Partial Differential Equations Commons^™

Proof-Of-Concept For Converging Beam Small Animal Irradiator, Benjamin Insley

Dissertations and Theses (Open Access)

The Monte Carlo particle simulator TOPAS, the multiphysics solver COMSOL., and

several analytical radiation transport methods were employed to perform an in-depth proof-ofconcept

for a high dose rate, high precision converging beam small animal irradiation platform.

In the first aim of this work, a novel carbon nanotube-based compact X-ray tube optimized for

high output and high directionality was designed and characterized. In the second aim, an

optimization algorithm was developed to customize a collimator geometry for this unique Xray

source to simultaneously maximize the irradiator’s intensity and precision. Then, a full

converging beam irradiator apparatus was fit with a multitude …

Domain Decomposition Methods For Fluid-Structure Interaction Problems Involving Elastic, Porous, Or Poroelastic Structures, Hemanta Kunwar

All Dissertations

We introduce two global-in-time domain decomposition methods, namely the Steklov-Poincare method and Schwarz waveform relaxation (SWR) method using Robin transmission conditions (or the Robin method), for solving fluid-structure interaction systems involving elastic, porous, or poroelastic structure. These methods allow us to formulate the coupled system as a space-time interface problem and apply iterative algorithms directly to the evolutionary problem. Each time-dependent fluid and the structure subdomain problem is solved independently, which enables the use of different time discretization schemes and time step sizes in the subsystems. This leads to an efficient way of simulating time-dependent multiphysics phenomena. For the fluid-porous …

Bioheat Equation Analysis, Johnathan Makar

Mathematics Student Work

In our research, we are investigating Pennes Bioheat equation, which is used for simulating the propagation of heat energy in human tissues. This equation was proposed by Pennes in 1948 based on his experiments of measuring the radial temperature distribution in the forearm of nine subjects. Pennes' equation provides the theoretical basis for studying heat transfer in perfused tissue and has been widely studied since then. However, Pennes' equation has been criticized for various reasons, including the fact that his experimental data did not seem to match the model. One of the objectives of our work is to find the …

An Augmented Matched Interface And Boundary (Amib) Method For Solving Problems On Irregular 2d Domains, Benjamin Pentecost

Mathematics Student Work

A new method called Augmented Matched Interface and Boundary (AMIB) has been developed to solve partial differential equation models, such as the heat equation, over irregular two-dimensional domains. The original AMIB method features unique numerical treatments to solve problems with various boundary conditions and shapes, resulting in highly accurate and efficient numerical solutions. However, recent numerical experiments have revealed that the original AMIB method can fail when dealing with sharply curved boundaries. To address this issue, new numerical techniques have been introduced in our latest work to enhance the robustness of the AMIB method. These techniques have been numerically verified …

Predicting Biomolecular Properties And Interactions Using Numerical, Statistical And Machine Learning Methods, Elyssa Sliheet

Mathematics Theses and Dissertations

We investigate machine learning and electrostatic methods to predict biophysical properties of proteins, such as solvation energy and protein ligand binding affinity, for the purpose of drug discovery/development. We focus on the Poisson-Boltzmann model and various high performance computing considerations such as parallelization schemes.

Tools For Biomolecular Modeling And Simulation, Xin Yang

Mathematics Theses and Dissertations

Electrostatic interactions play a pivotal role in understanding biomolecular systems, influencing their structural stability and functional dynamics. The Poisson-Boltzmann (PB) equation, a prevalent implicit solvent model that treats the solvent as a continuum while describes the mobile ions using the Boltzmann distribution, has become a standard tool for detailed investigations into biomolecular electrostatics. There are two primary methodologies: grid-based finite difference or finite element methods and body-fitted boundary element methods. This dissertation focuses on developing fast and accurate PB solvers, leveraging both methodologies, to meet diverse scientific needs and overcome various obstacles in the field.

Generation, Dynamics, And Interaction Of Quartic Solitary Waves In Nonlinear Laser Systems, Sabrina Hetzel

Mathematics Theses and Dissertations

Solitons are self-reinforcing localized wave packets that have remarkable stability features that arise from the balanced competition of nonlinear and dispersive effects in the medium. Traditionally, the dominant order of dispersion has been the lowest (second), however in recent years, experimental and theoretical research has shown that high, even order dispersion may lead to novel applications. Here, the focus is on investigating the interplay of dominant quartic (fourth-order) dispersion and the self-phase modulation due to the nonlinear Kerr effect in laser systems. One big factor to consider for experimentalists working in laser systems is the effect of noise on the …

Effects Of Magnetic Field And Chemical Reaction On A Time Dependent Casson Fluid Flow, Akhil Mittal, Harshad Patel, Ramesh Patoliya, Vimalkumar Gohil

Applications and Applied Mathematics: An International Journal (AAM)

This research paper deals with the effect of chemical reactions and magnetic fields on the hydrodynamics fluid flow of Casson fluid. The novelty of this work is the inclusion of time-dependent flow across a vertical plate with a stepped concentration at the surface in a porous media. The stated phenomenon is modeled in the PDE system and is adapted in the ODE system through similarity transformation. The LT (Laplace Transform) and ILT (Inverse LT) are used to obtain the analytical results for regulating dimension-free movement, thermals, and concentration expression. The exact expression of shear rate, heat exchange rate, and mass …

Total Variation Flow In R^N Dimensions With Examples Relating To Perimeters Of Level Sets, Luis Schneegans, Victoria Shumakovich

Undergraduate Research Symposium

In this project, we explore radial solutions to the Total Variation Flow (TVF) equation with the help of the Sign Fast Diffusion Equation (SFDE) and prior results in the 1-dimensional case. Specifically for radial solutions, we derive equations and explicit solutions relating to the n-dimensional case. Lastly, we look at how level sets and (time) profiles change.

Using A Sand Tank Groundwater Model To Investigate A Groundwater Flow Model, Christopher Evrard, Callie Johnson, Michael A. Karls, Nicole Regnier

CODEE Journal

A Sand Tank Groundwater Model is a tabletop physical model constructed of plexiglass and filled with sand that is typically used to illustrate how groundwater water flows through an aquifer, how water wells work, and the effects of contaminants introduced into an aquifer. Mathematically groundwater flow through an aquifer can be modeled with the heat equation. We will show how a Sand Tank Groundwater Model can be used to simulate groundwater flow through an aquifer with a no flow boundary condition.

Optimal Control Frameworks For A Class Of Epidemiological And Oncological Models, Asma Ali H Alghamdi

Mathematics Dissertations - Archive

In this thesis, we employ optimal control frameworks in two distinct contexts: Human immunodeficiency virus (HIV) and esophageal cancer. For HIV, we introduce a comprehensive data-driven nonlinear optimization framework designed for personalized therapies. This framework utilizes a deterministic in-host nonlinear ordinary differential equation (ODE) model and formulates two optimization problems using individual patient data. The first problem focuses on estimating patient-specific parameters through constrained optimization, while the second problem determines optimal combination therapies to reduce viral load to undetectable levels. Several numerical experiments suggest that our framework can provide a robust and effective optimal dosages with lower toxicity levels to …

Exploring Sigmoidal Bounded Confidence Models With Mean Field Methods, Tian Dong

HMC Senior Theses

Mathematicians use models of opinion dynamics to describe how opinions in a group of people change over time, which can yield insight into mechanisms behind phenomena like polarization and consensus. In these models, mathematicians represent the community as a graph, where nodes represent agents and edges represent possible interactions. Opinion updates are modeled with a system of differential equations (ODEs). Our work focuses on the sigmoidal bounded confidence model (SBCM), where agents update their opinion toward a weighted average of their neighbors' opinions by weighting similar opinions more heavily. Using tools developed in physics (mean-field theory), we derive a continuity …

Integrable Evolution Equations, Ramesh C. Sharma

Mathematics Dissertations - Archive

Integrable evolution equations are certain nonlinear partial differential equations or semidiscrete nonlinear difference equations that are used to model wave propagation in various media. The goal of this thesis is to present the derivation of integrable evolution equations in a way accessible to nonexperts in the field of integrable systems and to illustrate those derivations by various explicit examples. In the case of nonlinear partial differential equations, both the spacial variable x and temporal variable t are continuous independent variables. In the case of semidiscrete nonlinear difference equations, the spacial variable n is a discrete independent variable and the temporal …

Simulation Of Wave Propagation In Granular Particles Using A Discrete Element Model, Syed Tahmid Hussan

College of Graduate Studies: Theses & Dissertations

The understanding of Bender Element mechanism and utilization of Particle Flow Code (PFC) to simulate the seismic wave behavior is important to test the dynamic behavior of soil particles. Both discrete and finite element methods can be used to simulate wave behavior. However, Discrete Element Method (DEM) is mostly suitable, as the micro scaled soil particle cannot be fully considered as continuous specimen like a piece of rod or aluminum. Recently DEM has been widely used to study mechanical properties of soils at particle level considering the particles as balls. This study represents a comparative analysis of Voigt and Best …

Multiscale Modelling Of Brain Networks And The Analysis Of Dynamic Processes In Neurodegenerative Disorders, Hina Shaheen

Theses and Dissertations (Comprehensive)

The complex nature of the human brain, with its intricate organic structure and multiscale spatio-temporal characteristics ranging from synapses to the entire brain, presents a major obstacle in brain modelling. Capturing this complexity poses a significant challenge for researchers. The complex interplay of coupled multiphysics and biochemical activities within this intricate system shapes the brain's capacity, functioning within a structure-function relationship that necessitates a specific mathematical framework. Advanced mathematical modelling approaches that incorporate the coupling of brain networks and the analysis of dynamic processes are essential for advancing therapeutic strategies aimed at treating neurodegenerative diseases (NDDs), which afflict millions of …

Last Passage Time And Excursion Theory For Solvable Diffusions With Applications In Mathematical Finance, Yaode Sui

Theses and Dissertations (Comprehensive)

In this dissertation, we investigate the properties of last passage times and excursion theory in one-dimensional solvable diffusions, emphasizing their applications in financial modeling, particularly in option pricing. We derive closed-form formulas for the marginal distribution of last passage times and their joint distribution with process values, including the maximum and minimum of the process value. The focus is on time-homogeneous diffusions with various boundaries and imposed killing. Employing spectral expansion theory, we derive explicit formulas for distributions of last passage times in common processes such as Drifted Brownian Motion (BM), Squared Bessel (SQB), Ornstein-Uhlenbeck (OU), and Cox-Ingersoll-Ross (CIR) models. …

Analysis And Detection Of Cyber Attacks In Multi Vehicle Systems Using Macroscopic Models, Abhishek Kashyap

Mechanical and Aerospace Engineering Dissertations - Archive

The study of potential cyber-attacks in different domains is an active area of research. Given that systems are becoming more and more interconnected, cyber physical systems that operate infrastructure and/or plants can make these assets more vulnerable and open to different attack vectors. The primary focus of this research is the modeling, analysis and detection of cyber-attacks on platoons of autonomous cars and swarms of UAVs. In this work, we consider scenarios wherein an attacker may hack into a subset of vehicles in a multi-vehicle system and make subtle modifications in their parameters. Due to the interconnected nature of the …

Uniform Regularity Estimates For The Stokes System In Perforated Domains, Jamison R. Wallace

Theses and Dissertations--Mathematics

We consider the Stokes equations in an unbounded domain $\omega_{\epsilon,\eta}$ perforated by small obstacles, where $\epsilon$ represents the minimal distance between obstacles and $\eta$ is the ratio between the obstacle size and $\epsilon$. We are able to obtain uniform $W^{1,q}$ estimates for solutions to the Stokes equations in such domains with bounding constants depending explicitly on $\epsilon$ and $\eta$.

Advancements In Elliptic Mesh Redistribution And Automated Overset Grid Generation For Computational Fluid Dynamics, Chase Ashby

Theses and Dissertations--Mathematics

Automated and robust structured curvilinear overset grid generation remains a significant challenge for the application of computational fluid dynamics. This thesis intro- duces a specialized anisotropic Mach cone aligned adaptation algorithm for low-boom simulations and an automated procedure for generating structured curvilinear overset grids for immersed boundary simulations. Results demonstrate that anisotropic mesh adaptation can reduce computational resource usage by over 50% while maintaining sonic boom prediction accuracy across the entire sonic boom domain compared to user-constructed Mach cone aligned grids. The proposed immersed overset grid gen- eration procedure eliminates the need for complex surface generation algorithms, producing grids suitable …

A Class Of Game-Theoretic And Fokker-Planck Optimal Control Frameworks In Colon And Esophageal Cancer, Mesfer Alajmi Phd

Mathematics Dissertations - Archive

In this dissertation, we first present a new stochastic framework for parameter estimation and uncertainty quantification in colon cancer-induced immune responses. A stochastic process that captures the system's inherent randomness determines the dynamics of colon cancer. The stochastic framework is based on the Fokker-Planck equation, which represents the evolution of the probability density function corresponding to the stochastic process. We formulate an optimization problem that takes individual patient data with randomness present and solves it to obtain the unknown parameters corresponding to the individual tumor characteristics. Furthermore, we perform a sensitivity analysis of the optimal parameter set to identify the …