Applied Mathematics Commons^™

Estimating Per-Infection Cost And Burden For Dengue And Zika As A Function Of Antibody-Dependent Enhancement, Christopher M. Kribs

Mathematics Faculty Publications - Archive

The complex immune interactions produced by the tetravalent dengue vaccine Dengvaxia have foregrounded the important role of antibody-dependent enhancement (ADE) in dengue infection. Some evidence exists that ADE may extend beyond the four dengue serotypes to Zika, a closely related flavivirus transmitted by the same mosquito species as dengue, and may also account for the increased severity of some cases. Estimates of the public health impact of dengue vaccination may then need to include its effects on the transmission of Zika in addition to dengue. This study gathers primary references to build estimates of per-case economic cost and disease burden …

Optimizing Decision-Making In A Cerebral Palsy Model Using Reinforcement Learning, Richard Ampah

Pitzer Senior Theses

This study presents an original interdisciplinary investigation into how reinforcement learning (RL) can model motor and cognitive defects and potentially improve motor and cognitive functions in individuals with cerebral palsy (CP), a non-progressive neurological disorder that impairs movement and adaptability. Integrating computational neuroscience and machine learning, the research applies policy gradient methods and Markov Decision Processes (MDPs) to simulate adaptive learning in agents with and without CP-related constraints.

The central aim is to compare the cumulative rewards of optimal policies, derived from value iteration, and human-like learning policies using the REINFORCE algorithm, both with and without the Bellman baseline. The …

The Anatomy Of A Reconstruction: From Fourier Space To Image Recovery In Computed Tomography, Charlotte P. Maurer

Honors Theses

This thesis develops the mathematical foundations of computed tomography (CT) reconstruction through the lens of harmonic analysis. Beginning with the Schwartz class, we introduce the Fourier transform and its role in expressing the Radon transform and its inversion via a fractional Laplacian. After constructing the Radon transform in general dimension R^d, we specialize to the cases d = 2 and d = 3, demonstrating explicit inversion formulas and the associated instability in lower dimensions. For its computational advantages, we study filtered back-projection using classical low-pass filters (Ram-Lak, Shepp–Logan, Cosine, Gaussian) and formulate a discrete reconstruction algorithm grounded in …

Wave Reflections In A Biophysically Detailed Model Of Cardiac Tissue, Grace Moberg

Honors Theses

Regular heart rhythms are governed by the coordinated spread of action potentials through cardiac tissue. The interaction of an action potential with a tissue heterogeneity may lead to a reflection, where both a retrograde and an anterograde wave propagate off of the initial impulse. Reflections have been experimentally linked to cardiac arrhythmias, but their mechanisms of generation are not well-understood. Mathematically, reflections in phenomenological models of cardiac tissue have been linked to an unstable periodic orbit. These models typically sacrifice detail about the variety of ionic currents and processes involved in action potential propagation in favor of mathematical simplicity. Biophysically …

Estimating Pedestrian Crossing Times At Scramble Crossings Via Machine Learning And Agent-Based Modeling, Sho Takami

CURE Proceedings

Scramble crosswalks differ from conventional crosswalks in their ability for pedestrians to cross diagonally. This research compares the average crossing times and investigates the walking behaviors that pedestrians adopt to produce the speediest times in the two crosswalk configurations. Identification of the most efficient set of walking behaviors is done through an agent-based model, whereas producing polynomials relating crossing times to the most prominent walking behaviors is done through regression algorithms in machine learning. With the combination of these two approaches, it is revealed that pedestrians must adopt a relaxed walking style to make each crosswalk configuration efficient. Additionally, between …

Integrating Sentiment Analysis In Predictive Models: A Comparative Study On Game Popularity On Steam, Khaleefa Alhemeiri

CMC Senior Theses

Over the past decades, the gaming industry has managed to evolve into a multi-billion-dollar enterprise. Gaming platforms such as Steam foster unprecedented amounts of engagement among players worldwide daily. In this thesis, we investigate the effect of incorporating sentiment-driven metrics, specifically YouTube view counts and positive reviews, into predictive models for game popularity. In addition, by comparing our linear regression sentiment-based approach to the Bayesian hierarchical folded normal model used by De Luisa et al. (2021), we can understand the many differences, strengths, and limitations of each methodology. In our thesis, we focus on three games. Each is of varying …

Forecasting Equity Betas Using Option-Implied Moments, Ivan Kolesnikov

CMC Senior Theses

Traditional beta estimates are constructed from historical stock‑and‑market returns and therefore adjust only as fast as realized data accrue. This thesis investigates whether the forward‑looking information embedded in equity‑option prices can enhance beta forecasts. Using near‑end‑of‑day quotes for 236 S&P 500 firms between 2007 and 2024, I extract risk‑neutral variance and skewness, construct five alternative beta estimators (historical, option‑implied, and three hybrids), and evaluate them against realized betas over six‑, twelve‑, and twenty‑four‑month windows. Rolling‑OLS beta remains the most accurate benchmark at short horizons, yet option‑implied moments add economically and statistically significant value when systematic exposure is expected to change …

Suntan (And Other Solar Trigonometric Functions): Solutions For Fermi Questions: February 2025, John Adam

Mathematics & Statistics Faculty Publications

The article discusses the intensity of sunlight on the side of the author's face as they walk to and from their office, focusing on the solar zenith angle θ. It presents a formula for solar irradiance and explores how the intensity changes based on the angle and elevation. The solutions to the questions posed in the article provide insights into the maximum irradiance levels at different angles and elevations.

The Presence Of Outer Giant Planets And Their Role In Inner Planet Formation With And Without Their Influence, Mateo E. Guerra Toro

Graduate Theses/Dissertations

We performed dynamical simulations of the giant impact phase of planet formation to investigate the formation of inner terrestrial planets under the influence of 4 solar system-like outer giant planets. We developed a new code using the N-body simulation suite REBOUND and REBOUNDx (Rein et al. (2019) and Tamayo et al. (2019)) to simulate 2 stages of planetary formation: a residual gaseous protoplanetary disk phase and subsequent dynamical evolution after the disk photoevaporates. The initial conditions for the inner planetary embryos were taken by Morrison et al. (2020) based on a range of solid surface densities that produced Super-Earth terrestrial …

Mathematical Modeling Of Cancer Tumor Evolution, Belgacem Al-Azem

CGU Theses & Dissertations

Several mathematical models of cancer tumor evolution are presented. The aim of this endeavor is to write a thesis that fosters numerical and analytical understanding of certain mathematical models in the area of oncology as well as to offer potential predictive tools of therapeutic and clinical applicability. In this work, we give a panoramic view of the cancer phenotype, for to understand cancer, we need to "see" its biophysics. Indeed, the discovery of oncogenes led to the thinking that cancer tumor is perhaps a genetic disease. But the role of angiogenesis and other microenvironment-related discoveries (such as the role of …

Comprehensive Benchmarking Of Several Machine Learning And Bayesian Models For Early-Stage Diabetes Risk Prediction: A Large-Scale Comparative Study, Md. Iqbal Hossain, Najila Alam Porno

Mathematics & Statistics Faculty Publications

Diabetes remains a critical global health challenge, with early detection is crucial for effective management. This study presents a comprehensive benchmarking analysis of 14 diverse machine learning and Bayesian models for early-stage diabetes risk prediction using clinical data [2] from Sylhet, Bangladesh. This research evaluated traditional methods (Logistic Regression, Decision Trees), ensemble techniques (Random Forest, XGBoost, LightGBM), Bayesian approaches (BART, Bayesian Logistic Regression), and advanced neural architectures (Deep Belief Networks) using both 70-30 train-test splits and 10-fold cross-validation. The results demonstrate that ensemble methods consistently outperformed other approaches, with Random Forest(RF) achieving the highest cross-validated AUC (0.9951) and accuracy (0.9699). …

Suntan (And Other Solar Tigonometric Functions), John Adam

Mathematics & Statistics Faculty Publications

Question 1: If I₀ is the solar irradiance (power per unit area, W/m²) reaching my head, express the intensity on the side of my face (I_s) in terms of θ. Assume for now that the irradiance is independent of path length through the atmosphere and that my face is normal to the direction θ = 90°.

Using the 1962 U.S. Standard Atmosphere,² Hottel (1976)³ expressed the solar irradiance using the formula

I = I₀(a₀ + a₁e^{−k sec θ}), where A is the elevation in kilometers and

a₀ = 0.4237 − 0.00821(6 − A)²; a₁ = 0.5055 …

Golden Spirals Everywhere?, John Adam

Mathematics & Statistics Faculty Publications

The article explores different types of spirals, including Archimedean, hyperbolic, and logarithmic spirals, with a focus on the golden ratio and golden spirals. It discusses the misconception that golden rectangles and spirals can be found in various natural and man-made objects, emphasizing the importance of understanding the properties of logarithmic spirals. The text provides mathematical equations for logarithmic spirals and poses questions for readers to explore the concept further. The author, John Adam, invites readers to engage in Fermi Questions and submit ideas for consideration.

Regularized Methods For Tensor Recovery And Processing, Katherine J. Henneberger

Theses and Dissertations--Mathematics

The rapid growth of high-dimensional data has exposed the limitations of traditional vector and matrix-based methods for data analysis. These methods often struggle with computational inefficiencies, loss of critical cross-dimensional correlations, and challenges inherent in high-dimensional data. Tensors—multidimensional arrays—offer a robust framework for modeling and analyzing complex data. Tensor methods have proven valuable in tasks such as dimensionality reduction, feature extraction, and data compression, underpinning advancements in machine learning, computer vision, signal processing, and remote sensing.

This thesis focuses on two challenges in tensor analysis: tensor recovery and tensor processing. Tensor recovery addresses the reconstruction of incomplete or corrupted tensors. …

Novel Generative And Language Model Architectures With Applications, Edison Mucllari

Theses and Dissertations--Mathematics

This dissertation investigates novel architectures to address fundamental challenges in machine learning, particularly focusing on transformer models, recurrent neural networks, GAN and continual learning and their applications in natural language processing and computer vision. We propose the Neumann-Cayley Gated Recurrent Unit (NC-GRU), which leverages a Neumann series-based Scaled Cayley transformation to maintain orthogonal weight matrices, effectively mitigating exploding gradients problems while improving long-term memory retention across prediction tasks. We demonstrate the practical applications of NC-GRU by implementing our proposed architecture into an autoencoder to derive neural molecular fingerprints. Building upon these advancements, we turn our attention to the transformer architecture, …

Weathering And Beyond: Leveraging Mathematical Modeling To Simulate Erosion In Digital Media, Fiona Irving-Beck

Scripps Senior Theses

How might we bring an idea to life from both a mathematical and an artistic perspective? Within Weathering, I use imagery of environmental erosion to explore the differences between physical and digital forms of representation. I created a physical painting of an abandoned copper mine, digitized the work, and then used a mathematical model to digitally “erode” it, which I re-translated into paintings. While the explicit texture present in physical work speaks best to my practice/intent, the mathematical framework that is the basis for my digital work affords a powerful mode of temporal flexibility. Used in conjunction, these two …

Bound Preserving Discontinuous Galerkin Methods For Euler Equations And Nonequilibrium Flows, Fangyao Zhu

Dissertations, Master's Theses and Master's Reports

This dissertation is composed of four chapters in which we will closely examine the high order bound preserving discontinuous Galerkin methods for solving partial differential equations, specifically non-equilibrium chemical reacting flows and Euler equations under gravitational fields. A shared requirement between the two is the necessity for positive values of both density and pressure. Due to this physical nature of the two systems, constructing a positivity preserving scheme become very essential in our research.

For non-equilibrium flows where multi-reactions and multi-species are involved, we are also required to keep the bounds of the mass fraction of each species in between …

Theory And Applications Surrounding Markov Chains, Joseph J. Quisito Jr., Gallean Brown, Elijah Yoder

Capstone Showcase

This capstone project explores the Markov Chain – a mathematical model used to describe systems that transition between states based on probabilities. It begins by introducing the fundamental concepts, including transition matrices, state classifications, and stationary distributions. The paper then applies Markov Chain theory to real-world scenarios, such as simulating Snakes and Ladders games, predicting soccer match outcomes for Manchester United, and generating texts from movie lines. Finally, it discusses key findings, challenges, and potential areas for future research in the field.

A Mathematical Modeling Approach To Investigate The Impacts Of Post-Infection Mortality And Partial Immunity On Disease Endemicity, Brendan M. Shrader

Honors Undergraduate Theses

A number of infectious diseases cause post-infection conditions or complications, such as COVID- 19, Q fever, and Polio. These conditions result in recovered individuals having a higher mortality rate than susceptibles, and this can impact disease dynamics. An existing mass-action model in the literature that incorporated post-infection mortality was shown to have limit cycles, or persistent oscillations, in the infected population. To better understand what causes these limit cycles, we develop and analyze a new epidemiological model with standard incidence. We show standard results, including the existence, uniqueness, and stability of the disease-free and endemic equilibria, and we rule out …

Time-Marching Quantum Algorithm For Simulation Of Nonlinear Lorenz Dynamics, Efstratios Koukoutsis, George Vahala, Min Soe, Kyriakos Hizanidis, Linda Vahala, Abhay K. Ram

Electrical & Computer Engineering Faculty Publications

Simulating nonlinear classical dynamics on a quantum computer is an inherently challenging task due to the linear operator formulation of quantum mechanics. In this work, we provide a systematic approach to alleviate this difficulty by developing an explicit quantum algorithm that implements the time evolution of a second-order time-discretized version of the Lorenz model. The Lorenz model is a celebrated system of nonlinear ordinary differential equations that has been extensively studied in the contexts of climate science, fluid dynamics, and chaos theory. Our algorithm possesses a recursive structure and requires only a linear number of copies of the initial state …