratcheting Arthrodesis Nail., Kristen Billiar, Jeremy Mccornick, Xinning Li, Douglas Weiss, John Wixted
Biomechanical Investigation Of A Novel Ratcheting Arthrodesis Nail., Kristen Billiar, Jeremy Mccornick, Xinning Li, Douglas Weiss, John Wixted
Kristen L. Billiar
Background: Knee or tibiotalocalcaneal arthrodesis is a salvage procedure, often with unacceptable rates of nonunion. Basic science of fracture healing suggests that compression across a fusion site may decrease nonunion. A novel ratcheting arthrodesis nail designed to improve dynamic compression is mechanically tested in comparison to existing nails. Methods: A novel ratcheting nail was designed and mechanically tested in comparison to a solid nail and a threaded nail using sawbones models (Pacific Research Laboratories, Inc.). Intramedullary nails (IM) were implanted with a load cell (Futek LTH 500) between fusion surfaces. Constructs were then placed into a servo-hydraulic test frame (Model …
Femur Flap For Tibial Reconstruction: Percent Circumference Required To Convey A Mechanical Advantage Over The Fibula, Kristen Billiar, Genevieve Broderick, Janice Lalikos, Matthew Chowaniec, Meghan Collins, Elias Wilson, Russell Babbitt, Julie O'Brien, Raymond Dunn
Femur Flap For Tibial Reconstruction: Percent Circumference Required To Convey A Mechanical Advantage Over The Fibula, Kristen Billiar, Genevieve Broderick, Janice Lalikos, Matthew Chowaniec, Meghan Collins, Elias Wilson, Russell Babbitt, Julie O'Brien, Raymond Dunn
Kristen L. Billiar
The fibula flap is commonly used to reconstruct the tibia. This has risk of postoperative fracture despite long-term non-weight bearing. A flap using noncircumferential distal femur is proposed. This study is to determine the circumference of femur required to produce greater strength than the fibular flap. Femurs and fibulas were harvested from eight cadavers. The structural strength of fibula and femur flaps was assessed using three-point bend. Compression testing was performed on osteotomized and whole femurs to assess donor site morbidity. The 35% flap (mean maximum force at fracture 869 N) was not significantly stronger than the fibula flap (626 …
Pre-Swing Deficits In Forward Propulsion, Swing Initiation And Power Generation By Individual Muscles During Hemiparetic Walking, Carrie Peterson, Allison Kinney, Stephen Kautz, Richard Neptune
Pre-Swing Deficits In Forward Propulsion, Swing Initiation And Power Generation By Individual Muscles During Hemiparetic Walking, Carrie Peterson, Allison Kinney, Stephen Kautz, Richard Neptune
Allison Kinney
No abstract provided.
Antimicrobial And Antioxidant Activities Of Essential Oil And Methanol Extract Of Jasminum Sambac From Djibouti, Fatou Abdoul-Latif, Prosper Edou, François Eba, Nabil Mohamed, Adwa Ali, Samatar Djama, Louis-Clément Obame, Mamoudou Hama Dicko
Antimicrobial And Antioxidant Activities Of Essential Oil And Methanol Extract Of Jasminum Sambac From Djibouti, Fatou Abdoul-Latif, Prosper Edou, François Eba, Nabil Mohamed, Adwa Ali, Samatar Djama, Louis-Clément Obame, Mamoudou Hama Dicko
Pr. Mamoudou H. DICKO, PhD
The essential oil of jasminum sambac from Djibouti was subjected to screening for their possible antioxidant activity by two complementary test systems, namely DPPH free radical scavenging and beta-carotene-linoleic acid assays. Butylated hydroxytoluene (BHT) was used as positive control in both test systems. In the DPPH test system, the IC50 value of essential oil and methanol extract were respectively 7.43 and 2.30 μg/ml. In the beta-carotene-linoleic acid system, oxidation was effectively inhibited by Jasminum sambac, the RAA value of essential oil and methanol extract were respectively 96.6 and 93.9%. When compared to BHT, the essential oil and methanol extract had …
Dynamic Failure Properties Of The Porcine Medial Collateral Ligament-Bone Complex For Predicting Injury In Automotive Collisions., Kristen Billiar, Louis Peck, Malcolm Ray
Dynamic Failure Properties Of The Porcine Medial Collateral Ligament-Bone Complex For Predicting Injury In Automotive Collisions., Kristen Billiar, Louis Peck, Malcolm Ray
Kristen L. Billiar
The goal of this study was to model the dynamic failure properties of ligaments and their attachment sites to facilitate the development of more realistic dynamic finite element models of the human lower extremities for use in automotive collision simulations. Porcine medial collateral ligaments were chosen as a test model due to their similarities in size and geometry with human ligaments. Each porcine medial collateral ligament-bone complex (n = 12) was held in a custom test fixture placed in a drop tower to apply an axial impulsive impact load, applying strain rates ranging from 0.005 s(-1) to 145 s(-1). The …
Quantitative Assessment Of Sample Stiffness And Sliding Friction From Force Curves In Atomic Force Microscopy, Nancy Burnham, Jon Pratt, Gordon Shaw, Lee Kumanchik
Quantitative Assessment Of Sample Stiffness And Sliding Friction From Force Curves In Atomic Force Microscopy, Nancy Burnham, Jon Pratt, Gordon Shaw, Lee Kumanchik
Nancy A. Burnham
It has long been recognized that the angular deflection of an atomic force microscope(AFM) cantilever under “normal” loading conditions can be profoundly influenced by the friction between the tip and the surface. It is shown here that a remarkably quantifiable hysteresis occurs in the slope of loading curves whenever the normal flexural stiffness of the AFM cantilever is greater than that of the sample. This situation arises naturally in cantilever-on-cantilever calibration, but also when trying to measure the stiffness of nanomechanical devices or test structures, or when probing any type of surface or structure that is much more compliant along …
Cuda Implementation Of A Navier-Stokes Solver On Multi-Gpu Desktop Platforms For Incompressible Flows, Julien C. Thibault, Inanc Senocak
Cuda Implementation Of A Navier-Stokes Solver On Multi-Gpu Desktop Platforms For Incompressible Flows, Julien C. Thibault, Inanc Senocak
Inanc Senocak
Graphics processor units (GPU) that are traditionally designed for graphics rendering have emerged as massively-parallel "co-processors" to the central processing unit (CPU). Small-footprint desktop supercomputers with hundreds of cores that can deliver teraflops peak performance at the price of conventional workstations have been realized. A computational fluid dynamics (CFD) simulation capability with rapid computational turnaround time has the potential to transform engineering analysis and design optimization procedures. We describe the implementation of a Navier-Stokes solver for incompressible fluid flow using desktop platforms equipped with multi-GPUs. Specifically, NVIDIA’s Compute Unified Device Architecture (CUDA) programming model is used to implement the discretized …
Stochastic Event Reconstruction Of Atmospheric Contaminant Dispersion Using Bayesian Inference, Inanc Senocak, Nicolas W. Hengartner, Margaret B. Short, W. Brent Daniel
Stochastic Event Reconstruction Of Atmospheric Contaminant Dispersion Using Bayesian Inference, Inanc Senocak, Nicolas W. Hengartner, Margaret B. Short, W. Brent Daniel
Inanc Senocak
Environmental sensors have been deployed in various cities for early detection of contaminant releases into the atmosphere. Event reconstruction and improved dispersion modeling capabilities are needed to estimate the extent of contamination, which is required to implement effective strategies in emergency management. To this end, a stochastic event reconstruction capability that can process information from an environmental sensor network is developed. A probability model is proposed to take into account both zero and non-zero concentration measurements that can be available from a sensor network because of a sensor’s specified limit of detection. The inference is based on the Bayesian paradigm …
Optimization And Economic Evaluation Of Industrial Gas Production, Yasar Demirel, A. Kumar, D.D. Jones, M.A. Hanna
Optimization And Economic Evaluation Of Industrial Gas Production, Yasar Demirel, A. Kumar, D.D. Jones, M.A. Hanna
YASAR DEMIREL
Thermochemical gasification is one of the most promising technologies for converting biomass into power, fuels and chemicals. The objectives of this study were to maximize the net energy efficiency for biomass gasification, and to estimate the cost of producing industrial gas and combined heat and power (CHP) at a feedrate of 2000 kg/h. Aspen Plus-based model for gasification was combined with a CHP generation model, and optimized using corn stover and dried distillers grains with solubles (DDGS) as the biomass feedstocks. The cold gas efficiencies for gas production were 57% and 52%, respectively, for corn stover and DDGS. The selling …
A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale
A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale
Edward Yu
The focus of this review is on the relationships between autoimmune diseases and cancer from two closely related perspectives: 1.Those autoimmune diseases which are often associated with malignancies. 2.Those prevalent cancers which may increase the risks of developing autoimmune disorders. The review concludes with a brief discussion of some selected innovative approaches to cancer immunotherapy.